Pippa Thomson

Search results

• 2011

  DISC1 and Huntington's disease-overlapping pathways of vulnerability to neurological disorder?

  Boxall, R., Porteous, D. J. & Thomson, P. A., 26 Jan 2011, In: PLoS ONE. 6, 1, p. - 4 p., e16263.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Huntington's Disease 100%
  • Scaffold Protein 100%
  • Nervous System Disorder 100%
  • Huntingtin 100%
  • Cell Function 50%

• DISC1 in schizophrenia: genetic mouse models and human genomic imaging

  Johnstone, M., Thomson, P. A., Hall, J., McIntosh, A. M., Lawrie, S. M. & Porteous, D. J., 2011, In: Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders. 37, 1, p. 14-20 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetics 100%
  • Human Genomics 100%
  • Mouse Model 100%
  • Dementia Praecox 100%
  • Gene Locus 10%
• 2010

  Association of GPR50, an X-linked orphan G protein-coupled receptor, and affective disorder in an independent sample of the Scottish population

  MacIntyre, D. J., McGhee, K. A., MacLean, A. W., Afzal, M., Briffa, K., Henry, B., Thomson, P. A., Muir, W. J. & Blackwood, D. H. R., 21 May 2010, In: Neuroscience Letters. 475, 3, p. 169-173 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Sample 100%
  • Association 100%
  • Mood Disorder 100%
  • Bipolar Disorder 55%
  • Genotyping 22%

• Variation in DISC1 is associated with anxiety, depression and emotional stability in elderly women

  Harris, S. E., Hennah, W., Thomson, P. A., Luciano, M., Starr, J., Porteous, D. J. & Deary, I. J., 1 Mar 2010, In: Molecular Psychiatry. 15, 3, p. 232-234 4 p.

  Research output: Contribution to journal › Article › peer-review

• Association analysis of Neuregulin 1 candidate regions in schizophrenia and bipolar disorder

  Walker, R., Christoforou, A., Thomson, P., McGhee, K., Maclean, A., Muhleisen, T. W., Strohmaier, J., Nieratschker, V., Nothen, M. M., Rietschel, M., Cichon, S., Morris, S. W., Jilani, O., Stclair, D., Blackwood, D., Muir, W., Porteous, D. J. & Evans, K. L., 2010, In: Neuroscience Letters. 478, 1, p. 9-13 5 p.

  Research output: Contribution to journal › Article › peer-review

  File

  • Sample 100%
  • Association 100%
  • Neuregulin 1 100%
  • Haplotype 57%
  • Candidate Gene 14%
• 2009

  DISC1 association, heterogeneity and interplay in schizophrenia and bipolar disorder

  Hennah, W., Thomson, P., Mcquillin, A., Bass, N., Loukola, A., Anjorin, A., Blackwood, D., Curtis, D., Deary, I. J., Harris, S. E., Isometsä, E. T., Lawrence, J., Lönnqvist, J., Muir, W., Palotie, A., Partonen, T., Paunio, T., Pylkkö, E., Robinson, M., Soronen, P., & 7 othersSuominen, K., Suvisaari, J., Thirumalai, S., Clair, D. S., Gurling, H., Peltonen, L. & Porteous, D., Sept 2009, In: Molecular Psychiatry. 14, 9, p. 865-873 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia Praecox 100%
  • Bipolar Disorder 100%
  • Association 100%
  • Single-Nucleotide Polymorphism 42%
  • Asperger Syndrome 14%

• Interacting haplotypes at the NPAS3 locus alter risk of schizophrenia and bipolar disorder

  Pickard, B. S., Christoforou, A., Thomson, P. A., Fawkes, A., Evans, K. L., Morris, S. W., Porteous, D. J., Blackwood, D. H. & Muir, W. J., Sept 2009, In: Molecular Psychiatry. 14, 9, p. 874-884 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Haplotype 100%
  • PAS Domain 100%
  • Nested Gene 80%
  • Mouse 20%
  • Population 20%

• GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth

  Grunewald, E., Kinnell, H. L., Porteous, D. J. & Thomson, P. A., 2009, In: Molecular and Cellular Neuroscience. 42, 4, p. 363-371 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Neurite Outgrowth 100%
  • G Protein Coupled Receptor 100%
  • Cells 25%
  • Mental Disorder 25%
  • Lamellipodium 12%
• 2007

  Haplotype Analysis and a Novel Allele-Sharing Method Refines a Chromosome 4p Locus Linked to Bipolar Affective Disorder

  Le Hellard, S., Lee, A. J., Underwood, S., Thomson, P. A., Morris, S. W., Torrance, H. S., Anderson, S. M., Adams, R. R., Navarro, P., Christoforou, A., Houlihan, L. M., Detera-Wadleigh, S., Owen, M. J., Asherson, P., Muir, W. J., Blackwood, D. H. R., Wray, N. R., Porteous, D. J. & Evans, K. L., 15 Mar 2007, In: Biological Psychiatry. 61, 6, p. 797-805 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Autosome 100%
  • Chromosome 4p 100%
  • Haplotype 100%
  • Allele 100%
  • Bipolar Disorder 100%

• Are some genetic risk factors common to schizophrenia, bipolar disorder and depression? Evidence from DISC1, GRIK4 and NRG1

  Blackwood, D. H., Pickard, B. J., Thomson, P. A., Evans, K., Porteous, D. J. & Muir, W. J., 2007, In: Neurotoxicity Research. 11, 1, p. 73-83 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Neu Differentiation Factor 100%
  • Bipolar Depression 100%
  • Genetic Risk Factor 100%
  • Bipolar Disorder 100%
  • Dementia Praecox 100%

• Association analysis of the chromosome 4p15-p16 candidate region for bipolar disorder and schizophrenia

  Christoforou, A., Le Hellard, S., Thomson, P. A., Morris, S. W., Tenesa, A., Pickard, B. S., Wray, N. R., Muir, W. J., Blackwood, D. H., Porteous, D. J. & Evans, K. L., 2007, In: Molecular Psychiatry. 12, 11, p. 1011-25 15 p.

  Research output: Contribution to journal › Article › peer-review

  • P16 100%
  • Association 100%
  • Chromosome 100%
  • Haplotype 66%
  • Single-Nucleotide Polymorphism 66%

• Association of Neuregulin 1 with schizophrenia and bipolar disorder in a second cohort from the Scottish population

  Thomson, P. A., Christoforou, A., Morris, S. W., Adie, E., Pickard, B. S., Porteous, D. J., Muir, W. J., Blackwood, D. H. & Evans, K. L., 2007, In: Molecular Psychiatry. 12, 1, p. 94-104 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Haplotype 100%
  • Association 100%
  • Neuregulin 1 100%
  • Isoform 37%
  • Exon 25%

• The PDE4B gene confers sex-specific protection against schizophrenia

  Pickard, B. S., Thomson, P. A., Christoforou, A., Evans, K. L., Morris, S. W., Porteous, D. J., Blackwood, D. H. & Muir, W. J., 2007, In: Psychiatric Genetics. 17, 3, p. 129-133 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphodiesterase 100%
  • Nested Gene 100%
  • Haplotype 60%
  • Single-Nucleotide Polymorphism 40%
  • Sample 20%
• 2006

  Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia

  Underwood, S. L., Christoforou, A., Thomson, P. A., Wray, N. R., Tenesa, A., Whittaker, J., Adams, R. A., Le Hellard, S., Morris, S. W., Blackwood, D. H. R., Muir, W. J., Porteous, D. J. & Evans, K. L., Apr 2006, In: Molecular Psychiatry. 11, 4, p. 384-94 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Chromosome 4p 100%
  • Association 100%
  • Nested Gene 100%
  • G Protein Coupled Receptor 100%
  • Dementia Praecox 100%

• A case-control association study on the NPAS3 gene

  Pickard, B., Christoforou, A., Thomson, P., Evans, K., Morris, S., Porteous, D., Blackwood, D. & Muir, W., 2006, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 141B, 7, p. 761 1 p.

  Research output: Contribution to journal › Article › peer-review

• A neuregulin 1 variant associated with abnormal cortical function and psychotic symptoms

  Hall, J., Whalley, H. C., Job, D. E., Baig, B. J., McIntosh, A. M., Evans, K. L., Thomson, P. A., Porteous, D. J., Cunningham-Owens, D. G., Johnstone, E. C. & Lawrie, S. M., 2006, In: Nature Neuroscience. 9, 12, p. 1477-1478 2 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia Praecox 100%
  • Neu Differentiation Factor 100%
  • Frontal Lobe 50%
  • Gene 50%
  • Temporal Lobe 50%

• Association of the NRG1 gene in schizophrenia and bipolar disorder in a second Scottish sample

  Evans, K., Thomson, P., Christoforou, A., Pickard, B., Porteous, D., Muir, W. & Blackwood, D., 2006, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 141B, 7, p. 759 1 p.

  Research output: Contribution to journal › Article › peer-review

• Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder

  Pickard, B. S., Malloy, M. P., Christoforou, A., Thomson, P. A., Evans, K. L., Morris, S. W., Hampson, M., Porteous, D. J., Blackwood, D. H. & Muir, W. J., 2006, In: Molecular Psychiatry. 11, 9, p. 847-857 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia Praecox 100%
  • Cytogenetics 100%
  • Bipolar Disorder 100%
  • Glutamate Receptor 100%
  • Receptor Gene 100%

• Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness

  Hennah, W., Thomson, P., Peltonen, L. & Porteous, D., 2006, In: Schizophrenia Bulletin: The Journal of Psychoses and Related Disorders. 32, 3, p. 409-416 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia Praecox 100%
  • Gene 100%
  • Nested Gene 100%
  • Genetics 36%
  • Neuronal Migration 9%

• Large-scale association analysis of the chromosome 4p15-16 candidate region in bipolar affective disorder and schizophrenia

  Christoforou, A., Le Hellard, S., Thomson, P. A., Morris, S. W., Tenesa, A., Pickard, B. S., Wray, N. R., Muir, W. J., Blackwood, D. H., Porteous, D. J. & Evans, K., 2006, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 141B, 7, p. 747 1 p.

  Research output: Contribution to journal › Article › peer-review

• The genetics and biology of DISC1--an emerging role in psychosis and cognition

  Porteous, D. J., Thomson, P., Brandon, N. J. & Millar, J. K., 2006, In: Biological Psychiatry. 60, 2, p. 123-31 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Cognition 100%
  • DISC1 100%
  • Genetics 100%
  • Psychosis 100%
  • Dementia Praecox 28%
• 2005

  Association between genotype at an exonic SNP in DISC1 and normal cognitive aging

  Thomson, P. A., Harris, S. E., Starr, J., Whalley, L. J., Porteous, D. J. & Deary, I. J., 25 Nov 2005, In: Neuroscience Letters. 389, 1, p. 41-45 5 p.

  Research output: Contribution to journal › Article › peer-review

  • DISC1 100%
  • Single Nucleotide Polymorphism 100%
  • Association 100%
  • Genotyping 100%
  • Cognitive Aging 100%

• DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signalling

  James, R., Millar, J. K., Pickard, B., Mackie, S., Christie, S., Buchanan, S., Malloy, P., Chubb, J. E., Huston, E., Baillie, G. S., Thomson, P. A., Brandon, N. J., Rain, J-C., Whiting, P., Houslay, M. D., Blackwood, D., Muir, W. & Porteous, D. J., 18 Nov 2005, In: Science.

  Research output: Contribution to journal › Article › peer-review

• Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population

  Thomson, P. A., Wray, N. R., Millar, J. K., Evans, K. L., Hellard, S. L., Condie, A., Muir, W. J., Blackwood, D. H. & Porteous, D. J., 2005, In: Molecular Psychiatry. 10, 7, p. 657-68, 616

  Research output: Contribution to journal › Article › peer-review

  • Dementia Praecox 100%
  • Bipolar Disorder 100%
  • Factor X 100%
  • Association 100%
  • Blood Clotting Factor 10 100%

• Beyond cytogenetics: Assessing the wider contribution of disrupted genes to schizophrenia and affective disorders through association studies

  Pickard, B. S., Christoforou, A., Thomson, P. A., Malloy, M. P., Evans, K. L., LeHellard, S., Morris, S. W., Wray, N. R., Porteous, D. J., Muir, W. J. & Blackwood, D. H., 2005, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 138B, 1, p. 51-52 2 p.

  Research output: Contribution to journal › Article › peer-review

• DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

  Millar, J. K., Pickard, B. S., Mackie, S., James, R., Christie, S., Buchanan, S. R., Malloy, M. P., Chubb, J. E., Huston, E., Baillie, G. S., Thomson, P. A., Hill, E. V., Brandon, N. J., Rain, J. C., Camargo, L. M., Whiting, P. J., Houslay, M. D., Blackwood, D. H., Muir, W. J. & Porteous, D. J., 2005, In: Science. 310, 5751, p. 1187-1191 5 p.

  Research output: Contribution to journal › Article › peer-review

  • cAMP Signaling 100%
  • Phosphodiesterase 100%
  • Genetic Determinism 100%
  • Cyclic Adenosine Monophosphate 50%
  • Nested Gene 33%

• Disrupted in schizophrenia 1 and phosphodiesterase 4B are genetic factors in schizophrenia that interact to regulate cAMP signalling

  Porteous, D., Millar, K., Pickard, B., Mackie, S., James, R., Malloy, P., Thomson, P., Chubb, J., Brandon, N., Carmargo, M., Whiting, P., Houslay, M., Blackwood, D. & Muir, W., 2005, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 138B, 1, p. 132 1 p.

  Research output: Contribution to journal › Article › peer-review

• Haplotype and allele sharing analysis of chromosome 4p linked families with bipolar affective disorder

  Evans, K. L., Le Hellard, S., Lee, A. J., Thomson, P. A., Christoforou, A., Houlihan, L., McLean, M., Wray, N. R., Muir, W. J., Blackwood, D. H. & Porteous, D. J., 2005, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 138B, 1, p. 76-77 2 p.

  Research output: Contribution to journal › Article › peer-review

• Sequence analysis of a sex-specific association between bipolar affective disorder in women and GPR50

  Thomson, P. A., Wray, N. R., Thomson, A. M., Grassie, M. A., Pulford, D. J., Muir, W. J., Blackwood, D. H. & Porteous, D. J., 2005, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 138B, 1, p. 81 1 p.

  Research output: Contribution to journal › Article › peer-review

• Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor

  Thomson, P. A., Wray, N. R., Thomson, A. M., Dunbar, D. R., Grassie, M. A., Condie, A., Walker, M. T., Smith, D. J., Pulford, D. J., Muir, W., Blackwood, D. H. R. & Porteous, D. J., 2005, In: Molecular Psychiatry. 10, 5, p. 470-478 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Bipolar Disorder 100%
  • Association 100%
  • G Protein Coupled Receptor 100%
  • Major Depressive Disorder 71%
  • Dementia Praecox 57%
• 2004

  A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42

  Macgregor, S., Visscher, P. M., Knott, S. A., Thomson, P., Porteous, D. J., Millar, J. K., Devon, R. S., Blackwood, D. & Muir, W. J., 2004, In: Molecular Psychiatry. 9, 12, p. 1083-1090 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Follow up 100%
  • Chromosome 100%
  • Bipolar Disorder 100%
  • Family 100%
  • Gene Linkage 71%

• Association between DISC1 polymorphisms and major mental illness in the Scottish population

  Thomson, P. A., Wray, N. R., Millar, J. K., Condie, A., Walker, M., Muir, W., Blackwood, D. H. R. & Porteous, D. J., 2004, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 130B, 1, p. 128 1 p.

  Research output: Contribution to journal › Article › peer-review

• Sex-specific association between women with bipolar affective disorder and GPR50, an X-linked orphan G protein-coupled receptor

  Thomson, P. A., Wray, N. R., Thomson, A. M., Dunbar, D. R., Grassie, M. A., Condie, A., Pulford, D. J., Muir, W., Blackwood, D. H. R. & Porteous, D. J., 2004, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 130B, 1, p. 11 1 p.

  Research output: Contribution to journal › Article › peer-review

• 2003

  Biodiversity of 52 chicken populations assessed by microsatellite typing of DNA pools

  Hillel, J., Groenen, M. A. M., Tixier-Boichard, M., Korol, A. B., David, L., Kirzhner, V. M., Burke, T., Barre-Dirie, A., Crooijmans, R. P. M. A., Elo, K., Feldman, M. W., Freidlin, P. J., Mäki-Tanila, A., Oortwijn, M., Thomson, P., Vignal, A., Wimmers, K. & Weigend, S., 2003, In: Genetics Selection Evolution. 35, 5, p. 533-57 25 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chicken 100%
  • Microsatellite DNA 100%
  • DNA 100%
  • Biodiversity 100%
  • Mutation 75%

• Haplotype map of the TRAX/DISC locus

  Thomson, P. A., Wray, N., Millar, J. K., Condie, A., Walker, M. T., Muir, W. J., Blackwood, D. H. R. & Porteous, D. J., 2003, In: Americal Journal of Medical Genetics. 122B, 1, p. 171 1 p.

  Research output: Contribution to journal › Article › peer-review

• Investigation of DISC1, a candidate gene for susceptibility to schizophrenia and related major psychiatric illness

  Millar, K., James, R., Thomson, P., Christie, S., Buchanan, S., Muir, W., Blackwood, D. & Porteous, D., 2003, In: Society for Neuroscience Abstract Viewer and Itinerary Planner. 2003, p. Abstract No. 312.3

  Research output: Contribution to journal › Article › peer-review

  • DISC1 100%
  • Candidate Gene 100%
  • Family 37%
  • DISC2 25%
  • Genetics 25%

• Response to Amar J. Klar: The chromosome 1;11 translocation provides the best evidence supporting genetic etiology for schizophrenia and bipolar affective disorders

  Millar, J. K., Thomson, P. A., Wray, N. R., Muir, W. J., Blackwood, D. H. & Porteous, D. J., 2003, In: Genetics. 163, 2, p. 833-5; author reply 837-8

  Research output: Contribution to journal › Article › peer-review
• 2002

  An integrated approach towards the identification of a susceptibility gene for psychosis

  Evans, K. L., Le Hellard, S., Warne, S., Thomson, P. A., Morris, S. W., Ballereau, S., Torrance, H. S., Anderson, S., Anderson, I., Muir, W. J., Blackwood, D. H. R. & Porteous, D. J., 2002, In: American Journal of Medical Genetics. 114, 7, p. 847 1 p.

  Research output: Contribution to journal › Article › peer-review

• 2000

  First report on chicken genes and chromosomes 2000

  Schmid, M., Nanda, I., Guttenbach, M., Steinlein, C., Hoehn, M., Schartl, M., Haaf, T., Weigend, S., Fries, R., Buerstedde, J. M., Wimmers, K., Burt, D. W., Smith, J., A'Hara, S., Law, A., Griffin, D. K., Bumstead, N., Kaufman, J., Thomson, P., Burke, T., & 14 othersGroenen, M. A., Crooijmans, R. P., Vignal, A., Fillon, V., Morisson, M., Pitel, F., Tixier-Boichard, M., Ladjali-Mohammedi, K., Hillel, J., Mäki-Tanila, A., Cheng, H. H., Delany, M. E., Burnside, J. & Mizuno, S., 2000, In: Cytogenetics and Cell Genetics. 90, 3-4, p. 169-218 50 p.

  Research output: Contribution to journal › Article › peer-review
• 1998

  Unordered arrangement of chromosomes in the nuclei of chicken spermatozoa

  Solovei, I., Joffe, B., Hori, T., Thomson, P., Mizuno, S. & MacGregor, H., 1 Jun 1998, In: Chromosoma. 107, 3, p. 184 188 p.

  Research output: Contribution to journal › Article › peer-review