Personal profile
My research in a nutshell
I am an analytical chemist and biomedical scientist, using bioanalytical innovations to measure small molecules in a clinical and biological setting. With particular interest in quantitative steroid measurement to investigate the role of glucocorticoids, progesterones, estrogens, and androgens in humans, translating across to pre-clinical, avian and veterinary studies. I am also involved in investigations into other small molecule measurements including drugs, other lipid like molecules and metabolites of endogenous and exogenous molecules.
I have run the Mass Spectrometry Core, part of the Edinburgh Clinical Research Facility developing targeted and untargeted methodologies in LC-MS, GC-MS and mass spectrometry imaging, for over two decades. With this experience working in a technology-driven core facility I am interested in how best to support the careers of those working in core facilities, underpinned by the Technician Commitment and aiming to improve research culture.
Collaborative Activity
Collaborators outside of University of Edinburgh include
Collaborative Activity
Dr Bidesh Mahata | Department of Pathology
Lisa Nolan | King's College London
Prof Susan Healy - School of Biology
Professor Alexandra Johnstone | The University of Aberdeen
Gro Dehli Andersen - Norwegian Institute of Public Health
Katri Räikkönen - University of Helsinki
Marius Lahti-Pulkkinen - University of Helsinki
Education/Academic qualification
Chemistry, Doctor of Science, Erythrocyte Oxidative Stress; Focus on Hormone Replacement Therapy, University of Strathclyde
1 Sept 1998 → 1 Jul 2002
Award Date: 20 Jan 2003
External positions
Scotland Representative, Policy Advisory Panel, Biochemical Society
1 Jan 2024 → …
Vice Treasurer, Core Technologies for Life Sciences
5 Jan 2023 → …
Treasurer, Scottish Metabolomics Network
1 Aug 2022 → …
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Collaborations and top research areas from the last five years
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Cortisol-resistant CAR-NK cells overcome steroid-induced immunosuppression in lung cancer
Chakraborty, S., Pramanik, J., Alviter-Raymundo, G., Ward, C. J., Shaji, S. K., Yamashita-Kanemaru, Y., Ali, F. A. Z., Banik, D., Zhang, Z., Veiga-Villauriz, C., Homer, N. Z. M., Simpson, J., Laforest, S., Tong, S., Zhao, Q., Roy, J., Iqbal, M., Morris, A. C., Chapman, M. A. & Roychoudhuri, R. & 4 others, , 9 Apr 2026, In: Signal Transduction and Targeted Therapy. 11, 128.Research output: Contribution to journal › Article › peer-review
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Maternal prenatal depression and anxiety and steroid hormones in amniotic fluid
Seikku, T., Lahti-Pulkkinen, M., Girchenko, P., Salo, V., Heinonen, K., Tukiainen, T., Phelan, E., Billen, M., Simpson, J. P., Reynolds, R. M., Homer, N. Z. M. & Räikkönen, K., 1 Apr 2026, In: Psychoneuroendocrinology. 186, p. 107758Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Abcc1 deficiency protects from corticosterone but not cortisol-induced adiposity and insulin resistance in a sex-specific manner
Paul, M. A., Nagy, B., Laforest, S., Simpson, J. P., Mungall, W., Homer, N. Z. M., Semple, R. K., Andrew, R., Stimson, R. H. & Nixon, M., 4 Mar 2026, (E-pub ahead of print) In: The Journal of Physiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Localisation of corticosteroids in male mouse kidney by mass spectrometry imaging
Stasinopoulos, I., Khan, S., Melhem, S., Roumain, M., Cobice, D. F., Homer, N. Z. M., Mackay, C. L., Brown, R. W., Bailey, M. A. & Andrew, R., 20 Feb 2026, In: Journal of molecular endocrinology. 76, 2, e250099.Research output: Contribution to journal › Article › peer-review
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Pharmacological inhibition of hydroxysteroid 11-beta dehydrogenase type 1 (11-βHSD1) after myocardial infarction preserves cardiac function in a translational mini-pig model
Al Disi, S., Ascione, R., Khan, S., Johnson, T., Sammut, E., Bruno, V. D., Baz Lopez, D., James, C.-A., Simpson, J., Homer, N. Z., Millar, M., Singh, T., von Kreigsheim, A., Mills, N. L., Walker, B. R., Andrew, R., Webster, S. P., Whittaker, A., Freeman, A. & Gray, G. A., 28 Dec 2025, (E-pub ahead of print) In: British Journal of Pharmacology.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Prizes
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Fellow Institute of Biomedical Sciences
Homer, N. (Recipient), 1 Oct 2023
Prize: Election to learned society
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Research Technical Professionals: Recognising Leadership & Expertise
Homer, N. (Principal Investigator), Cook, S. (Co-investigator) & Murphy, L. (Co-investigator)
1/05/25 → 30/06/26
Project: Research
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Delivering Knowledge, Skills and Opportunities to Research Technical Professionals (RTPs) Nationally Leveraging the UK Technology Specialist Network
Homer, N. (Principal Investigator), Johnston, S. (Co-investigator) & Murphy, L. (Co-investigator)
1/04/24 → 31/03/27
Project: Research
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The transition from a sexual to a parental brain via nest building
Meddle, S. (Principal Investigator), Andrew, R. (Co-investigator), Homer, N. (Co-investigator) & Homer, N. (Co-investigator)
Biotechnology and Biological Sciences Research Council
1/12/23 → 30/11/26
Project: Research
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Defining the molecular mechanisms underlying sex-differences in the maintenance of hearing
Homer, N. (Principal Investigator)
1/08/22 → 31/07/30
Project: Research
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Unravelling challenges to lifelong health by next generation Mass Spectrometry
Homer, N. (Principal Investigator), Andrew, R. (Co-investigator), Meddle, S. (Co-investigator), Morgan, R. (Co-investigator), Nixon, M. (Co-investigator), Reynolds, R. (Co-investigator), Stimson, R. (Co-investigator), Denham, S. (Researcher), Meddle, S. (Researcher) & Simpson, J. (Researcher)
Biotechnology and Biological Sciences Research Council
1/08/24 → 31/07/25
Project: Research
Datasets
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JCM-2373852 Caco-2-HepaRG Cell Culture Media Optimisation & LC-MSMS analysis of APAP metabolism during Caco-2 cell culture
Homer, N. (Creator) & Morgan, K. (Creator), Edinburgh DataShare, 9 Jun 2023
DOI: 10.7488/ds/7471
Dataset
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Development of a UPLC-MS/MS method for the simultaneous analysis of AT7519 and acetaminophen in a mouse model of acute inflammation
Rossi, A. (Creator), Simpson, J. (Creator), Cartwright, J. (Creator) & Homer, N. (Creator), Edinburgh DataShare, 19 May 2023
DOI: 10.7488/ds/7453
Dataset
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Analysis of AT7519 and acetaminophen in a mouse model of acute inflammation by LC-MS/MS
Homer, N. (Creator), Cartwright, J. (Creator), Rossi, A. (Creator) & Simpson, J. (Creator), Edinburgh DataShare, 27 Feb 2024
DOI: 10.7488/ds/7686
Dataset
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Data from: Higher insulin resistance & adiposity in post-menopausal women with breast cancer treated with aromatase inhibitors
Gibb, F. W. (Creator), Dixon, J. M. (Creator), Clarke, C. (Creator), Homer, N. Z. (Creator), Faqehi, A. M. M. (Creator), Andrew, R. (Creator) & Walker, B. R. (Creator), Dryad, 3 May 2019
DOI: 10.5061/dryad.2n054k4, https://datadryad.org/dataset/doi:10.5061/dryad.2n054k4
Dataset
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Dataset: Deletion of Hsd11b1 suppresses caloric-restriction-induced bone marrow adiposity in male but not female mice_v2024_05_07
Chapman, K. (Creator), Suchacki, K. (Creator), Cawthorn, W. (Creator), Lovdel, A. (Creator), Thomas, B. (Creator), Roberts, F. (Creator) & Homer, N. (Creator), Edinburgh DataShare, 8 May 2024
DOI: 10.7488/ds/7730
Dataset