Research output per year
Research output per year
Personal profile
Current Research Interests
Host-pathogen interactions in the mucosal immune system.
Research Interests
My research aims to understand the pathogenesis of infectious diseases within the immune system. Particular interests include understanding host-pathogen interactions within the mucosal immune system, especially prion diseases and other gastrointestinal pathogens such as Salmonella and nematodes.
Studies are also focused on the effects of host age on the function of the immune system and how this influences susceptibility to gastrointestinal pathogens.
A systems biology approach is also being used to compare the transcriptomic profiles of distinct immune cell populations in the steady-state, and also during ageing.
This research benefits greatly from the availability of precisely defined mouse prion pathogenesis models, unique transgenic and immunodeficient mice and state-of-the-art bio-imaging and bioinformatics expertise.
Media
Inaugural lecture (19/3/2018) - Prions: ninja pathogens and immune system hijackers
Media
Roslin Reels - The Roslin Institute's Professor Neil Mabbott talks about his team's work on boosting immunity against infection.
Media
Podcast-Meet the Microbiologist: When Proteins Become Infectious: Understanding Prion Disease With Neil Mabbott
https://asm.org/podcasts/mtm/episodes/when-proteins-become-infectious-understanding-prio
https://open.spotify.com/episode/2ygZZvF3vorSueM1jVPLo1?si=A2cLu2OMS1OokeEe6qS3kA
Media
Annimation video describing effects of ageing on the splenic marginal zone. Data from BBSRC grant BB/L007452/1
https://media.ed.ac.uk/media/What+happens+to+your+spleen+when+you+get+oldF/1_4wmqldeh
Media
Seminar given at the Edinburgh Infectious Diseases Symposium June 2014
Websites
The Conversation: Neil Mabbott
Biography
1989-1992, BSc (Hons) Microbiology, University of Leeds, UK
1992-1995, PhD Immunoparasitology, University of Aberdeen, UK
1995-2003, Post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh UK
2003-2005, Senior post-doc, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh UK
2006-2007, Principal scientist, Neuropathogenesis Unit, Institute for Animal Health, Edinburgh UK
2007-2009, Principal scientist, The Roslin Institute, Edinburgh UK
2009-2015, Reader, The Roslin Institute & Royal (Dick) School of Veterinary Studies, Edinburgh UK
2015-present, Professor, Personal Chair in Immunopathology, The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK
2021-present, Director of Teaching (The Roslin Institute), The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK
2023-present, Head of the Immunology Division, The Roslin Institute & Royal (Dick) School of Veterinary Studies, University of Edinburgh, UK
Education/Academic qualification
Immunoparisitology, Doctor of Philosophy (PhD), Nitric oxide, friend or foe during trypanosomiasis?, Robert Gordon University
Award Date: 4 Jul 1995
Microbiology, Bachelor of Science, University of Leeds
Award Date: 1 Jul 1992
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility
Donaldson, D., Sehgal, A., Rios, D., Williams, I. R. & Mabbott, N., 14 Dec 2016, In: PLoS Pathogens. 12, 12, e1006075.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Derivation of marker gene signatures from human skin and their use in the interpretation of the transcriptional changes associated with dermatological disorders
Shih, B.-J., Nirmal, A. J., Headon, D., Akbar, A. N., Mabbott, N. & Freeman, T., Apr 2017, In: The Journal of Pathology. 241, 5, p. 600-613Research output: Contribution to journal › Article › peer-review
Open AccessFile -
The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice
Kobayashi, A., Donaldson, D. S., Erridge, C., Kanaya, T., Williams, I. R., Ohno, H., Mahajan, A. & Mabbott, N. A., 30 Jan 2013, In: Mucosal Immunology. 6, 5, p. 1027-1037Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Follicular Dendritic Cell-Specific Prion Protein (PrP) Expression Alone Is Sufficient to Sustain Prion Infection in the Spleen
McCulloch, L., Brown, K. L., Bradford, B. M., Hopkins, J., Bailey, M., Rajewsky, K., Manson, J. C. & Mabbott, N. A., Dec 2011, In: PLoS Pathogens. 7, 12, 20 p., e1002402.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Prion uptake in the gut: identification of the first uptake and replication sites
Kujala, P., Raymond, C. R., Romeijn, M., Godsave, S. F., van Kasteren, S. I., Wille, H., Prusiner, S. B., Mabbott, N. A. & Peters, P. J., 2011, In: PLoS Pathogens. 7, 12, e1002449.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Roslin Foundation - Funding for Pump Priming 2025-26 RF2610
Stevens, M. (Principal Investigator), Bronsvoort, M. (Co-investigator), Fitzgerald, R. (Co-investigator), Forlenza, M. (Co-investigator), Headon, D. (Co-investigator), Hope, J. (Co-investigator), Mabbott, N. (Co-investigator), Mazeri, S. (Co-investigator), McDougall, C. (Co-investigator), Steketee, P. (Co-investigator) & Sutton, K. (Co-investigator)
1/04/25 → 30/09/26
Project: Research
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Bovine organoids 2.0: Further development, validation, and use of bovine organoids to study host-pathogen interactions
Mabbott, N. (Principal Investigator) & Morrison, L. (Co-investigator)
1/07/24 → 30/06/27
Project: Research
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Roslin Foundation PhD Studentships-RF2023/001
Digard, P. (Co-investigator), Gaunt, E. (Co-investigator), Hassan, M. (Co-investigator), Mabbott, N. (Co-investigator), Mabbott, N. (Co-investigator), Morrison, L. (Co-investigator), Prendergast, J. (Co-investigator), Stevens, M. (Co-investigator) & Sutton, K. (Co-investigator)
1/10/23 → 30/09/27
Project: Research
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ISP 2023/28 Consumables - Immunology
Whitelaw, B. (Principal Investigator), Connelley, T. (Co-investigator), Hassan, M. (Co-investigator), Hope, J. (Co-investigator), Houston, F. (Co-investigator), Mabbott, N. (Co-investigator), Morrison, L. (Co-investigator), Regan, T. (Co-investigator), Sutton, K. (Co-investigator) & Vervelde, L. (Co-investigator)
Biotechnology and Biological Sciences Research Council
1/04/23 → 31/03/28
Project: Research
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IDG2023/28 - PP2023 - Capability - Tom Burdon
Burdon, T. (Principal Investigator), Mabbott, N. (Co-investigator), McGrew, M. (Co-investigator), Meek, S. (Co-investigator), Rainger, J. (Co-investigator) & Robledo, D. (Co-investigator)
Biotechnology and Biological Sciences Research Council
1/08/23 → 31/03/24
Project: Research
Datasets
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"Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility"
Donaldson, D. (Creator), Sehgal, A. (Creator), Rios, D. (Creator), Williams, I. R. (Creator) & Mabbott, N. (Creator), Edinburgh DataShare, 23 Nov 2016
DOI: 10.7488/ds/1563
Dataset
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Suppressing inflammation to enhance antigen-specific immunity in older humans using p38MAPK inhibitors and vitaminD3 (MRC grant MR/M003833/1)
Shih, B. (Creator), Simpson, C. (Data Manager), Akbar, A. (Owner), Mabbott, N. (Owner) & Freeman, T. (Owner), Edinburgh DataVault, 13 Feb 2019
Dataset
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Mabbott Group data archive
Mabbott, N. (Creator) & Law, D. (Other), Edinburgh DataVault, 3 Apr 2023
Dataset
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M cells and the FAE
Mabbott, N. (Creator), Oxford University Press, 2012
http://www.roslin.ed.ac.uk/neil-mabbott/m-cells-and-the-fae/
Dataset
Press/Media
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Scientists create antivenom that protects against whole family of deadly snakes
29/10/25
1 Media contribution
Press/Media: Research
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From Qin Shi Huang to Xi Jinping, mankind pursues a millennium of longevity
10/09/25
1 Media contribution
Press/Media: Research
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Xi Jinping talks on "Long Life" BBC: Organ transplant is to cure illness, not to live 150 years old
7/09/25
1 Media contribution
Press/Media: Research
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Xi Jinping talks on "Long Life" BBC: Organ transplant is to cure illness, not to live 150 years old
7/09/25
1 Media contribution
Press/Media: Research
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Talk privately about how long you will never be old! Xi Jinping, Puting talk draws attention to experts: Organ transplant is not for life to 150 years old
7/09/25
1 Media contribution
Press/Media: Research