Nicholas Parkinson, MA MS VetMB CertEM(Int.Med.) DACVIM MRCVS

Search results

• 2024

  Management of paracondylar process fracture in three horses

  Beldeanu, S., Tay, MCA., Daniel, C., Dosi, M., Hahn, C., James, O., Townsend, N., Liuti, T., Schwarz, T. & Parkinson, N., Nov 2024, In: Equine Veterinary Journal. 56, 6, p. 1193-1200 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Facial Nerve Paralysis 100%
  • Occipital Bone 49%
  • Nonunion 49%

• Bovine papillomavirus gene expression and inflammatory pathway activation vary between equine sarcoid tumour subtypes

  Parkinson, N., Ward, A., Malbon, A., Reardon, R. & Kelly, P., 1 Oct 2024, (E-pub ahead of print) In: Veterinary Immunology and Immunopathology. 277, p. 1-9 9 p., 110838.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Papillomaviridae 100%
  • Sarcoidosis 100%
  • Bovine Papillomavirus 100%
  • TLR9 20%
  • CCL5 20%
• 2023

  NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

  Ryan, E., Sadiku, P., Coelho, P., Watts, E. R., Zhang, A., Howden, A. J. M., Sanchez Garcia, M. A., Bewley, M. A., Cole, J., McHugh, B., Vermaelen, W., Ghesquiere, B., Carmeliet, P., Rodriguez Blanco, G., von Kriegsheim, A., Sanchez, Y., Rumsey, W., Callahan, J. F., Cooper, G., Parkinson, N., & 8 othersBaillie, J. K., Cantrell, D., McCafferty, J., Choudhury, G., Singh, D., Dockrell, D. H., Whyte, M. K. B. & Walmsley, S. R., 1 Feb 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Obstructive Pulmonary Disease 100%
  • Macrophage Function 100%
  • Aerobic Metabolism 100%
  • Macrophage 37%
  • Respiratory Tract Inflammation 25%
• 2022

  Systematic comparison of ranking aggregation methods for gene lists in experimental results

  Wang, B., Law, A., Regan, T., Parkinson, N., Cole, J., Russell, C. D., Dockrell, D. H., Gutmann, M. U. & Baillie, J. K., 31 Oct 2022, In: Bioinformatics. 38, 21, p. 4927-4933

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Experimental Result 100%
  • Algorithms 100%
  • Evaluation 75%
  • Simulated Data 75%
  • Database 25%

• Whole genome sequencing reveals host factors underlying critical Covid-19

  GenOMICC Investigators, Kousathanas, A., Pairo-Castineira, E., Rawlik, K., Stuckey, A., Odhams, C. A., Walker, S., Russell, C. D., Malinauskas, T., Wu, Y., Millar, J., Shen, X., Elliott, K. S., Griffiths, F., Oosthuyzen, W., Morrice, K., Keating, S., Wang, B., Rhodes, D., Klaric, L., & 57 othersZechner, M., Parkinson, N., Siddiq, A., Goddard, P., Donovan, S., Maslove, D., Nichol, A., Semple, M. G., Zainy, T., Maleady-Crowe, F., Todd, L., Salehi, S., Knight, J., Elgar, G., Chan, G., Arumugam, P., Patch, C., Rendon, A., Bentley, D., Kingsley, C., Kosmicki, J. A., Horowitz, J. E., Baras, A., Abecasis, G. R., Ferreira, M. A. R., Justice, A., Mirshahi, T., Oetjens, M., Rader, D. J., Ritchie, M. D., Verma, A., Fowler, T. A., Shankar-Hari, M., Summers, C., Hinds, C., Horby, P., Ling, L., McAuley, D., Montgomery, H., Openshaw, P. J. M., Elliott, P., Walsh, T., Tenesa, A., Fawkes, A., Murphy, L., Rowan, K., Ponting, C. P., Vitart, V., Wilson, J. F., Yang, J., Bretherick, A. D., Scott, R. H., Hendry, S. C., Moutsianas, L., Law, A., Caulfield, M. J. & Baillie, J. K., 7 Jul 2022, In: Nature. 607, p. 97-103

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Whole Genome Sequencing 100%
  • Host Factor 100%
  • Host 100%
  • Association 40%
  • Population Dynamics 40%

• Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

  Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Sanchez Garcia, M. A., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Morrison, T., Ly, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R., Reyes, L., Cooper, G., Clark, S., Lewis, D., Kelly, V., & 22 othersSpanos, C., Musgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N., Rostron, A. J., Baillie, J. K., Clohisey, S., Pridans, C., Campana, L., Starkey Lewis, P., Simpson, A. J., Dockrell, D. H., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. B. & Walmsley, S. R., 27 May 2022, In: Nature Immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lung Injury 100%
  • Hypoxia 100%
  • Serositis 100%
  • Lung 100%
  • Immunity 100%

• A common TMPRSS2 variant has a protective effect against severe COVID-19

  David, A., Parkinson, N., Peacock, T. P., Pairo-Castineira, E., Khanna, T., Cobat, A., Tenesa, A., Sancho-Shimizu, V., Casanova, J-L., Abel, L., Barclay, W. S., Baillie, J. K. & Sternberg, M. J. E., May 2022, In: Current Research in Translational Medicine. 70, 2, 103333.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Serine Protease 100%
  • SARS Coronavirus 33%
  • Association 16%
  • Protein 16%
  • Age 16%
• 2021

  A genome-wide CRISPR/Cas9 screen reveals the requirement of host sphingomyelin synthase 1 for infection with Pseudorabies virus mutant gD–Pass

  Hölpe, J. E. R., Grey, F., Baillie, J. K., Regan, T., Parkinson, N., Hoper, D., Thamamongood, T., Schwemmle, M., Pannhorst, K., Wendt, L., Mettenleiter, T. C. & Klupp, B. G., 9 Aug 2021, (E-pub ahead of print) In: Viruses. 13, 8, 1574.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clustered Regularly Interspaced Short Palindromic Repeat 100%
  • Sphingomyelin 100%
  • Virus Mutant 100%
  • Cas9 100%
  • Synthetase 100%
• 2020

  Dynamic data-driven meta-analysis for prioritisation of host genes implicated in COVID-19

  Parkinson, N., Rodgers, N., Fourman, M. H., Wang, B., Zechner, M., Swets, M. C., Millar, J., Law, A., Russell, C. D., Baillie, J. K. & Clohisey, S., 18 Dec 2020, (E-pub ahead of print) In: Scientific Reports. 10, 1

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Host 100%
  • Dynamics 100%
  • COVID-19 100%
  • Gene 100%
  • Nested Gene 100%

• Genetic mechanisms of critical illness in Covid-19

  The GenOMICC Investigators, The ISARIC4C Investigators, The Covid-19 Human Genetics Initiative, 23andMe Investigators, BRACOVID Investigators, Gen-COVID Investigators, Pairo-Castineira, E., Clohisey, S., Klaric, L., Bretherick, A., Rawlik, K., Parkinson, N., Pasko, D., Walker, S., Richmond, A., Fourman, M. H., Law, A., Furniss, J., Gountouna, E., Wrobel, N., & 42 othersRussell, C. D., Moutsianas, L., Wang, B., Meynert, A. M., Yang, Z., Zhai, R., Zheng, C., Griffith, F., Oosthuyzen, W., Shih, B., Keating, S., Zechner, M., Haley, C. S., Porteous, D., Hayward, C., Knight, J., Summers, C., Shankar-Hari, M., Turtle, L., Ho, A., Hinds, C., Horby, P., Nichol, A., Maslove, D. M., Ling, L., Klenerman, P., McAuley, D. F., Montgomery, H. E., Walsh, T. S., Shen, X., Rowan, K., Fawkes, A., Murphy, L., Ponting, C. P., Tenesa, A., Caulfield, M., Scott, R., Openshaw, P., Semple, M. G., Vitart, V., Wilson, J. & Baillie, J. K., 11 Dec 2020, (E-pub ahead of print) In: Nature. n/a, n/a.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetics 100%
  • Genome-Wide Association Study 66%
  • Mutation 33%
  • Host 33%
  • Interferon 33%

• Functional annotation of human long noncoding RNAs via molecular phenotyping

  Ramilowski, J. A., Yip, C. W., Agrawal, S., Chang, J-C., Ciani, Y., Kulakovskiy, I. V., Mendez, M., Ooi, J. L. C., Ouyang, J. F., Parkinson, N., Petri, A., Roos, L., Severin, J., Yasuzawa, K., Abugessaisa, I., Akalin, A., Antonov, I. V., Arner, E., Bonetti, A., Bono, H., & 96 othersBorsari, B., Brombacher, F., Cameron, C. J. F., Cannistraci, C. V., Cardenas, R., Cardon, M., Chang, H., Dostie, J., Ducoli, L., Favorov, A., Fort, A., Garrido, D., Gil, N., Gimenez, J., Guler, R., Handoko, L., Harshbarger, J., Hasegawa, A., Hasegawa, Y., Hashimoto, K., Hayatsu, N., Heutink, P., Hirose, T., Imada, E. L., Itoh, M., Kaczkowski, B., Kanhere, A., Kawabata, E., Kawaji, H., Kawashima, T., Kelly, S. T., Kojima, M., Kondo, N., Koseki, H., Kouno, T., Kratz, A., Kurowska-Stolarska, M., Kwon, A. T. J., Leek, J., Lennartsson, A., Lizio, M., López-Redondo, F., Luginbühl, J., Maeda, S., Makeev, V. J., Marchionni, L., Medvedeva, Y. A., Minoda, A., Müller, F., Muñoz-Aguirre, M., Murata, M., Nishiyori, H., Nitta, K. R., Noguchi, S., Noro, Y., Nurtdinov, R., Okazaki, Y., Orlando, V., Paquette, D., Parr, C. J. C., Rackham, O. J. L., Rizzu, P., Sánchez Martinez, D. F., Sandelin, A., Sanjana, P., Semple, C. A. M., Shibayama, Y., Sivaraman, D. M., Suzuki, T., Szumowski, S. C., Tagami, M., Taylor, M. S., Terao, C., Thodberg, M., Thongjuea, S., Tripathi, V., Ulitsky, I., Verardo, R., Vorontsov, I. E., Yamamoto, C., Young, R. S., Baillie, J. K., Forrest, A. R. R., Guigó, R., Hoffman, M. M., Hon, C. C., Kasukawa, T., Kauppinen, S., Kere, J., Lenhard, B., Schneider, C., Suzuki, H., Yagi, K., de Hoon, M. J. L., Shin, J. W. & Carninci, P., 27 Jul 2020, (E-pub ahead of print) In: Genome Research. 30, p. 1060-1072

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Long Noncoding RNA 100%
  • Phenotype 100%
  • Gene Expression 60%
  • Introspection 20%
  • Deep Sequencing 20%

• Comprehensive characterisation of transcriptional activity during influenza A virus infection reveals biases in cap-snatching of host RNA sequences.

  Clohisey, S., Parkinson, N., Wang, B., Bertin, N., Wise, H., Tomoiu, A., FANTOM consortium, T., Summers, K. M., Hendry, R. W., Carninci, P., Forrest, A. A., Hayashizaki, Y., Digard, P., Hume, D. & Baillie, K., 11 Mar 2020, (E-pub ahead of print) In: Journal of Virology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Host 100%
  • Influenzavirus A 100%
  • RNA Sequence 100%
  • Viral Disease 100%
  • Influenza A Virus 100%

• Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection

  Li, B., Clohisey, S. M., Chia, B. S., Wang, B., Cui, A., Eisenhaure, T., Schweitzer, L. D., Hoover, P., Parkinson, N. J., Nachshon, A., Smith, N., Regan, T., Farr, D., Gutmann, M. U., Bukhari, S. I., Law, A., Sangesland, M., Gat-viks, I., Digard, P., Vasudevan, S., & 5 othersLingwood, D., Dockrell, D. H., Doench, J. G., Baillie, J. K. & Hacohen, N., 9 Jan 2020, In: Nature Communications. 11, 1, 18 p., 164.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clustered Regularly Interspaced Short Palindromic Repeat 100%
  • Host 100%
  • Influenzavirus A 100%
  • Viral Disease 100%
  • CRISPR 100%
• 2018

  Catheter-associated venous air embolism in hospitalized horses: 32 cases

  Parkinson, N., McKenzie, H., Barton, M., Davis, J., Dunkel, B., Johnson, A. & MacDonald, E., 20 Feb 2018, In: Journal of Veterinary Internal Medicine. p. 1-10

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Horse 100%
  • Fasciculation 11%
  • Muscle 11%
  • Tachycardia 11%
• 2017

  Mediastinal paraganglioma as a cause of hemothorax and thoracic spinal cord compression in a Quarter Horse gelding

  Parkinson, N., Wilson, K., Saunders, G., Buechner-Maxwell, V., Scarratt, W. K., Pleasant, R. S. & Funk, R., 7 Oct 2017, (E-pub ahead of print) In: Journal of equine veterinary science.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hemothorax 100%
  • Horse 100%
  • Neuroendocrine Tumor 50%
  • Gelding 25%
  • Dog 25%

• Prostaglandin E2 stimulates adaptive IL-22 production and promotes allergic contact dermatitis

  Robb, C. T., McSorley, H. J., Lee, J., Aoki, T., Yu, C., Crittenden, S., Astier, A., Felton, J. M., Parkinson, N., Ayele, A., Breyer, R. M., Anderton, S. M., Narumiya, S., Rossi, A. G., Howie, S., Guttman-Yassky, E., Weller, R. B. & Yao, C., 3 Jun 2017, In: Journal of Allergy and Clinical Immunology. 141, 1, p. 152-162

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Prostaglandin E2 100%
  • Skin Allergy 100%
  • Atopic Dermatitis 45%
  • Skin 36%
  • T Cell 27%

• Characterization of basal and lipopolysaccharide-induced microRNA expression in equine peripheral blood mononuclear cells using Next-Generation Sequencing

  Parkinson, N., Buechner-Maxwell, V., Witonsky, S., Pleasant, R. S., Werre, S. R. & Ahmed, S. A., 26 May 2017, In: PLoS ONE.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Peripheral Blood Mononuclear Cell 100%
  • Horse 100%
  • Tumor Necrosis Factor 16%
  • Leukocytes 16%
• 2013

  Severe hypertriglyceridaemia in horses and ponies with endocrine disorders

  Dunkel, B., Wilford, S. A., Parkinson, N. J., Ward, C., Smith, P., Grahame, L., Brazil, T. & Schott, H. C., 12 Apr 2013, (E-pub ahead of print) In: Equine Veterinary Journal. 46, 1, p. 118-22 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Horse 100%
  • Insulin 42%
  • Pituitary Pars Intermedia Dysfunction 28%
  • Adrenocorticotropic Hormone 14%
  • Dexamethasone 14%
• 2011

  Molecular epidemiology of strangles outbreaks in the UK during 2010

  Parkinson, N. J., Robin, C., Newton, J. R., Slater, J. & Waller, A. S., 25 Jun 2011, In: Veterinary Record. 168, 25, 1 p.

  Research output: Contribution to journal › Article › peer-review

  • Strangles 100%
  • Allele 100%
  • Proteins 44%
  • Equus 44%
  • Prevalence 33%
• 2003

  A postmortem study of the mediodorsal nucleus of the thalamus in schizophrenia

  Cullen, T. J., Parkinson, N., Craven, R., Crow, T. J. & Esiri, M. M., 1 Apr 2003, In: Schizophrenia Research. 60, 2-3, p. 157-166 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Neuron 100%
  • Thalamus 100%
  • Dementia Praecox 100%
  • Hemisphere 10%
  • Pathology 10%