Research output per year
Research output per year
Personal profile
Biography
Roly Megaw is an academic ophthalmologist with a clinical and research interest in the inherited retinal dystrophies (IRDs), a group of untreatable, monogenic conditions that are the leading cause of visual loss in children and working adults.
He runs the IRD service in NHS Lothian and is a PI for interventional clinical trials (gene therapy, exon skipping therapy) and natural history studies, amongst others.
His research lab uses animal and stem cell models to better understand the pathogenesis of IRDs and define the pathways disrupted in disease that eventually lead to retinal degeneration, with the ultimate aim of identifying novel therapies.
External positions
Trustee, Ciliopathy Alliance charity, Ciliopathy Alliance
2022 → …
Member RCOphth curriculum committee, British Ophthalmic Surveillance Unit, The Royal College of Ophthalmologists, London, UK.
2020 → …
Member of Northern Alliance Advanced Therapeutics Treatment Centre (NA-ATTC) clinical advisory group, Newcastle University
2020 → …
Board of examiners: MSc in Primary Care Ophthalmology & ChM in Clinical Ophthalmology, University of Edinburgh
2019 → …
Member RCOphth academic committee, British Ophthalmic Surveillance Unit, The Royal College of Ophthalmologists, London, UK.
2017 → …
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Ciliary tip actin dynamics regulate photoreceptor outer segment integrity
Megaw, R., Moye, A., Zhang, Z., Newton, F., McPhie, F., Murphy, L., McKie, L., He, F., Jungnicke, M. K., von Kriegsheim, A., Tennant, P., Brotherton, C., Gurniak, C., Gross, A. K., Machesky, L. M., Wensel, T. G. & Mill, P., 21 May 2024, In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Autophagy disruption and mitochondrial stress precede photoreceptor necroptosis in multiple mouse models of inherited retinal disorders
Newton, F., Halachev, M., Nguyen, L., McKie, L., Mill, P. & Megaw, R., 29 Apr 2025, In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Microvascular disease and severe COVID-19 outcomes in UKBiobank participants with diabetes
Tochel, C., Engelmann, J., Giarratano, Y., Dhillon, B., Megaw, R. & Bernabeu, M. O., 21 Nov 2024, (E-pub ahead of print) In: Acta Diabetologica. 9 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Molecular Mechanisms Governing Sight Loss in Inherited Cone Disorders
Brotherton, C. & Megaw, R., 1 Jun 2024, In: Genes. 15, 6, 727.Research output: Contribution to journal › Literature review › peer-review
Open AccessFile -
Ciliopathy patient variants reveal organelle-specific functions for TUBB4B in axonemal microtubules
Scottish Genomes Partnership, Genomics England Research Consortium & Undiagnosed Diseases Network, 26 Apr 2024, In: Science. 384, 6694Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Towards photoreceptor protection strategies for prevention of visual loss in age-related macular degeneration
Megaw, R. (Principal Investigator)
1/05/25 → 30/04/26
Project: Research
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Towards a non-invasive therapy for inherited retinal dystrophies and macular degeneration
Megaw, R. (Principal Investigator)
Edinburgh and Lothian Health Foundation
1/09/24 → 31/08/25
Project: Research
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Deciphering RPGR’s role in cone-mediated disc formation
Megaw, R. (Principal Investigator)
1/09/23 → 31/08/26
Project: Research
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Visual Function evaluation and inherited retinal dystrophy: detecting decline
Dhillon, B. (Principal Investigator), Li, R. (Co-investigator) & Megaw, R. (Co-investigator)
1/03/23 → 29/02/24
Project: Research
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Determining genetic causes of previously unsolved inherited retinal dystrophies
Megaw, R. (Principal Investigator) & Meynert, A. (Co-investigator)
Royal College of Surgeons of Edinburgh
1/01/23 → 31/12/24
Project: Research
Press/Media
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Roly Megaw discovers gene linked to sight loss in middle age
5/09/17 → 7/09/17
4 items of Media coverage
Press/Media: Research