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Personal profile

Biography

  • 2014 - present: Lecturer, University of Edinburgh
  • 2013-2014: Senior Scientist, University of Manchester
  • 2003-2011: Career Track Appointment, NIMR, London
  • 1993-2003 Post-doctoral Researcher, NIMR, London
  • 1990-1993: Post-doctoral Reseracher, University of Sydney
  • 1986-1990: PhD, Reading University

Qualifications

BSc, Universiy of Reading

PhD, University of Reading

Current Research Interests

The anterior pituitary gland is an important regulator of many physiological processes, controlling growth, reproduction, lactation, metabolism and stress.

In different physiological states (puberty, pregnancy, lactation, etc) both the amount and pattern of hormone output change and a combination of these determines how target organ function is modified in response to hormone stimulation.

I use an integrated approach, from the level of individual cells and their organisation to their secretory activity and its effect on whole animal physiology.

Collaborative Activity

  • Ulrich Boehm, Hamburg, Germany: Use of optogenetics to study hypothalamic and pituitary function; Development of knock-in Cre models
  • Helen Christian, Oxford, UK: Studies of pituitary function at EM resolution
  • Mehul Dattani, London, UK: Studies of mutations leading to altered pituitary function in humans
  • Jacques Drouin, Montreal, Canada: Microarray analysis of gene expression in different pituitary cell types
  • Dave Grattan, Dunedin, New Zealand: Development of tools for measurement of pulsatile hormone secretion in mice; generation and use of mouse with floxed PRLR
  • Kagan Kerman, Toronto, Canada: Development of electrochemical biosensors of pituitary hormones
  • Andy Levy, Bristol, UK: Control of pituitary cell populations and foetal programming of the GH axis
  • Juan Pedro Martinez-Barbera, London, UK: Consequence of altered signalling in adult and embryonic pituitary
  • Cynthia Andoniadou, London, UK: Stem cells and the control of pituitary regeneration
  • Patrice Mollard, Montpellier, France: Organisation and function of cells in the pituitary and hypothalamus
  • Marta Korbonits, London, UK: Modelling the role of the gsp oncogene in pituitary tumours in humans

My research in a nutshell

I study the function of the pituitary gland which regulates a broad range of physiological functions, from reproduction to growth, stress response and metabolism.

Keywords

  • QP Physiology
  • pituitary
  • prolactin
  • growth hormone
  • hypothalamus

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