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Current Research Interests

Host-pathogen interactions in the mucosal immune system.

Research Interests

My research aims to understand the pathogenesis of infectious diseases within the immune system. Particular interests include understanding host-pathogen interactions within the mucosal immune system, especially prion diseases and other gastrointestinal pathogens such as Salmonella and nematodes.

Studies are also focused on the effects of host age on the function of the immune system and how this influences susceptibility to gastrointestinal pathogens.

A systems biology approach is also being used to compare the transcriptomic profiles of distinct immune cell populations in the steady-state, and also during ageing.

This research benefits greatly from the availability of precisely defined mouse prion pathogenesis models, unique transgenic and immunodeficient mice and state-of-the-art bio-imaging and bioinformatics expertise.

Media

Seminar given at the Edinburgh Infectious Diseases Symposium June 2014

https://www.youtube.com/watch?v=wO6ijucCyGo

Media

Annimation video describing effects of ageing on the splenic marginal zone.  Data from BBSRC grant BB/L007452/1

https://media.ed.ac.uk/media/What+happens+to+your+spleen+when+you+get+oldF/1_4wmqldeh

Biography

1989-1992 BSc (Hons) Microbiology, University of Leeds, UK

1992-1995 PhD Immunoparasitology, University of Aberdeen, UK

1995-2003 Post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh

2003-2005 Senior post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh

2006-2007 Principal scientist, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh

2007-2009 Principal scientist, The Roslin Institute, Edinburgh, UK

2009-2015 Reader, The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK

2015-present Professor, Personal Chair in Immunopathology, The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK

Education/Academic qualification

Immunoparisitology, Doctor of Philosophy (PhD), University of Aberdeen

Award Date: 4 Jul 1995

Microbiology, Bachelor of Science, University of Leeds

Award Date: 1 Jul 1992

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