Rhona Aird

Search results

• 2022

  Hypoxia-driven metabolic reprogramming of adipocytes fuels cancer cell proliferation

  Aird, R., Wills, J., Roby, K. F., Benezech, C., Stimson, R. H., Wabitsch, M., Pollard, J. W., Finch, A. & Michailidou, Z., 18 Oct 2022, In: Frontiers in Endocrinology. 13, 12 p., 989523.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adipocytes 100%
  • Hypoxia 82%
  • Cell Proliferation 69%
  • Metabolome 35%
  • Neoplasms 33%

• Human biliary epithelial cells from discarded donor livers rescue bile duct structure and function in a mouse model of biliary disease

  Hallett, J., Ferreira-Gonzalez, S., Man, J., Kilpatrick, A., Esser, H., Thirwell, K., Macmillan, M., Rodrigo Torres, D., Dwyer, B., Gadd, V., Ashmore-Harris, C., Lu, W-Y., Thomson, J., Jansen, M., O'Duibhir, E., Starkey Lewis, P., Campana, L., Aird, R., Bate, T., Fraser, A. R., & 5 othersCampbell, J. D. M., Oniscu, G. C., Hay, D. C., Callanan, A. & Forbes, S. J., 3 Mar 2022, In: Cell Stem Cell.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2020

  Alternatively activated macrophages promotes necrosis resolution following acute liver injury

  Starkey Lewis, P., Campana, L., Aleksieva, N., Cartwright, J. A., Mackinnon, A., O'Duibhir, E., Kendall, T., Vermeren, M., Thomson, A., Gadd, V., Dwyer, B., Aird, R., Man, T-Y., Rossi, A. G., Forrester, L., Park, B. K. & Forbes, S. J., 11 Mar 2020, (E-pub ahead of print) In: Journal of Hepatology. 73, 2, p. 349-360 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Acetaminophen 100%
  • Necrosis 97%
  • Macrophages 88%
  • Liver 65%
  • Wounds and Injuries 61%
• 2017

  MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

  Ho, G., Aird, R. E., Liu, B., Boyapati, R. K., Kennedy, N. A., Dorward, D. A., Noble, C. L., Shimizu, T., Carter, R. N., Chew, E. T. S., Morton, N. M., Rossi, A. G., Sartor, R. B., Iredale, J. P. & Satsangi, J., 12 Apr 2017, (E-pub ahead of print) In: Mucosal Immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Multiple Drug Resistance 100%
  • Homeostasis 70%
  • Colitis 65%
  • Inflammation 56%
  • Inflammatory Bowel Diseases 45%
• 2016

  Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness

  Morton, N. M., Beltram, J., Carter, R. N., Michailidou, Z., Gorjanc, G., McFadden, C., Barrios-Llerena, M. E., Rodriguez-Cuenca, S., Gibbins, M. T. G., Aird, R. E., Moreno-Navarrete, J. M., Munger, S. C., Svenson, K. L., Gastaldello, A., Ramage, L., Naredo, G., Zeyda, M., Wang, Z. V., Howie, A. F., Saari, A., & 13 othersSipilä, P., Stulnig, T. M., Gudnason, V., Kenyon, C. J., Seckl, J. R., Walker, B. R., Webster, S. P., Dunbar, D. R., Churchill, G. A., Vidal-Puig, A., Fernandez-Real, J. M., Emilsson, V. & Horvat, S., Jul 2016, In: Nature Medicine. 22, 7, p. 771-779 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Thiosulfate Sulfurtransferase 100%
  • Thiosulfate 70%
  • Thinness 66%
  • Insulin Derivative 60%
  • Fat 58%
• 2008

  ABCB1 genetic polymorphism influences the pharmacology of the new pyrrolobenzodiazepine derivative SJG-136

  Aird, R. E., Thomson, M., Macpherson, J. S., Thurston, D. E., Jodrell, D. I. & Guichard, S. M., Aug 2008, In: Pharmacogenomics Journal. 8, 4, p. 289-296 8 p.

  Research output: Contribution to journal › Article › peer-review

  • 1,1'-((propane-1,3-diyl)dioxy)bis(7-methoxy-2-methylidene-1,2,3,10,11,11a-hexahydro-5H-pyrrolo(2,1-c)(1,4)benzodiazepin-5,11-dione) 100%
  • pyrrolo(2,1-c)(1,4)benzodiazepine 88%
  • Genetic Polymorphisms 49%
  • Pharmacology 31%
  • Colonic Neoplasms 28%

• A clinical study assessing the tolerability and biological effects of infliximab, a TNF-alpha inhibitor, in patients with advanced cancer

  Brown, E. R., Charles, K. A., Hoare, S. A., Rye, R. L., Jodrell, D. I., Aird, R. E., Vora, R., Prabhakar, U., Nakada, M., Corringham, R. E., DeWitte, M., Sturgeon, C., Propper, D., Balkwill, F. R. & Smyth, J. F., Jul 2008, In: Annals of Oncology. 19, 7, p. 1340-1346 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Tumor Necrosis Factor Inhibitors 100%
  • Infliximab 96%
  • Tumor Necrosis Factor-alpha 58%
  • Clinical Studies 57%
  • Neoplasms 26%
• 2006

  Structure-activity relationships for cytotoxic ruthenium(II) arene complexes containing N,N-, N,O-, and O,O-chelating ligands

  Habtemariam, A., Melchart, M., Fernandez, R., Parsons, S., Oswald, I. D. H., Parkin, A., Fabbiani, F. P. A., Davidson, J. E., Dawson, A., Aird, R. E., Jodrell, D. I. & Sadler, P. J., 16 Nov 2006, In: Journal of Medicinal Chemistry. 49, 23, p. 6858-6868 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ruthenium 100%
  • ethylenediamine 91%
  • Structure-Activity Relationship 74%
  • Benzene Derivatives 58%
  • 1,2-diaminobenzene 57%

• Tuning the reactivity of osmium(II) and ruthenium(II) arene complexes under physiological conditions

  Peacock, A. F. A., Habtemariam, A., Fernandez, R., Walland, V., Fabbiani, F. P. A., Parsons, S., Aird, R. E., Jodrell, D. I. & Sadler, P. J., 8 Feb 2006, In: Journal of the American Chemical Society. 128, 5, p. 1739-1748 10 p.

  Research output: Contribution to journal › Literature review › peer-review

  • acetyl acetonate 100%
  • Osmium 95%
  • Ruthenium 80%
  • Hydrolysis 61%
  • Dimers 57%
• 2005

  Controlling ligand substitution reactions of organometallic complexes: Tuning cancer cell cytotoxicity

  Wang, F. Y., Habtemariam, A., van der Geer, E. P. L., Fernandez, R., Melchart, M., Deeth, R. J., Aird, R., Guichard, S., Fabbiani, F. P. A., Lozano-Casal, P., Oswald, I. D. H., Jodrell, D. I., Parsons, S. & Sadler, P. J., 20 Dec 2005, In: Proceedings of the National Academy of Sciences. 102, 51, p. 18269-18274 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Arene 100%
  • Substitution Reaction 78%
  • Hexamethylbenzene 71%
  • Ligand 54%
  • Chemical Reactivity 52%
• 2001

  5-fluorouracil steady state pharmacokinetics and outcome in patients receiving protracted venous infusion for advanced colorectal cancer

  Jodrell, D. I., Stewart, M., Aird, R., Knowles, G., Bowman, A., Wall, L., Cummings, J. & Mclean, C., 2001, In: British Journal of Cancer. 84, 5, p. 600-603

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fluorouracil 100%
  • Colorectal Neoplasms 83%
  • Pharmacokinetics 78%
  • Mucositis 9%
  • Diarrhea 6%