Research output per year
Research output per year
PROF
Wellcome Trust and Royal Society Sir Henry Dale fellow
Nathalie Rochefort studied biology and epistemology at the University Paris-VII and the Ecole Normale Supérieure in Paris. She then obtained a European PhD in Neuroscience from the University Paris-VI and the Ruhr-Universität-Bochum in Germany. By using in vivo imaging methods in the cat and the mouse visual cortex, her work during her PhD and post-doctoral training has contributed to a new understanding of how visual information is processed in the intact brain. She joined the University of Edinburgh in 2013 to establish her research group and has been awarded a Sir Henry Dale Fellowship as well as a Marie Curie Career Integration grant.
Our research focuses on understanding how brain neuronal networks process visual information and how experience durably modifies the activity of these networks.
Centre for Discovery Brain Sciences
Edinburgh Neuroscience,
Simons Initiative for the Developing Brain (SIDB)
Team members
Lab alumni
Brain functions such as sensations and thoughts depend on the coordinated activity of neuronal networks. The aim of my research group is to reveal how neuronal networks integrate sensory information in order to create a representation of the outside world that is relevant for the animal’s behaviour. We are using the mouse primary visual cortex as a model system of cortical integration of sensory and non-sensory information.
Using such information, we apply the same approach to study how network activity is disrupted in the brain of mouse models for autistic spectrum disorders and intellectual disabilities.
https://www.ed.ac.uk/discovery-brain-sciences/our-staff/research-groups/nathalie-rochefort
Year 3
Neuroscience 3: Vision
Year 4:
Physiology 4
Honours elective:
Neural circuits for learning and memory
Sensory Physiology and Dysfunction
Synaptic Function and Plasticity in Health and Disease
Postgraduate (MsC):
MSc by Research Integrative Neuroscience
2018- Co-convenor of the Biomedical Sciences Opportunity Committee.
2015-2017 Member of the Centre for Integrative Physiology executive committee
2016-2017 Writing group for the application to the Athena Swan Award, Biomedical Sciences, University of Edinburgh.
2015-present Member of the Biomedical Sciences Opportunity Committee.
2015-present Organization of Women in Science round table discussions
We use the mouse primary visual cortex as a model system of cortical integration of sensory and non-sensory information. Neurons in the primary visual cortex respond to specific features of visual stimuli such as their location, their orientation and their direction of movement.
These visual responses do not only depend on the characteristics of the stimuli but are also strongly modulated by the context in which they are perceived, such as the animal’s behavioural state and its previous experience associated with these stimuli.
Locomotion, for example, increases the gain of visual responses in the primary visual cortex. Past experience can also durably modify visual cortical responses, for example through the association of a given stimulus with a positive or negative outcome.
By using two-photon calcium imaging combined with electrophysiological recordings in awake behaving mice, our current projects investigate:
1. How visually-guided behaviour modulates neuronal activity in the visual cortex
2. How individual pyramidal neurons integrate feed-forward visual inputs with contextual inputs
3. How cortical information processing is impacted by metabolic state
Using such information, we apply the same combination of methods to study how this network activity is disrupted in the brain of mouse models for autistic spectrum disorders and intellectual disabilities.
https://www.ed.ac.uk/discovery-brain-sciences/our-staff/research-groups/nathalie-rochefort
Research output: Working paper › Preprint
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
1/03/24 → 31/03/29
Project: Research
1/09/20 → 28/02/27
Project: Research
1/09/20 → 31/08/25
Project: Research
Rochefort, N. (Creator), Padamsey, Z. (Creator) & Katsanevaki, D. (Creator), Edinburgh DataShare, 30 Nov 2021
DOI: 10.7488/ds/3214, https://doi.org/10.1016/j.neuron.2021.10.024
Dataset
Rochefort, N. (Creator), Padamsey, Z. (Creator) & Francioni, V. (Creator), Edinburgh DataShare, 9 Apr 2021
DOI: 10.7488/ds/3013, https://elifesciences.org/articles/49145
Dataset
Rochefort, N. (Creator), Padamsey, Z. (Creator) & Katsanevaki, D. (Creator), Edinburgh DataShare, 8 Jul 2024
DOI: 10.7488/ds/7768, https://doi.org/10.7554/eLife.93052.1
Dataset
25/10/24
1 Media contribution
Press/Media: Research