Research output per year
Research output per year
Personal profile
Current Research Interests
Replication and pathogenesis of influenza viruses.
Research Interests
Professor Digard is a virologist who has published on herpesviruses, plus strand RNA viruses and (primarily) on influenza A virus.
His laboratory is interested in the molecular and cellular biology of how influenza virus replicates, using this information to understand the basis of virus pathogenesis and host range, as well as for translational studies on antiviral drug development and virus control measures.
In recent years, the group has focused on three main areas: identifying cellular pathways and viral elements involved in genome trafficking and virus assembly, on the function of the viral RNA synthesis machinery and its role in setting host range, and in identifying novel virus polypeptides, at least three of which affect virus pathogenicity.
Websites
http://www.roslin.ed.ac.uk/paul-digard/
Biography
| 2006-2011 | Honorary Researcher, Cambridge University Hospitals Trust |
| 2005-2011 | Senior Lecturer |
| 2004-2005 | University Lecturer |
| 2003-2004 |
Senior Research Associate, Funded by Wellcome Trust Value in People award |
| 1995-2003 |
Royal Society University Research Fellow |
| 1993-1995 |
Research Associate, Division of Virology, Department of Pathology, University of Cambridge |
| 1989-1993 |
Fellow, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School |
Qualifications
| .1982-1985 | St John's College, University of Cambridge, U.K. M.A.(2i.) in Natural Science |
| 1985-1989 | Division of Virology, Department of Pathology, University of Cambridge. Ph.D. in virology |
Administrative Roles
PhD Student Thesis Committees
| 2012-present | Chair: Charles Vander Broek |
| 2012-2014 | Advisor: Seema Jasim |
| 2012-present | Chair: Dung Nguyen |
| 2012-present | Advisor: Alexander Brown |
| 2013-present |
Advisor: Andrew Mason |
Other Committees etc
| 2012-2013 | Promotions Committee, The Pirbright Institute |
| 2012-2014 | Roslin Institute, Biological Safety Committee |
| 2012-2014 | Roslin Institute Senior Management Group |
| 2014 | Acting Head of Division, Infection and Immunity |
| 2014- | Roslin Institute Bioimaging Committee |
Teaching
Lecturing
| 1997-present | Virology option of Pathology Part II, University of Cambridge | |
| 2000 | Virology MSc. course, London School of Hygiene and Tropical Medicine. | |
| 2000-2005 | Virology module, The Gulbenkian Foundation, Lisbon, Portugal. | |
| 2003-2011 | Wellcome Trust 4 yr PhD program: Infection and Immunity | |
| 2005-2012 | Part IB Pathology, University of Cambridge | |
| 2012-present | One Health/Animal Biosciences MSc, University of Edinburgh | |
| 2012-present | Infectious Diseases, BSc Honours, University of Edinbugh |
Practical Classes:
| 1985-1988 | Virology practical, Pathology IB, University of Cambridge |
| 1993-2011 | Virology practical, Pathology IB, University of Cambridge. Class organiser, 2006-2011. Class of 500 students. |
| 1993-1999 | Virology practical, Pathology II, University of Cambridge. Class of 20 students. |
| 2000 | Virology module, The Gulkenkian Foundation, Lisbon, Portugal. Class of 12 students |
Research Projects
| 1993-2011 | Pathology Part II final year research projects, University of Cambridge |
| 2001 | Biomedical Sciences BSc course, Anglia Polytechnic University |
| 2015 | Infectious Diseases (Honours) final year research project, University of Edinburgh |
Small Group Teaching
| 1986-1989, 2001-2013 | Virology & parasitology supervisions, Pathology IB, University of Cambridge | |
| 1993-2011 | Virology supervisions, Pathology II, University of Cambridge | |
| 2004-2011 | Virology Part II data handling sessions and paper presentations, University of Cambridge | |
| 2004 | Part IB Infectious Diseases in Animals & Man, University of Cambridge | |
| 2013-present | 1st year BVM&S (Vet Med), The Animal Body 2, University of Edinburgh |
Media
Newspaper articles
Rebirth for killer of 40 million. The Scotsman, p15; 23/10/00.
Can we learn from Spanish Flu? The Guernsey Evening Press, p26-27; 17/11/00.
Deadly virus has hidden dangers for mankind. The Guernsey Press, p25, 9/3/01. (With J. Greatorex).
Germ warfare: the true, grim facts. The Guernsey Press, p25, 19/10/01. (With J. Greatorex).
Is death waiting in the wings?. The Guernsey Press, p20-21, 4/2/04.
Bird flu - what are the dangers? The Guernsey Press, 7/11/05
Only time will tell whether swine flu is next pandemic. The Guernsey Press, 28/4/09
Media Appearances
I have given interviews on the subject of influenza on Radio 4, Radio 5, BBC World Service, The Naked Scientist Radio Show/Podcast as well as various BBC local radio stations. I have also provided BBC News with background briefings on the subject of avian and swine influenza.
Public lectures/events
Jan 2006 Cambridge University Scientific Society, Cambridge.
Nov 2012 Our Changing World series, University of Edinburgh (http://www.youtube.com/watch?v=vZlkW5PxIog)
October 2013 Science in the saddle, Midlothian Science Festival.
April 2014. The virus hunters. Edinburgh Science Festival.
Research students
Matt Smith, PhD
Alice Coburn, PhD, joint with Glasgow University
Rebecca Dewar, PhD
Anabel Clements, PhD
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Evolutionary Conservation of the PA-X Open Reading Frame in Segment 3 of Influenza A Virus
Shi, M., Jagger, B. W., Wise, H. M., Digard, P., Holmes, E. C. & Taubenberger, J. K., Nov 2012, In: Journal of Virology. 86, 22, p. 12411-12413 3 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Nucleozin Targets Cytoplasmic Trafficking of Viral Ribonucleoprotein-Rab11 Complexes in Influenza A Virus Infection
Amorim, M. J., Kao, R. Y. & Digard, P., Apr 2013, In: Journal of Virology. 87, 8, p. 4694-4703 10 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response
Jagger, B. W., Wise, H. M., Kash, J. C., Walters, K. A., Wills, N. M., Xiao, Y. L., Dunfee, R. L., Schwartzman, L. M., Ozinsky, A., Bell, G. L., Dalton, R. M., Lo, A., Efstathiou, S., Atkins, J. F., Firth, A. E., Taubenberger, J. K. & Digard, P., Jul 2012, In: Science. 337, 6091, p. 199-204 6 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A Complicated Message: Identification of a Novel PB1-Related Protein Translated from Influenza A Virus Segment 2 mRNA
Wise, H. M., Foeglein, A., Sun, J., Dalton, R. M., Patel, S., Howard, W., Anderson, E. C., Barclay, W. S. & Digard, P., Aug 2009, In: Journal of Virology. 83, 16, p. 8021-8031 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase
Muratore, G., Goracci, L., Mercorelli, B., Foeglein, A., Digard, P., Cruciani, G., Palu, G. & Loregian, A., 2012, In: Proceedings of the National Academy of Sciences (PNAS). 109, 16, p. 6247-6252 6 p.Research output: Contribution to journal › Article › peer-review
Activities
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The past, present and possible future of bird flu
Paul Digard (Assessor)
27 Nov 2023Activity: Academic talk or presentation types › Invited talk
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House of Commons, Science, Innovation and Technology Committee
Paul Digard (Advisor)
21 Jun 2023Activity: Consultancy types › Providing oral or written evidence for non-academic board, committee, working group or advisory panel
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Misleading to the Public’: Students, Experts Criticize Harvard Study Suggesting Early Emergence of Covid-19 in Wuhan
Paul Digard (Advisor)
12 May 2021Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
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“Connections: COVID 19 One Year On”
Paul Digard (Advisor)
31 Mar 2021Activity: Participating in or organising an event types › Public Engagement – Public lecture/debate/seminar
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Owen Thompson MP Visit to Roslin Institute
Bruce Whitelaw (Advisor), Paul Digard (Advisor), Val White (Advisor), David Argyle (Advisor) & Christine Tait-Burkard (Advisor)
12 Aug 2020Activity: Participating in or organising an event types › Public Engagement – Schools engagement
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Quantifying Exhaled Aerosolised Respiratory Virus In Acutely Hospitalised Patients
Walsh, T., Arvind, D. K., Digard, P. & Viola, I. M.
1/09/24 → 31/08/26
Project: Research
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ECOFLU : Understanding the ecology of Highly Pathogenic Avian Influenza in wild bird populations
Cunningham, E., Cunningham, E., Bronsvoort, M., Digard, P., Digard, P., Gaunt, E., Gaunt, E., Lycett, S., Lycett, S., Nichol, C., Silk, M. & Smith, J.
Natural Environment Research Council
15/04/24 → 14/04/26
Project: Research
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Assessing the risk of transmissible zoonotic avian and swine influenza viruses
1/02/24 → 31/01/27
Project: Research
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Flu Trailmap (Transmission and risk of avian influenza: learning more to advance preparedness)
Kao, R., Bronsvoort, M., Digard, P., Gaunt, E., Lycett, S., Smith, J. & Sutton, K.
15/11/23 → 31/03/26
Project: Research
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Roslin Foundation PhD Studentships-RF2023/001
Digard, P., Gaunt, E., Hassan, M., Mabbott, N., Mabbott, N., Morrison, L., Prendergast, J., Stevens, M. & Sutton, K.
1/10/23 → 30/09/27
Project: Research
Datasets
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Data from A Brief History of Bird Flu
Lycett, S. (Creator), Duchatel, F. (Project Member) & Digard, P. (Project Member), Dryad, 6 May 2019
Dataset
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Raw red counts from a CRISPR screen for host factors required for influenza virus replication
Clohisey Hendry, S. (Creator), Chia, B. S. (Creator), Wang, B. (Creator), Cui, A. (Creator), Eisenhaure, T. (Creator), Schweitzer, L. D. (Creator), Hoover, P. (Creator), Nachshon, A. (Creator), Smith, N. (Creator), Regan, T. (Creator), Farr, D. (Creator), Gutmann, M. (Creator), Bukhari, S. I. (Creator), Law, A. (Creator), Sangesland, M. (Creator), Gat-Viks, I. (Creator), Digard, P. (Creator), Vasudevan, S. (Creator), Lingwood, D. (Creator), Dockrell, D. (Creator), Doench, J. G. (Creator), Baillie, K. (Creator), Hacohen, N. (Creator), Parkinson, N. J. (Creator) & Li, B. (Creator), Edinburgh DataShare, 14 Oct 2024
DOI: 10.7488/ds/7818
Dataset
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Face coverings and respiratory tract droplet dispersion
Bandiera, L. (Creator), Pavar, G. (Creator), Pisetta, G. (Creator), Otomo, S. (Creator), Mangano, E. (Creator), Seckl, J. (Creator), Digard, P. (Creator), Molinari, E. (Creator), Menolascina, F. (Creator) & Viola, I. M. (Creator), Edinburgh DataShare, 11 Aug 2020
DOI: 10.7488/ds/2897, https://datashare.is.ed.ac.uk/handle/10283/3729
Dataset
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Face Coverings, Aerosol Dispersion and Mitigation of Virus Transmission Risk. Dataset 3: raw and processed data for tests 97 - 174
Viola, I. M. (Creator), Peterson, B. (Creator), Pisetta, G. (Creator), Pavar, G. (Creator), Akhtar, H. (Creator), Menoloascina, F. (Creator), Mangano, E. (Creator), Nila, A. (Creator), Molinari, E. (Creator), Cummins, C. (Creator), McDougall, C. (Creator), Denison, F. (Creator), Dunn, K. (Creator), Gabl, R. (Creator), Digard, P. (Creator), Dunn, M. (Creator), Lo, T. Y. M. (Creator) & Mehendale, F. V. (Creator), Edinburgh DataShare, 25 May 2020
DOI: 10.7488/ds/2832
Dataset
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Face Coverings, Aerosol Dispersion and Mitigation of Virus Transmission Risk. Dataset 1: videos, images and spirometry results
Peterson, B. (Creator), Pisetta, G. (Creator), Pavar, G. (Creator), Akhtar, H. (Creator), Menoloascina, F. (Creator), Mangano, E. (Creator), Nila, A. (Creator), Molinari, E. (Creator), McDougall, C. (Creator), Denison, F. (Creator), Dunn, K. (Creator), Gabl, R. (Creator), Digard, P. (Creator), Dunn, M. (Creator), Lo, T. Y. M. (Creator), Mehendale, F. V. (Creator), Cummins, C. (Creator) & Viola, I. M. (Creator), Edinburgh DataShare, 19 May 2020
DOI: 10.7488/ds/2826
Dataset
Press/Media
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The threat of a bird flu pandemic is rising but experts say the risk remains low. Are they right?
1/08/24
1 Media contribution
Press/Media: Research
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Avian influenza: new human infections and an accelerating epizootic in the United States
8/06/24
1 Media contribution
Press/Media: Expert Comment
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Bird flu outbreak in US cattle sparks fears over next global health crisis
3/05/24
1 Media contribution
Press/Media: Research
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Commentary: How worried should we be about bird flu in US cows and milk?
1/05/24
1 Media contribution
Press/Media: Research
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How worried should we be about the return of bird flu?
1/05/24
1 Media contribution
Press/Media: Research