Nikhil Hirani

Phone0131 242 6556/1874
Emailn.hiranied.acuk

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1 Similar Profiles

55 Article
12 Meeting abstract
2 Book
1 Chapter (peer-reviewed)
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An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE): A Phase Ib/IIa Randomised Controlled Trial
Gaughan, E. E., Quinn, T. M., Mills, A., Bruce, A. M., Antonelli, J., Mackinnon, A., Aslanis, V., Li, F., O'connor, R., Boz, C., Mills, R., Emanuel, P., Burgess, M., Rinaldi, G., Valanciute, A., Mills, B., Scholefield, E., Hardisty, G., Gwyer Findlay, E., Parker, R. A., & 19 othersNorrie, J., Dear, J. W., Akram, A. R., Koch, O., Templeton, K., Dockrell, D. H., Walsh, T. S., Partridge, S., Humphries, D., Wang-jairaj, J., Slack, R. J., Schambye, H., Phung, D., Gravelle, L., Lindmark, B., Shankar-Hari, M., Hirani, N., Sethi, T. & Dhaliwal, K., 16 Aug 2022, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation
Humphries, D., Mills, R., Boz, C., McHugh, B., Hirani, N., Rossi, A. G., Pedersen, A., Schambye, H., Slack, R. J., Nilsson, U. J., Wang, W., Sethi, T. & Mackinnon, A., 8 Aug 2022, In: Frontiers in pharmacology. 13, 12 p., 949264.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Sanchez Garcia, M. A., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Morrison, T., Ly, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R., Reyes, L., Cooper, G., Clark, S., Lewis, D., Kelly, V., & 22 othersSpanos, C., Musgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N., Rostron, A. J., Baillie, J. K., Clohisey, S., Pridans, C., Campana, L., Starkey Lewis, P., Simpson, A. J., Dockrell, D. H., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. B. & Walmsley, S. R., 27 May 2022, In: Nature Immunology.
Research output: Contribution to journal › Article › peer-review

Open Access
File
Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence
Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Sanchez-Garcia, M. A., Reyes, L., Morrison, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R. S., Clark, S., Ly, T., Lewis, D., Kelly, V., Spanos, C., & 21 othersMusgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N. J., Rostron, A. J., Baillie, K. J., Clohisey, S., Pridans, C., Campana, L., Starkey-Lewis, P., Simpson, A. J., Dockrell, D., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. & Walmsley, S. R., 12 Mar 2022, bioRxiv, p. 1-53, 53 p.
Research output: Working paper › Preprint
Candidate Role for Toll-like Receptor 3 L412F Polymorphism and Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
McElroy, A. N., Invernizzi, R., Laskowska, J. W., O'Neill, A., Doroudian, M., Moghoofei, M., Mostafaei, S., Li, F., Przybylski, A. A., O'Dwyer, D. N., Bowie, A. G., Fallon, P. G., Maher, T. M., Hogaboam, C. M., Molyneaux, P. L., Hirani, N., Armstrong, M. E. & Donnelly, S. C., 1 Mar 2022, In: American Journal of Respiratory and Critical Care Medicine. 205, 5, p. 550-562
Research output: Contribution to journal › Article › peer-review

Modulation Of Fibrotic Pathways By Novel Inhibitors Of Galectin-3
Hirani, N., Henderson, N. & Mackinnon, A.
Other
1/08/19 → 31/01/22
Project: Research
Measurement Of TGF-beta Related Biomarkers In Bronchial Alveolar Lavage Fluid (BALF)
Hirani, N.
Other
1/02/18 → 31/01/19
Project: Research
Development of anti-galectin-3 antibodies for the treatment of Idiopathic Pulmonary Fibrosis (IPF)
Mackinnon, A. & Hirani, N.
MRC
1/09/17 → 30/11/18
Project: Research
Mechanism of action characterization for a galectin-3 inhibitor as treatment for lung injury
Mackinnon, A., Henderson, N., Hirani, N. & Rossi, A.
Non-EU other
1/09/15 → 31/08/19
Project: Research
RB0375 Clinical Sample Analysis for RD676/25641
Hirani, N. & Dhaliwal, K.
EU other
1/03/15 → 31/08/18
Project: Research

Datasets for Low-Cost High Sensitivity Pulsed Endomicroscopy to Visualize Tri-Color Optical Signatures
Mills, B. (Creator), Murray, I. (Creator), Marshall, A. (Creator), Craven, T. (Creator), Emanuel, P. (Creator), Choudhary, T. (Creator), Norberg, D. (Creator), Scholefield, E. (Creator), Akram, A. (Creator), Davie, A. (Creator), Hirani, N. (Creator), Bruce, A. (Creator), Moore, A. (Creator), Bradley, M. (Creator), Dhaliwal, K. (Creator) & Krstajic, N. (Creator), Edinburgh DataShare, 1 Jul 2018
DOI: 10.7488/ds/2355
Dataset

Dr Nik Hirani comments on newly available treatment for lung disease
Nikhil Hirani
13/08/13
1 item of Media coverage
Press/Media: Expert Comment
Dr Nikhil Hirani collaborates in study into pulmonary fibrosis.
Nikhil Hirani
15/01/14
1 item of Media coverage
Press/Media: Research
Dr Nik Hirani discusses efforts to develop drugs to treat pulmonary fibrosis
Nikhil Hirani
27/06/14
1 item of Media coverage
Press/Media: Research

Nikhil Hirani

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Dive into details

An Inhaled Galectin-3 Inhibitor in COVID-19 Pneumonitis (DEFINE): A Phase Ib/IIa Randomised Controlled Trial

Galectin-3 inhibitor GB0139 protects against acute lung injury by inhibiting neutrophil recruitment and activation

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

Candidate Role for Toll-like Receptor 3 L412F Polymorphism and Infection in Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Modulation Of Fibrotic Pathways By Novel Inhibitors Of Galectin-3

Measurement Of TGF-beta Related Biomarkers In Bronchial Alveolar Lavage Fluid (BALF)

Development of anti-galectin-3 antibodies for the treatment of Idiopathic Pulmonary Fibrosis (IPF)

Mechanism of action characterization for a galectin-3 inhibitor as treatment for lung injury

RB0375 Clinical Sample Analysis for RD676/25641

Datasets for Low-Cost High Sensitivity Pulsed Endomicroscopy to Visualize Tri-Color Optical Signatures

Dr Nik Hirani comments on newly available treatment for lung disease

Dr Nikhil Hirani collaborates in study into pulmonary fibrosis.

Dr Nik Hirani discusses efforts to develop drugs to treat pulmonary fibrosis

Nikhil Hirani

Fingerprint

Network

Research output

Projects

Datasets

Press/Media