Personal profile
Biography
- 2014 - present: Lecturer, University of Edinburgh
- 2013-2014: Senior Scientist, University of Manchester
- 2003-2011: Career Track Appointment, NIMR, London
- 1993-2003 Post-doctoral Researcher, NIMR, London
- 1990-1993: Post-doctoral Reseracher, University of Sydney
- 1986-1990: PhD, Reading University
Qualifications
BSc, Universiy of Reading
PhD, University of Reading
Current Research Interests
The anterior pituitary gland is an important regulator of many physiological processes, controlling growth, reproduction, lactation, metabolism and stress.
In different physiological states (puberty, pregnancy, lactation, etc) both the amount and pattern of hormone output change and a combination of these determines how target organ function is modified in response to hormone stimulation.
I use an integrated approach, from the level of individual cells and their organisation to their secretory activity and its effect on whole animal physiology.
Collaborative Activity
- Ulrich Boehm, Hamburg, Germany: Use of optogenetics to study hypothalamic and pituitary function; Development of knock-in Cre models
- Helen Christian, Oxford, UK: Studies of pituitary function at EM resolution
- Mehul Dattani, London, UK: Studies of mutations leading to altered pituitary function in humans
- Jacques Drouin, Montreal, Canada: Microarray analysis of gene expression in different pituitary cell types
- Dave Grattan, Dunedin, New Zealand: Development of tools for measurement of pulsatile hormone secretion in mice; generation and use of mouse with floxed PRLR
- Kagan Kerman, Toronto, Canada: Development of electrochemical biosensors of pituitary hormones
- Andy Levy, Bristol, UK: Control of pituitary cell populations and foetal programming of the GH axis
- Juan Pedro Martinez-Barbera, London, UK: Consequence of altered signalling in adult and embryonic pituitary
- Cynthia Andoniadou, London, UK: Stem cells and the control of pituitary regeneration
- Patrice Mollard, Montpellier, France: Organisation and function of cells in the pituitary and hypothalamus
- Marta Korbonits, London, UK: Modelling the role of the gsp oncogene in pituitary tumours in humans
My research in a nutshell
I study the function of the pituitary gland which regulates a broad range of physiological functions, from reproduction to growth, stress response and metabolism.
Keywords
- QP Physiology
- pituitary
- prolactin
- growth hormone
- hypothalamus
Fingerprint
- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Dynamic transcriptional heterogeneity in pituitary corticotrophs
Yuan, Z., Laiho, L., Smith, E., McDougall, C., Duncan, P. J., Tissier, P. L., Shipston, M. J. & Romanò, N., 5 Apr 2025, bioRxiv.Research output: Working paper › Preprint
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Long-term, Dynamic Remodelling of the Corticotroph Transcriptome and Excitability After a Period of Chronic Stress
Duncan, P. J., Romanò, N., Nair, S. V., McClafferty, H., Le Tissier, P. & Shipston, M. J., Dec 2024, In: Endocrinology . 165, 12, bqae139.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Sex differences in pituitary corticotroph excitability
Duncan, P. J., Romanò, N., Nair, S. V., Murray, J. F., Le Tissier, P. & Shipston, M. J., 18 Jul 2023, In: Frontiers in physiology. 14, 1205162.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Corticotroph isolation from Pomc-eGFP mice reveals sustained transcriptional dysregulation characterising a mouse model of glucocorticoid-induced suppression of the Hypothalamus-Pituitary-Adrenal axis
Duncan, P., McClafferty, H., Nolan, O., Homer, N. Z. M., Le Tissier, P., Walker, B. R., Shipston, M. J., Romanò, N. & Chambers, T., 16 May 2022, (E-pub ahead of print) In: Journal of Neuroendocrinology.Research output: Contribution to journal › Article › peer-review
Open Access -
Chronic Stress Facilitates Bursting Electrical Activity in Pituitary Corticotrophs
Duncan, P., Fazli, M., Romanò, N., Le Tissier, P., Bertram, R. & Shipston, M. J., 2 Dec 2021, (E-pub ahead of print) In: The Journal of Physiology.Research output: Contribution to journal › Article › peer-review
Open Access
Projects
- 5 Finished
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Angiogenic pathway proteins in pituitary adenoma
Le Tissier, P. (Principal Investigator) & Shipston, M. (Co-investigator)
Royal College of Surgeons of Edinburgh
1/04/24 → 31/03/25
Project: Research
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The role of the interaction of the melanocortin and ghrelin receptors in growth hormone secretion
Le Tissier, P. (Principal Investigator)
13/06/22 → 7/08/22
Project: Research
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STRESS recovery
Shipston, M. (Principal Investigator), Chambers, T. (Co-investigator), Le Tissier, P. (Co-investigator) & Romano, N. (Co-investigator)
1/08/21 → 30/09/24
Project: Research
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Remodelling of corticotroph excitability in chronic stress: an integrated physiological and modelling analysis
Shipston, M. (Principal Investigator) & Le Tissier, P. (Co-investigator)
1/02/18 → 31/01/21
Project: Research
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How does pituitary androgen signalling support lifelong health and wellbeing? An integrated transgenic and systems biology approach
Smith, L. (Principal Investigator), Freeman, T. (Co-investigator), Le Tissier, P. (Co-investigator), O'Hara, L. (Co-investigator) & O'Hara, L. (Co-Investigator (External))
Biotechnology and Biological Sciences Research Council
1/04/16 → 31/03/19
Project: Research
Datasets
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Supplementary material - Long-term, dynamic remodelling of the corticotroph transcriptome and excitability after a period of chronic stress
Nair, S. (Creator), McClafferty, H. (Creator), Shipston, M. (Creator), Duncan, P. (Creator), Le Tissier, P. (Creator) & Romano, N. (Creator), Edinburgh DataShare, 14 Oct 2024
DOI: 10.7488/ds/7791
Dataset