Research output per year
Research output per year
Personal profile
Research Interests
My group’s primary research goal is to use computational models to understand the molecular mechanisms that underlie Alzheimer’s disease and to enhance prediction of the disease. We have a passion for research into ageing and, in particular, examining the genetic and environmental contributions to health, cognitive ageing, and dementia. Our work is at the intersection of the biomedical and social sciences.
We work with data from large, population-based cohorts including Generation Scotland, UK Biobank, and the Lothian Birth Cohorts of 1921 and 1936.
Qualifications
2005 - 2006 MSc with distinction in Operational Research
The University of Edinburgh, Edinburgh, UK.
The School of Mathematics
Thesis: `A model describing the value of a gain in productivity among persons with rheumatoid arthritis.'
2001 - 2005 BSc (Hons) in Mathematics and Statistics (First Class)
The University of Aberdeen, Aberdeen, UK.
Websites
Biography
I am a Senior Research Fellow and Group Leader based in the Centre for Genomic and Experimental Medicine.
I previously held a Chancellor's Felloswhip (2013 - 2018) that was part-funded by the University of Queensland where I was an Adjunct Research Fellow between 2013-2016.
My postdoctoral research included a year at the Department of Public Health and Primary Care at the University of Cambridge (2009-2010). Whilst there, I was awarded an Alzheimer's Research UK fellowship (2010-2013) in conjunction with the Medical Research Council Biostatistics Unit, Cambridge, the Department of Biostatistics, INSERM U897, Bordeaux and the University of Edinburgh Department of Psychology, to develop and apply longitudinal statistical methods for cognitive ageing.
I completed my PhD (2006-2009) in Genetic and Cognitive Epidemiology at the University of Edinburgh. My thesis title was "Inflammation and cognition: The association between biomarker levels, their genetic determinants, and age-related cognitive decline".
Collaborative Activity
Local Collaborators:
Generation Scotland and Lothian Birth Cohort teams, Tamir Chandra, Catalina Vallejos
National and international collaborators:
The PREVENT Dementia and EPAD teams. Steve Horvath (UCLA), Peter Visscher and Naomi Wray (University of Queensland), Matt Robinson (IST Vienna), Elliot Tucker-Drob (UTexas at Austin)
Current Research Interests
Epi/genetic epidemiology
Biostatistics and longitudinal data analysis
Ageing
Alzheimer's disease
Education/Academic qualification
Doctor of Philosophy (PhD), Inflammation and cognition: the association between biomarker levels, their genetic determinants, and age-related cognitive decline, University of Edinburgh
Award Date: 1 Jan 2009
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Bayesian reassessment of the epigenetic architecture of complex traits
Trejo Baños, D., McCartney, D. L., Patxot, M., Anchieri, L., Battram, T., Christiansen, C., Costeira, R., Walker, R. M., Morris, S. W., Campbell, A., Zhang, Q., Porteous, D. J., McRae, A. F., Wray, N. R., Visscher, P. M., Haley, C. S., Evans, K. L., Deary, I. J., McIntosh, A. M. & Hemani, G. & 3 others, , 8 Jun 2020, In: Nature Communications. 11, 2865.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936
Hillary, R., McCartney, D. L., Harris, S., Stevenson, A., Seeboth, A., Zhang, Q., Liewald, D., Evans, K. L., Ritchie, C., Tucker-Drob, E. M., Wray, N. R., Mcrae, A. F., Visscher, P. M., Deary, I. & Marioni, R. E., Dec 2019, In: Nature Communications. 10, 3160.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
DNA methylation Aging Clocks: Challenges & Recommendations
Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., Ideker, T., Issa, J.-P. J., Kelsey, K. T., Marioni, R., Reik, W., Relton, C. L., Schalkwyk, L. C., Teschendorff, A. E., Wagner, W. & Zhang, K. & 1 others, , 25 Nov 2019, (E-pub ahead of print) In: Genome Biology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Epigenetic prediction of complex traits and death
McCartney, D. L., Hillary, R., Stevenson, A. J., Ritchie, S. J., Walker, R. M., Zhang, Q., Morris, S. W., Bermingham, M. L., Campbell, A., Murray, A. D., Whalley, H. C., Gale, C. R., Porteous, D. J., Haley, C. S., McRae, A. F., Wray, N. R., Visscher, P. M., McIntosh, A. M., Evans, K. L. & Deary, I. J. & 1 others, , 27 Sept 2018, In: Genome Biology. 19, 136.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
GWAS on family history of Alzheimer’s disease
Marioni, R. E., Harris, S. E., Zhang, Q., McRae, A. F., Hagenaars, S. P., Hill, W. D., Davies, G., Ritchie, C. W., Gale, C. R., Starr, J. M., Goate, A. M., Porteous, D. J., Yang, J., Evans, K. L., Deary, I. J., Wray, N. R. & Visscher, P. M., 18 May 2018, In: Translational Psychiatry. 8, 99.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Activities
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Jim Sikela
Riccardo Marioni (Host)
10 Sept 2018Activity: Hosting a visitor types › Hosting an academic visitor
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Epigenetic prediction of age and modifiable lifestyle factors
Riccardo Marioni (Assessor)
Sept 2018Activity: Academic talk or presentation types › Invited talk
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The epigenetic clock and biological ageing
Riccardo Marioni (Assessor)
Sept 2018Activity: Academic talk or presentation types › Invited talk
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DNA methylation and prediction of complex traits
Riccardo Marioni (Assessor)
Jun 2018Activity: Academic talk or presentation types › Invited talk
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Do different biological clocks tell the same time?
Riccardo Marioni (Assessor)
May 2018Activity: Academic talk or presentation types › Oral presentation
Prizes
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Anatomical Society Aging Cell Best Paper Prize 2019
Olova, Nelly (Recipient), Simpson, Daniel (Recipient), Marioni, Riccardo (Recipient) & Chandra, Tamir (Recipient), 21 May 2020
Prize: Prize (including medals and awards)
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The environmental drivers of senescence: an experimental test in the wild
Little, T., Chandra, T., Marioni, R. & Wilson, A. B. P.
Natural Environment Research Council
1/03/23 → 28/02/26
Project: Research
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Preterm birth, Neurodevelopment and Cognition in Children: Causal Evidence and Mechanisms
Boardman, J., Cox, S., Marioni, R., Reynolds, R., Richardson, H., Tsanas, T. & Whalley, H.
1/11/22 → 31/10/27
Project: Research
Datasets
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Associations between alcohol use and accelerated biological ageing
Wootton, R. E. (Creator), Clarke, T. (Creator), Cox, S. (Creator), Bostrand, S. (Creator), Vaher, K. (Creator), De Nooij, L. (Creator), Harris, M. A. (Creator), Cole, J. H. (Creator), Marioni, R. (Creator), Mccartney, D. (Creator), Walker, R. (Creator), McIntosh, A. (Creator), Evans, K. (Creator) & Whalley, H. (Creator), Edinburgh DataShare, 24 Nov 2020
DOI: 10.7488/ds/2956
Dataset
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GWAS summary stats for meta-analysis of epigenetic age acceleration - Gibson et al, (2019)
Clarke, T. (Creator), McIntosh, A. (Creator) & Marioni, R. (Creator), Edinburgh DataShare, 30 Nov 2019
DOI: 10.7488/ds/2631, https://doi.org/10.1101/585299
Dataset
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Summary statistics from epigenome-wide association studies and meta-analysis comparing APOE ε4 and APOE ε2 allele carriers in Generation Scotland
Hayward, C. (Creator), Porteous, D. (Creator), McIntosh, A. (Creator), Marioni, R. (Creator), Evans, K. (Creator), Campbell, A. (Creator), Walker, R. (Creator), Vaher, K. (Creator), Bermingham, M. (Creator), Morris, S. (Creator), Bretherick, A. (Creator), Zeng, Y. (Creator), Rawlik, K. (Creator), Amador, C. (Creator) & Haley, C. (Creator), Edinburgh DataShare, 10 Nov 2020
DOI: 10.7488/ds/2948
Dataset
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cAge and bAge EWAS - Epigenome-wide association study of chronological age (linear and quadratic) and of survival
Campbell, A. (Creator), Harris, S. (Creator), Liewald, D. (Creator), Hayward, C. (Creator), Porteous, D. (Creator), Sudlow, C. (Creator), Evans, K. (Creator), Horvath, S. (Creator), McIntosh, A. (Creator), Robinson, M. R. (Creator), Vallejos Meneses, C. (Creator), Marioni, R. (Creator), Bernabeu Gómez, E. (Creator), Cox, S. (Creator), Mccartney, D. (Creator), Gadd, D. (Creator), Hillary, R. (Creator), Lu, A. T. (Creator), Murphy, L. (Creator) & Wrobel, N. (Creator), Edinburgh DataShare, 1 Oct 2022
DOI: 10.7488/ds/3792, https://doi.org/10.1101/2022.09.08.507115
Dataset
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Blood-based epigenome-wide analyses of chronic low-grade inflammation across diverse population cohorts - Bayesian EWAS and CRP Predictors
Loh, M. (Creator), Marioni, R. (Creator), Yousefi, P. (Creator), Suderman, M. (Creator), Relton, C. (Creator), Hillary, R. (Creator), Ng, H. K. (Creator), Mccartney, D. (Creator), Elliott, H. (Creator), Walker, R. (Creator), Campbell, A. (Creator), Huang, F. (Creator), Direk, K. (Creator), Welsh, P. (Creator), Sattar, N. (Creator), Corley, J. (Creator), Hayward, C. (Creator), McIntosh, A. (Creator), Sudlow, C. (Creator), Evans, K. (Creator), Cox, S. (Creator) & Chambers, J. C. (Creator), Edinburgh DataShare, 16 Jan 2024
DOI: 10.7488/ds/7546, https://www.medrxiv.org/content/10.1101/2023.11.02.23298000v1
Dataset
Press/Media
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Riccardo Marioni receives funding to research links between Alzheimer’s, genes and lifestyle
20/09/17 → 21/09/17
2 items of Media coverage
Press/Media: Research
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Genetic links to male baldness revealed by Dr Riccardo Marioni and Saskia Hagenaars
Riccardo Marioni, Saskia Hagenaars & David Hill
14/02/17 → 6/08/17
75 items of Media coverage
Press/Media: Research
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Riccardo Marioni suggests link between height and intelligence in gene study
2/03/14
40 items of Media coverage
Press/Media: Research
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Dr Riccardo Marioni says biological clock gives clues about mortality
6/02/15
2 items of Media coverage
Press/Media: Research
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Dr Riccardo Marioni says biological clock gives clues about mortality
7/05/15
1 item of Media coverage
Press/Media: Research