Research output per year
Research output per year
Personal profile
Current Research Interests
Host-pathogen interactions in the mucosal immune system.
Research Interests
My research aims to understand the pathogenesis of infectious diseases within the immune system. Particular interests include understanding host-pathogen interactions within the mucosal immune system, especially prion diseases and other gastrointestinal pathogens such as Salmonella and nematodes.
Studies are also focused on the effects of host age on the function of the immune system and how this influences susceptibility to gastrointestinal pathogens.
A systems biology approach is also being used to compare the transcriptomic profiles of distinct immune cell populations in the steady-state, and also during ageing.
This research benefits greatly from the availability of precisely defined mouse prion pathogenesis models, unique transgenic and immunodeficient mice and state-of-the-art bio-imaging and bioinformatics expertise.
Media
Seminar given at the Edinburgh Infectious Diseases Symposium June 2014
https://www.youtube.com/watch?v=wO6ijucCyGo
Media
Annimation video describing effects of ageing on the splenic marginal zone. Data from BBSRC grant BB/L007452/1
https://media.ed.ac.uk/media/What+happens+to+your+spleen+when+you+get+oldF/1_4wmqldeh
Biography
1989-1992 BSc (Hons) Microbiology, University of Leeds, UK
1992-1995 PhD Immunoparasitology, University of Aberdeen, UK
1995-2003 Post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh
2003-2005 Senior post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh
2006-2007 Principal scientist, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh
2007-2009 Principal scientist, The Roslin Institute, Edinburgh, UK
2009-2015 Reader, The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK
2015-present Professor, Personal Chair in Immunopathology, The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK
Education/Academic qualification
Immunoparisitology, Doctor of Philosophy (PhD), Nitric oxide, friend or foe during trypanosomiasis?, Robert Gordon University
Award Date: 4 Jul 1995
Microbiology, Bachelor of Science, University of Leeds
Award Date: 1 Jul 1992
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility
Donaldson, D., Sehgal, A., Rios, D., Williams, I. R. & Mabbott, N., 14 Dec 2016, In: PLoS Pathogens. 12, 12, e1006075.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders
Shih, B-J., Nirmal, A. J., Headon, D., Akbar, A. N., Mabbott, N. & Freeman, T., Apr 2017, In: The Journal of Pathology. 241, 5, p. 600-613Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice
Kobayashi, A., Donaldson, D. S., Erridge, C., Kanaya, T., Williams, I. R., Ohno, H., Mahajan, A. & Mabbott, N. A., 30 Jan 2013, In: Mucosal Immunology. 6, 5, p. 1027-1037Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Follicular Dendritic Cell-Specific Prion Protein (PrP) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen
McCulloch, L., Brown, K. L., Bradford, B. M., Hopkins, J., Bailey, M., Rajewsky, K., Manson, J. C. & Mabbott, N. A., Dec 2011, In: PLoS Pathogens. 7, 12, 20 p., e1002402.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Prion uptake in the gut: identification of the first uptake and replication sites
Kujala, P., Raymond, C. R., Romeijn, M., Godsave, S. F., van Kasteren, S. I., Wille, H., Prusiner, S. B., Mabbott, N. A. & Peters, P. J., 2011, In: PLoS Pathogens. 7, 12, e1002449.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Roslin Foundation PhD Studentships-RF2023/001
Digard, P., Gaunt, E., Hassan, M., Mabbott, N., Mabbott, N., Morrison, L., Prendergast, J., Stevens, M. & Sutton, K.
1/10/23 → 30/09/27
Project: Research
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ISP 2023/28 Consumables - Immunology
Whitelaw, B., Connelley, T., Hassan, M., Hope, J., Houston, F., Mabbott, N., Morrison, L., Regan, T., Sutton, K. & Vervelde, L.
1/04/23 → 31/03/28
Project: Research
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Japan Partnering Award: Defining the factors that regulate M cell-development in the intestines of livestock species
1/09/19 → 31/08/25
Project: Research
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IDG2023/28 - PP2023 - Capability - Tom Burdon
Burdon, T., Mabbott, N., McGrew, M., Meek, S., Rainger, J. & Robledo, D.
1/08/23 → 31/03/24
Project: Research
Datasets
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"Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility"
Donaldson, D. (Creator), Sehgal, A. (Creator), Rios, D. (Creator), Williams, I. R. (Creator) & Mabbott, N. (Creator), Edinburgh DataShare, 23 Nov 2016
DOI: 10.7488/ds/1563
Dataset
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Suppressing inflammation to enhance antigen-specific immunity in older humans using p38MAPK inhibitors and vitaminD3 (MRC grant MR/M003833/1)
Shih, B. (Creator), Simpson, C. (Data Manager), Akbar, A. (Owner), Mabbott, N. (Owner) & Freeman, T. (Owner), Edinburgh DataVault, 13 Feb 2019
Dataset
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M cells and the FAE
Mabbott, N. (Creator), Oxford University Press, 2012
http://www.roslin.ed.ac.uk/neil-mabbott/m-cells-and-the-fae/
Dataset
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Mabbott Group data archive
Mabbott, N. (Creator) & Law, D. (Other), Edinburgh DataVault, 3 Apr 2023
Dataset
Press/Media
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Covid boosters are a gamechanger - if they are free for everyone
3/04/24
1 Media contribution
Press/Media: Research
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A case of classical BSE found on Aberdeenshire farm in 2018
18/10/18
2 Media contributions
Press/Media: Expert Comment
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Prof Neil Mabbott finds vCJD infection begins in small intestine before spreading to brain
5/08/15
24 items of Media coverage
Press/Media: Research
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Dr Neil Mabbott pinpoints the protein that enables vCJD to spread
2/12/11
5 items of Media coverage
Press/Media: Research