Research output per year
Research output per year
- 33 results
Search results
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2024
Preneoplastic cells switch to Warburg metabolism from their inception exposing multiple vulnerabilities for targeted elimination
Myllymaki, H., Kelly, L., Elliot, A., Nicholas Carter, R., Morton, N. M. & Feng, Y., 25 Jan 2024, In: Oncogenesis.Research output: Contribution to journal › Article › peer-review
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2023
The serotonin transporter sustains human brown adipose tissue thermogenesis
Suchacki, K. J., Ramage, L. E., Choong Kwok, T., Kelman, A., McNeill, B. T., Rodney, S., Keegan, M., Gray, C., MacNaught, G., Patel, D., Fletcher, A. M., Simpson, J. P., N Carter, R., Semple, R. K., Homer, N. Z. M., Morton, N. M., van Beek, E. J. R., Wakelin, S. J. & Stimson, R. H., 3 Aug 2023, In: Nature Metabolism. 5, p. 1319-1336Research output: Contribution to journal › Article › peer-review
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2022
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes
Hughes, R. E., Elliott, R. J. R., Li, X., Munro, A. F., Makda, A., Carter, R. N., Morton, N. M., Fujihara, K., Clemons, N. J., Fitzgerald, R., O’neill, J. R., Hupp, T. & Carragher, N. O., 13 Jun 2022, (E-pub ahead of print) In: Acs chemical biology.Research output: Contribution to journal › Article › peer-review
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Genomic loci mispositioning in Tmem120a knockout mice yields latent lipodystrophy
Czapiewski, R., Batrakou, D. G., de las Heras, J., Nicholas Carter, R., Sivakumar, A., Sliwinska, M., Dixon, C., Webb, S., Lattanzi, G., Morton, N. M. & Schirmer, E. C., 13 Jan 2022, In: Nature Communications. 13, 1, 18 p., 321.Research output: Contribution to journal › Article › peer-review
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2021
The Hepatic Compensatory Response to Elevated Systemic Sulfide Promotes Diabetes
Nicholas Carter, R., Gibbins, M. T. G., Barrios-Llerena, M. E., Wilkie, S. E., Freddolino, P. L., Libiad, M., Vitvitsky, V., Emerson, B., Le Bihan, T., Brice, M., Su, H., Denham, S. G., Homer, N. Z. M., McFadden, C., Tailleux, A., Faresse, N., Sulpice, T., Briand, F., Gillingwater, T. H., Han Ahn, K., & 9 others, 9 Nov 2021, In: Cell Reports.Research output: Contribution to journal › Article › peer-review
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Glucocorticoids regulate mitochondrial fatty acid oxidation in fetal cardiomyocytes
Ivy, J. R., Carter, R. N., Zhao, J-F., Buckley, C., Urquijo, H., Rog-Zielinska, E. A., Panting, E., Hrabalkova, L., Nicholson, C., Agnew, E. J., Kemp, M. W., Morton, N. M., Stock, S. J., Wyrwoll, C., Ganley, I. G. & Chapman, K. E., 10 Sept 2021, In: The Journal of Physiology.Research output: Contribution to journal › Article › peer-review
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JMJD6 promotes self-renewal and regenerative capacity of hematopoietic stem cells
Lawson, H., Sepulveda, C., van de Lagemaat, L. N., Durko, J., Barile, M., Tavosanis, A., Georges, E., Shmakova, A., Timms, P., Carter, R. N., Allen, L., Campos, J., Vukovic, M., Guitart, A. V., Giles, P., O'Shea, M., Vernimmen, D., Morton, N. M., Rodrigues, N. P., Göttgens, B., & 4 others, 9 Feb 2021, In: Blood Advances. 5, 3, p. 889-899 11 p.Research output: Contribution to journal › Article › peer-review
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A human pluripotent stem cell model for the analysis of metabolic dysfunction in hepatic steatosis
Sinton, M. C., Meseguer-Ripolles, J., Lucendo-Villarin, B., Wernig-Zorc, S., Thomson, J. P., Carter, R. N., Lyall, M. J., Walker, P. D., Thakker, A., Meehan, R. R., Lavery, G. G., Morton, N. M., Ludwig, C., Tennant, D. A., Hay, D. C. & Drake, A. J., 22 Jan 2021, In: iScience. 24, 1, 101931.Research output: Contribution to journal › Article › peer-review
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Fibroblast Growth Factor 7 Releasing Particles Enhance Islet Engraftment and Improve Metabolic Control Following Islet Transplantation in Mice with Diabetes
Alwahsh, S., Qutachi, O., Starkey Lewis, P., Bond, A., Noble, J., Burgoyne, P., Morton, N. M., Nicholas Carter, R., Mann, J., Ferreira-Gonzalez, S., Alvarez-Paino, M., Forbes, S. J., Shakesheff, K. M. & Forbes, S., 11 Jan 2021, (E-pub ahead of print) In: American Journal of Transplantation.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis
Mehta, A. R., Gregory, J. M., Dando, O., Carter, R. N., Burr, K., Nanda, J., Story, D., Mcdade, K., Smith, C., Morton, N. M., Mahad, D. J., Hardingham, G. E., Chandran, S. & Selvaraj, B. T., 4 Jan 2021, In: Acta Neuropathologica.Research output: Contribution to journal › Article › peer-review
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2020
Enhanced axonal response of mitochondria to demyelination offers neuroprotection: Implications for multiple sclerosis
Licht-Mayer, S., Campbell, G. R., Canizares, M., Mehta, A. R., Gane, A. B., McGill, K., Ghosh, A., Fullerton, A., Menezes, N., Dean, J., Dunham, J., Al-Azki, S., Pryce, G., Zandee, S., Zhao, C., Kipp, M., Smith, K. J., Baker, D., Altmann, D., Anderton, S. M., & 17 others, 31 Aug 2020, In: Acta Neuropathologica. 140, 2, p. 143–167 24 p.Research output: Contribution to journal › Article › peer-review
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Tst gene mediates protection against palmitate-induced inflammation in 3T3-L1 adipocytes
Lainšček, D., Šuštar, U., Nicholas Carter, R., Morton, N. & Horvat, S., 20 May 2020, (E-pub ahead of print) In: Biochemical and Biophysical Research Communications.Research output: Contribution to journal › Article › peer-review
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Strain-specificity in the hydrogen sulphide signalling network following dietary restriction in recombinant inbred mice
Wilkie, S. E., Mulvey, L., Sands, W. A., Marcu, D. E., Carter, R. N., Morton, N. M., Hine, C., Mitchell, J. R. & Selman, C., 11 Mar 2020, (E-pub ahead of print) In: GeroScience.Research output: Contribution to journal › Article › peer-review
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Human umbilical cord perivascular cells improve human pancreatic islet transplant function by increasing vascularization
Forbes, S., Bond, A. R., Thirlwell, K. L., Burgoyne, P., Samuel, K., Noble, J., Borthwick, G., Colligan, D., McGowan, N. W. A., Lewis, P. S., Fraser, A. R., Mountford, J. C., Carter, R. N., Morton, N. M., Turner, M. L., Graham, G. J. & Campbell, J. D. M., 15 Jan 2020, In: Science Translational Medicine. 12, 526, eaan5907.Research output: Contribution to journal › Article › peer-review
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2019
Repurposing dichloroacetate for the treatment of women with endometriosis
Horne, A. W., Ahmad, S. F., Carter, R., Simitsidellis, I., Greaves, E., Hogg, C., Morton, N. M. & Saunders, P. T. K., 17 Dec 2019, In: Proceedings of the National Academy of Sciences (PNAS). 116, 51, p. 25389-25391 3 p.Research output: Contribution to journal › Article › peer-review
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Osteocalcin Regulates Arterial Calcification via Altered Wnt Signalling and Glucose Metabolism
Rashdan, N. A., Sim, A. M., Cui, L., Phadwal, K., Roberts, F. L., Carter, R., Ozdemir, D. D., Hohenstein, P., Hung, J., Kaczynski, J., Newby, D. E., Baker, A. H., Karsenty, G., Morton, N. M. & MacRae, V. E., 9 Oct 2019, (E-pub ahead of print) In: Journal of Bone and Mineral Research.Research output: Contribution to journal › Article › peer-review
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Camk2n1 is a negative regulator of blood pressure, left ventricular mass, insulin sensitivity and promotes adiposity
Alfazema, N., Barrier, M., Marion de Procé, S., Menzies, R., Nicholas Carter, R., Stewart, K., Diaz, A. G., Moyon, B., Webster, Z., Bellamy, C. O. C., Arends, M. J., Stimson, R. H., Morton, N. M., Aitman, T. J. & Coan, P., Sept 2019, In: Hypertension. 74, 3, p. 687-696 10 p.Research output: Contribution to journal › Article › peer-review
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The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity
Sirey, T. M., Roberts, K., Haerty, W., Bedoya-Reina, O., Rogatti-Granados, S., Tan, J. Y., Li, N., Heather, L. C., Carter, R. N., Cooper, S., Finch, A. J., Wills, J., Morton, N. M., Marques, A. C. & Ponting, C. P., 12 Aug 2019, In: eLIFE. 8, 31 p., e45051.Research output: Contribution to journal › Article › peer-review
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2018
Mouse Idh3a Mutations Cause Retinal Degeneration and Reduced Mitochondrial Function
Findlay, A., Carter, R. N., Starbuck, B., McKie, L., Novakova, K., Budd, P. S., Keighren, M., Marsh, J. A., Cross, S., Simon, M., Potter, P., Morton, N. M. & Jackson, I. J., Dec 2018, In: Disease Models and Mechanisms.Research output: Contribution to journal › Article › peer-review
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2017
COMPLEMENT FACTOR B IS A DETERMINANT OF BOTH METABOLIC AND CARDIOVASCULAR FEATURES OF METABOLIC SYNDROME
Coan, P., Barrier, M., Alfazema, N., Carter, R. N., Marion de Proce, S., Castro Dopico, X., Diaz, A. G., Thomson, A. J. W., Jackson-Jones, L., Moyon, B., Webster, Z., Ross, D., Moss, J., Arends, M. J., Morton, N. M. & Aitman, T. J., Sept 2017, In: Hypertension.Research output: Contribution to journal › Article › peer-review
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Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy
Boyd, P. J., Tu, W-Y., Shorrock, H. K., Groen, E. J. N., Carter, R. N., Powis, R. A., Thomson, S. R., Thomson, D., Graham, L. C., Motyl, A. A. L., Wishart, T. M., Highley, J. R., Morton, N. M., Becker, T., Becker, C. G., Heath, P. R. & Gillingwater, T. H., 20 Apr 2017, (E-pub ahead of print) In: PLoS Genetics. 13, 4, e1006744.Research output: Contribution to journal › Article › peer-review
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Fumarate hydratase is a critical metabolic regulator of haematopoietic stem cell functions
Guitart, A., Panagopoulou, T., Villacreces, A., Vukovic, M., Sepulveda, C., Allen, L., Carter, R. N., van de Lagemaat, L., Morgan, M., Giles, P., Sas, Z., Vila Gonzalez, M., Lawson, H., Paris, J., Edward-Hicks, J., Schaak, K., Subramani, C., Gezer, D., Armesilla-Diaz, A., Bukowski-Wills, J., & 10 others, 15 Feb 2017, In: Journal of Experimental Medicine. 214, 3, p. 719-735Research output: Contribution to journal › Article › peer-review
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Sideroflexin 3 is a α-synuclein-1 dependent mitochondrial protein 2 that regulates synaptic morphology
Amorim, I., Graham, L., Carter, R. N., Morton, N. M., Hammachi, F., Kunath, T., Pennetta, G., Carpanini, S., Manson, J., Lamont, D. J., Wishart, T. & Gillingwater, T., 15 Jan 2017, In: Journal of Cell Science. 130, 2, p. 325-331Research output: Contribution to journal › Article › peer-review
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2016
Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation
Ramage, L. E., Akyol, M., Fletcher, A. M., Forsythe, J., Nixon, M., Carter, R. N., van Beek, E. J. R., Morton, N. M., Walker, B. R. & Stimson, R. H., 12 Jul 2016, In: Cell Metabolism. 24, 1, p. 130-141 12 p.Research output: Contribution to journal › Article › peer-review
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Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
Morton, N. M., Beltram, J., Carter, R. N., Michailidou, Z., Gorjanc, G., McFadden, C., Barrios-Llerena, M. E., Rodriguez-Cuenca, S., Gibbins, M. T. G., Aird, R. E., Moreno-Navarrete, J. M., Munger, S. C., Svenson, K. L., Gastaldello, A., Ramage, L., Naredo, G., Zeyda, M., Wang, Z. V., Howie, A. F., Saari, A., & 13 others, Jul 2016, In: Nature Medicine. 22, 7, p. 771-779 9 p.Research output: Contribution to journal › Article › peer-review
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2014
β-Cell-Specific Glucocorticoid Reactivation Attenuates Inflammatory β-Cell Destruction
Liu, X., Turban, S., Carter, R. N., Ahmad, S., Ramage, L., Webster, S. P., Walker, B. R., Seckl, J. R. & Morton, N. M., 14 Oct 2014, In: Frontiers in Endocrinology. 5, p. 165Research output: Contribution to journal › Article › peer-review
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Increased anxiety in corticotropin-releasing factor type 2 receptor-null mice requires recent acute stress exposure and is associated with dysregulated serotonergic activity in limbic brain areas
Issler, O., Carter, R. N., Paul, E. D., Kelly, P. A., Olverman, H. J., Neufeld-Cohen, A., Kuperman, Y., Lowry, C. A., Seckl, J. R., Chen, A. & Jamieson, P. M., 21 Jan 2014, In: Biology of Mood and Anxiety Disorders. 4, 1, p. 1-10Research output: Contribution to journal › Article › peer-review
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2012
Chronic Activation of Corticotropin-Releasing Factor Type 2 Receptors Reveals a Key Role for 5-HT1A Receptor Responsiveness in Mediating Behavioral and Serotonergic Responses to Stressful Challenge
Neufeld-Cohen, A., Kelly, P. A. T., Paul, E. D., Carter, R. N., Skinner, E., Olverman, H. J., Vaughan, J. M., Issler, O., Kuperman, Y., Lowry, C. A., Vale, W. W., Seckl, J. R., Chen, A. & Jamieson, P. M., Sept 2012, In: Biological Psychiatry. 72, 6, p. 437-447 11 p.Research output: Contribution to journal › Article › peer-review
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2010
11β-Hydroxysteroid Dehydrogenase Type 1 Expression Is Increased in the Aged Mouse Hippocampus and Parietal Cortex and Causes Memory Impairments
Holmes, M. C., Carter, R. N., Noble, J., Chitnis, S., Dutia, A., Paterson, J. M., Mullins, J. J., Seckl, J. R. & Yau, J. L. W., 19 May 2010, In: The Journal of Neuroscience. 30, 20, p. 6916-6920 5 p.Research output: Contribution to journal › Article › peer-review
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2009
Prenatal Programming of Metabolic Syndrome in the Common Marmoset Is Associated With Increased Expression of 11 beta-Hydroxysteroid Dehydrogenase Type 1
Nyirenda, M. J., Carter, R., Tang, J. I., de Vries, A., Schlumbohm, C., Hillier, S. G., Streit, F., Oellerich, M., Armstrong, V. W., Fuchs, E. & Seckl, J. R., Dec 2009, In: Diabetes. 58, 12, p. 2873-2879 7 p.Research output: Contribution to journal › Article › peer-review
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Overexpression of 5-HT2C receptors in forebrain leads to elevated anxiety and hypoactivity
Kimura, A., Stevenson, P. L., Carter, R. N., MacColl, G., French, K. L., Simons, J. P., Al-Shawi, R., Kelly, V., Chapman, K. E. & Holmes, M. C., Jul 2009, In: European Journal of Neuroscience. 30, 2, p. 299-306 8 p.Research output: Contribution to journal › Article › peer-review
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2007
Forebrain mineralocorticoid receptor overexpression enhances memory, reduces anxiety and attenuates neuronal loss in cerebral ischaemia
Lai, M., Horsburgh, K., Bae, S-E., Carter, R. N., Stenvers, D. J., Fowler, J. H., Yau, J. L., Gomez-Sanchez, C. E., Holmes, M. C., Kenyon, C. J., Seckl, J. R. & Macleod, M. R., Mar 2007, In: European Journal of Neuroscience. 25, 6, p. 1832-1842 11 p.Research output: Contribution to journal › Article › peer-review
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Liver-selective transgene rescue of hypothalamic-pituitary-adrenal axis dysfunction in 11 beta-hydroxysteroid dehydrogenase type 1-deficient mice
Paterson, J. M., Holmes, M. C., Kenyon, C. J., Carter, R., Mullins, J. J. & Seckl, J. R., Mar 2007, In: Endocrinology . 148, 3, p. 961-966 6 p.Research output: Contribution to journal › Article › peer-review