Paul Timmers

Search results

• 2017

  Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

  Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., Clark, D. W., Nutile, T., Barnes, C. L. K., Timmers, P. R. H. J., Shen, X., Gandin, I., Mcdaid, A. F., Hansen, T. F., Gordon, S. D., Giulianini, F., Boutin, T. S., Abdellaoui, A., Zhao, W., Medina-Gomez, C. & 93 others, Bartz, T. M., Trompet, S., Lange, L. A., Raffield, L., van der Spek, A., Galesloot, T. E., Proitsi, P., Yanek, L. R., Bielak, L. F., Payton, A., Murgia, F., Concas, M. P., Biino, G., Tajuddin, S. M., Seppälä, I., Amin, N., Boerwinkle, E., Børglum, A. D., Campbell, A., Demerath, E. W., Demuth, I., Faul, J. D., Ford, I., Gialluisi, A., Gögele, M., Graff, M., Hingorani, A., Hottenga, J-J., Hougaard, D. M., Hurme, M. A., Ikram, M. A., Jylhä, M., Kuh, D., Ligthart, L., Lill, C. M., Lindenberger, U., Lumley, T., Mägi, R., Marques-Vidal, P., Medland, S. E., Milani, L., Nagy, R., Ollier, W. E. R., Peyser, P. A., Pramstaller, P. P., Ridker, P. M., Rivadeneira, F., Ruggiero, D., Saba, Y., Schmidt, R., Schmidt, H., Slagboom, P. E., Smith, B. H., Smith, J. A., Sotoodehnia, N., Steinhagen-Thiessen, E., van Rooij, F. J. A., Verbeek, A. L., Vermeulen, S. H., Vollenweider, P., Wang, Y., Werge, T., Whitfield, J. B., Zonderman, A. B., Lehtimäki, T., Evans, M. K., Pirastu, M., Fuchsberger, C., Bertram, L., Pendleton, N., Kardia, S. L. R., Ciullo, M., Becker, D. M., Wong, A., Psaty, B. M., van Duijn, C. M., Wilson, J. G., Jukema, J. W., Kiemeney, L., Uitterlinden, A. G., Franceschini, N., North, K. E., Weir, D. R., Metspalu, A., Boomsma, D. I., Hayward, C., Chasman, D., Martin, N. G., Sattar, N., Campbell, H., Esko, T., Kutalik, Z. & Wilson, J. F., 13 Oct 2017, In: Nature Communications. 8, 13 p., 910.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • High-Density Lipoprotein Cholesterol 100%
  • HLA-DQA1 antigen 97%
  • HLA-DRB1 Chains 84%
  • genome 82%
  • coronary artery disease 74%
• 2019

  Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

  Understanding Society Scientific Group, 20 May 2019, (E-pub ahead of print) In: Nature Genetics.

  Research output: Contribution to journal › Comment/debate

  • Chronic Obstructive Pulmonary Disease 100%
  • Lung 60%

• Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

  SpiroMeta Consortium, Int COPD Genetics Consortium & Understanding Soc Sci Grp, Mar 2019, In: Nature Genetics. 51, 3, p. 494-+ 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Obstructive Pulmonary Disease 100%
  • Phenotype 67%
  • Genetic Loci 39%
  • Lung 34%
  • Genetic Heterogeneity 18%

• Low-frequency variation in TP53 has large effects on head circumference and intracranial volume

  Haworth, S., Shapland, C. Y., Hayward, C., Prins, B. P., Felix, J. F., Medina-Gómez, C., Rivadeneira, F., Wang, C., Ahluwalia, T. S., Vrijheid, M., Guxens, M., Sunyer, J., Tachmazidou, I., Walter, K., Iotchkova, V., Jackson, A., Cleal, L., Huffman, J., Min, J. L., Sass, L. & 17 others, Timmers, P. R. H. J., UK10K Consortium, Davey Smith, G., Fisher, S. E., Wilson, J. F., Cole, T. J., Fernandez-Orth, D., Bønnelykke, K., Bisgaard, H., Pennell, C. E., Jaddoe, V. W. V., Dedoussis, G., Timpson, N., Zeggini, E., Vitart, V., St Pourcain, B. & McKechanie, A. G., 21 Jan 2019, In: Nature Communications. 10, 16 p., 357.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Intracranial 100%
  • circumferences 74%
  • Head 45%
  • low frequencies 43%
  • Volume 35%

• Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances

  eQTLGen Consortium, 15 Jan 2019, In: eLIFE. 8, e39856.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genomics 100%
  • Longevity 88%
  • Lipid 68%
  • Furin 46%
  • Proteostasis 43%

• Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences

  23and Me Research Team, 14 Jan 2019, (E-pub ahead of print) In: Nature Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetic Loci 100%
  • Genome-Wide Association Study 85%
  • Single Nucleotide Polymorphism 17%
  • Driving Under the Influence 14%
  • Computational Biology 9%

• New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

  Shrine, N. R. G., Guyatt, A., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C., Batini, C., Fawcett, K. A., Song, K., Sakornsakolpat, P., Li, X., Boxall, R., Reeve, N. F., Obeidat, M., Zhao, J. H., Wielscher, M., Understanding Society Scientific Group, Weiss, S., Kentistou, K., Cook, J. P. & 88 others, Sun, B. B., Zhou, J., Hui, J., Karrasch, S., Imboden, M., Harris, S., Marten, J., Enroth, S., Kerr, S., Surakka, I., Vitart, V., Lehtimäki, T., Allen, R. J., Bakke, P. S., Beaty, T. H., Bleecker, E. R., Bossé, Y., Brandsma, C-A., Chen, Z., Crapo, J. D., Danesh, J., Demeo, D. L., Dudbridge, F., Ewert, R., Gieger, C., Gulsvik, A., Hansell, A. L., Hao, K., Hoffman, J. D., Hokanson, J. E., Homuth, G., Joshi, P., Joubert, P., Langenberg, C., Li, X., Li, L., Lin, K., Lind, L., Locantore, N., Luan, J., Mahajan, A., Maranville, J. C., Murray, A., Nickle, D. C., Packer, R., Parker, M. M., Paynton, M. L., Porteous, D., Prokopenko, D., Qiao, D., Rawal, R., Runz, H., Sayers, I., Sin, D. D., Smith, B. H., Soler Artigas, M., Sparrow, D., Tal-Singer, R., Timmers, P. RHJ., van den Berge, M., Woodruff, P. G., Yerges-Armstrong, L. M., Troyanskaya, O. G., Raitakar, O. ., Kähönen, M., Polasek, O., Rudan, I., Deary, I., Probst-Hensch, N. M., Schulz, H., James, A. L., Wilson, J. F., Stubbe, B., Zeggini, E., Jarvelin, M-R., Wareham, N., Silverman, E. K., Hayward, C., Morris, A. P., Butterworth, A. S., Scott, R. A., Walters, R. G., Meyers, D. A., Cho, M. H., Strachan, D. P., Hall, I. P., Tobin, M. D. & Wain, L. V., 2019, In: Nature Genetics. 51, p. 481–493

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Obstructive Pulmonary Disease 100%
  • Lung 60%
  • Smokers 47%
  • Genome-Wide Association Study 29%
  • Mortality 14%
• 2020

  Multivariate genomic scan implicates novel loci and haem metabolism in human ageing

  Timmers, P. R. H. J., Wilson, J., Joshi, P. & Deelen, J., 16 Jul 2020, (E-pub ahead of print) In: Nature Communications. 11, 1, p. 3570

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • phenotype 100%
  • genome 92%
  • metabolism 87%
  • genes 82%
  • loci 79%

• Trends in disease incidence and survival and their effect on mortality in Scotland: nationwide cohort study of linked hospital admission and death records 2001–2016

  Timmers, P., Kerssens, J. J., Minton, J., Grant, I., Wilson, J., Campbell, H., Fischbacher, C. M. & Joshi, P. K., 25 Mar 2020, In: BMJ Open.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Death Certificates 100%
  • Scotland 95%
  • Hospital Records 94%
  • Cohort Studies 56%
  • Survival 45%

• Genomic analysis of male puberty timing highlights shared genetic basis with hair colour and lifespan

  PRACTICAL Consortium, 24 Mar 2020, In: Nature Communications. 11, 1, p. 1536

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hair Color 100%
  • hair 77%
  • Puberty 70%
  • Longevity 59%
  • time measurement 52%
• 2021

  Genetic insights into biological mechanisms governing human ovarian ageing

  Biobank-based Integrative Omics Study (BIOS) Consortium, 4 Aug 2021, (E-pub ahead of print) In: Nature.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Damage 100%
  • Fertility 80%
  • Menopause 59%
  • Ovarian Reserve 38%
  • Healthy Aging 35%

• The trans-ancestral genomic architecture of glycemic traits

  The Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC), 31 May 2021, In: Nature Genetics. 149

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Glucose 100%
  • Fasting 84%
  • Glycated Hemoglobin A 55%
  • Genome-Wide Association Study 55%
  • Psychological Power 49%