I have longstanding interests in endocrine disorders and the origin of hypertension, especially renal and endocrine mechanisms. I have been involved in characterising pathways involved in these mechanisms (e.g. identifying and cloning 11B-Hydroxysteroid dehydrogenase 2 involved in corticosteroid related effects on blood pressure and WNK Kinase pathways involved in renal blood pressure and electrolyte handling). I am a Consultant Endocrinologist and Hypertension Specialist, with clinics looking after patients with a wide range of hormonal and hypertensive problems, which has led to interests in imaging characteristics and markers of medication use which may link to outcomes. I have become involved in work with families with rare endocrine disorders, national studies of rare endocrine tumours affecting blood pressure and studies of anti-hypertensive use.