Research output per year
Research output per year
Accepting PhD Students
It is now almost routinely possible to identify genetic mutations across the human genome which drive disease or regulate complex human traits. However, the majority of these mutations are found in noncoding regions beyond the borders of known genes which makes their interpretation challenging. These noncoding regions encode a range of regulatory functions to control when and where genes are expressed.
Promoters and enhancers represent such types of noncoding loci, responsible for regulating gene expression and which are significantly enriched for these phenotypically-associated variants. I have shown that these elements have undergone pervasive birth and death during mammalian evolution. Surprisingly, it is those elements which are evolutionarily volatile which are most likely to harbour functionally important, regulatory variants within the human population.
My research studies the regulatory landscape of the human genome to discover how its rewiring drives variation in medical phenotypes and disease risk across individuals, populations and species.
Bioinformatics, Doctor of Philosophy (PhD), University of Oxford
1 Oct 2007 → 28 Sept 2011
Award Date: 28 Sept 2011
Quantitative Genetics and Genome Analysis, Master of Science, University of Edinburgh
1 Sept 2005 → 31 Aug 2006
Award Date: 28 Nov 2006
Natural Sciences, Bachelor of Arts, University of Cambridge
1 Sept 2002 → 30 Jun 2005
Award Date: 30 Jun 2005
Lecturer, ZJU-UoE Institute, Zhejiang University, Haining, Zhejiang, 314400, P.R. China
2 May 2019 → …
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Review article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Young, R. (Creator) & Taylor, M. (Creator), Edinburgh DataShare, 21 Dec 2017
DOI: 10.7488/ds/2266
Dataset