Riccardo Marioni

2019

DNA methylation Aging Clocks: Challenges & Recommendations

Bell, C. G., Lowe, R., Adams, P. D., Baccarelli, A. A., Beck, S., Bell, J. T., Christensen, B. C., Gladyshev, V. N., Heijmans, B. T., Horvath, S., Ideker, T., Issa, J-P. J., Kelsey, K. T., Marioni, R., Reik, W., Relton, C. L., Schalkwyk, L. C., Teschendorff, A. E., Wagner, W., Zhang, K., & 1 othersRakyan, V. K., 25 Nov 2019, (E-pub ahead of print) In: Genome Biology.

Research output: Contribution to journal › Article › peer-review

Open Access

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A meta-analysis of genome-wide association studies of epigenetic age acceleration

Gibson, J., Russ, T. C., Clarke, T-K., Howard, D. M., Hillary, R., Evans, K. L., Walker, R. M., Bermingham, M. L., Morris, S. W., Campbell, A., Hayward, C., Murray, A. D., Porteous, D. J., Horvath, S., Lu, A. T., McIntosh, A. M., Whalley, H. C. & Marioni, R. E., 18 Nov 2019, (E-pub ahead of print) In: PLoS Genetics. 15, 11, e1008104.

Research output: Contribution to journal › Article › peer-review

Open Access

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Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936

Corley, J., Cox, S., Harris, S., Valdes Hernandez, M., Munoz-Maniega, S., Bastin, M., Wardlaw, J., Starr, J., Marioni, R. & Deary, I., 7 Oct 2019, In: Translational Psychiatry. 9, 248.

Research output: Contribution to journal › Article › peer-review

Open Access

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Epigenome-wide association study of leukocyte telomere length

Lee, Y., Sun, D., Ori, A. P. S., Lu, A. T., Seeboth, A., Harris, S., Deary, I., Marioni, R., Soerensen, M., Mengel-From, J., Hjelmborg, J., Christensen, K., Wilson, J. G., Levy, D., Reiner, A. P., Chen, W., Li, S., Harris, J. R., Magnus, P., Aviv, A., & 2 othersJugessur, A. & Horvath, S., 26 Aug 2019, (E-pub ahead of print) In: Aging.

Research output: Contribution to journal › Article › peer-review

Open Access

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Improved precision of epigenetic clock estimates across tissues and its implication for biological ageing

Zhang, Q., Vallerga, C. L., Walker, R. M., Lin, T., Henders, A. K., Montgomery, G. W., He, J., Fan, D., Fowdar, J., Kennedy, M., Pitcher, T., Pearson, J., Halliday, G., Kwok, J. B., Hickie, I., Lewis, S., Anderson, T., Silburn, P. A., Mellick, G. D., Harris, S. E., & 13 othersRedmond, P., Murray, A. D., Porteous, D. J., Haley, C. S., Evans, K. L., Mcintosh, A. M., Yang, J., Gratten, J., Marioni, R. E., Wray, N. R., Deary, I. J., Mcrae, A. F. & Visscher, P. M., 23 Aug 2019, In: Genome Medicine. 11, 1, 54.

Research output: Contribution to journal › Article › peer-review

Open Access

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Age-related clonal haematopoiesis is associated with increased epigenetic age

Robertson, N. A., Hillary, R., McCartney, D. L., Terradas-Terradas, M., Higham, J., Sproul, D., Deary, I. J., Kirschner, K., Marioni, R. E. & Chandra, T., 19 Aug 2019, In: Current Biology. 29, 16, p. R786-R787

Research output: Contribution to journal › Article › peer-review

Open Access

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DNA methylation-based estimator of telomere length

Lu, A. T., Seeboth, A., Tsai, P-C., Sun, D., Quach, A., Reiner, A. P., Kooperberg, C., Ferrucci, L., Hou, L., Baccarelli, A. A., Li, Y., Harris, S. E., Corley, J., Taylor, A., Deary, I. J., Stewart, J. D., Whitsel, E. A., Assimes, T. L., Chen, W., Li, S., & 7 othersMangino, M., Bell, J. T., Wilson, J., Aviv, A., Marioni, R. E., Raj, K. & Horvath, S., 18 Aug 2019, (E-pub ahead of print) In: Aging. 11

Research output: Contribution to journal › Article › peer-review

Open Access

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Correction: GWAS on family history of Alzheimer’s disease

Marioni, R. E., Harris, S. E., Zhang, Q., Mcrae, A. F., Hagenaars, S. P., Hill, W. D., Davies, G., Ritchie, C. W., Gale, C. R., Starr, J. M., Goate, A. M., Porteous, D. J., Yang, J., Evans, K. L., Deary, I. J., Wray, N. R. & Visscher, P. M., 6 Jun 2019, In: Translational Psychiatry. 9, 1

Research output: Contribution to journal › Comment/debate

Open Access

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Identification of novel differentially methylated sites with potential as clinical predictors of impaired respiratory function and COPD

Bermingham, M., Walker, R., Marioni, R., Morris, S., Rawlik, K., Zeng, Y., Campbell, A., Redmond, P., Whalley, H., Adams, M. J., Hayward, C., Deary, I., Porteous, D. J., McIntosh, A. & Evans, K., 4 Jun 2019, In: EBioMedicine. 43, p. 576-586

Research output: Contribution to journal › Article › peer-review

Open Access

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Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-Ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-Olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., DeRosse, P., Djurovic, S., & 202 othersEspeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., van der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S-C., Lill, C. M., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L-P., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-Heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-Falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Dan Rujescu, Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., McIntosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T. & Deary, I. J., 1 May 2019, In: Nature Communications. 10, 1, p. 2068

Research output: Contribution to journal › Article

Open Access

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Publisher Correction: Parent of origin genetic effects on methylation in humans are common and influence complex trait variation

Zeng, Y., Amador, C., Xia, C., Marioni, R., Sproul, D., Walker, R. M., Morris, S. W., Bretherick, A., Canela-Xandri, O., Boutin, T. S., Clark, D. W., Campbell, A., Rawlik, K., Hayward, C., Nagy, R., Tenesa, A., Porteous, D. J., Wilson, J. F., Deary, I. J., Evans, K. L., & 3 othersMcIntosh, A. M., Navarro, P. & Haley, C. S., 1 May 2019, In: Nature Communications. 10, 1, p. 2069

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Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Grotzinger, A., Rhemtulla, M., Vlaming, R. D., Ritchie, S. J., Mallard, T. T., Hill, W. D., Hill, F., Marioni, R., McIntosh, A., Deary, I., Koellinger, P. D., Harden, K. P., Nivard, M. G. & Tucker-Drob, E. M., May 2019, In: Nature Human Behaviour. 3, 5, p. 513-525

Research output: Contribution to journal › Article › peer-review

Open Access

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Examining the Impact of Imputation Errors on Fine-Mapping Using DNA Methylation QTL as a Model Trait

Chundru, V. K., Marioni, R. E., Prendergast, J. G. D., Vallerga, C. L., Lin, T., Berveridge, A. J., Consortium, S., Gratten, J., Hume, D. A., Deary, I. J., Wray, N. R., Visscher, P. M. & McRae, A. F., 30 Apr 2019, (E-pub ahead of print) In: Genetics.

Research output: Contribution to journal › Article › peer-review

Open Access

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Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

Howard, D. M., Adams, M. J., Clarke, T-K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J. R. I., Hagenaars, S. P., Ward, J., Wigmore, E. M., Alloza, C., Shen, X., Barbu, M. C., Xu, E. Y., Whalley, H. C., Marioni, R. E., Porteous, D. J., Davies, G., Deary, I. J., Hemani, G., & 20 othersBerger, K., Teismann, H., Rawal, R., Arolt, V., Baune, B. T., Dannlowski, U., Domschke, K., Tian, C., Hinds, D. A., 23andMe Research Team, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Trzaskowski, M., Byrne, E. M., Ripke, S., Smith, D. J., Sullivan, P. F., Wray, N. R., Breen, G., Lewis, C. M. & McIntosh, A. M., 31 Mar 2019, In: Nature Neuroscience. 22, 3, p. 343–352 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Parent of origin genetic effects on methylation in humans are common and influence complex trait variation

Zeng, Y., Amador, C., Xia, C., Marioni, R., Sproul, D., Walker, R. M., Morris, S. W., Bretherick, A., Canela-Xandri, O., Boutin, T. S., Clark, D. W., Campbell, A., Rawlik, K., Hayward, C., Nagy, R., Tenesa, A., Porteous, D. J., Wilson, J. F., Deary, I. J., Evans, K. L., & 3 othersMcIntosh, A. M., Navarro, P. & Haley, C. S., 27 Mar 2019, In: Nature Communications. 10, 13 p., 1383.

Research output: Contribution to journal › Article › peer-review

Open Access

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DNA methylation signatures of impaired respiratory function aids prediction of major depressive disorder in chronic obstructive pulmonary disease

Bermingham, M., Evans, K., Porteous, D., Deary, I., Hayward, C., Walker, R., Marioni, R., Morris, S., Rawlik, K., Zeng, Y., Campbell, A., Redmond, P., Sibley, H. & Adams, M. J., 12 Mar 2019.

Research output: Contribution to conference › Poster › peer-review

Leveraging DNA methylation signatures in peripheral blood as predictors of impaired respiratory function and chronic obstructive pulmonary disease.

Bermingham, M., Evans, K., McIntosh, A., Porteous, D., Deary, I., Hayward, C., Walker, R., Marioni, R., Morris, S., Rawlik, K., Zeng, Y., Campbell, A., Redmond, P., Sibley, H. & Adams, M. J., 12 Mar 2019.

Research output: Contribution to conference › Paper › peer-review

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Hamilton, O., Zhang, Q., Mcrae, A. F., Walker, R., Morris, S., Redmond, P., Campbell, A., Murray, A., Porteous, D., Evans, K., McIntosh, A., Deary, I. & Marioni, R., 6 Mar 2019, In: International Journal of Obesity.

Research output: Contribution to journal › Article › peer-review

Open Access

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A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence

Hill, W. D., Marioni, R. E., Maghzian, O., Ritchie, S. J., Hagenaars, S. P., McIntosh, A. M., Gale, C. R., Davies, G. & Deary, I. J., 28 Feb 2019, In: Molecular Psychiatry. 24, 2, p. 169-181 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Age‐dependent DNA methylation patterns on the Y chromosome in elderly males

Lund, J., Li, S., Christensen, K., Mengel-From, J., Soerensen, M., Marioni, R., Starr, J., Pattie, A., Deary, I., Baumbach, J. & Tan, Q., 21 Feb 2019, (E-pub ahead of print) In: Aging Cell.

Research output: Contribution to journal › Article › peer-review

Open Access

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Polygenic predictors of age-related decline in cognitive ability

Ritchie, S. J., Hill, W. D., Marioni, R., Davies, G., Hagenaars, S., Harris, S., Cox, S., Taylor, A., Corley, J., Pattie, A., Redmond, P., Starr, J. & Deary, I., 13 Feb 2019, In: Molecular Psychiatry. p. 1-15

Research output: Contribution to journal › Article › peer-review

Open Access

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Partial reprogramming induces a steady decline in epigenetic age before loss of somatic identity

Olova, N., Simpson, D. J., Marioni, R. E. & Chandra, T., 1 Feb 2019, In: Aging Cell. 18, 1, e12877.

Research output: Contribution to journal › Article › peer-review

Open Access

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DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns

Lund, J., Li, S., Baumbach, J., Svane, A. M., Hjelmborg, J., Christiansen, L., Christensen, K., Redmond, P., Marioni, R., Deary, I. & Tan, Q., Feb 2019, In: Clinical Epigenetics. 11, 23, p. 1-8

Research output: Contribution to journal › Article › peer-review

Open Access

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Author Correction: Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism

Luciano, M., Hagenaars, S. P., Davies, G., Hill, W. D., Clarke, T., Shirali, M., Harris, S. E., Marioni, R. E., Liewald, D. C., Fawns-ritchie, C., Adams, M. J., Howard, D. M., Lewis, C. M., Gale, C. R., Mcintosh, A. M. & Deary, I. J., 29 Jan 2019, (E-pub ahead of print) In: Nature Genetics.

Research output: Contribution to journal › Comment/debate

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R. D., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S., Boehnke, M., & 156 othersBots, M. L., Brazel, D. M., Chambers, J. C., Chang-claude, J., Chen, C., Corley, J., Chou, Y., David, S. P., De Boer, R. A., De Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A., Hsu, C., Iacono, W. G., Kanoni, S., Kapoor, M., Kaprio, J., Kardia, S. L., Karpe, F., Kontto, J., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Laakso, M., Lai, D., Langenberg, C., Le, N., Lettre, G., Loukola, A., Luan, J., Madden, P. A. F., Mangino, M., Marioni, R. E., Marouli, E., Marten, J., Martin, N. G., Mcgue, M., Michailidou, K., Mihailov, E., Moayyeri, A., Moitry, M., Müller-nurasyid, M., Naheed, A., Nauck, M., Neville, M. J., Nielsen, S. F., North, K., Perola, M., Pharoah, P. D. P., Pistis, G., Polderman, T. J., Posthuma, D., Poulter, N., Qaiser, B., Rasheed, A., Reiner, A., Renström, F., Rice, J., Rohde, R., Rolandsson, O., Samani, N. J., Samuel, M., Schlessinger, D., Scholte, S. H., Scott, R. A., Sever, P., Shao, Y., Shrine, N., Smith, J. A., Starr, J. M., Stirrups, K., Stram, D., Stringham, H. M., Tachmazidou, I., Tardif, J., Thompson, D. J., Tindle, H. A., Tragante, V., Trompet, S., Turcot, V., Tyrrell, J., Vaartjes, I., Van Der Leij, A. R., Van Der Meer, P., Varga, T. V., Verweij, N., Völzke, H., Wareham, N. J., Warren, H. R., Weir, D. R., Weiss, S., Wetherill, L., Yaghootkar, H., Yavas, E., Jiang, Y., Chen, F., Zhan, X., Zhang, W., Zhao, W., Zhao, W., Zhou, K., Amouyel, P., Blankenberg, S., Caulfield, M. J., Chowdhury, R., Cucca, F., Deary, I. J., Deloukas, P., Di Angelantonio, E., Ferrario, M., Ferrières, J., Franks, P. W., Frayling, T. M., Frossard, P., Hall, I. P., Hayward, C., Jansson, J., Jukema, J. W., Kee, F., Männistö, S., Metspalu, A., Munroe, P. B., Nordestgaard, B. G., Palmer, C. N. A., Salomaa, V., Sattar, N., Spector, T., Strachan, D. P., Van Der Harst, P., Zeggini, E., Saleheen, D., Butterworth, A. S., Wain, L. V., Abecasis, G. R., Danesh, J., Tobin, M. D., Vrieze, S., Liu, D. J. & Howson, J. M. M., 7 Jan 2019, (E-pub ahead of print) In: Molecular Psychiatry.

Research output: Contribution to journal › Article › peer-review

Open Access

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Tracking the epigenetic clock across the human life course: A meta-analysis of longitudinal cohort data

Marioni, R., Suderman, M. J., Chen, B. H., Horvath, S., Bandinelli, S., Morris, T. J., Becker, S., Ferrucci, L., Pedersen, N. L., Relton, C. L., Deary, I. & Hägg, S., Jan 2019, In: The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. 74, 1, p. 1-5 gly060.

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

Stevenson, A., McCartney, D. L., Harris, S., Taylor, A., Redmond, P., Starr, J., Zhang, Q., McRae, A. F., Wray, N. R., Spires-Jones, T., McColl, B., McIntosh, A., Deary, I. & Marioni, R., 20 Dec 2018, In: Clinical Epigenetics.

Research output: Contribution to journal › Article › peer-review

Open Access

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Identification of 55,000 Replicated DNA Methylation QTL

McRae, A. F., Marioni, R. E., Shah, S., Yang, J., Powell, J. E., Harris, S. E., Gibson, J., Henders, A. K., Bowdler, L., Painter, J. N., Murphy, L., Martin, N. G., Starr, J. M., Wray, N. R., Deary, I. J., Visscher, P. M. & Montgomery, G. W., 4 Dec 2018, In: Scientific Reports. 8, 1, p. 1-9 17605.

Research output: Contribution to journal › Article › peer-review

Open Access

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GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

Franceschini, N., Giambartolomei, C., De Vries, P. S., Finan, C., Bis, J. C., Huntley, R. P., Lovering, R. C., Tajuddin, S. M., Winkler, T. W., Graff, M., Kavousi, M., Dale, C., Smith, A. V., Hofer, E., Van Leeuwen, E. M., Nolte, I. M., Lu, L., Scholz, M., Sargurupremraj, M., Pitkänen, N., & 137 othersFranzén, O., Joshi, P. K., Noordam, R., Marioni, R. E., Hwang, S., Musani, S. K., Schminke, U., Palmas, W., Isaacs, A., Correa, A., Zonderman, A. B., Hofman, A., Teumer, A., Cox, A. J., Uitterlinden, A. G., Wong, A., Smit, A. J., Newman, A. B., Britton, A., Ruusalepp, A., Sennblad, B., Hedblad, B., Pasaniuc, B., Penninx, B. W., Langefeld, C. D., Wassel, C. L., Tzourio, C., Fava, C., Baldassarre, D., O’leary, D. H., Teupser, D., Kuh, D., Tremoli, E., Mannarino, E., Grossi, E., Boerwinkle, E., Schadt, E. E., Ingelsson, E., Veglia, F., Rivadeneira, F., Beutner, F., Chauhan, G., Heiss, G., Snieder, H., Campbell, H., Völzke, H., Markus, H. S., Deary, I. J., Jukema, J. W., De Graaf, J., Price, J., Pott, J., Hopewell, J. C., Liang, J., Thiery, J., Engmann, J., Gertow, K., Rice, K., Taylor, K. D., Dhana, K., Kiemeney, L. A. L. M., Lind, L., Raffield, L. M., Launer, L. J., Holdt, L. M., Dörr, M., Dichgans, M., Traylor, M., Sitzer, M., Kumari, M., Kivimaki, M., Nalls, M. A., Melander, O., Raitakari, O., Franco, O. H., Rueda-ochoa, O. L., Roussos, P., Whincup, P. H., Amouyel, P., Giral, P., Anugu, P., Wong, Q., Malik, R., Rauramaa, R., Burkhardt, R., Hardy, R., Schmidt, R., De Mutsert, R., Morris, R. W., Strawbridge, R. J., Wannamethee, S. G., Hägg, S., Shah, S., Mclachlan, S., Trompet, S., Seshadri, S., Kurl, S., Heckbert, S. R., Ring, S., Harris, T. B., Lehtimäki, T., Galesloot, T. E., Shah, T., De Faire, U., Plagnol, V., Rosamond, W. D., Post, W., Zhu, X., Zhang, X., Guo, X., Saba, Y., Dehghan, A., Seldenrijk, A., Morrison, A. C., Hamsten, A., Psaty, B. M., Van Duijn, C. M., Lawlor, D. A., Mook-kanamori, D. O., Bowden, D. W., Schmidt, H., Wilson, J. G., Rotter, J. I., Wardlaw, J. M., Deanfield, J., Halcox, J., Lyytikäinen, L., Loeffler, M., Evans, M. K., Debette, S., Humphries, S. E., Völker, U., Gudnason, V., Hingorani, A. D., Björkegren, J. L. M., Casas, J. P. & O’donnell, C. J., 3 Dec 2018, In: Nature Communications. 9, 1, 5141.

Research output: Contribution to journal › Article › peer-review

Open Access

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Association of facial ageing with DNA methylation and epigenetic age predictions

Marioni, R. E., Belsky, D. W., Deary, I. J. & Wagner, W., 8 Nov 2018, In: Clinical Epigenetics. 10, 140, p. 1-3

Research output: Contribution to journal › Short survey › peer-review

Open Access

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Epigenetic signatures of starting and stopping smoking

McCartney, D. L., Stevenson, A. J., Hillary, R., Walker, R. M., Bermingham, M. L., Morris, S. W., Clarke, T-K., Campbell, A., Murray, A. D., Whalley, H. C., Porteous, D. J., Visscher, P. M., McIntosh, A. M., Evans, K. L., Deary, I. J. & Marioni, R. E., 1 Nov 2018, In: EBioMedicine. 37, p. 214-220

Research output: Contribution to journal › Article › peer-review

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Genome-wide association analyses of >200,000 individuals identify 58 genetic loci for chronic inflammation and highlights pathways that link inflammation and complex disorders

Ligthart, S., Vaez, A., Võsa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., Schraut, K. E., Joshi, P., Campbell, H., Wilson, J., Marioni, R. & Deary, I., 1 Nov 2018, In: American Journal of Human Genetics. 103, 5, p. 691-706

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Genotype effects contribute to variation in longitudinal methylome patterns in older people

Zhang, Q., Marioni, R., Robinson, M. R., Higham, J., Sproul, D., Wray, N. R., Deary, I., Mcrae, A. F. & Visscher, P. M., 22 Oct 2018, In: Genome Medicine. 10, 75, p. 1-11

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DNA Methylation Signatures of Depressive Symptoms in Middle-aged and Elderly Persons: Meta-analysis of Multiethnic Epigenome-wide Studies

Story Jovanova, O., Nedeljkovic, I., Spieler, D., Walker, R. M., Liu, C., Luciano, M., Bressler, J., Brody, J., Drake, A. J., Evans, K. L., Gondalia, R., Kunze, S., Kuhnel, B., Lahti, J., Lemaitre, R. N., Marioni, R. E., Swenson, B., Himali, J. J., Wu, H., Li, Y., & 29 othersMcRae, A. F., Russ, T. C., Stewart, J., Wang, Z., Zhang, G., Ladwig, K-H., Uitterlinden, A. G., Guo, X., Peters, A., Räikkönen, K., Starr, J. M., Waldenberger, M., Wray, N. R., Whitsel, E. A., Sotoodehnia, N., Seshadri, S., Porteous, D. J., Van Meurs, J., Mosley, T. H., McIntosh, A. M., Mendelson, M. M., Levy, D., Hou, L., Eriksson, J. G., Fornage, M., Deary, I. J., Baccarelli, A., Tiemeier, H. & Amin, N., 30 Sept 2018, In: JAMA Psychiatry. 75, 9, p. 949-959 11 p.

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Epigenetic influences on aging: A longitudinal genome-wide methylation study in old Swedish twins

Wang, Y., Karlsson, R., Lampa, E., Zhang, Q., Hedman, Å. K., Almgren, M., Almqvist, C., Mcrae, A. F., Marioni, R. E., Ingelsson, E., Visscher, P. M., Deary, I. J., Lind, L., Morris, T., Beck, S., Pedersen, N. L. & Hägg, S., 28 Sept 2018, (E-pub ahead of print) In: Epigenetics.

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Epigenetic prediction of complex traits and death

McCartney, D. L., Hillary, R., Stevenson, A. J., Ritchie, S. J., Walker, R. M., Zhang, Q., Morris, S. W., Bermingham, M. L., Campbell, A., Murray, A. D., Whalley, H. C., Gale, C. R., Porteous, D. J., Haley, C. S., McRae, A. F., Wray, N. R., Visscher, P. M., McIntosh, A. M., Evans, K. L., Deary, I. J., & 1 othersMarioni, R. E., 27 Sept 2018, In: Genome Biology. 19, 136.

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Addendum: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Howard, D. M., Adams, M. J., Shirali, M., Clarke, T-K., Marioni, R. E., Davies, G., Coleman, J. R. I., Alloza, C., Shen, X., Barbu, M. C., Wigmore, E. M., Gibson, J., Hagenaars, S. P., Lewis, C. M., Ward, J., Smith, D. J., Sullivan, P. F., Haley, C. S., Breen, G., Deary, I. J., & 1 othersMcIntosh, A. M., 30 Aug 2018, In: Nature Communications. 9, 1, p. 3578

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DNA methylation and the epigenetic clock in relation to physical frailty in older people: The Lothian Birth Cohort 1936

Gale, C., Marioni, R., Harris, S., Starr, J. & Deary, I., 3 Aug 2018, (E-pub ahead of print) In: Clinical Epigenetics. 10, 101, p. 1-8

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Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer’s disease

Mccartney, D., Stevenson, A., Walker, R., Gibson, J., Morris, S. W., Campbell, A., Murray, A. D., Whalley, H., Porteous, D., McIntosh, A., Evans, K., Deary, I. & Marioni, R., 21 Jun 2018, (E-pub ahead of print) In: Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

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Using tree-based methods for detection of gene-gene interactions in the presence of a polygenic signal: simulation study with appli-cation to educational attainment in the Genera-tion Scotland Cohort Study

Meijsen, J., Rammos, A., Campbell, A., Hayward, C., Porteous, D., Deary, I., Marioni, R. & Nicodemus, K., 19 Jun 2018, In: Bioinformatics.

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Brain age and other bodily ‘ages’: Implications for neuropsychiatry

Cole, J. H., Marioni, R. E., Harris, S. E. & Deary, I. J., 11 Jun 2018, In: Molecular Psychiatry. 16 p.

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Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

Qi, T., Wu, Y., Zeng, J., Zhang, F., Xue, A., Jiang, L., Zhu, Z., Kemper, K., Yengo, L., Zheng, Z., Marioni, R. E., Montgomery, G. W., Deary, I. J., Wray, N. R., Visscher, P. M., Mcrae, A. F. & Yang, J., 11 Jun 2018, In: Nature Communications. 9, 1, p. 1-12 2282.

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Brain age predicts mortality

Cole, J. H., Ritchie, S. J., Bastin, M. E., Valdés Hernández, M. C., Muñoz Maniega, S., Royle, N., Corley, J., Pattie, A., Harris, S. E., Zhang, Q., Wray, N. R., Redmond, P., Marioni, R. E., Starr, J. M., Cox, S. R., Wardlaw, J. M., Sharp, D. J. & Deary, I. J., 31 May 2018, In: Molecular Psychiatry. 23, p. 1385-1392 8 p.

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Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, G., Lam, M., Harris, S. E., Trampush, J. W., Luciano, M., Hill, W. D., Hagenaars, S. P., Ritchie, S. J., Marioni, R. E., Fawns-ritchie, C., Liewald, D. C. M., Okely, J. A., Ahola-olli, A. V., Barnes, C. L. K., Bertram, L., Bis, J. C., Burdick, K. E., Christoforou, A., Derosse, P., Djurovic, S., & 201 othersEspeseth, T., Giakoumaki, S., Giddaluru, S., Gustavson, D. E., Hayward, C., Hofer, E., Ikram, M. A., Karlsson, R., Knowles, E., Lahti, J., Leber, M., Li, S., Mather, K. A., Melle, I., Morris, D., Oldmeadow, C., Palviainen, T., Payton, A., Pazoki, R., Petrovic, K., Reynolds, C. A., Sargurupremraj, M., Scholz, M., Smith, J. A., Smith, A. V., Terzikhan, N., Thalamuthu, A., Trompet, S., Van Der Lee, S. J., Ware, E. B., Windham, B. G., Wright, M. J., Yang, J., Yu, J., Ames, D., Amin, N., Amouyel, P., Andreassen, O. A., Armstrong, N. J., Assareh, A. A., Attia, J. R., Attix, D., Avramopoulos, D., Bennett, D. A., Böhmer, A. C., Boyle, P. A., Brodaty, H., Campbell, H., Cannon, T. D., Cirulli, E. T., Congdon, E., Conley, E. D., Corley, J., Cox, S. R., Dale, A. M., Dehghan, A., Dick, D., Dickinson, D., Eriksson, J. G., Evangelou, E., Faul, J. D., Ford, I., Freimer, N. A., Gao, H., Giegling, I., Gillespie, N. A., Gordon, S. D., Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Hartmann, A. M., Hatzimanolis, A., Heiss, G., Holliday, E. G., Joshi, P. K., Kähönen, M., Kardia, S. L. R., Karlsson, I., Kleineidam, L., Knopman, D. S., Kochan, N. A., Konte, B., Kwok, J. B., Le Hellard, S., Lee, T., Lehtimäki, T., Li, S., Liu, T., Koini, M., London, E., Longstreth, W. T., Lopez, O. L., Loukola, A., Luck, T., Lundervold, A. J., Lundquist, A., Lyytikäinen, L., Martin, N. G., Montgomery, G. W., Murray, A. D., Need, A. C., Noordam, R., Nyberg, L., Ollier, W., Papenberg, G., Pattie, A., Polasek, O., Poldrack, R. A., Psaty, B. M., Reppermund, S., Riedel-heller, S. G., Rose, R. J., Rotter, J. I., Roussos, P., Rovio, S. P., Saba, Y., Sabb, F. W., Sachdev, P. S., Satizabal, C. L., Schmid, M., Scott, R. J., Scult, M. A., Simino, J., Slagboom, P. E., Smyrnis, N., Soumaré, A., Stefanis, N. C., Stott, D. J., Straub, R. E., Sundet, K., Taylor, A. M., Taylor, K. D., Tzoulaki, I., Tzourio, C., Uitterlinden, A., Vitart, V., Voineskos, A. N., Kaprio, J., Wagner, M., Wagner, H., Weinhold, L., Wen, K. H., Widen, E., Yang, Q., Zhao, W., Adams, H. H. H., Arking, D. E., Bilder, R. M., Bitsios, P., Boerwinkle, E., Chiba-falek, O., Corvin, A., De Jager, P. L., Debette, S., Donohoe, G., Elliott, P., Fitzpatrick, A. L., Gill, M., Glahn, D. C., Hägg, S., Hansell, N. K., Hariri, A. R., Ikram, M. K., Jukema, J. W., Vuoksimaa, E., Keller, M. C., Kremen, W. S., Launer, L., Lindenberger, U., Palotie, A., Pedersen, N. L., Pendleton, N., Porteous, D. J., Räikkönen, K., Raitakari, O. T., Ramirez, A., Reinvang, I., Rudan, I., Dan Rujescu, Schmidt, R., Schmidt, H., Schofield, P. W., Schofield, P. R., Starr, J. M., Steen, V. M., Trollor, J. N., Turner, S. T., Van Duijn, C. M., Villringer, A., Weinberger, D. R., Weir, D. R., Wilson, J. F., Malhotra, A., Mcintosh, A. M., Gale, C. R., Seshadri, S., Mosley, T. H., Bressler, J., Lencz, T. & Deary, I. J., 29 May 2018, In: Nature Communications. 9, 1, 2098.

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GWAS on family history of Alzheimer’s disease

Marioni, R. E., Harris, S. E., Zhang, Q., McRae, A. F., Hagenaars, S. P., Hill, W. D., Davies, G., Ritchie, C. W., Gale, C. R., Starr, J. M., Goate, A. M., Porteous, D. J., Yang, J., Evans, K. L., Deary, I. J., Wray, N. R. & Visscher, P. M., 18 May 2018, In: Translational Psychiatry. 8, 99.

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Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Howard, D. M., Adams, M. J., Shirali, M., Clarke, T-K., Marioni, R. E., Davies, G., Coleman, J. R. I., Alloza, C., Shen, X., Barbu, M. C., Wigmore, E. M., Gibson, J., 23andMe Research Team, Hagenaars, S. P., Lewis, C. M., Ward, J., Smith, D. J., Sullivan, P. F., Haley, C. S., Breen, G., & 2 othersDeary, I. J. & McIntosh, A. M., 16 Apr 2018, In: Nature Communications. 9, 1, p. 1-10 10 p., 1470.

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Association of methylation signals with incident coronary heart disease in an epigenome-wide assessment of circulating tumor necrosis factor α

Aslibekyan, S., Agha, G., Colicino, E., Do, A. N., Lahti, J., Ligthart, S., Marioni, R., Marzi, C., Mendelson, M. M., Tanaka, T., Wielscher, M., Absher, D. M., Ferrucci, L., Franco, O. H., Gieger, C., Grallert, H., Hernandez, D., Huan, T., Iurato, S., Joehanes, R., & 28 othersJust, A. C., Kunze, S., Lin, H., Liu, C., Meigs, J. B., vVan Meurs, J. B. J., Moore, A. Z., Peters, A., Räikkönen, K., Rathmann, W., Roden, M., Schramm, K., Schwartz, J. D., Starr, J., Uitterlinden, A. G., Vokonas, P., Waldenberger, M., Yao, C., Zhi, D., Baccarelli, A. A., Bandinelli, S., Deary, I., Dehghan, A., Eriksson, J., Herder, C., Järvelin, M-R., Levy, D. & Arnett, D. K., 4 Apr 2018, (E-pub ahead of print) In: JAMA Cardiology.

Research output: Contribution to journal › Article › peer-review

Cognitive ability does not predict objectively measured sedentary behaviour: Evidence from three older cohorts

Čukić, I., Shaw, R., Marioni, R., Chastin, S., Der, G., Dontje, M., Gill, J. M. R., Starr, J., Skelton, D. A., Radakovic, R., Cox, S., Dall, P., Gale, C. & Deary, I., 30 Mar 2018, In: Psychology and Aging. 33, 2, p. 288-296

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Altered DNA methylation associated with a translocation linked to major mental illness

McCartney, D. L., Walker, R. M., Morris, S. W., Anderson, S. M., Duff, B. J., Marioni, R. E., Millar, J. K., McCarthy, S. E., Ryan, N. M., Lawrie, S. M., Watson, A. R., Blackwood, D. H. R., Thomson, P. A., McIntosh, A. M., McCombie, W. R., Porteous, D. J. & Evans, K. L., 19 Mar 2018, In: npj Schizophrenia. 4, 1, p. 5

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Phenotypic and genetic analysis of cognitive performance in Major Depressive Disorder in the Generation Scotland: Scottish Family Health Study

Meijsen, J. J., Campbell, A., Hayward, C., Porteous, D. J., Deary, I. J., Marioni, R. E. & Nicodemus, K. K., 13 Mar 2018, (E-pub ahead of print) In: Translational Psychiatry. 8, 1, p. 63

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Riccardo Marioni

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