Research output per year
Research output per year
Personal profile
Biography
Roly Megaw is an academic ophthalmologist with a clinical and research interest in the inherited retinal dystrophies (IRDs), a group of untreatable, monogenic conditions that are the leading cause of visual loss in children and working adults.
He runs the IRD service in NHS Lothian and is a PI for interventional clinical trials (gene therapy, exon skipping therapy) and natural history studies, amongst others.
His research lab uses animal and stem cell models to better understand the pathogenesis of IRDs and define the pathways disrupted in disease that eventually lead to retinal degeneration, with the ultimate aim of identifying novel therapies.
External positions
Trustee, Ciliopathy Alliance charity, Ciliopathy Alliance
2022 → …
Member RCOphth curriculum committee, British Ophthalmic Surveillance Unit, The Royal College of Ophthalmologists, London, UK.
2020 → …
Member of Northern Alliance Advanced Therapeutics Treatment Centre (NA-ATTC) clinical advisory group, Newcastle University
2020 → …
Board of examiners: MSc in Primary Care Ophthalmology & ChM in Clinical Ophthalmology, University of Edinburgh
2019 → …
Member RCOphth academic committee, British Ophthalmic Surveillance Unit, The Royal College of Ophthalmologists, London, UK.
2017 → …
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Collaborations and top research areas from the last five years
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Anterior segment phenotypic changes in late-onset retinal degeneration with Ser163Arg mutation in CTRP5/C1QTNF5
Lando, L., Nguyen, A. X-L., Li, R. T. H., Megaw, R., Dhillon, B. & Borooah, S., 12 Apr 2023, (E-pub ahead of print) In: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.Research output: Contribution to journal › Article › peer-review
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Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis
Hall, E. A., Kumar, D., Prosser, S. L., Yeyati, P. L., Herranz-Pérez, V., García-Verdugo, J. M., Rose, L., Mckie, L., Dodd, D. O., Tennant, P. A., Megaw, R., Murphy, L. C., Ferreira, M. F., Grimes, G., Williams, L., Quidwai, T., Pelletier, L., Reiter, J. F. & Mill, P., 15 Feb 2023, In: eLIFE. 12, e79299.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Impact of the COVID-19 pandemic on the research activities of UK ophthalmologists
Royal College of Ophthalmologists’ Academic and Research Subcommittee, Hogg, H. D. J., Low, L., Self, J. E. & Rahi, J. S., 31 Oct 2022, (E-pub ahead of print) In: Eye (Basingstoke).Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Emerging Gene Manipulation Strategies for the Treatment of Monogenic Eye Disease
Burgess, F. R., Hall, H. N. & Megaw, R., 30 Jul 2022, In: Asia-Pacific Journal of Ophthalmology. 11, 4, p. 380-391 12 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
BBS1 branchpoint variant is associated with non-syndromic retinitis pigmentosa
Fadaie, Z., Whelan, L., Dockery, A., Li, C. H. Z., Van Den Born, L. I., Hoyng, C. B., Gilissen, C., Corominas, J., Rowlands, C., Megaw, R., Lampe, A. K., Cremers, F. P. M., Farrar, G. J., Ellingford, J. M., Kenna, P. F. & Roosing, S., 1 May 2022, In: Journal of Medical Genetics. 59, 5, p. 438-444 7 p.Research output: Contribution to journal › Article › peer-review
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Visual Function evaluation and inherited retinal dystrophy: detecting decline
Dhillon, B., Li, R. & Megaw, R.
1/03/23 → 29/02/24
Project: Research
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Building a photoreceptor: Defining RPGR¿s role in disc morphogenesis
6/02/20 → 4/02/24
Project: Research
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Identifying therapeutic targets for retinitis pigmentosa by defining photoreceptor cell death
1/10/20 → 30/09/21
Project: Research
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In vivo genome editing of post-mitotic mammalian photoreceptors as therapeutics for inherited retinal dystrophies
6/06/19 → 5/06/21
Project: Research
Press/Media
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Roly Megaw discovers gene linked to sight loss in middle age
5/09/17 → 7/09/17
4 items of Media coverage
Press/Media: Research