Owen Davies

2024

BRCA2 stabilises RAD51 and DMC1 nucleoprotein filaments through a conserved interaction mode

Dunce, J. M. & Davies, O., 27 Sept 2024, In: Nature Communications. 15, 11 p., 8292 .

Research output: Contribution to journal › Article › peer-review

Open Access

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Structural basis for Mis18 complex assembly and its implications for centromere maintenance

Thamkachy, R., Medina-Pritchard, B., Park, S. H., Chiodi, C. G., Zou, J., de la Torre-Barranco, M., Shimanaka, K., Abad, M. A., Gallego Páramo, C., Feederle, R., Ruksenaite, E., Heun, P., Davies, O. R., Rappsilber, J., Schneidman-Duhovny, D., Cho, U-S. & Jeyaprakash, A. A., 9 Aug 2024, In: EMBO Reports. 25, 8, p. 3348-3372 25 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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MEILB2-BRME1 forms a V-shaped DNA clamp upon BRCA2-binding in meiotic recombination

Manickam, G., Zhang, J., Zhang, K., Shibuya, H. & Davies, O., 2 Aug 2024, In: Nature Communications. 15, 16 p., 6552.

Research output: Contribution to journal › Article › peer-review

Open Access

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A conserved CENP-E region mediates BubR1-independent recruitment to the outer corona at mitotic onset

Weber, J., Legal, T., Perez Lezcano, A., Gluszek-Kustusz, A., Paterson, C., Eibes, S., Barisic, M., Davies, O. R. & Welburn, J. P. I. ., 11 Mar 2024, In: Current Biology. 34, 5, p. 1133-1141.e4 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The crystal structure of SUN1-KASH6 reveals an asymmetric LINC complex architecture compatible with nuclear membrane insertion

Manickam, G., Erlandsen, B. S. & Davies, O. R., 30 Jan 2024, In: Communications Biology. 7, 14 p., 138.

Research output: Contribution to journal › Article › peer-review

Open Access

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2023

Protein target highlights in CASP15: Analysis of models by structure providers

Alexander, L. T., Durairaj, J., Kryshtafovych, A., Abriata, L. A., Bayo, Y., Bhabha, G., Breyton, C., Caulton, S. G., Chen, J., Degroux, S., Ekiert, D. C., Erlandsen, B. S., Freddolino, P. L., Gilzer, D., Greening, C., Grimes, J. M., Grinter, R., Gurusaran, M., Hartmann, M. D., Hitchman, C. J., & 31 othersKeown, J. R., Kropp, A., Kursula, P., Lovering, A. L., Lemaitre, B., Lia, A., Liu, S., Logotheti, M., Lu, S., Markússon, S., Miller, M. D., Minasov, G., Niemann, H. H., Opazo, F., Phillips Jr, G. N., Davies, O. R., Rommelaere, S., Rosas‐Lemus, M., Roversi, P., Satchell, K., Smith, N., Wilson, M. A., Wu, KL., Xia, X., Xiao, H., Zhang, W., Zhou, Z. H., Fidelis, K., Topf, M., Moult, J. & Schwede, T., 1 Dec 2023, In: Proteins: Structure, Function, and Bioinformatics. 91, 12, p. 1571-1599 29 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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SYCP1 head-to-head assembly is required for chromosome synapsis in mouse meiosis

Billmyre, K. K., Kesler, E. A., Tsuchiya, D., Corbin, T. J., Weaver, K., Moran, A., Yu, Z., Adams, L., Delventhal, K., Durnin, M., Davies, O. R. & Hawley, R. S., 20 Oct 2023, In: Science Advances. 9, 42, 13 p., eadi156.

Research output: Contribution to journal › Article › peer-review

Open Access

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Meiotic Chromosome Structure, the Synaptonemal Complex, and Infertility

Adams, I. R. & Davies, O., 25 Aug 2023, In: Annual Review of Genomics and Human Genetics. 24, p. 35-61

Research output: Contribution to journal › Review article › peer-review

Open Access

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Molecular insights into LINC complex architecture through the crystal structure of a luminal trimeric coiled-coil domain of SUN1

Manickam, G., Biemans, J. J., Wood, C. W. & Davies, O. R., 21 Jun 2023, In: Frontiers in Cell and Developmental Biology. 11, 15 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

Garner, K. E. L., Salter, A., Lau, C. K., Gurusaran, M., Villemant, C. M., Granger, E. P., McNee, G., Woodman, P. G., Davies, O. R., Burke, B. E. & Allan, V. J., 22 Mar 2023, In: The Journal of cell biology. 222, 5, 32 p., e202204042.

Research output: Contribution to journal › Article › peer-review

Open Access

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Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3

Crichton, J., Dunce, J. M., Dunne, O. M., Salmon, L., Devenney, P. S., Lawson, J., Adams, I. R. & Davies, O., Feb 2023, In: Nature Structural & Molecular Biology. 30, p. 188-199 32 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

Coiled-coil structure of meiosis protein TEX12 and conformational regulation by its C-terminal tip

Dunce, J., Salmon, L. & Davies, O., 7 Sept 2022, In: Communications Biology. 5, 1, 14 p., 921.

Research output: Contribution to journal › Article › peer-review

Open Access

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2021

Centrosome dysfunction associated with somatic expression of the synaptonemal complex protein TEX12

Sandhu, S., Sou, I. F., Hunter, J. E., Salmon, L., Wilson, C. L., Perkins, N. D., Hunter, N., Davies, O. R. & McClurg, U. L., 8 Dec 2021, In: Communications Biology. 4, 1, 13 p., 1371.

Research output: Contribution to journal › Article › peer-review

Open Access

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Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12

Dunce, J., Salmon, L. & Davies, O. R., 9 Aug 2021, In: Nature Structural & Molecular Biology. 28, p. 681–693 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Thomas, C., Wetherall, B., Levasseur, M. D., Harris, R. J., Kerridge, S. T., Higgins, J. M. G., Davies, O. R. & Madgwick, S., 14 Jul 2021, In: Nature Communications. 12, 13 p., 4322.

Research output: Contribution to journal › Article › peer-review

Open Access

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Structural basis for the coiled-coil architecture of human CtIP

Morton, C. R., Rzechorzek, N. J., Maman, J. D., Kuramochi, M., Sekiguchi, H., Rambo, R., Sasaki, Y. C., Davies, O. R. & Pellegrini, L., 16 Jun 2021, In: Open Biology. 11, 6, 12 p., 210060.

Research output: Contribution to journal › Article › peer-review

Open Access

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Structural basis for the coiled-coil architecture of human CtIP

Morton, C. R., Rzechorzek, N. J., Maman, J. D., Kuramochi, M., Sekiguchi, H., Rambo, R., Sasaki, Y. C., Davies, O. R. & Pellegrini, L., 5 Mar 2021, bioRxiv, at Cold Spring Harbor Laboratory.

Research output: Working paper

SUMO is a pervasive regulator of meiosis

Bhagwat, N. R., Owens, S. N., Ito, M., Boinapalli, J. V., Poa, P., Ditzel, A., Kopparapu, S., Mahalawat, M., Davies, O. R., Collins, S. R., Johnson, J. R., Krogan, N. J. & Hunter, N., 27 Jan 2021, In: eLIFE. 10, 44 p., e57720.

Research output: Contribution to journal › Article › peer-review

Open Access

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A molecular mechanism for LINC complex branching by structurally diverse SUN-KASH 6:6 assemblies

Gurusaran, M. & Davies, O. R., 4 Jan 2021, In: eLIFE. 10, 25 p., e60175.

Research output: Contribution to journal › Article › peer-review

Open Access

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2020

Structural basis of meiotic chromosome synaptic elongation through hierarchical fibrous assembly of SYCE2-TEX12

Dunce, J. M., Salmon, L. J. & Davies, O. R., 31 Dec 2020, bioRxiv, at Cold Spring Harbor Laboratory.

Research output: Working paper

Helical ensembles outperform ideal helices in molecular replacement

Rodríguez, F. S., Simpkin, A. J., Davies, O. R., Keegan, R. M. & Rigden, D. J., 1 Oct 2020, In: Acta Crystallographica Section D: Structural Biology. p. 962-970 9 p., D76.

Research output: Contribution to journal › Article › peer-review

Open Access

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Meiotic chromosome synapsis depends on multivalent SYCE1-SIX6OS1 interactions that are disrupted in cases of human infertility

Sánchez-Sáez, F., Gómez-H, L., Dunne, O. M., Gallego-Páramo, C., Felipe-Medina, N., Sánchez-Martín, M., Llano, E., Pendas, A. M. & Davies, O. R., 2 Sept 2020, In: Science Advances. 6, 36, 15 p., eabb1660.

Research output: Contribution to journal › Article › peer-review

Open Access

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The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

Zhang, J., Gurusaran, M., Fujiwara, Y., Zhang, K., Echbarthi, M., Vorontsov, E., Guo, R., Pendlebury, D. F., Alam, I., Livera, G., Emmanuelle, M., Wang, P. J., Nandakumar, J., Davies, O. R. & Shibuya, H., 28 Apr 2020, In: Nature Communications. 11, 1, 18 p., 2055.

Research output: Contribution to journal › Article › peer-review

Open Access

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Obtaining tertiary protein structures by the ab initio interpretation of small angle X-ray scattering data

Prior, C., Davies, O. R., Bruce, D. & Pohl, E., 10 Mar 2020, In: Journal of Chemical Theory and Computation. 16, 3, p. 1985-2001 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Extending the scope of coiled-coil crystal structure solution by AMPLE through improved ab initio modelling

Thomas, J. M. H., Keegan, R. M., Rigden, D. J. & Davies, O. R., 1 Mar 2020, In: Acta Crystallographica Section D: Structural Biology. p. 272-284 13 p., D76.

Research output: Contribution to journal › Article › peer-review

Open Access

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2019

Target highlights in CASP13: Experimental target structures through the eyes of their authors

Lepore, R., Kryshtafovych, A., Alahuhta, M., Veraszto, H. A., Bomble, Y. J., Bufton, J. C., Bullock, A. N., Caba, C., Cao, H., Davies, O. R., Desfosses, A., Dunne, M., Fidelis, K., Goulding, C. W., Gurusaran, M., Gutsche, I., Harding, C. J., Hartmann, M. D., Hayes, C. S., Joachimiak, A., & 15 othersLeiman, P. G., Loppnau, P., Lovering, A. L., Lunin, V. V., Michalska, K., Mir-Sanchis, I., Mitra, A. K., Moult, J., Phillips, G. N., Pinkas, D. M., Rice, P. A., Tong, Y., Topf, M., Walton, J. D. & Schwede, T., 1 Dec 2019, In: Proteins: Structure, Function and Bioinformatics. 87, 12, p. 1037-1057 21 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Delineation of the SUMO-modified proteome reveals regulatory functions throughout meiosis

Bhagwat, N. R., Owens, S. N., Ito, M., Boinapalli, J. V., Poa, P., Ditzel, A., Kopparapu, S., Mahalawat, M., Davies, O. R., Collins, S. R., Johnson, J. R., Krogan, N. J. & Hunter, N., 12 Nov 2019, bioRxiv, at Cold Spring Harbor Laboratory.

Research output: Working paper

Synchronous chromosome segregation in mouse oocytes is ensured by biphasic securin destruction and cyclin B1-Cdk1

Thomas, C., Levasseur, M. D., Harris, R. J., Davies, O. R. & Madgwick, S., 30 Oct 2019, bioRxiv, at Cold Spring Harbor Laboratory, 37 p.

Research output: Working paper

Molecular structure of human synaptonemal complex protein SYCE1

Dunne, O. M. & Davies, O. R., 1 Sept 2019, In: Chromosoma. 128, p. 223–236 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Crossover recombination and synapsis are linked by adjacent regions within the N terminus of the Zip1 synaptonemal complex protein

Voelkel-Meiman, K., Cheng, S-Y., Parziale, M., Morehouse, S. J., Feil, A., Davies, O. R., Muyt, A. D., Borde, V. & MacQueen, A. J., 20 Jun 2019, In: PLoS Genetics. 15, 6, 40 p., e1008201.

Research output: Contribution to journal › Article › peer-review

Open Access

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A molecular model for self-assembly of the synaptonemal complex protein SYCE3

Dunne, O. M. & Davies, O. R., 7 Jun 2019, In: Journal of Biological Chemistry. 294, 23, p. 9260-9275 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Aneuploidy in oocytes is prevented by sustained CDK1 activity through degron masking in cyclin B1

Levasseur, M. D., Thomas, C., Davies, O. R., Higgins, J. M. G. & Madgwick, S., 11 Mar 2019, In: Developmental Cell. 48, 5, p. 672-684.e5 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1

Dunce, J. M., Milburn, A. E., Gurusaran, M., Cruz, I. D., Sen, L. T., Benavente, R. & Davies, O. R., 17 Dec 2018, In: Nature Communications. 9, 18 p., 5355.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Structural basis of meiotic chromosome synapsis through SYCP1 self-assembly

Dunce, J. M., Dunne, O. M., Ratcliff, M., Millán, C., Madgwick, S., Usón, I. & Davies, O. R., 1 Jul 2018, In: Nature Structural & Molecular Biology. 25, p. 557–569 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Single-molecule observation of DNA compaction by meiotic protein SYCP3

Syrjänen, J. L., Heller, I., Candelli, A., Davies, O. R., Peterman, E. J. G., Wuite, G. J. L. & Pellegrini, L., 13 Mar 2017, In: eLIFE. 6, 14 p., e22582.

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

Erratum: Correction: Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

Carroll, B., Maetzel, D., Maddocks, O. D., Otten, G., Ratcliff, M., Smith, G. R., Dunlop, E. A., Passos, J. F., Davies, O. R., Jaenisch, R., Tee, A. R., Sarkar, S. & Korolchuk, V. I., 16 Dec 2016, In: eLIFE. 5, 23 p., e11058.

Research output: Contribution to journal › Article › peer-review

Open Access

C14ORF39/SIX6OS1 is a constituent of the synaptonemal complex and is essential for mouse fertility

Gómez-H, L., Felipe-Medina, N., Sánchez-Martín, M., Davies, O. R., Ramos, I., García-Tuñón, I., Rooij, D. G. D., Dereli, I., Tóth, A., Barbero, J. L., Benavente, R., Llano, E. & Pendas, A. M., 31 Oct 2016, In: Nature Communications. 7, 16 p., 13298.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

Carroll, B., Maetzel, D., Maddocks, O. D., Otten, G., Ratcliff, M., Smith, G. R., Dunlop, E. A., Passos, J. F., Davies, O. R., Jaenisch, R., Tee, A. R., Sarkar, S. & Korolchuk, V. I., 7 Jan 2016, In: eLIFE. 5, 23 p., e11058.

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

CtIP tetramer assembly is required for DNA-end resection and repair

Davies, O. R., Forment, J. V., Sun, M., Belotserkovskaya, R., Coates, J., Galanty, Y., Demir, M., Morton, C. R., Rzechorzek, N. J., Jackson, S. P. & Pellegrini, L., 1 Feb 2015, In: Nature Structural & Molecular Biology. 22, p. 150–157 8 p.

Research output: Contribution to journal › Article › peer-review

2014

A molecular model for the role of SYCP3 in meiotic chromosome organisation.

Syrjänen, J. L., Pellegrini, L. & Davies, O. R., 20 Jun 2014, In: eLIFE. 3, 18 p., e02963.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2012

Structural analysis of the human SYCE2-TEX12 complex provides molecular insights into synaptonemal complex assembly

Davies, O. R., Maman, J. D. & Pellegrini, L., 1 Jul 2012, In: Open Biology. 2, 7, 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2010

Defining the molecular basis of BubR1 kinetochore interactions and APC/C-CDC20 inhibition

D'Arcy, S., Davies, O. R., Blundell, T. L. & Bolanos-Garcia, V. M., 7 May 2010, In: Journal of Biological Chemistry. 285, 19, p. 14764-14776 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

2007

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

Li, Y., Chirgadze, D. Y., Bolanos-Garcia, V. M., Sibanda, B. L., Davies, O. R., Ahnesorg, P., Jackson, S. P. & Blundell, T. L., 29 Nov 2007, (E-pub ahead of print) In: EMBO Journal. 27, 1, p. 290-300 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

Correction: Corrigendum: Interaction with the BRCA2 C terminus protects RAD51–DNA filaments from disassembly by BRC repeats

Davies, O. R. & Pellegrini, L., Jul 2007, In: Nature Structural and Molecular Biology. 14, 7, 1 p., 680.

Research output: Contribution to journal › Comment/debate › peer-review

Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats

Davies, O. R. & Pellegrini, L., 21 May 2007, In: Nature Structural & Molecular Biology. 14, p. 475–483 9 p.

Research output: Contribution to journal › Article › peer-review

2006

Structural analysis and classification of native proteins from E. coli commonly co-purified by immobilised metal affinity chromatography

Bolanos-Garcia, VM. & Davies, O. R., 1 Sept 2006, In: BBA - General Subjects. 1760, 9, p. 1304-1313 10 p.

Research output: Contribution to journal › Review article › peer-review

A region of human BRCA2 containing multiple BRC repeats promotes RAD51-mediated strand exchange

Shivji, M. K. K., Davies, O. R., Savill, J. M., Bates, D. L., Pellegrini, L. & Venkitaraman, A. R., 16 Aug 2006, In: Nucleic Acids Research. 34, 14, p. 4000-4011 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Structural biology and bioinformatics in drug design: Opportunities and challenges for target identification and lead discovery

Blundell, T. L., Sibanda, B. L., Montalvão, R. W., Brewerton, S., Chelliah, V., Worth, C. L., Harmer, N. J., Davies, O. & Burke, D., 29 Mar 2006, In: Philosophical Transactions of the Royal Society B: Biological Sciences. 361, 1467

Research output: Contribution to journal › Article › peer-review

Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode

Doré, A. S., Furnham, N., Davies, O. R., Sibanda, B. L., Chirgadze, D. Y., Pellegrini, L. & Blundell, T. L., 7 Mar 2006, In: DNA Repair. 5, 3, p. 362-368 7 p.

Research output: Contribution to journal › Article › peer-review

Owen Davies

Research output

Search results