Research output per year
Research output per year
Personal profile
Biography
RM is a genetics graduate of TCD (Dublin) and has been studying DNA methylation dynamics for over 25 years. Research landmarks include the identification of methyl-CpG binding proteins (MeCP1 and MeCP2), non-catalytic roles for DNMT1 and alternate hypotheses regarding DNA methylation reprogramming in development and disease states. He is currently a Professor at the MRC Human Genetics Unit in Edinburgh and investigating how 5-hydroxymethylcytosine profiling can be used as a cell identifier.
Education/Academic qualification
Doctor in Philosophy, Molecular Genetic Analysis of Hepatic Cytochrome P-450s., University of Edinburgh
Award Date: 1 Jan 1988
Bachelor of Science, Trinity College Dublin
Award Date: 1 Jan 1982
Keywords
- QH426 Genetics
- DNA Methylation
- Epigenetics
- Transcription
- Chromatin biology
- Disease
- Developmental Biology
- Repression
- Cellular identity
- Reprogramming
- DNA repeat silencing
- Germ line
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis
Sadiku, P., Willson, J. A., Ryan, E. M., Sammut, D., Coelho, P., Watts, E. R., Grecian, R., Young, J. M., Bewley, M., Arienti, S., Mirchandani, A. S., Sanchez Garcia, M. A., Morrison, T., Zhang, A., Reyes, L., Griessler, T., Jheeta, P., Paterson, G. G., Graham, C. J., Thompson, J. P., & 16 others, 2 Feb 2021, In: Cell Metabolism. 33, 2, p. 411-423.e4Research output: Contribution to journal › Article › peer-review
Open AccessFile -
A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis
Sinton, M. C., Meseguer-Ripolles, J., Lucendo-Villarin, B., Wernig-Zorc, S., Thomson, J. P., Carter, R. N., Lyall, M. J., Walker, P. D., Thakker, A., Meehan, R. R., Lavery, G. G., Morton, N. M., Ludwig, C., Tennant, D. A., Hay, D. C. & Drake, A. J., 22 Jan 2021, In: iScience. 24, 1, 101931.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes
Shukla, R., Mjoseng, H. K., Thomson, J., Kling, S., Sproul, D., Dunican, D., Ramsahoye, B., Wongtawan, T., Treindl, F., Templin, M. F., Adams, I., Pennings, S. & Meehan, R., 20 Aug 2020, In: Nucleic Acids Research.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells
Dunican, D. S., Mjoseng, H. K., Duthie, L., Flyamer, I. M., Bickmore, W. A. & Meehan, R. R., 4 Mar 2020, In: BMC Biology. 18, 1, 25.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency
McLaughlin, K., Flyamer, I. M., Thomson, J. P., Mjoseng, H. K., Shukla, R., Williamson, I., Grimes, G. R., Illingworth, R. S., Adams, I. R., Pennings, S., Meehan, R. R. & Bickmore, W. A., 12 Nov 2019, In: Cell Reports. 29, 7, p. 1974-1985.e6 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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The functional requirement for epigenetic systems in development and disease
1/04/18 → 31/03/23
Project: Research
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Analysis of genome-wide 5-hydroxymethylcytosine patterns in human hepatoblastoma tumours during chemotherapy treatment
1/04/17 → 31/03/18
Project: Research
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Vitamin C programming of self-renewal and pluripotency in rat embryonic stem cells
1/09/15 → 28/02/19
Project: Research
Press/Media
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Dr Richard Meehan says cell cultures used in research may not faithfully mimic real tissue
4/02/15
1 item of Media coverage
Press/Media: Research
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Richard Meehan finds that aging cells in human are more likely to be affected by cancer
2/12/13
4 items of Media coverage
Press/Media: Research