Research output per year
Research output per year
- 1 - 50 out of 139 results
Search results
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2025
Pasteurisation temperatures effectively inactivate influenza A viruses in milk
Schafers, J., Warren, C., Yang, J., Zhang, J., Cole, S., Cooper, J., Drewek, K., Kolli, B., McGinn, N., Qureshi, M., Reid, S., Peacock, T. P., Brown, I., James, J., Banyard, A., Iqbal, M., Digard, P. & Hutchinson, E., 30 Jan 2025, In: Nature Communications. 16, 1, p. 1-9 9 p., 1173.Research output: Contribution to journal › Article › peer-review
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Assessing stakeholder inclusion within high pathogenicity avian influenza risk governance strategies in the UK and USA
Lyons, K., Kapczynski, D. R., Lycett, S., Digard, P. & Boden, L., 2025, In: Frontiers in Veterinary Science. 12, p. 1-18 18 p., 1547628.Research output: Contribution to journal › Article › peer-review
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2024
Towards the development of a mini-genome assay for species A Rotaviruses
Diebold, O., Zhou, S., Sharp, C., Tesla, B., Chook, H. W., Digard, P. & Gaunt, E., 31 Aug 2024, In: Viruses. 16, 9, p. 1-12 12 p., 1396.Research output: Contribution to journal › Article › peer-review
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An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts
Guo, Y., Shu, S., Zhou, Y., Peng, W., Jiang, Z., Li, Y., Li, T., Du, F., Dong, J., Zhao, C., Wang, M. H., Sun, Y., Sun, H., Lu, L., Digard, P., Chang, K.-C., Wang, L., Chen, X., Liu, J. & Pu, J., 26 Jul 2024, (E-pub ahead of print) bioRxiv, p. 1-39, 39 p.Research output: Working paper › Preprint
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Validation of host cell entry factors for Bovine Herpes Virus Type-1 from a genome-wide CRISPR knockout screen
Tan, S., Rong, E., Dry, I., Lillico, S., Law, A., Digard, P., Whitelaw, B. & Dalziel, R., 15 Feb 2024, In: Viruses. 16, 297, p. 1-22 22 p.Research output: Contribution to journal › Article › peer-review
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Highly Pathogenic Avian Influenza and its Complex Patterns of Reassortment
Lycett, S., Harvey, W., Lu, L., Pohlmann, A., Beer, M., Kuiken, T., Pinto, R., Kapczynski, D., Ruiz-Pérez, D. & Digard, P., 16 Jan 2024, p. P3.092.Research output: Contribution to conference › Poster
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2023
Evaporation of Concentrated Polymer Solutions is Insensitive to Relative Humidity
Huisman, M., Digard, P., Poon, W. C. K. & Titmuss, S., 15 Dec 2023, In: Physical Review Letters. 131, p. 1-5 5 p., 248102.Research output: Contribution to journal › Article › peer-review
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GARP and EARP are required for efficient BoHV-1 replication as identified by a genome wide CRISPR knockout screen
Tan, W. S., Rong, E., Dry, I., Lillico, S. G., Law, A., Digard, P., Whitelaw, B. & Dalziel, R. G., Dec 2023, In: PLoS Pathogens. 19, 12, p. 1-29 29 p., e1011822.Research output: Contribution to journal › Article › peer-review
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One for all – Human kidney Caki-1 cells are highly susceptible to infection with corona and other respiratory viruses
Daniels, A., Fletcher, S., Kerr, H., Kratze, A., Pinto, R., Kriplani, N., Craig, N., Hastie, C. J., Davies, P., Digard, P., Thiel, V. & Tait-Burkard, C., 28 Sept 2023, In: Journal of Virology. 97, 9, p. 1-22 22 p.Research output: Contribution to journal › Article › peer-review
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BTN3A3 evasion promotes the zoonotic potential of influenza A viruses
Pinto, R. M., Bakshi, S., Lytras, S., Zakaria, M. K., Swingler, S., Worrell, J. C., Herder, V., Hargrave, K. E., Varjak, M., Cameron-Ruiz, N., Collados Rodriguez, M., Varela, M., Wickenhagen, A., Loney, C., Pei, Y., Hughes, J., Valette, E., Turnbull, M. L., Furnon, W. & Gu, Q. & 13 others, , 13 Jul 2023, In: Nature. 619, 7969, p. 338-347 33 p.Research output: Contribution to journal › Article › peer-review
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Novel clade 2.3.4.4b H5N1 avian influenza virus reassortants identified from migratory birds in China: posing risks to birds and public health
Yang, J., Zhang, C., Yuan, Y., Sun, J., Lu, L., Sun, H., Sun, H., Chu, D., Qin, S., Chen, J., Zhang, C., Hao, X., Shi, W., Liu, W., Gao, G. F., Digard, P., Lycett, S. & Bi, Y., Jun 2023, In: Emerging Infectious Diseases. 29, 6, p. 1244-1249Research output: Contribution to journal › Article › peer-review
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CpG dinucleotide enrichment in the influenza A virus genome as a live attenuated vaccine development strategy
Sharp, C. P., Thompson, B. H., Nash, T. J., Diebold, O., Pinto, R. M., Thorley, L., Lin, Y.-T., Sives, S., Wise, H., Clohisey Hendry, S., Grey, F., Vervelde, L., Simmonds, P., Digard, P. & Gaunt, E. R., May 2023, In: PLoS Pathogens. 19, 5, p. 1-34 33 p., e1011357.Research output: Contribution to journal › Article › peer-review
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The P323L substitution in the SARS-CoV-2 polymerase (NSP12) confers a selective advantage during infection
ISARIC4C Investigators, Baillie, J. K. & Digard, P., 13 Mar 2023, (E-pub ahead of print) In: Genome Biology. 24, 1, p. 1-23 22 p., 47.Research output: Contribution to journal › Article › peer-review
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The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility
Morris, K., Mishra, A., Raut, A. A., Gaunt, E., Borowska, D., Kuo, R., Wang, B., Vijayakumar, P., Chingtham, S., Dutta, R., Baillie, J. K., Digard, P., Vervelde, L., Burt, D. & Smith, J., 28 Feb 2023, (E-pub ahead of print) In: Frontiers in Cellular and Infection Microbiology. 13, p. 1-17 16 p.Research output: Contribution to journal › Article › peer-review
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Comparative analysis of different inbred chicken lines highlights how a hereditary inflammatory state affects susceptibility to avian influenza virus
Bryson, K., Sives, S., Lee, H.-M., Borowska, D., Smith, J., Digard, P. & Vervelde, L., 21 Feb 2023, In: Viruses. 15, 3, p. 1-20 19 p., 591.Research output: Contribution to journal › Article › peer-review
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Corrigendum: The molecular basis of differential host responses to avian influenza viruses in avian species with differing susceptibility
Morris, K. M., Mishra, A., Raut, A. A., Gaunt, E. R., Borowska, D., Kuo, R. I., Wang, B., Vijayakumar, P., Chingtham, S., Dutta, R., Baillie, K., Digard, P., Vervelde, L., Burt, D. W. & Smith, J., 2023, In: Frontiers in Cellular and Infection Microbiology. 13, p. 1-1 1 p., 1194878.Research output: Contribution to journal › Comment/debate › peer-review
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2022
Personalised 3D printed respirators for healthcare workers during the COVID-19 pandemic
Roche, A., McConnell, A., Donaldson, K., Lawson, A., Tan, S., Toft, K., Cairns, G., Colle, A., Coleman, A. A., Stewart, K., Digard, P., Norrie, J. & Stokes, A. A., 1 Aug 2022, (E-pub ahead of print) In: Frontiers in Medical Technology. 4, 963541.Research output: Contribution to journal › Article › peer-review
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TRIM25 inhibits influenza A virus infection, destabilises viral mRNA, but is redundant for activating the RIG-I pathway
Roy Choudhury, N., trus, I., Heikel, G., Wolczyk, M., Szymanski, J., Bolembach, A., Dos Santos Pinto, R. M., Smith, N., Trubitsyna, M., Gaunt, E., Digard, P. & Michlewski, G., 8 Jul 2022, In: Nucleic Acids Research. 50, 12, p. 7097-7114Research output: Contribution to journal › Article › peer-review
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Using species A rotavirus reverse genetics to engineer chimeric viruses expressing SARS-CoV-2 spike epitopes: Heterologous viral peptide expression by rotavirus A
Diebold, O., Gonzalez-martinez, V., Venditti, L., Sharp, C., Blake, R., Tan, S., Stevens, J., Caddy, S., Digard, P., Borodavka, A. & Gaunt, E., 27 Jun 2022, In: Journal of Virology. 96, 14, p. 1-25 25 p.Research output: Contribution to journal › Article › peer-review
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TRIM25 inhibits influenza A virus infection, destabilizes viral mRNA, but is redundant for activating the RIG-I pathway
Choudhury, N. R., Trus, I., Heikel, G., Wolczyk, M., Szymanski, J., Bolembach, A., Dos santos pinto, R. M., Smith, N., Trubitsyna, M., Gaunt, E., Digard, P. & Michlewski, G., 23 Jun 2022, In: Nucleic Acids Research.Research output: Contribution to journal › Article › peer-review
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2021
Heterogeneity of Early Host Response to Infection with Four Low-Pathogenic H7 Viruses with a Different Evolutionary History in the Field
Zamperin, G., Bianco, A., Smith, J., Bortolami, A., Vervelde, L., Schivo, A., Fortin, A., Marciano, S., Panzarin, V. M., Mazzetto, E., Milani, A., Berhane, Y., Digard, P., Bonfante, F. & Monne, I., 21 Nov 2021, (E-pub ahead of print) In: Viruses. 13, 11Research output: Contribution to journal › Article › peer-review
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Constitutive TRIM22 expression in the respiratory airway confers a pre-existing defence against influenza A virus infection
Charman, M., Mcfarlane, S. T., Wojtus, J. K., Sloan, E., Digard, P., Leeming, G. H., Al-Saadi, M., Hunter, L., Carroll, M. W., Stewart, J. P., Digard, P., Hutchinson, E. & Boutell, C., 21 Sept 2021, (E-pub ahead of print) In: Frontiers in Cellular and Infection Microbiology.Research output: Contribution to journal › Article › peer-review
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STING Nuclear Partners Contribute to Innate Immune Signalling Responses
Dixon, C., Malik, P., de las Heras, J., Saiz ros, N., Alves, F. L., Tingey, M., Gaunt, E., Richardson, A. C., Kelly, D., Goldberg, M., Towers, G. J., Yang, W., Rappsilber, J., Digard, P. & Schirmer, E. C., 28 Aug 2021, (E-pub ahead of print) In: iScience. 103055.Research output: Contribution to journal › Article › peer-review
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Secreted SARS-CoV-2 ORF8 modulates the cytokine expression profile of human macrophages
Kriplani, N., Clohisey, S., Fonseca, S., Fletcher, S., Lee, H.-M., Ashworth, J., Kurian, D., Lycett, S. J., Tait-Burkard, C., Baillie, J. K., Woolhouse, M. E. J., Carding, S. R., Stewart, J. P. & Digard, P., 18 Aug 2021, (E-pub ahead of print) bioRxiv, at Cold Spring Harbor Laboratory.Research output: Working paper
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Compositional biases in RNA viruses: causes, consequences and applications
Gaunt, E. & Digard, P., 21 Jun 2021, (E-pub ahead of print) In: Wiley Interdisciplinary Reviews: RNA. e1679.Research output: Contribution to journal › Article › peer-review
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PA-X is an avian virulence factor in H9N2 avian influenza virus
Clements, A. L., Peacock, T. P., Sealy, J. E., Lee, H. M., Hussain, S., Sadeyen, J.-R., Shelton, H., Digard, P. & Iqbal, M., 5 Feb 2021, (E-pub ahead of print) In: Journal of General Virology.Research output: Contribution to journal › Article › peer-review
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Face coverings, aerosol dispersion and mitigation of virus transmission risk
Viola, I. M., Peterson, B., Pisetta, G., Pavar, G., Akhtar, H., Menolaoscina, F., Mangano, E., Dunn, K., Gabl, R., Nila, A., Molinari, E., Cummins, C., Thompson, G., Lo, T.-Y. M., Denison, F. C., Digard, P., Malik, O., Dunn, M. J. G., McDougall, C. M. & Mehendale,, F. V., 20 Jan 2021, In: IEEE Open Journal of Engineering in Medicine and Biology.Research output: Contribution to journal › Article › peer-review
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2020
Face Coverings and Respiratory Tract Droplet Dispersion
Bandiera, L., Pavar, G., Pisetta, G., Otomo, S., Mangano, E., Seckl, J. R., Digard, P., Molinari, E., Menolascina, F. & Viola, I. M., 23 Dec 2020, In: Royal Society Open Science.Research output: Contribution to journal › Article › peer-review
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Face masks: what the data say
Peeples, L. & Digard, P., 6 Oct 2020, (E-pub ahead of print) Nature, p. 186-189 4 p.Research output: Contribution to specialist publication › Featured article
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Accessory gene products of influenza A virus
Pinto, R., Lycett, S., Gaunt, E. & Digard, P., 28 Sept 2020, (E-pub ahead of print) Perspectives in Medicine. Cold Spring Harbor Laboratory Press, (Cold spring harbor perspectives in medicine)(Additional Perspectives articles for Influenza: The Cutting Edge).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
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Intra-genome variability in the dinucleotide composition of SARS-CoV-2
Digard, P., Lee, H.-M., Sharp, C., Grey, F. & Gaunt, E., 13 Aug 2020, (E-pub ahead of print) In: Virus Evolution.Research output: Contribution to journal › Article › peer-review
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Contribution of segment 3 to the acquisition of virulence in contemporary H9N2 avian influenza viruses
Clements, A. L., Sealy, J. E., Peacock, T. P., Sadeyen, J.-R., Hussain, S., Lycett, S. J., Shelton, H., Digard, P. & Iqbal, M., 29 Jul 2020, (E-pub ahead of print) In: Journal of Virology.Research output: Contribution to journal › Article › peer-review
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Staphylococcus aureus lipase 1 enhances influenza A virus replication
Goncheva, M., Conceição, C., Tuffs, S., Lee, H.-M., Quigg-Nicol, M., Bennet, I., Sargison, F., Pickering, A., Hussain, S., Gill, A., Dutia, B., Digard, P. & Fitzgerald, R., 7 Jul 2020, (E-pub ahead of print) In: mBio. 11, 4, 16 p., e00975-20.Research output: Contribution to journal › Article › peer-review
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Hybrid Gene Origination Creates Human-Virus Chimeric Protein During Infection
Yuin Ho, J. S., Angel, M., Ma, Y., Sloan, E., Wang, G., Martinez-Romero, C., Alenquer, M., Roudko, V., Chung, L., Zheng, S., Chang, M., Fstkchyan, Y., Clohisey, S., Dinan, A. M., Gibbs, J., Gifford, R., Shen, R., Gu, Q., Irigoyen, N. & Campisi, L. & 34 others, , 25 Jun 2020, In: Cell. 181, 7, p. 1502-1517Research output: Contribution to journal › Article › peer-review
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Comprehensive characterisation of transcriptional activity during influenza A virus infection reveals biases in cap-snatching of host RNA sequences.
Clohisey, S., Parkinson, N., Wang, B., Bertin, N., Wise, H., Tomoiu, A., FANTOM consortium, T., Summers, K. M., Hendry, R. W., Carninci, P., Forrest, A. A., Hayashizaki, Y., Digard, P., Hume, D. & Baillie, K., 11 Mar 2020, (E-pub ahead of print) In: Journal of Virology.Research output: Contribution to journal › Article › peer-review
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Engineered Recombinant Single Chain Variable Fragment of Monoclonal Antibody Provides Protection to Chickens Infected with H9N2 Avian Influenza
Lukosaityte, D., Sadeyen, J.-R., Shrestha, A., Sealy, J. E., Bhat, S., Chang, P., Digard, P. & Iqbal, M., 3 Mar 2020, In: Vaccines. 8, 1Research output: Contribution to journal › Article › peer-review
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Precision cut lung slices: a novel versatile tool to examine host-pathogen interaction in the chicken lung
Bryson, K., Garrido, D., Esposito, M., McLachlan, G., Digard, P., Schouler, C., Guabiraba, R., Trapp, S. & Vervelde, L., 10 Jan 2020, In: Veterinary Research. 51, 2.Research output: Contribution to journal › Article › peer-review
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Genome-wide CRISPR screen identifies host dependency factors for influenza A virus infection
Li, B., Clohisey, S. M., Chia, B. S., Wang, B., Cui, A., Eisenhaure, T., Schweitzer, L. D., Hoover, P., Parkinson, N. J., Nachshon, A., Smith, N., Regan, T., Farr, D., Gutmann, M. U., Bukhari, S. I., Law, A., Sangesland, M., Gat-viks, I., Digard, P. & Vasudevan, S. & 5 others, , 9 Jan 2020, In: Nature Communications. 11, 1, 18 p., 164.Research output: Contribution to journal › Article › peer-review
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2019
Asparagine deprivation causes a reversible inhibition of Human Cytomegalovirus acute virus replication
Lee, A., Griffiths, S., Digard, P., Pham, N., Auer, M., Haas, J. & Grey, F., 8 Oct 2019, (E-pub ahead of print) In: mBio. 10, 5, e01651-19.Research output: Contribution to journal › Article › peer-review
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Segment 2 from influenza A(H1N1) 2009 pandemic viruses confers temperature-sensitive haemagglutinin yield on candidate vaccine virus growth in eggs that can be epistatically complemented by PB2 701D
Hussain, S., Pinto, R. M., McCauley, J. W., Engelhardt, O. G. & Digard, P., 6 Jun 2019, (E-pub ahead of print) In: Journal of General Virology.Research output: Contribution to journal › Article › peer-review
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PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection
Rigby, R. E., Wise, H. M., Smith, N., Digard, P. & Rehwinkel, J., 10 May 2019, In: Scientific Reports. 9, 1, p. 7216Research output: Contribution to journal › Article › peer-review
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A Brief History of Bird Flu
Lycett, S., Duchatel, F. & Digard, P., 6 May 2019, In: Philosophical Transactions of the Royal Society B: Biological Sciences. RSTB-2018-0257.Research output: Contribution to journal › Article › peer-review
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The cellular localization of avian influenza virus PB1-F2 protein alters the magnitude of IFN2 promoter and NFκB-dependent promoter antagonism in chicken cells
James, J., Smith, N., Ross, C., Iqbal, M., Goodbourn, S., Digard, P., Barclay, W. S. & Shelton, H., 23 Jan 2019, (E-pub ahead of print) In: Journal of General Virology.Research output: Contribution to journal › Article › peer-review
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Mutation of influenza A virus PA-X decreases pathogenicity in chicken embryos and can increase the yield of reassortant candidate vaccine viruse
Hussain, S., Turnbull, M., Wise, H., Jagger, B., Beard, P., Kovacikova, K., Taubenberger, J. K., Vervelde, L., Engelhardt, O. & Digard, P., 4 Jan 2019, In: Journal of Virology. 93, 2, 19 p., e01551-18.Research output: Contribution to journal › Article › peer-review
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2018
A chicken bioreactor for efficient production of functional cytokines
Herron, L. R., Pridans, C., Turnbull, M. L., Smith, N., Lillico, S., Sherman, A., Gilhooley, H. J., Wear, M., Kurian, D., Papadakos, G., Digard, P., Hume, D. A., Gill, A. C. & Sang, H. M., 29 Dec 2018, In: BMC Biotechnology. 18, 1, p. 82Research output: Contribution to journal › Article › peer-review
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Effects of mutations in the effector domain of influenza A virus NS1 protein
Pereira, C., Wise, H., Thekkedath Kurian, D., Pinto, R., Amorim, M. J., Gill, A. & Digard, P., 18 Sept 2018, (E-pub ahead of print) In: BMC Research Notes. 11, 1, 673.Research output: Contribution to journal › Article › peer-review
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Comparison of the efficacy of a commercial inactivated influenza A/H1N1/pdm09 virus (pH1N1) vaccine and two experimental M2e-based vaccines against pH1N1 challenge in the growing pig model
Opriessnig, T., Gauger, P. C., Gerber, P. F., de Castro, A. M. M. G., Shen, H., Murphy, L., Digard, P., Halbur, P. G., Xia, M., Jiang, X. & Tan, M., 30 Jan 2018, In: PLoS ONE. 13, 1, p. e0191739Research output: Contribution to journal › Article › peer-review
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An innate defense peptide BPIFA1/SPLUNC1 restricts influenza A virus infection
Akram, K. M., Moyo, N. A., Leeming, G. H., Bingle, L., Jasim, S., Hussain, S., Schorlemmer, A., Kipar, A., Digard, P., Tripp, R. A., Shohet, R. V., Bingle, C. D. & Stewart, J. P., Jan 2018, In: Mucosal Immunology. 11, 1, p. 71-81Research output: Contribution to journal › Article › peer-review
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2017
The influenza A virus NS1 protein promotes efficient nuclear export of unspliced viral M1 mRNA
Pereira, C., Read, E., Wise, H., Amorim, M. & Digard, P., Aug 2017, In: Journal of Virology. 91, 15, e00528-17 .Research output: Contribution to journal › Article › peer-review
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2016
Vaccinia virus uses retromer-independent cellular retrograde transport pathways to facilitate the wrapping of intracellular mature virions during viral morphogenesis
Harrison, K., Haga, I. R., Pechenick Jowers, T., Jasim, S., Cintrat, J.-C., Gillet, D., Schmitt-John, T., Digard, P. & Beard, P. M., 28 Oct 2016, In: Journal of Virology. 90, 22, p. 10120-10132Research output: Contribution to journal › Article › peer-review
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