Research output per year
Research output per year
Personal profile
Research Interests
My group’s primary research goal is to use computational models to understand the molecular mechanisms that underlie Alzheimer’s disease and to enhance prediction of the disease. We have a passion for research into ageing and, in particular, examining the genetic and environmental contributions to health, cognitive ageing, and dementia. Our work is at the intersection of the biomedical and social sciences.
We work with data from large, population-based cohorts including Generation Scotland, UK Biobank, and the Lothian Birth Cohorts of 1921 and 1936.
Qualifications
2005 - 2006 MSc with distinction in Operational Research
The University of Edinburgh, Edinburgh, UK.
The School of Mathematics
Thesis: `A model describing the value of a gain in productivity among persons with rheumatoid arthritis.'
2001 - 2005 BSc (Hons) in Mathematics and Statistics (First Class)
The University of Aberdeen, Aberdeen, UK.
Websites
Biography
I am a Senior Research Fellow and Group Leader based in the Centre for Genomic and Experimental Medicine.
I previously held a Chancellor's Felloswhip (2013 - 2018) that was part-funded by the University of Queensland where I was an Adjunct Research Fellow between 2013-2016.
My postdoctoral research included a year at the Department of Public Health and Primary Care at the University of Cambridge (2009-2010). Whilst there, I was awarded an Alzheimer's Research UK fellowship (2010-2013) in conjunction with the Medical Research Council Biostatistics Unit, Cambridge, the Department of Biostatistics, INSERM U897, Bordeaux and the University of Edinburgh Department of Psychology, to develop and apply longitudinal statistical methods for cognitive ageing.
I completed my PhD (2006-2009) in Genetic and Cognitive Epidemiology at the University of Edinburgh. My thesis title was "Inflammation and cognition: The association between biomarker levels, their genetic determinants, and age-related cognitive decline".
Collaborative Activity
Local Collaborators:
Generation Scotland and Lothian Birth Cohort teams, Tamir Chandra, Catalina Vallejos
National and international collaborators:
The PREVENT Dementia and EPAD teams. Steve Horvath (UCLA), Peter Visscher and Naomi Wray (University of Queensland), Matt Robinson (IST Vienna), Elliot Tucker-Drob (UTexas at Austin)
Current Research Interests
Epi/genetic epidemiology
Biostatistics and longitudinal data analysis
Ageing
Alzheimer's disease
Education/Academic qualification
Doctor of Philosophy (PhD), Inflammation and cognition: the association between biomarker levels, their genetic determinants, and age-related cognitive decline, University of Edinburgh
Award Date: 1 Jan 2009
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Bayesian reassessment of the epigenetic architecture of complex traits
Trejo Baños, D., McCartney, D. L., Patxot, M., Anchieri, L., Battram, T., Christiansen, C., Costeira, R., Walker, R. M., Morris, S. W., Campbell, A., Zhang, Q., Porteous, D. J., McRae, A. F., Wray, N. R., Visscher, P. M., Haley, C. S., Evans, K. L., Deary, I. J., McIntosh, A. M., Hemani, G., & 3 others, 8 Jun 2020, In: Nature Communications. 11, 2865.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
Hillary, R., McCartney, D. L., Harris, S., Stevenson, A., Seeboth, A., Zhang, Q., Liewald, D., Evans, K. L., Ritchie, C., Tucker-Drob, E. M., Wray, N. R., Mcrae, A. F., Visscher, P. M., Deary, I. & Marioni, R. E., Dec 2019, In: Nature Communications. 10, 3160.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
DNA methylation Aging Clocks: Challenges & Recommendations
Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., Ideker, T., Issa, J-P. J., Kelsey, K. T., Marioni, R., Reik, W., Relton, C. L., Schalkwyk, L. C., Teschendorff, A. E., Wagner, W., Zhang, K., & 1 others, 25 Nov 2019, (E-pub ahead of print) In: Genome Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Epigenetic prediction of complex traits and death
McCartney, D. L., Hillary, R., Stevenson, A. J., Ritchie, S. J., Walker, R. M., Zhang, Q., Morris, S. W., Bermingham, M. L., Campbell, A., Murray, A. D., Whalley, H. C., Gale, C. R., Porteous, D. J., Haley, C. S., McRae, A. F., Wray, N. R., Visscher, P. M., McIntosh, A. M., Evans, K. L., Deary, I. J., & 1 others, 27 Sept 2018, In: Genome Biology. 19, 136.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
GWAS on family history of Alzheimer’s disease
Marioni, R. E., Harris, S. E., Zhang, Q., McRae, A. F., Hagenaars, S. P., Hill, W. D., Davies, G., Ritchie, C. W., Gale, C. R., Starr, J. M., Goate, A. M., Porteous, D. J., Yang, J., Evans, K. L., Deary, I. J., Wray, N. R. & Visscher, P. M., 18 May 2018, In: Translational Psychiatry. 8, 99.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
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Edinburgh International Science Festival 2015
Ian Deary (Advisor), Riccardo Marioni (Presenter), Adele Taylor (Presenter) & Danielle Page (Presenter)
7 Apr 2018 → 9 Apr 2018Activity: Participating in or organising an event types › Public Engagement – Festival/Exhibition
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Do different biological clocks tell the same time?
Riccardo Marioni (Assessor)
May 2018Activity: Academic talk or presentation types › Oral presentation
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24th Nordic Congress of Gerontology
Tom Booth (Speaker), Zander Crook (Participant), Ian Deary (Advisor) & Riccardo Marioni (Participant)
2018Activity: Participating in or organising an event types › Participation in conference
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Epigenetic prediction of age and modifiable lifestyle factors
Riccardo Marioni (Assessor)
Sept 2018Activity: Academic talk or presentation types › Invited talk
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Jim Sikela
Riccardo Marioni (Host)
10 Sept 2018Activity: Hosting a visitor types › Hosting an academic visitor
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Integrated gene and brain mapping of language and reading abilities
1/02/20 → 31/01/25
Project: Research
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Large-Scale Genomic Analysis of Aging-Related Cognitive Change Prior to Dementia Onset
15/08/21 → 31/07/22
Project: Research
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Integrated multi-omics prediction of incident Alzheimer's disease and its risk factors
1/09/20 → 31/08/23
Project: Research
Datasets
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Marioni_et_al_AD_GWAS_Sumstats_June2019_Correction - Data supporting Marioni et al. "GWAS on family history of Alzheimer's disease"
Marioni, R. (Creator), Gale, C. (Creator), Goate, A. (Creator), Porteous, D. (Creator), Yang, J. (Creator), Evans, K. (Creator), Deary, I. (Creator), Wray, N. R. (Creator), Visscher, P. (Creator), Starr, J. (Creator), Harris, S. (Creator), Zhang, Q. (Creator), Mcrae, A. F. (Creator), Hagenaars, S. (Creator), Hill, D. (Creator), Davies, G. (Creator) & Ritchie, C. (Creator), Edinburgh DataShare, 21 Jun 2019
DOI: 10.7488/ds/2578
Dataset
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Multi-method genome and epigenome wide studies of inflammatory protein levels in healthy older adults - BayesR+ GWAS Proteins
Ojavee, S. E. (Creator), Zhang, Q. (Creator), Liewald, D. (Creator), Evans, K. (Creator), Tucker-Drob, E. (Creator), Wray, N. (Creator), McRae, A. (Creator), Visscher, P. (Creator), Deary, I. (Creator), Robinson, M. (Creator), Marioni, R. (Creator), Ritchie, C. (Creator), Hillary, R. (Creator), Trejo baños, D. (Creator), Kousathanas, A. (Creator), Mccartney, D. (Creator), Harris, S. (Creator), Stevenson, A. (Creator) & Patxot, M. (Creator), Edinburgh DataShare, 16 Jul 2020
DOI: 10.7488/ds/2854
Dataset
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Associations between alcohol use and accelerated biological ageing
Wootton, R. E. (Creator), Clarke, T. (Creator), Cox, S. (Creator), Bostrand, S. (Creator), Vaher, K. (Creator), De Nooij, L. (Creator), Harris, M. A. (Creator), Cole, J. H. (Creator), Marioni, R. (Creator), Mccartney, D. (Creator), Walker, R. (Creator), McIntosh, A. (Creator), Evans, K. (Creator) & Whalley, H. (Creator), Edinburgh DataShare, 24 Nov 2020
DOI: 10.7488/ds/2956
Dataset
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Summary statistics from epigenome-wide association studies and meta-analysis comparing APOE ε4 and APOE ε2 allele carriers in Generation Scotland
Hayward, C. (Creator), Porteous, D. (Creator), McIntosh, A. (Creator), Marioni, R. (Creator), Evans, K. (Creator), Campbell, A. (Creator), Walker, R. (Creator), Vaher, K. (Creator), Bermingham, M. (Creator), Morris, S. (Creator), Bretherick, A. (Creator), Zeng, Y. (Creator), Rawlik, K. (Creator), Amador, C. (Creator) & Haley, C. (Creator), Edinburgh DataShare, 10 Nov 2020
DOI: 10.7488/ds/2948
Dataset
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'Hill_CB_2016' - Data supporting paper "Molecular genetic contributions to social deprivation and household income in UK Biobank". Current Biology (2016).
Deary, I. (Creator), Hagenaars, S. (Creator), Marioni, R. (Creator), Davies, G. (Creator), Hill, D. (Creator), Liewald, D. (Creator), Gale, C. (Creator), McIntosh, A. (Creator), Okbay, A. (Creator) & Harris, S. (Creator), Edinburgh DataShare, 4 Jun 2019
DOI: 10.7488/ds/2562
Dataset
Press/Media
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Riccardo Marioni receives funding to research links between Alzheimer’s, genes and lifestyle
20/09/17 → 21/09/17
2 items of Media coverage
Press/Media: Research
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Genetic links to male baldness revealed by Dr Riccardo Marioni and Saskia Hagenaars
Riccardo Marioni, Saskia Hagenaars & David Hill
14/02/17 → 6/08/17
75 items of Media coverage
Press/Media: Research
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University scientists have identified a biological clock that provides vital clues about how long a person is likely to live
30/01/15
56 items of Media coverage
Press/Media: Research
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Dr Riccardo Marioni says biological clock gives clues about mortality
6/02/15
2 items of Media coverage
Press/Media: Research
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Riccardo Marioni suggests link between height and intelligence in gene study
2/03/14
40 items of Media coverage
Press/Media: Research