Pat Langridge-Smith

2016

Mass spectrometry analysis of the oxidation states of the pro-oncogenic protein anterior gradient-2 reveals covalent dimerization via an intermolecular disulphide bond

Clarke, D. J., Murray, E., Faktor, J., Mohtar, A., Vojtesek, B., MacKay, C. L., Smith, P. L. & Hupp, T. R., May 2016, In: BBA - Bioenergetics.

Research output: Contribution to journal › Article › peer-review

Open Access

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Determination of Protein Thiol Reduction Potential by Isotope Labeling and Intact Mass Measurement

Thurlow, S. E., Kilgour, D. P., Campopiano, D. J., Mackay, C. L., Langridge-Smith, P. R. R., Clarke, D. J. & Campbell, C. J., 1 Mar 2016, In: Analytical Chemistry. 88, 5, p. 2727-33 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Screen-printed digital microfluidics combined with surface acoustic wave nebulization for hydrogen-deuterium exchange measurements

Monkkonen, L., Edgar, J. S., Winters, D., Heron, S. R., Mackay, C. L., Masselon, C. D., Stokes, A. A., Langridge-Smith, P. R. R. & Goodlett, D. R., Mar 2016, In: Journal of Chromatography A. 1439, p. 161-6 6 p.

Research output: Contribution to journal › Article › peer-review

File

2015

Nebulization of water/glycerol droplets generated by ZnO/Si surface acoustic wave devices

Guo, Y. J., Denison, A. P., Li, Y., Luo, J., Zhu, X. T., Mackay, C. L. M., Langridge-Smith, P., Walton, A. & Fu, R., 2015, In: Microfluidics and Nanofluidics. 19, p. 273-282 10 p.

Research output: Contribution to journal › Article › peer-review

2014

Dissecting the Dynamic Conformations of the Metamorphic Protein Lymphotactin

Harvey, S. R., Porrini, M., Konijnenberg, A., Clarke, D. J., Tyler, R. C., Langridge-Smith, P. R. R., MacPhee, C. E., Volkman, B. F. & Barran, P. E., 30 Oct 2014, In: Journal of Physical Chemistry B (Soft Condensed Matter and Biophysical Chemistry). 118, 43, p. 12348-59 12 p.

Research output: Contribution to journal › Article › peer-review

A novel two-laser interface for coupling capillary electrochromatography with ion-trap time-of-flight mass spectrometry

Simpson, D. C., Yates, A. J., Knox, J. H. & Langridge-smith, P. R. R., 15 Apr 2014, In: International Journal of Mass Spectrometry. 363, p. 8-15

Research output: Contribution to journal › Article › peer-review

Open Access

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2013

Mass Spectrometry Imaging for Dissecting Steroid Intracrinology within Target Tissues

Cobice, D. F., Mackay, C. L., Goodwin, R. J. A., McBride, A., Langridge-Smith, P. R., Webster, S. P., Walker, B. R. & Andrew, R., 3 Dec 2013, In: Analytical Chemistry. 85, 23, p. 11576-11584 9 p.

Research output: Contribution to journal › Article › peer-review

Microscale Volcano of Microdroplet by ZnO Surface Acoustic Waves

Fu, Q. Y., Li, Y., Placido, F., Mackay, C., Langridge-Smith, P. & Walton, A., 7 Oct 2013, p. WP-2-3. 2 p.

Research output: Contribution to conference › Paper › peer-review

The chemical basis of serine palmitoyltransferase inhibition by myriocin

Wadsworth, J. M., Clarke, D. J., McMahon, S. A., Lowther, J. P., Beattie, A. E., Langridge-Smith, P. R. R., Broughton, H. B., Dunn, T. M., Naismith, J. H. & Campopiano, D. J., 25 Sept 2013, In: Journal of the American Chemical Society. 135, 38, p. 14276-85 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Competition between glutathione and DNA oligonucleotides for ruthenium(II) arene anticancer complexes

Wang, F., Xu, J., Wu, K., Weidt, S. K., Mackay, C. L., Langridge-Smith, P. R. R. & Sadler, P. J., 7 Mar 2013, In: Dalton Transactions. 42, 9, p. 3188-3195 8 p.

Research output: Contribution to journal › Article › peer-review

Redox regulation of tumour suppressor protein p53: identification of the sites of hydrogen peroxide oxidation and glutathionylation

Scotcher, J., Clarke, D. J., Mackay, C. L., Hupp, T., Sadler, P. J. & Langridge-Smith, P. R. R., Mar 2013, In: Chemical Science. 4, 3, p. 1257-1269 13 p.

Research output: Contribution to journal › Article › peer-review

2012

Conductive carbon tape used for support and mounting of both whole animal and fragile heat-treated tissue sections for MALDI MS imaging and quantitation

Goodwin, R. J. A., Nilsson, A., Borg, D., Langridge-Smith, P. R. R., Harrison, D. J., Mackay, C. L., Iverson, S. L. & Andrén, P. E., 30 Aug 2012, In: Journal of proteomics. 75, 16, p. 4912-4920 9 p.

Research output: Contribution to journal › Article › peer-review

Test Structures for Characterizing the Integration of EWOD and SAW Technologies for Microfluidics

Li, Y., Fu, R. Y., Winters, D., Flynn, B. W., Parkes, B., Brodie, D. S., Liu, Y., Terry, J., Haworth, L. I., Bunting, A. S., Stevenson, T., Smith, S., MacKay, C. L., Langridge-Smith, P. R. R., Stokes, A. A. & Walton, A. J., 3 Aug 2012, In: IEEE Transactions on Semiconductor Manufacturing. 25, 3, p. 323-330 8 p.

Research output: Contribution to journal › Article › peer-review

L-Penicillamine is a mechanism-based inhibitor of serine palmitoyltransferase by forming a pyridoxal-5 '-phosphate-thiazolidine adduct

Lowther, J., Beattie, A. E., Langridge-Smith, P. R. R., Clarke, D. J. & Campopiano, D. J., Aug 2012, In: Medchemcomm. 3, 8, p. 1003-1008 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression

Latham, T., Mackay, L., Sproul, D., Karim, M., Culley, J., Harrison, D. J., Hayward, L., Langridge-Smith, P., Gilbert, N. & Ramsahoye, B. H., Jun 2012, In: Nucleic Acids Research. 40, 11, p. 4794-4803 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

File

An affinity purification procedure to isolate oxidized p53

Scotcher, J., Clarke, D. J. & Langridge-Smith, P. R. R., 1 Jan 2012, In: Analytical Biochemistry. 420, 1, p. 96-98 3 p.

Research output: Contribution to journal › Article › peer-review

Appropriate degree of trust: deriving confidence metrics for automatic peak assignment in high-resolution mass spectrometry

Kilgour, D. P. A., Mackay, C. L., Langridge-Smith, P. R. R. & O'Connor, P. B., 2012, In: Analytical Chemistry. 84, 17, p. 7431-5 5 p.

Research output: Contribution to journal › Article › peer-review

Ferric ion (hydr)oxo clusters in the "Venus flytrap" cleft of FbpA: Mössbauer, calorimetric and mass spectrometric studies

Mukherjee, A., Bilton, P. R., Mackay, L., Janoschka, A., Zhu, H., Rea, D., Langridge-Smith, P. R. R., Campopiano, D. J., Teschner, T., Trautwein, A. X., Schünemann, V. & Sadler, P. J., 2012, In: JBIC Journal of Biological Inorganic Chemistry.

Research output: Contribution to journal › Article › peer-review

Use of an artificial immune system derived method for the charge state assignment of small-molecule mass spectra

Kilgour, D. P. A., Mackay, C. L., Langridge-Smith, P. R. R. & O'Connor, P. B., 2012, In: Analytical Chemistry. 84, 17, p. 7436-9 4 p.

Research output: Contribution to journal › Article › peer-review

2011

Integrated Top-Down/Bottom-Up Mass Spectrometry of Proteins Using a Droplet Microfluidic Platform

Stokes, A., Mackay, L., Gruber, D., Li, Y., Clarke, D., Walton, A. & Langridge-Smith, P., 2 Oct 2011, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences. p. 1644 3 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Identification of Two Reactive Cysteine Residues in the Tumor Suppressor Protein p53 Using Top-Down FTICR Mass Spectrometry

Scotcher, J., Clarke, D., Weidt, S., Mackay, L., Hupp, T., Sadler, P. & Langridge-Smith, P., May 2011, In: Journal of the American Society for Mass Spectrometry. 22, 5, p. 888-897

Research output: Contribution to journal › Article › peer-review

Test structures and a measurement system for characterising the lifetime of EWOD devices

Gruber, D., Li, Y., Smith, S., Tiwari, A., Deng, F., Stokes, A., Terry, J., Bunting, A., Mackay, C., Langridge-Smith, P. & Walton, A., Apr 2011, 2011 IEEE International Conference on Microelectronic Test Structures (ICMTS). NEW YORK: Institute of Electrical and Electronics Engineers, p. 80-84 5 p.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Mapping a noncovalent protein-peptide interface by top-down FTICR mass spectrometry using electron capture dissociation

Clarke, D. J., Murray, E., Hupp, T., Mackay, C. L. & Langridge-Smith, P. R. R., 2011, In: Journal of the American Society for Mass Spectrometry. 22, 8, p. 1432-40 9 p.

Research output: Contribution to journal › Article › peer-review

Matrix-free mass spectrometric imaging using laser desorption ionisation Fourier transform ion cyclotron resonance mass spectrometry

Goodwin, R. J. A., Pitt, A. R., Harrison, D., Weidt, S. K., Langridge-Smith, P. R. R., Barrett, M. P. & Logan Mackay, C., 2011, In: Rapid communications in mass spectrometry. 25, 7, p. 969-72 4 p.

Research output: Contribution to journal › Article › peer-review

2010

Online Quench-Flow Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Elucidating Kinetic and Chemical Enzymatic Reaction Mechanisms

Clarke, D. J., Stokes, A., Langridge-Smith, P. & Mackay, C. L., 1 Mar 2010, In: Analytical Chemistry. 82, 5, p. 1897-1904 8 p.

Research output: Contribution to journal › Article › peer-review

Top-down protein sequencing by CID and ECD using desorption electrospray ionisation (DESI) and high-field FTICR mass spectrometry

Stokes, A. A., Clarke, D. J., Weidt, S., Langridge-Smith, P. & Mackay, C. L., 1 Jan 2010, In: International Journal of Mass Spectrometry. 289, 1, p. 54-57 4 p.

Research output: Contribution to journal › Article › peer-review

Subdivision of the bacterioferritin comigratory protein family of bacterial peroxiredoxins based on catalytic activity

Clarke, D. J., Ortega, X. P., Mackay, C. L., Valvano, M. A., Govan, J. R. W., Campopiano, D. J., Langridge-Smith, P. & Brown, A. R., 2010, In: Biochemistry. 49, 6, p. 1319-30 12 p.

Research output: Contribution to journal › Article › peer-review

2009

Interrogating the molecular details of the peroxiredoxin activity of the Escherichia coli bacterioferritin comigratory protein using high-resolution mass spectrometry

Clarke, D. J., Mackay, C. L., Campopiano, D. J., Langridge-Smith, P. & Brown, A. R., May 2009, In: Biochemistry. 48, 18, p. 3904-14 11 p.

Research output: Contribution to journal › Article › peer-review

Development of a Microfluidic Quench-Flow Interface Compatible with ESI-FT-ICR-MS for the Characterisation of Enzyme Mechanisms

Clarke, D., Stokes, A., Langridge-Smith, P. & Mackay, L., 2009, 57th ASMS Conference on Mass Spectrometry.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Development of Digital Microfluidics for Low-Volume Multiplexed Sample Handling in Biological Mass Spectrometry

Stokes, A., Li, Y., Parkes, W., Clarke, D., Langridge-Smith, P., Mackay, L. & Walton, A., 2009, 57th ASMS Conference on Mass Spectrometry.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Precursor ion independent algorithm for top-down shotgun proteomics

Tsai, Y., Scherl, A., Shaw, J., Mackay, L., Schaffer, S., Langridge-Smith, P. & Goodlett, D., 2009, In: Journal of the American Society for Mass Spectrometry. 20, 11, p. 2154-2166

Research output: Contribution to journal › Article › peer-review

2008

Sensitive, Specific and Quantitative FT-ICR Mass Spectrometry of Combinatorial Post-Translational Modifications in Intact Histone H4

Mackay, L., Ramsahoye, B., Burgess, K., Cook, K., Weidt, S., Creanor, J., Harrison, D., Langridge-Smith, P., Hupp, T. & Hayward, L., Jun 2008, In: Analytical Chemistry. 80, 11, p. 4147-4153

Research output: Contribution to journal › Article › peer-review

Development of Automated Protein Identification by nLC EWOD DESI FT-ICR ECD MS/MS

Stokes, A., Galloway, C., Li, Y., Parkes, W., Dryden, D., Walton, A., Langridge-Smith, P. & Mackay, L., 2008, 56th ASMS Conference on Mass Spectrometry.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Identification of clusters from reactions of ruthenium arene anticancer complex with glutathione using nanoscale liquid chromatography Fourier transform ion cyclotron mass spectrometry combined with (18)O-labeling

Wang, F., Weidt, S., Xu, J., Mackay, C. L., Langridge-Smith, P. R. R. & Sadler, P. J., 2008, In: Journal of the American Society for Mass Spectrometry. 19, 4, p. 544-549 6 p.

Research output: Contribution to journal › Article › peer-review

Sensitive, specific, and quantitative FTICR mass spectrometry of combinatorial post-translational modifications in intact histone H4

Mackay, C. L., Ramsahoye, B., Burgess, K., Cook, K., Weidt, S., Creanor, J., Harrison, D., Langridge-Smith, P., Hupp, T. & Hayward, L., 2008, In: Analytical Chemistry. 80, 11, p. 4147-4153 7 p.

Research output: Contribution to journal › Article › peer-review

2007

Microarray-formatted clinical biomarker assay development using peptide aptamers to anterior gradient-2

Murray, E., McKenna, E. O., Burch, L. R., Dillon, J., Langridge-Smith, P., Kolch, W., Pitt, A. & Hupp, T. R., 2007, In: Biochemistry. 46, 48, p. 13742-51 10 p.

Research output: Contribution to journal › Article › peer-review

Platination of superoxide dismutase with cisplatin: tracking the ammonia ligands using Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)

Weidt, S. K., Mackay, C. L., Langridge-Smith, P. R. R. & Sadler, P. J., 2007, In: Chemical Communications. 17, p. 1719-21 3 p.

Research output: Contribution to journal › Article › peer-review

2006

Destabilizing missense mutations in the tumour suppressor protein p53 enhance its ubiquitination in vitro and in vivo

Shimizu, H., Saliba, D., Wallace, M., Finlan, L., Langridge-Smith, P. R. R. & Hupp, T. R., 2006, In: Biochemical Journal. 397, 2, p. 355-67 13 p.

Research output: Contribution to journal › Article › peer-review

2005

Structural investigation of naturally occurring peptides by electron capture dissociation and AMBER force field modelling

Polfer, N. C., Haselmann, K. F., Langridge-Smith, P. R. R. & Barran, P. E., 10 Jun 2005, In: Molecular Physics. 103, 11-12, p. 1481-1489 9 p.

Research output: Contribution to journal › Article › peer-review

Is it biologically relevant to measure the structures of small peptides in the gas-phase?

Barran, P. E., Polfer, N. C., Campopiano, D. J., Clarke, D. J., Langridge-Smith, P. R. R., Langley, R. J., Govan, J. R. W., Maxwell, A., Dorin, J. R., Millar, R. P. & Bowers, M. T., 1 Feb 2005, In: International Journal of Mass Spectrometry. 240, 3, p. 273-284 12 p.

Research output: Contribution to journal › Article › peer-review

2004

Analysis of low oxidation state transition metal clusters by laser desorption/ionization time-of-flight mass spectrometry

Dyson, P. J., Hearley, A. K., Johnson, B. F. G., Langridge-Smith, P. R. R. & McIndoe, J. S., 9 Aug 2004, In: Inorganic Chemistry. 43, 16, p. 4962-4973 12 p.

Research output: Contribution to journal › Article › peer-review

2003

Inert site in a protein zinc cluster: Isotope exchange by high resolution mass spectrometry

Blindauer, C. A., Polfer, N. C., Keiper, S. E., Harrison, M. D., Robinson, N. J., Langridge-Smith, P. R. R. & Sadler, P. J., 19 Mar 2003, In: Journal of the American Chemical Society. 125, 11, p. 3226-3227 2 p.

Research output: Contribution to journal › Article › peer-review

A strategy for generating naked-metal clusters for gas-phase reactivity studies by FTICR-MS

Butcher, C. P. G., Dinca, A., Dyson, P. J., Johnson, B. F. G., Langridge-Smith, P. R. R. & McIndoe, J. S., 2003, In: Angewandte Chemie International Edition. 42, 46, p. 5752-5755 4 p.

Research output: Contribution to journal › Article › peer-review

2002

Electron capture dissociation of polypeptides using a 3 Tesla Fourier transform ion cyclotron resonance mass spectrometer

Polfer, N. C., Haselmann, K. F., Zubarev, R. A. & Langridge-Smith, P. R. R., 2002, In: Rapid communications in mass spectrometry. 16, 10, p. 936-943 8 p.

Research output: Contribution to journal › Article › peer-review

On the use of breakdown graphs combined with energy-dependent mass spectrometry to provide a complete picture of fragmentation processes

Butcher, C. P. G., Dyson, P. J., Johnson, B. F. G., Langridge-Smith, P. R. R., McIndoe, J. S. & Whyte, C., 2002, In: Rapid communications in mass spectrometry. 16, 16, p. 1595-1598 4 p.

Research output: Contribution to journal › Article › peer-review

Pat Langridge-Smith

Research output

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