No photo of Rory Mitchell

View Scopus Profile

Rory Mitchell

DR

 https://orcid.org/0000-0002-0260-1075

Personal profile

Biography

Following a BSc in Medical Biochemistry (University of Birmingham; Faculty of Science Undergraduate Prize), RM gained his PhD in the MRC Neuropharmacology Unit on the mechanism of action of benzodiazepines, involving a first author publication in Nature. After 2 years as a Parkinson’s Disease Society Fellow, RM was appointed to a tenure-track (then tenured group leader) position in the MRC Brain Metabolism Unit, Edinburgh, working on molecular pharmacology and signalling of receptors for neurotransmitters and neuroendocrine hormones. RM and his group were then programme-funded as MRC External Scientific Staff (generating a further breakthrough paper in Nature) before RM was appointed to the University of Edinburgh staff.

Qualifications

BSc (Hons) Medical Biochemistry, University of Birmingham, 1973-76

PhD, Molecular Neuropharmacology, MRC Neuropharmacology Unit, 1976-79

Research Interests

We are interested in the biochemical signaling events that occur in neurons in the central nervous system (CNS) that result from the interaction of neurotransmitters and hormones with receptors on the neuronal cell surface. These processes crucially mediate or adjust neuronal transmission. Great diversity in receptors and their signaling events allows multiple levels of fine control. The molecules involved often represent ideal targets for new drugs to treat CNS disorders. Our focus is on the molecular pharmacology and signaling associated with psychiatric disorders and chronic pain states, in order to find new therapeutic approaches to treat these unmet needs.

Research Groups

Centre for Integrative Physiology (CIP)

My research in a nutshell

We investigate receptor biology and intracellular signalling in the nervous system to find novel treatments that can improve psychiatric disorders and chronic pain.

Teaching

Undergraduate

Year 2:

Biomedical Sciences 2 (in-course assessor and lab practical organiser).

Year 3:

Biomedical Sciences 3 (lecturer, lab practical organiser and assessor).

Physiology 3 (lecturer and in course assessor).

Pharmacology 3 (lecturer and deputy course organiser).

Applied Pharmacology (deputy course organiser).

Year 4:

Honours core programmes:

Honours Pharmacology (lecturer, tutor, project supervisor and Exam Board member).

Honours Neuroscience (in-course assessor).

Honours electives:

Receptors, Signalling and Regulation of Cell Responsiveness (co-organiser and lecturer).

MBChB

MBChB Year 1 (Fundamentals of Medicine Module Organiser, assessor and Exam Board member).

 

Postgraduate (MSc)

Taught or Research MSc:

MSc by Research Integrative Neuroscience (lecturer and project supervisor).

Fingerprint

Dive into the research topics where Rory Mitchell is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
  • 1 Similar Profiles
View full fingerprint

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Explore network further

  • Polygenic prediction of body mass index and obesity through the life course and across ancestries

    23andMe Research Team, DiscovEHR (DiscovEHR and MyCode Community Health Initiative), eMERGE (Electronic Medical Records and Genomics Network), GPC-Uganda Genome Resource (UGR), The PRACTICAL consortium, CRUK, BPC3, CAPS, PEGASUS, Understanding Society Scientific Group, VA Million Veteran Program, Smit, R. A. J., Wade, K. H., Hui, Q., Arias, J. D., Yin, X., Christiansen, M. R., Yengo, L., Preuss, M. H., Nakabuye, M., Rocheleau, G., Graham, S. E., Buchanan, V. L. & Chittoor, G. & 614 others, Graff, M., Guindo-Martínez, M., Lu, Y., Marouli, E., Sakaue, S., Spracklen, C. N., Vedantam, S., Wilson, E. P., Chen, S.-H., Ferreira, T., Ji, Y., Karaderi, T., Lüll, K., Machado, M., Malden, D. E., Medina-Gomez, C., Moore, A., Rüeger, S., Akiyama, M., Allison, M. A., Alvarez, M., Andersen, M. K., Appadurai, V., Arbeeva, L., Bartell, E., Bhaskar, S., Bielak, L. F., Bis, J. C., Bollepalli, S., Bork-Jensen, J., Bradfield, J. P., Bradford, Y., Brandl, C., Braund, P. S., Brody, J. A., Broeckel, U., Burgdorf, K. S., Cade, B. E., Cai, Q., Camarda, S., Campbell, A., Cañadas-Garre, M., Chai, J.-F., Chesi, A., Choi, S. H., Christofidou, P., Couture, C., Cuellar-Partida, G., Danning, R., Degenhardt, F., Delgado, G. E., Delitala, A., Demirkan, A., Deng, X., Dietl, A., Dimitriou, M., Dimitrov, L., Dorajoo, R., Eichelmann, F., Eliasen, A. U., Engmann, J. E., Erdos, M. R., Fairhurst-Hunter, Z., Farmaki, A.-E., Faul, J. D., Fernandez-Lopez, J.-C., Forer, L., Frank, M., Freitag-Wolf, S., Fritsche, L. G., Fuchsberger, C., Galesloot, T. E., Gao, Y., Geller, F., Giannakopoulou, O., Giulianini, F., Gjesing, A. P., Goel, A., Gordon, S. D., Gorski, M., Grove, J., Guo, X., Gustafsson, S., Haessler, J., Hansen, T. F., Havulinna, A. S., Haworth, S. J., Heard-Costa, N., Hemerich, D., Highland, H. M., Hindy, G., Ho, Y.-L., Hofer, E., Holliday, E., Horn, K., Hornsby, W. E., Hottenga, J.-J., Huang, H., Huang, J., Huerta-Chagoya, A., Huo, S., Hwang, M. Y., Hwu, C.-M., Iha, H., Ikeda, D. D., Isono, M., Jackson, A. U., Jansen, I. E., Jiang, Y., Johansson, I., Jonsson, A., Jørgensen, T., Kalafati, I. P., Kanai, M., Kanoni, S., Kårhus, L. L., Kasturiratne, A., Katsuya, T., Kawaguchi, T., Kember, R. L., Kentistou, K. A., Kim, D., Kim, H.-N., Kim, Y. J., Kleber, M. E., Knol, M. J., Kurbasic, A., Lauzon, M., Le, P., Lea, R., Lee, J.-Y., Lee, W.-J., Leonard, H. L., Li, H., Li, S. A., Li, X., Li, X., Liang, J., Lin, H., Lin, K., Liu, J., Liu, X., Lo, K. S., Long, J., Lores-Motta, L., Luan, J., Lyssenko, V., Lyytikäinen, L.-P., Mahajan, A., Malik, M. Z., Mamakou, V., Mangino, M., Manichaikul, A., Marten, J., Mattheisen, M., McDaid, A. F., Mei, Q., Meiselbach, H., Melendez, T. L., Milaneschi, Y., Miller, J. E., Millwood, I. Y., Mishra, P. P., Mitchell, R. E., Møllehave, L. T., Mononen, N., Mucha, S., Munz, M., Mykkänen, J., Nakatochi, M., Nardone, G. G., Nelson, C. P., Nethander, M., Nho, C. W., Nielsen, A. A., Nolte, I. M., Nongmaithem, S. S., Noordam, R., Ntalla, I., Nutile, T., Pandit, A., Pauper, M., Petersen, E. R. B., Petersen, L. V., Piluso, F., Polašek, O., Poveda, A., Pyarajan, S., Raffield, L. M., Rakugi, H., Ramirez, J., Rasheed, A., Raven, D., Rayner, N. W., Riveros, C., Rohde, R., Ruggiero, D., Ruotsalainen, S. E., Ryan, K. A., Sabater-Lleal, M., Santin, A., Saxena, R., Scholz, M., Shen, B., Shi, J., Shin, J. H., Sidore, C., Sidorenko, J., Sim, X., Slieker, R. C., Smith, A. V., Smith, J. A., Smyth, L. J., Southam, L., Steinthorsdottir, V., Sun, L., Takeuchi, F., Taylor, K. D., Tayo, B. O., Tcheandjieu, C., Terzikhan, N., Tesolin, P., Teumer, A., Theusch, E., Thompson, D. J., Thorleifsson, G., Timmers, P. R. H. J., Trompet, S., Turman, C., Vaccargiu, S., van der Laan, S. W., van der Most, P. J., van Klinken, J. B., van Setten, J., Verma, S. S., Verweij, N., Veturi, Y., Wang, C. A., Wang, C., Wang, J.-S., Wang, L., Wang, Y. X., Wang, Z., Warren, H. R., Bin Wei, W., Wen, W., Wheeler, W. A., Wickremasinghe, A. R., Wielscher, M., Winsvold, B. S., Wong, A., Wuttke, M., Xia, R., Yamamoto, K., Yang, J., Yao, J., Young, H., Yousri, N. A., Yu, L., Zeng, L., Zhang, W., Zhang, X., Zhao, J.-H., Zhao, W., Zhou, W., Zimmermann, M. E., Zoledziewska, M., ‘t Hart, L. M., Adair, L. S., Adams, H. H. H., Aguilar-Salinas, C. A., Al-Mulla, F., Arnett, D. K., Asselbergs, F. W., Åsvold, B. O., Attia, J., Banas, B., Bandinelli, S., Beilin, L. J., Bennett, D. A., Bergler, T., Bharadwaj, D., Biino, G., Boerwinkle, E., Böger, C. A., Borja, J. B., Bouchard, C., Bowden, D. W., Brandslund, I., Brumpton, B., Buring, J. E., Caulfield, M. J., Chambers, J. C., Chandak, G. R., Chanock, S. J., Chaturvedi, N., Ida Chen, Y.-D., Chen, Z., Cheng, C.-Y., Cho, Y. S., Christensen, K., Christophersen, I. E., Ciullo, M., Cole, J. W., Collins, F. S., Concas, M. P., Cooper, R. S., Cruz, M., Cucca, F., Cutler, M. J., Damrauer, S. M., Dantoft, T. M., de Borst, G. J., de Geus, E. J. C., de Groot, L. C. P. G. M., De Jager, P. L., de Kleijn, D. P. V., de Silva, H. J., Dedoussis, G. V., den Hollander, A. I., Du, S., Easton, D. F., Eckardt, K.-U., Elders, P. J. M., Eliassen, A. H., Ellinor, P. T., Elmståhl, S., Erdmann, J., Evans, M. K., Fatkin, D., Feenstra, B., Feitosa, M. F., Ferrucci, L., Florez, J. C., Ford, I., Fornage, M., Franke, A., Franks, P. W., Freedman, B. I., Gieger, C., Girotto, G., Golightly, Y. M., Gonzalez-Villalpando, C., Gordon-Larsen, P., Grallert, H., Grant, S. F. A., Grarup, N., Griffiths, L., Gudnason, V., Haiman, C., Hakonarson, H., Hansen, T., Hartman, C. A., Hattersley, A. T., Hayward, C., Heid, I. M., Heng, C.-K., Hengstenberg, C., Herzig, K.-H., Hewitt, A. W., Hishigaki, H., Hougaard, D. M., Hoyng, C. B., Huang, P. L., Huang, W., Huang, W.-Y., Huffman, J. E., Hunt, S. C., Hutri, N., Hveem, K., Hyppönen, E., Iacono, W. G., Ichihara, S., Ikram, M. A., Isasi, C. R., Jarvelin, M.-R., Jin, Z.-B., Jöckel, K.-H., Jonas, J. B., Joshi, P. K., Jousilahti, P., Jukema, J. W., Kähönen, M., Kamatani, Y., Kang, K. D., Kaprio, J., Kardia, S. L. R., Karpe, F., Kato, N., Kavousi, M., Kee, F., Kessler, T., Khera, A. V., Khor, C. C., Kiemeney, L. A. L. M., Kim, B.-J., Kim, E. K., Kim, H.-L., Kirchhof, P., Kivimaki, M., Koh, W.-P., Koistinen, H. A., Kokkinos, A., Kooner, J. S., Kooperberg, C., Kovacs, P., Kraaijeveld, A., Kraft, P., Krauss, R. M., Kumari, M., Kutalik, Z., Laakso, M., Lange, L. A., Langenberg, C., Launer, L. J., Lee, H., Lee, N. R., Lehtimäki, T., Lemaitre, R. N., Li, H., Li, L., Lieb, W., Lin, X., Lind, L., Linneberg, A., Liu, C.-T., Liu, J., Loeffler, M., London, B., Lu, F., Lubitz, S. A., Mackey, D. A., Magnusson, P. K. E., Manson, J. E., Marcus, G. M., Marques Vidal, P., Martin, N. G., März, W., Matsuda, F., McCarthy, M. I., McGarrah, R. W., McGue, M., McKnight, A. J., Medland, S. E., Mellström, D., Metspalu, A., Mitchell, B. D., Mitchell, P., Mook-Kanamori, D. O., Mori, T. A., Morris, A. D., Mucci, L. A., Munroe, P. B., Nalls, M. A., Nazarian, S., Nelson, A. E., Neville, M. J., Newton-Cheh, C., Nielsen, C. S., Niinikoski, H., Nikus, K., Nöthen, M. M., Ogunniyi, A., Ohlsson, C., Oldehinkel, A. J., Orozco, L., Pahkala, K., Pajukanta, P., Palmer, C. N. A., Parra, E. J., Pattaro, C., Pedersen, O., Pennell, C. E., Penninx, B. W. J. H., Perusse, L., Peters, A., Peyser, P. A., Porteous, D. J., Posthuma, D., Power, C., Pramstaller, P. P., Province, M. A., Psaty, B. M., Qi, Q., Qu, J., Rader, D. J., Raitakari, O. T., Rallidis, L. S., Rao, D. C., Redline, S., Reilly, D. F., Reiner, A. P., Rhee, S. Y., Ridker, P. M., Rienstra, M., Ripatti, S., Ritchie, M. D., Rivadeneira, F., Roden, D. M., Rosendaal, F. R., Rotter, J. I., Rudan, I., Rutters, F., Ryu, S., Sabanayagam, C., Salako, B., Saleheen, D., Salomaa, V., Samani, N. J., Sanghera, D. K., Sattar, N., Schmidt, B., Schmidt, H., Schmidt, R., Schulze, M. B., Schunkert, H., Scott, L. J., Scott, R. J., Sever, P., Sheu, W. H. H., Shoemaker, M. B., Shu, X.-O., Simonsick, E. M., Sims, M., Singleton, A. B., Sinner, M. F., Smith, J. G., Snieder, H., Spector, T. D., Spedicati, B., Stampfer, M. J., Stark, K. J., Strachan, D. P., Tabara, Y., Tai, E. S., Tang, H., Tardif, J.-C., Thanaraj, T. A., Tönjes, A., Tuomi, T., Tuomilehto, J., Tusié-Luna, M.-T., van Dam, R. M., van der Harst, P., Van der Velde, N., van Duijn, C. M., van Schoor, N. M., Vitart, V., Vohl, M.-C., Völker, U., Vollenweider, P., Völzke, H., Vrieze, S., Wacher-Rodarte, N. H., Walker, M., Wander, G. S., Wareham, N. J., Watanabe, R. M., Watkins, H., Weir, D. R., Werge, T. M., Widen, E., Willemsen, G., Willett, W. C., Wilson, J. F., Wilson, P. W. F., Wong, T. Y., Woo, J.-T., Wright, A. F., Xu, H., Yajnik, C. S., Yang, J., Yokota, M., Yuan, J.-M., Zeggini, E., Zemel, B. S., Zheng, W., Zhu, X., Zillikens, M. C., Zonderman, A. B., Zwart, J.-A., Abecasis, G. R., Assimes, T. L., Auton, A., Boehnke, M., Chasman, D. I., Esko, T., Stefansson, K., Lettre, G., Lindgren, C. M., Ng, M. C. Y., O’Donnell, C. J., Thorsteinsdottir, U., Visscher, P. M., Walters, R. G., Winkler, T. W., Wood, A. R., Deloukas, P., Frayling, T. M., Justice, A. E., Kilpeläinen, T. O., Locke, A. E., Mohlke, K. L., North, K. E., Okada, Y., Willer, C. J., Young, K. L., Fatumo, S., McCaffery, J. M., Timpson, N. J., Hirschhorn, J. N., Sun, Y. V., Berndt, S. I. & Loos, R. J. F., 21 Jul 2025, In: Nature Medicine. 31, p. 3151-3168

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus

    eQTLGen Consortium, BIOS Consortium, FinnGen Study & LifeLines Cohort Study, May 2023, In: Nature Human Behaviour. 7, 5, p. 790-801

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

    Million Veterans Program, 4 Aug 2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 22 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Scottish COVID CAncer iMmunity Prevalence (SCCAMP): A longitudinal study of patients with cancer receiving active anti-cancer treatment during the COVID-19 pandemic.

    Purshouse, K., Thomson, J. P., Vallet, M., Alexander, L., Bonisteel, I., Brennan, M., Cameron, D. A., Figueroa, J., Furrie, E., Haig, P., Heck, M., McCaughan, H., Mitchell, P., McVicars, H., Primrose, L., Templeton, K., Wilson, N. & Hall, P. S., 1 Jun 2022, In: Journal of Clinical Oncology. 40, 16_suppl, e18733.

    Research output: Contribution to journal › Meeting abstract › peer-review

  • The power of genetic diversity in genome-wide association studies of lipids

    VA Million Veteran Program, 9 Dec 2021, In: Nature. 600, 7890, p. 675-679 5 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
View all 59 research outputs
View all 10 projects