Research output per year
Research output per year
PROF
2024: Leading researcher of the year: cognition and neurodevelopment, Women in Neuroscience UK.
2019: EMBO Young Investigator (YIP) award
2017: The Physiological Society’s 2017 R Jean Banister Prize Lecture
2013: Schilling Research Award of the German Neuroscience Society 2013
2011: Bernard Katz Lecture Award, Alexander von Humboldt Foundation
2006: Research prize from the French national association for the blind and visually-disabled people (FAF)
Nathalie Rochefort is a Professor of Visual Neuroscience at the University of Edinburgh, studying the neural basis of visual perception. As an undergraduate, she studied Biology and Epistemology in Paris. She then obtained a European PhD in Neuroscience from the University Paris-VI and the Ruhr-Universität-Bochum and did her post-doctoral training at the Technical University in Munich. Her work during her PhD and post-doctoral training has contributed to a new understanding of how neurons acquire their functional properties in the visual cortex. This work also led to the development of in vivo two-photon calcium imaging, a powerful technique now widely used by neuroscientists. Her research group focuses on how brain neuronal circuits process visual information, and how experience durably modifies the activity of these circuits in health and disease. She has won various honours and grants including the prestigious Bernard Katz Lecture Award, the Schilling Research Award (German Neuroscience Society), the Sir Henry Dale fellowship (Wellcome Trust and Royal Society), the EMBO Young Investigator award and the ERC Consolidator grant.
Centre for Discovery Brain Sciences
Edinburgh Neuroscience,
Simons Initiative for the Developing Brain (SIDB)
Team members
Lab alumni
Brain functions such as sensations and thoughts depend on the coordinated activity of neuronal networks. The aim of my research group is to reveal how neuronal networks integrate sensory information in order to create a representation of the outside world that is relevant for the animal’s behaviour. We are using the mouse primary visual cortex as a model system of cortical integration of sensory and non-sensory information.
Using such information, we apply the same approach to study how network activity is disrupted in the brain of mouse models for autistic spectrum disorders and intellectual disabilities.
Year 3
Neuroscience 3: Vision
Year 4:
Physiology 4
Honours elective:
Neural circuits for learning and memory
Sensory Physiology and Dysfunction
Synaptic Function and Plasticity in Health and Disease
Postgraduate (MsC):
MSc by Research Integrative Neuroscience
Appointments
External committees
2024- Wellcome Trust, Chair of the Brain and Behavioural Sciences committee, Early-Career Awards.
2024-25 Grant panel, vice-president, French national research agency (ANR)
2023- Member of the Data working group of ALBA Network (a global diverse network of neuroscientists who are committed to diversity, equity and inclusion)
2023- Member of Scientific Advisory Board of Circuit Photonics, Marseille, France.
2021-24 NIH Scientific Steering Group as part of the BRAIN Initiative
2020-24 International Grant Panel: Swiss National Science Foundation (SNSF), Division Biology and Medicine. Member of focus group to reflect on and change policies for National Grant Schemes in order to increase the proportion of under-represented groups in funded projects. This resulted in revised policies and new practice for monitoring changes.
2018-21 Member of the Scientific Publications committee of the Society For Neuroscience, USA (Journal of Neuroscience and eNeuro), (3-4 meetings/year).
2019-21 International Grant Panel: German Research Foundation, DFG Priority Programme
2018 International evaluation committee: High Council for Evaluation of Research and Higher Education (HCERES), France.
Internal, University of Edinburgh
2021- Member of the Simons Initiative for the Developing Brain (SIDB) Executive and Strategic board (with Prof. Peter Kind and Prof. Adrian Bird), Neuronal circuits expert.
2021 Facilitator to support the University Leadership and Management Programmes, 4 sessions/year.
2018- Co-convenor of the Biomedical Sciences Opportunity Committee, 3-4 meetings/year; promoting Equality and Diversity within Biomedical Sciences.
2015- Organization of Women in Science round table discussions (3-4 sessions/year)
2017-20 Recruitment panels for Graduate programs (reviews and interviews): Simons Initiative for Developing Brain (SIDB), Biomedical Sciences, Dementia Research Institute graduate program
2015-17 Member of the Centre for Integrative Physiology executive committee. Strategic decisions regarding funding, management and policies.
2016-17 Member of the writing group for the application to the Athena Swan Award, Biomedical Sciences, University of Edinburgh.
We use the mouse primary visual cortex as a model system of cortical integration of sensory and non-sensory information. Neurons in the primary visual cortex respond to specific features of visual stimuli such as their location, their orientation and their direction of movement.
These visual responses do not only depend on the characteristics of the stimuli but are also strongly modulated by the context in which they are perceived, such as the animal’s behavioural state and its previous experience associated with these stimuli.
Locomotion, for example, increases the gain of visual responses in the primary visual cortex. Past experience can also durably modify visual cortical responses, for example through the association of a given stimulus with a positive or negative outcome.
By using two-photon calcium imaging combined with electrophysiological recordings in awake behaving mice, our current projects investigate:
1. How visually-guided behaviour modulates neuronal activity in the visual cortex
2. How individual pyramidal neurons integrate feed-forward visual inputs with contextual inputs
3. How cortical information processing is impacted by metabolic state
Using such information, we apply the same combination of methods to study how this network activity is disrupted in the brain of mouse models for autistic spectrum disorders and intellectual disabilities.
Research output: Working paper › Preprint
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
Research output: Working paper › Preprint
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Porter, I. (Principal Investigator), Booker, S. (Co-investigator), Choudhury, M. (Co-investigator), Davies, J. (Co-investigator), Evans, M. (Co-investigator), Garcia Burgos, A. (Co-investigator), Muir, C. (Co-investigator), Ribeiro dos Louros, S. (Co-investigator), Rochefort, N. (Co-investigator), Surmeli, G. (Co-investigator), Theil, T. (Co-investigator), Wheeler, A. (Co-investigator) & Zoupi, L. (Co-investigator)
Biotechnology and Biological Sciences Research Council
1/08/25 → 31/07/26
Project: Research
Porter, I. (Principal Investigator), Garcia Burgos, A. (Co-investigator), Wheeler, A. (Co-investigator), Muir, C. (Co-investigator), Surmeli, G. (Co-investigator), Davies, J. (Co-investigator), Zoupi, L. (Co-investigator), Evans, M. (Co-investigator), Choudhury, M. (Co-investigator), Rochefort, N. (Co-investigator), Booker, S. (Co-investigator), Ribeiro dos Louros, S. (Co-investigator) & Theil, T. (Co-investigator)
1/08/25 → 31/07/26
Project: Research
Rochefort, N. (Principal Investigator)
1/03/24 → 31/03/29
Project: Research
Rochefort, N. (Principal Investigator)
1/09/20 → 28/02/27
Project: Research
Rochefort, N. (Principal Investigator)
Biotechnology and Biological Sciences Research Council
1/12/23 → 28/02/25
Project: Research
Rochefort, N. (Creator), Padamsey, Z. (Creator) & Katsanevaki, D. (Creator), Edinburgh DataShare, 8 Jul 2024
DOI: 10.7488/ds/7768, https://doi.org/10.7554/eLife.93052.1
Dataset
Rochefort, N. (Creator), Padamsey, Z. (Creator) & Francioni, V. (Creator), Edinburgh DataShare, 9 Apr 2021
DOI: 10.7488/ds/3013, https://elifesciences.org/articles/49145
Dataset
Rochefort, N. (Creator), Padamsey, Z. (Creator) & Katsanevaki, D. (Creator), Edinburgh DataShare, 30 Nov 2021
DOI: 10.7488/ds/3214, https://doi.org/10.1016/j.neuron.2021.10.024
Dataset
9/04/25
1 Media contribution
Press/Media: Expert Comment
27/03/25
1 Media contribution
Press/Media: Research
Padamsey, Z. & Rochefort, N.
26/03/25
1 item of Media coverage
Press/Media: Research
Padamsey, Z., Katsanevaki, D., Maeso, P., Rizzi, M., Osterweil, E. E. & Rochefort, N. L.
10/09/24 → 4/11/24
2 items of Media coverage
Press/Media: Research