Rob Young

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  • 2022

    The contribution of evolutionarily volatile promoters to molecular phenotypes and human trait variation

    Young, R. S., Talmane, L., Marion de Proce, S. & Taylor, M. S., 4 Apr 2022, In: Genome Biology. 23, 89.

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  • 2021

    Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

    Grapotte, M., Saraswat, M., Bessière, C., Menichelli, C., Ramilowski, J. A., Severin, J., Hayashizaki, Y., Itoh, M., Tagami, M., Murata, M., Kojima-ishiyama, M., Noma, S., Noguchi, S., Kasukawa, T., Hasegawa, A., Suzuki, H., Nishiyori-sueki, H., Frith, M., Abugessaisa, I., Aitken, S., & 471 othersAken, B. L., Alam, I., Alam, T., Alasiri, R., Alhendi, A. M. N., Alinejad-rokny, H., Alvarez, M. J., Andersson, R., Arakawa, T., Araki, M., Arbel, T., Archer, J., Archibald, A. L., Arner, E., Arner, P., Asai, K., Ashoor, H., Astrom, G., Babina, M., Baillie, J. K., Bajic, V. B., Bajpai, A., Baker, S., Baldarelli, R. M., Balic, A., Bansal, M., Batagov, A. O., Batzoglou, S., Beckhouse, A. G., Beltrami, A. P., Beltrami, C. A., Bertin, N., Bhattacharya, S., Bickel, P. J., Blake, J. A., Blanchette, M., Bodega, B., Bonetti, A., Bono, H., Bornholdt, J., Bttcher, M., Bougouffa, S., Boyd, M., Breda, J., Brombacher, F., Brown, J. B., Bult, C. J., Burroughs, A. M., Burt, D. W., Busch, A., Caglio, G., Califano, A., Cameron, C. J., Cannistraci, C. V., Carbone, A., Carlisle, A. J., Carninci, P., Carter, K. W., Cesselli, D., Chang, J., Chen, J. C., Chen, Y., Chierici, M., Christodoulou, J., Ciani, Y., Clark, E. L., Coskun, M., Dalby, M., Dalla, E., Daub, C. O., Davis, C. A., De Hoon, M. J. L., De Rie, D., Denisenko, E., Deplancke, B., Detmar, M., Deviatiiarov, R., Di Bernardo, D., Diehl, A. D., Dieterich, L. C., Dimont, E., Djebali, S., Dohi, T., Dostie, J., Drablos, F., Edge, A. S. B., Edinger, M., Ehrlund, A., Ekwall, K., Elofsson, A., Endoh, M., Enomoto, H., Enomoto, S., Faghihi, M., Fagiolini, M., Farach-carson, M. C., Faulkner, G. J., Favorov, A., Fernandes, A. M., Ferrai, C., Forrest, A. R. R., Forrester, L. M., Forsberg, M., Fort, A., Francescatto, M., Freeman, T. C., Frith, M., Fukuda, S., Funayama, M., Furlanello, C., Furuno, M., Furusawa, C., Gao, H., Gazova, I., Gebhard, C., Geier, F., Geijtenbeek, T. B. H., Ghosh, S., Ghosheh, Y., Gingeras, T. R., Gojobori, T., Goldberg, T., Goldowitz, D., Gough, J., Greco, D., Gruber, A. J., Guhl, S., Guigo, R., Guler, R., Gusev, O., Gustincich, S., Ha, T. J., Haberle, V., Hale, P., Hallstrom, B. M., Hamada, M., Handoko, L., Hara, M., Harbers, M., Harrow, J., Harshbarger, J., Hase, T., Hasegawa, A., Hashimoto, K., Hatano, T., Hattori, N., Hayashi, R., Hayashizaki, Y., Herlyn, M., Hettne, K., Heutink, P., Hide, W., Hitchens, K. J., Sui, S. H., ’t Hoen, P. A. C., Hon, C. C., Hori, F., Horie, M., Horimoto, K., Horton, P., Hou, R., Huang, E., Huang, Y., Hugues, R., Hume, D., Ienasescu, H., Iida, K., Ikawa, T., Ikemura, T., Ikeo, K., Inoue, N., Ishizu, Y., Ito, Y., Itoh, M., Ivshina, A. V., Jankovic, B. R., Jenjaroenpun, P., Johnson, R., Jorgensen, M., Jorjani, H., Joshi, A., Jurman, G., Kaczkowski, B., Kai, C., Kaida, K., Kajiyama, K., Kaliyaperumal, R., Kaminuma, E., Kanaya, T., Kaneda, H., Kapranov, P., Kasianov, A. S., Kasukawa, T., Katayama, T., Kato, S., Kawaguchi, S., Kawai, J., Kawaji, H., Kawamoto, H., Kawamura, Y. I., Kawasaki, S., Kawashima, T., Kempfle, J. S., Kenna, T. J., Kere, J., Khachigian, L., Kiryu, H., Kishima, M., Kitajima, H., Kitamura, T., Kitano, H., Klaric, E., Klepper, K., Klinken, S. P., Kloppmann, E., Knox, A. J., Kodama, Y., Kogo, Y., Kojima, M., Kojima, S., Komatsu, N., Komiyama, H., Kono, T., Koseki, H., Koyasu, S., Kratz, A., Kukalev, A., Kulakovskiy, I., Kundaje, A., Kunikata, H., Kuo, R., Kuo, T., Kuraku, S., Kuznetsov, V. A., Kwon, T. J., Larouche, M., Lassmann, T., Law, A., Le-cao, K., Lecellier, C., Lee, W., Lenhard, B., Lennartsson, A., Li, K., Li, R., Lilje, B., Lipovich, L., Lizio, M., Lopez, G., Magi, S., Mak, G. K., Makeev, V., Manabe, R., Mandai, M., Mar, J., Maruyama, K., Maruyama, T., Mason, E., Mathelier, A., Matsuda, H., Medvedeva, Y. A., Meehan, T. F., Mejhert, N., Meynert, A., Mikami, N., Minoda, A., Miura, H., Miyagi, Y., Miyawaki, A., Mizuno, Y., Morikawa, H., Morimoto, M., Morioka, M., Morishita, S., Moro, K., Motakis, E., Motohashi, H., Mukarram, A. K., Mummery, C. L., Mungall, C. J., Murakawa, Y., Muramatsu, M., Murata, M., Nagasaka, K., Nagase, T., Nakachi, Y., Nakahara, F., Nakai, K., Nakamura, K., Nakamura, Y., Nakamura, Y., Nakazawa, T., Nason, G. P., Nepal, C., Nguyen, Q. H., Nielsen, L. K., Nishida, K., Nishiguchi, K. M., Nishiyori, H., Nitta, K., Noguchi, S., Noma, S., Notredame, C., Ogishima, S., Ohkura, N., Ohno, H., Ohshima, M., Ohtsu, T., Okada, Y., Okada-hatakeyama, M., Okazaki, Y., Oksvold, P., Orlando, V., Ow, G. S., Ozturk, M., Pachkov, M., Paparountas, T., Parihar, S. P., Park, S., Pascarella, G., Passier, R., Persson, H., Philippens, I. H., Piazza, S., Plessy, C., Pombo, A., Ponten, F., Poulain, S., Poulsen, T. M., Pradhan, S., Prezioso, C., Pridans, C., Qin, X., Quackenbush, J., Rackham, O., Ramilowski, J., Ravasi, T., Rehli, M., Rennie, S., Rito, T., Rizzu, P., Robert, C., Roos, M., Rost, B., Roudnicky, F., Roy, R., Rye, M. B., Sachenkova, O., Saetrom, P., Sai, H., Saiki, S., Saito, M., Saito, A., Sakaguchi, S., Sakai, M., Sakaue, S., Sakaue-sawano, A., Sandelin, A., Sano, H., Sasamoto, Y., Sato, H., Saxena, A., Saya, H., Schafferhans, A., Schmeier, S., Schmidl, C., Schmocker, D., Schneider, C., Schueler, M., Schultes, E. A., Schulze-tanzil, G., Semple, C. A., Seno, S., Seo, W., Sese, J., Severin, J., Sheng, G., Shi, J., Shimoni, Y., Shin, J. W., Simonsanchez, J., Sivertsson, A., Sjostedt, E., Soderhall, C., Laurent, G. S., Stoiber, M. H., Sugiyama, D., Summers, K. M., Suzuki, A. M., Suzuki, H., Suzuki, K., Suzuki, M., Suzuki, N., Suzuki, T., Swanson, D. J., Swoboda, R. K., Tagami, M., Taguchi, A., Takahashi, H., Takahashi, M., Takamochi, K., Takeda, S., Takenaka, Y., Tam, K. T., Tanaka, H., Tanaka, R., Tanaka, Y., Tang, D., Taniuchi, I., Tanzer, A., Tarui, H., Taylor, M. S., Terada, A., Terao, Y., Testa, A. C., Thomas, M., Thongjuea, S., Tomii, K., Triglia, E. T., Toyoda, H., Tsang, H. G., Tsujikawa, M., Uhlén, M., Valen, E., Van De Wetering, M., Van Nimwegen, E., Velmeshev, D., Verardo, R., Vitezic, M., Vitting-seerup, K., Von Feilitzen, K., Voolstra, C. R., Vorontsov, I. E., Wahlestedt, C., Wasserman, W. W., Watanabe, K., Watanabe, S., Wells, C. A., Winteringham, L. N., Wolvetang, E., Yabukami, H., Yagi, K., Yamada, T., Yamaguchi, Y., Yamamoto, M., Yamamoto, Y., Yamamoto, Y., Yamanaka, Y., Yano, K., Yasuzawa, K., Yatsuka, Y., Yo, M., Yokokura, S., Yoneda, M., Yoshida, E., Yoshida, Y., Yoshihara, M., Young, R., Young, R. S., Yu, N. Y., Yumoto, N., Zabierowski, S. E., Zhang, P. G., Zucchelli, S., Zwahlen, M., Chatelain, C., Carninci, P., De Hoon, M. J. L., Wasserman, W. W., Bréhélin, L. & Lecellier, C., 2 Jun 2021, In: Nature Communications. 12, 1

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  • 2020

    Comparative transcriptomics of primary cells in vertebrates

    Alam, T., Agrawal, S., Severin, J., Young, R., Andersson, R., Amer, E., Hasegawa, A., Lizio, M., Ramilowski, J., Abugessaisa, I., Ishizu, Y., Noma, S., Tarui, H., Taylor, M. S., Lassmann, T., Itoh, M., Kasukawa, T., Kawaji, H., Marchionni, L., Sheng, G., & 5 othersForrest, A. R. R., Khachigian, L. M., Hayashizaki, Y., Carninci, P. & De Hoon, M., 30 Jul 2020, In: Genome Research.

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  • Functional annotation of human long noncoding RNAs via molecular phenotyping

    Ramilowski, J. A., Yip, C. W., Agrawal, S., Chang, J-C., Ciani, Y., Kulakovskiy, I. V., Mendez, M., Ooi, J. L. C., Ouyang, J. F., Parkinson, N., Petri, A., Roos, L., Severin, J., Yasuzawa, K., Abugessaisa, I., Akalin, A., Antonov, I. V., Arner, E., Bonetti, A., Bono, H., & 96 othersBorsari, B., Brombacher, F., Cameron, C. J. F., Cannistraci, C. V., Cardenas, R., Cardon, M., Chang, H., Dostie, J., Ducoli, L., Favorov, A., Fort, A., Garrido, D., Gil, N., Gimenez, J., Guler, R., Handoko, L., Harshbarger, J., Hasegawa, A., Hasegawa, Y., Hashimoto, K., Hayatsu, N., Heutink, P., Hirose, T., Imada, E. L., Itoh, M., Kaczkowski, B., Kanhere, A., Kawabata, E., Kawaji, H., Kawashima, T., Kelly, S. T., Kojima, M., Kondo, N., Koseki, H., Kouno, T., Kratz, A., Kurowska-Stolarska, M., Kwon, A. T. J., Leek, J., Lennartsson, A., Lizio, M., López-Redondo, F., Luginbühl, J., Maeda, S., Makeev, V. J., Marchionni, L., Medvedeva, Y. A., Minoda, A., Müller, F., Muñoz-Aguirre, M., Murata, M., Nishiyori, H., Nitta, K. R., Noguchi, S., Noro, Y., Nurtdinov, R., Okazaki, Y., Orlando, V., Paquette, D., Parr, C. J. C., Rackham, O. J. L., Rizzu, P., Sánchez Martinez, D. F., Sandelin, A., Sanjana, P., Semple, C. A. M., Shibayama, Y., Sivaraman, D. M., Suzuki, T., Szumowski, S. C., Tagami, M., Taylor, M. S., Terao, C., Thodberg, M., Thongjuea, S., Tripathi, V., Ulitsky, I., Verardo, R., Vorontsov, I. E., Yamamoto, C., Young, R. S., Baillie, J. K., Forrest, A. R. R., Guigó, R., Hoffman, M. M., Hon, C. C., Kasukawa, T., Kauppinen, S., Kere, J., Lenhard, B., Schneider, C., Suzuki, H., Yagi, K., de Hoon, M. J. L., Shin, J. W. & Carninci, P., 27 Jul 2020, (E-pub ahead of print) In: Genome Research. 30, p. 1060-1072

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  • Identification of a localized Nonsense-Mediated Decay pathway at the Endoplasmic Reticulum

    Longman, D., Jackson-Jones, K., Maslon, M., Murphy, L., Young, R., Stoddart, J., Hug, N., Taylor, M., Papadopoulos, D. K. & Caceres, J. F., 2 Jul 2020, (E-pub ahead of print) In: Genes & Development. 34, 15-16, p. 1075-1088

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  • Codon Usage and Splicing Jointly Influence mRNA Localization

    Mordstein, C., Savisaar, R., Young, R. S., Bazile, J., Talmane, L., Luft, J., Liss, M., Taylor, M. S., Hurst, L. D. & Kudla, G., 22 Apr 2020, In: Cell Systems. 10, 4, p. 351-362.e8 12 p.

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  • 2017

    Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers

    Young, R. S., Kumar, Y., Bickmore, W. A. & Taylor, M. S., 28 Dec 2017, In: Genome Biology. 18, 11 p., 242.

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  • Aberrant ribonucleotide incorporation and multiple deletions in mitochondrial DNA of the murine MPV17 disease model

    Moss, C. F., Dalla Rosa, I., Hunt, L. E., Yasukawa, T., Young, R., Jones, A. W. E., Reddy, K., Desai, R., Virtue, S., Elgar, G., Voshol, P., Taylor, M. S., Holt, I. J., Reijns, M. A. M. & Spinazzola, A., 2 Nov 2017, In: Nucleic Acids Research.

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  • Genetic variation and RNA structure regulate microRNA biogenesis

    Fernandez, N., Cordiner, R. A., Young, R. S., Hug, N., Macias, S. & Cáceres, J. F., 3 May 2017, In: Nature Communications. 8, 12 p., 15114.

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  • 2016
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  • Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages

    Jubb, A. W., Young, R. S., Hume, D. A. & Bickmore, W. A., 15 Jan 2016, In: The Journal of Immunology. 196, 2, p. 813-822

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  • 2015

    The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

    Hurst, L. D., Ghanbarian, A. T., Forrest, A. R. R., FANTOM consortium & Huminiecki, L., 18 Dec 2015, In: PLoS Biology. 13, 12, e1002315.

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  • The frequent evolutionary birth and death of functional promoters in mouse and human

    Young, R. S., Hayashizaki, Y., Andersson, R., Sandelin, A., Kawaji, H., Itoh, M., Lassmann, T., Carninci, P., the FANTOM Consortium, Bickmore, W. A., Forrest, A. R. & Taylor, M. S., Oct 2015, In: Genome Research. 25, 10, p. 1546-1557 12 p.

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  • Divergent transcriptional activation by glucocorticoids in mouse and human macrophages

    Jubb, A., Young, R., Bickmore, W. & Hume, D., 26 Feb 2015, In: The Lancet. 385 , Suppl 1, p. S54

    Research output: Contribution to journalArticlepeer-review

  • 2014

    The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

    Mannion, N. M., Greenwood, S. M., Young, R., Cox, S., Brindle, J., Read, D., Nellåker, C., Vesely, C., Ponting, C. P., McLaughlin, P. J., Jantsch, M. F., Dorin, J., Adams, I. R., Scadden, A. D. J., Öhman, M., Keegan, L. P. & O'Connell, M. A., 20 Nov 2014, In: Cell Reports. 9, 4, p. 1482-1494 13 p.

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  • A promoter-level mammalian expression atlas

    FANTOM Consortium & RIKEN PMI CLST DGT, 27 Mar 2014, In: Nature. 507, 7493, p. 462-470 9 p.

    Research output: Contribution to journalArticlepeer-review

  • An atlas of active enhancers across human cell types and tissues

    Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., Suzuki, T., Ntini, E., Arner, E., Valen, E., Li, K., Schwarzfischer, L., Glatz, D., Raithel, J., Lilje, B., Rapin, N., Bagger, F. O., & 31 othersJørgensen, M., Andersen, P. R., Bertin, N., Rackham, O., Burroughs, A. M., Baillie, J. K., Ishizu, Y., Shimizu, Y., Furuhata, E., Maeda, S., Negishi, Y., Mungall, C. J., Meehan, T. F., Lassmann, T., Itoh, M., Kawaji, H., Kondo, N., Kawai, J., Lennartsson, A., Daub, C. O., Heutink, P., Hume, D. A., Jensen, T. H., Suzuki, H., Hayashizaki, Y., FANTOM Consortium, Young, R. S., Fisher, M. E., Meynert, A., Prendergast, J. G. D. & Taylor, M. S., 26 Mar 2014, In: Nature. 507, 7493, p. 455-61 7 p.

    Research output: Contribution to journalArticlepeer-review

  • 2013

    Identification and function of long non-coding RNAs

    Young, R. S. & Ponting, C., 2013, In: Essays in biochemistry. 54, p. 113-26 14 p.

    Research output: Contribution to journalArticlepeer-review

  • 2012

    Identification and properties of 1,119 candidate lincRNA loci in the Drosophila melanogaster genome

    Young, R. S., Marques, A. C., Tibbit, C., Haerty, W., Bassett, A. R., Liu, J-L. & Ponting, C. P., 2012, In: Genome Biology and Evolution. 4, 4, p. 427-42 16 p.

    Research output: Contribution to journalArticlepeer-review

  • 2011

    Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report

    Silverman, E. K., Vestbo, J., Agusti, A., Anderson, W., Bakke, P. S., Barnes, K. C., Barr, R. G., Bleecker, E. R., Boezen, H. M., Burkart, K. M., Celli, B. R., Cho, M. H., Cookson, W. O. C., Croxton, T., Daley, D., DeMeo, D. L., Gan, W., Garcia-Aymerich, J., Hall, I. P., Hansel, N. N., & 23 othersHersh, C. P., Kalsheker, N., Kiley, J. P., Kim, W. J., Lambrechts, D., Lee, S-D., Litonjua, A. A., Lomas, D. A., London, S. J., Nishimura, M., Nørdestgaard, B. G., O'Donnell, C. J., Postma, D. S., Puhan, M. A., Tesfaigzi, Y., Tobin, M. D., Vogelmeier, C., Wilk, J. B., Wouters, E., Young, R. P., Ziegler-Heitbrock, L., MacNee, W. & Crapo, J. D., 2011, In: COPD: Journal of Chronic Obstructive Pulmonary Disease. 8, 2, p. 121-35 15 p.

    Research output: Contribution to journalArticlepeer-review

  • 2009

    Ultrastructural changes in the retinopathy, globe enlarged (rge) chick cornea

    Boote, C., Hayes, S., Young, R. D., Kamma-Lorger, C. S., Hocking, P. M., Elsheikh, A., Inglehearn, C. F., Ali, M. & Meek, K. M., May 2009, In: Journal of Structural Biology. 166, 2, p. 195-204 10 p.

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  • 2008

    Genetic variation affecting host-parasite interactions: major-effect quantitative trait loci affect the transmission of sigma virus in Drosophila melanogaster

    Bangham, J., Knott, S. A., Kim, K-W., Young, R. S. & Jiggins, F. M., Sept 2008, In: Molecular Ecology. 17, 17, p. 3800-3807 8 p.

    Research output: Contribution to journalArticlepeer-review

  • 2007

    Interfacial stress transfer in an aramid reinforced thermoplastic elastomer

    Coffey, A. B., O Bradaigh, C. & Young, R. J., Oct 2007, In: Journal of Materials Science. 42, 19, p. 8053-8061 9 p.

    Research output: Contribution to journalArticlepeer-review

  • 1988

    Comparison of Fructosamine with Glycosylated Hemoglobin and Plasma-Proteins as Measures of Glycemic Control

    Smart, L. M., Howie, A. F., Young, R. J., Walker, S. W., Clarke, B. F. & Smith, A. F., 1988, In: Diabetes Care. 11, 5, p. 433-436 4 p.

    Research output: Contribution to journalArticlepeer-review