Research output per year
Research output per year
- 49 results
Search results
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2024
miR-7 is recruited to the High Molecular Weight 1 RNA-induced silencing complex in CD8+ T cells upon activation and suppresses IL-2 signaling
Toivakka, M., Gordon, K., Kumar, S., Bermudez Barrientos, J. R., Abreu-Goodger, C., Zamoyska, R. & Buck, A. H., Jan 2024, In: RNA. 30, 1, p. 26-36 12 p.Research output: Contribution to journal › Article › peer-review
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2023
Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion
Teagle, A. R., Castro-Sanchez, P., Brownlie, R. J., Logan, N., Kapoor, S. S., Wright, D., Salmond, R. J. & Zamoyska, R., 6 Dec 2023, In: Journal for immunotherapy of cancer. 11, 12, 15 p., e007614.Research output: Contribution to journal › Article › peer-review
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2022
Translation factor eIF5a is essential for IFNγ production and cell cycle regulation in primary CD8 T lymphocytes
Tan, T., Kelly, V., Zou, X., Wright, D., Ly, T. & Zamoyska, R., 17 Dec 2022, In: Nature Communications. 13, 16 p., 7796.Research output: Contribution to journal › Article › peer-review
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Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease
Tanaka, A., Maeda, S., Nomura, T., Llamas-Covarrubias, M. A., Tanaka, S., Jin, L., Lim, E. L., Morikawa, H., Kitagawa, Y., Akizuki, S., Ito, Y., Fujimori, C., Hirota, K., Murase, T., Hashimoto, M., Higo, J., Zamoyska, R., Ueda, R., Standley, D. M., Sakaguchi, N., & 1 others, 1 Dec 2022, In: The Journal of experimental medicine. 220, 2, 29 p., e20220386.Research output: Contribution to journal › Article › peer-review
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A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis
Robertson, N., Shchepachev, V., Wright, D., Turowski, T. W., Spanos, C., Helwak, A., Zamoyska, R. & Tollervey, D., 3 Feb 2022, In: Nature Communications. 13, 1, 14 p., 649.Research output: Contribution to journal › Article › peer-review
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2020
CRISPR-mediated deletion of the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) improves human T cell function for adoptive T cell therapy
Prade, S., Wright, D., Logan, N., Teagle, A. R., Stauss, H. & Zamoyska, R., 4 Dec 2020, bioRxiv.Research output: Working paper › Preprint
Open Access -
Analysis of high molecular weight RNA-induced silencing complex (HMW-RISC) in CD8+ T cells identifies miR-7 as a modulator of T cell activation
Toivakka, M., Gordon, K., Kumar, S., Zamoyska, R. & Buck, A., 17 May 2020, bioRxiv, 34 p.Research output: Working paper › Preprint
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PTPN22 acts in a cell intrinsic manner to restrict 1 the proliferation 2 and differentiation of T cells following antibody lymphodepletion
Knipper, J., Wright, D., Cope, A. P., Malissen, B. & Zamoyska, R., 28 Jan 2020, In: Frontiers in Immunology.Research output: Contribution to journal › Article › peer-review
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2019
Differential nanoscale organisation of LFA-1 modulates T cell migration
Shannon, M. J., Pineau, J., Griffié, J., Aaron, J., Peel, T., Williamson, D. J., Zamoyska, R., Cope, A. P., Cornish, G. H. & Owen, D. M., 30 Aug 2019, (E-pub ahead of print) In: Journal of Cell Science.Research output: Contribution to journal › Article › peer-review
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Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors
Brownlie, R. J., Wright, D., Zamoyska, R. & Salmond, R. J., 22 Aug 2019, In: JCI Insight. 4, 16, e127847.Research output: Contribution to journal › Article › peer-review
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mir-181A/B-1 controls thymic selection of treg cells and tunes their suppressive capacity
Łyszkiewicz, M., Winter, S. J., Witzlau, K., Föhse, L., Brownlie, R., Puchałka, J., Verheyden, N. A., Kunze-Schumacher, H., Imelmann, E., Blume, J., Raha, S., Sekiya, T., Yoshimura, A., Frueh, J. T., Ullrich, E., Huehn, J., Weiss, S., Gutierrez, M. G., Prinz, I., Zamoyska, R., & 2 others, 11 Mar 2019, In: PLoS Biology. 17, 3, e2006716.Research output: Contribution to journal › Article › peer-review
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2018
Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2
Bray, C., Wright, D., Haupt, S., Thomas, S., Stauss, H. & Zamoyska, R., 12 Nov 2018, In: Frontiers in Immunology. 9, 10 p.Research output: Contribution to journal › Article › peer-review
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Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses
Sanchez-Blanco, C., Clarke, F., Cornish, G. H., Depoil, D., Thompson, S. J., Dai, X., Rawlings, D. J., Dustin, M. L., Zamoyska, R., Cope, A. P. & Purvis, H. A., Nov 2018, In: Journal of autoimmunity. 94, p. 45-55 11 p.Research output: Contribution to journal › Article › peer-review
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The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens
Clarke, F., Purvis, H. A., Sanchez-Blanco, C., Gutiérrez-Martinez, E., Cornish, G. H., Zamoyska, R., Guermonprez, P. & Cope, A. P., 23 Aug 2018, (E-pub ahead of print) In: Scientific Reports. 8, 1, 12692.Research output: Contribution to journal › Article › peer-review
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Regulation of autoimmune and anti-tumour T-cell responses by PTPN22
Brownlie, R. J., Zamoyska, R. & Salmond, R. J., 7 Mar 2018, In: Immunology . 154, 3, p. 377-382 6 p.Research output: Contribution to journal › Review article › peer-review
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Protein tyrosine phosphatase PTPN22 regulates IL-1β dependent Th17 responses by modulating dectin-1 signaling in mice
Purvis, H. A., Clarke, F., Jordan, C. K., Blanco, C. S., Cornish, G. H., Dai, X., Rawlings, D. J., Zamoyska, R. & Cope, A. P., 1 Feb 2018, In: European Journal of Immunology. 48, 2, p. 306-315 10 p.Research output: Contribution to journal › Article › peer-review
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2017
Resistance to TGFβ suppression and improved anti-tumor responses in CD8+ T cells lacking PTPN22
Brownlie, R. J., Garcia, C., Ravasz, M., Zehn, D., Salmond, R. J. & Zamoyska, R., 7 Nov 2017, In: Nature Communications. 8, 10 p., 1343.Research output: Contribution to journal › Article › peer-review
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Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells
Clarke, F., Jordan, C. K., Gutiérrez-Martinez, E., Bibby, J. A., Sanchez-Blanco, C., Cornish, G. H., Dai, X., Rawlings, D. J., Zamoyska, R., Guermonprez, P., Cope, A. P. & Purvis, H. A., 17 Oct 2017, In: PLoS ONE. 12, 10, 17 p., e0186625.Research output: Contribution to journal › Article › peer-review
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Caveolin-1 influences LFA-1 redistribution upon TCR stimulation in CD8 T cells
Borger, J., Morrison, V. L., Filby, A., Garcia, C., Uotila, L. M., Simbari, F., Fagerholm, S. C. & Zamoyska, R., 1 Aug 2017, In: The Journal of Immunology. 199, 3, p. 874-884 11 p.Research output: Contribution to journal › Article › peer-review
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Suboptimal T cell receptor signaling compromises protein translation, ribosome biogenesis and proliferation of mouse CD8 T cells
Tan, T., Knight, J., Sbarrato, T., Dudek, K., Willis, A. & Zamoyska, R., 25 Jul 2017, In: Proceedings of the National Academy of Sciences (PNAS). 114, 30, p. 6117-6126 10 p.Research output: Contribution to journal › Article › peer-review
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2016
Cellular and humoral immunity in a wild mammal: Variation with age & sex and association with overwinter survival
Watson, R. L., Mcneilly, T. N., Watt, K. A., Pemberton, J. M., Pilkington, J. G., Waterfall, M., Hopper, P. R. T., Cooney, D., Zamoyska, R. & Nussey, D. H., 25 Dec 2016, In: Ecology and Evolution.Research output: Contribution to journal › Article › peer-review
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PTPN22 is a critical regulator of Fcg receptor 1mediated neutrophil activation
Vermeren, S., Miles, K., Chu, J. Y., Salter, D., Zamoyska, R. & Gray, M., 2 Nov 2016, (E-pub ahead of print) In: The Journal of Immunology.Research output: Contribution to journal › Article › peer-review
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Superresolution imaging of the cytoplasmic phosphatase PTPN22 links integrin-mediated T cell adhesion with autoimmunity
Burn, G. L., Cornish, G. H., Potrzebowska, K., Samuelsson, M., Griffié, J., Minoughan, S., Yates, M., Ashdown, G., Pernodet, N., Morrison, V. L., Sanchez-Blanco, C., Purvis, H., Clarke, F., Brownlie, R. J., Vyse, T. J., Zamoyska, R., Owen, D. M., Svensson, L. M. & Cope, A. P., 4 Oct 2016, In: Science Signaling. 9, 448, ra99.Research output: Contribution to journal › Article › peer-review
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IL-12 signals through the TCR to support CD8 innate immune responses
Goplen, N. P., Saxena, V., Knudson, K. M., Schrum, A. G., Gil, D., Daniels, M. A., Zamoyska, R. & Teixeiro, E., 15 Sept 2016, In: The Journal of Immunology. 197, 6, p. 2434-2443 10 p.Research output: Contribution to journal › Article › peer-review
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Loss of the protein tyrosine phosphatase PTPN22 reduces mannan-induced autoimmune arthritis in SKG mice
Sood, S., Brownlie, R. J., Garcia, C., Cowan, G., Salmond, R. J., Sakaguchi, S. & Zamoyska, R., 15 Jul 2016, In: The Journal of Immunology. 197, 2, p. 429-440 12 p.Research output: Contribution to journal › Article › peer-review
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2015
Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation
Salmond, R. J., Brownlie, R. J., Meyuhas, O. & Zamoyska, R., 15 Nov 2015, In: The Journal of Immunology. 195, 10, p. 4615-22 8 p.Research output: Contribution to journal › Article › peer-review
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Multifunctional roles of the autoimmune disease-associated tyrosine phosphatase PTPN22 in regulating T cell homeostasis
Salmond, R. J., Brownlie, R. J. & Zamoyska, R., 2015, In: Cell Cycle. 14, 5, p. 705-11 7 p.Research output: Contribution to journal › Article › peer-review
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2014
Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor
Casas, J., Brzostek, J., Zarnitsyna, V. I., Hong, J. S., Wei, Q., Hoerter, J. A. H., Fu, G., Ampudia, J., Zamoyska, R., Zhu, C. & Gascoigne, N. R. J., 27 Nov 2014, In: Nature Communications. 5, 5624.Research output: Contribution to journal › Article › peer-review
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The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals
Salmond, R. J., Brownlie, R. J., Morrison, V. L. & Zamoyska, R., 10 Aug 2014, In: Nature Immunology. 15, p. 875–883Research output: Contribution to journal › Article › peer-review
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Proximity of TCR and its CD8 coreceptor controls sensitivity of T cells
Borger, J., Zamoyska, R. & Gakamsky, D. M., 1 Jan 2014, In: Immunology Letters. 157, 1-2, p. 16-22Research output: Contribution to journal › Article › peer-review
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2013
The influence of PTPN22 on the development of autoimmunity
Zamoyska, R., Salmond, R., Brownlie, R. & Sood, S., Dec 2013, In: Immunology . 140, p. 4-4 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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T cell receptor signalling networks: Branched, diversified and bounded
Brownlie, R. J. & Zamoyska, R., 25 Mar 2013, In: Nature Reviews Immunology. 13, 4, p. 257-269 13 p.Research output: Contribution to journal › Review article › peer-review
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Differential Polarization of C-Terminal Src Kinase between Naive and Antigen-Experienced CD8+ T Cells
Borger, J. G., Filby, A. & Zamoyska, R., 2013, In: The Journal of Immunology. 190, 7, p. 3089-3099Research output: Contribution to journal › Article › peer-review
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2012
Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function
Brownlie, R. J., Miosge, L. A., Vassilakos, D., Svensson, L. M., Cope, A. & Zamoyska, R., 27 Nov 2012, In: Science Signaling. 5, 252, ra87.Research output: Contribution to journal › Article › peer-review
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Age-related variation in immunity in a wild mammal population
Nussey, D. H., Watt, K., Pilkington, J. G., Zamoyska, R. & McNeilly, T. N., Feb 2012, In: Aging Cell. 11, 1, p. 178-180 3 p.Research output: Contribution to journal › Article › peer-review
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Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells
Caserta, S., Nausch, N., Sawtell, A., Drummond, R., Barr, T., Macdonald, A. S., Mutapi, F. & Zamoyska, R., 2012, In: PLoS ONE. 7, 4, 13 p., e35466.Research output: Contribution to journal › Article › peer-review
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2011
Centrosome docking at the immunological synapse is controlled by Lck signaling
Tsun, A., Qureshi, I., Stinchcombe, J. C., Jenkins, M. R., de la Roche, M., Kleczkowska, J., Zamoyska, R. & Griffiths, G. M., 21 Feb 2011, In: Journal of Cell Biology. 192, 4, p. 663-674 12 p.Research output: Contribution to journal › Article › peer-review
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Mislocalization of Lck impairs thymocyte differentiation and can promote development of thymomas
Salmond, R. J., Filby, A., Pirinen, N., Magee, A. I. & Zamoyska, R., 6 Jan 2011, In: Blood. 117, 1, p. 108-117 10 p.Research output: Contribution to journal › Article › peer-review
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2010
Reduced Functional Avidity Promotes Central and Effector Memory CD4 T Cell Responses to Tumor-Associated Antigens
Caserta, S., Kleczkowska, J., Mondino, A. & Zamoyska, R., 1 Dec 2010, In: The Journal of Immunology. 185, 11, p. 6545-6554 10 p.Research output: Contribution to journal › Article › peer-review
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Lack of the phosphatase PEP results in increased number and function of T regulatory cells
Brownlie, R. J., Miosge, L., Vassilakos, D. & Zamoyska, R., Dec 2010, In: Immunology . 131, p. 142-142 1 p.Research output: Contribution to journal › Article › peer-review
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How does the mammalian target of rapamycin (mTOR) influence CD8 T cell differentiation?
Salmond, R. J. & Zamoyska, R., 1 Aug 2010, In: Cell Cycle. 9, 15, p. 2952-2957 6 p.Research output: Contribution to journal › Article › peer-review
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Improving T Cell Functional Avidity Through CD8 Co-Receptor Modification: A Novel Mechanism to Enhance TCR Gene Therapy
Chua, N. H., Holler, A., Zamoyska, R., Stauss, H. & Morris, E., Apr 2010, In: Human Gene Therapy. 21, 4, p. 522-522 1 p.Research output: Contribution to journal › Article › peer-review
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2009
MAPK, Phosphatidylinositol 3-Kinase, and Mammalian Target of Rapamycin Pathways Converge at the Level of Ribosomal Protein S6 Phosphorylation to Control Metabolic Signaling in CD8 T Cells
Salmond, R. J., Emery, J., Okkenhaug, K. & Zamoyska, R., 1 Dec 2009, In: The Journal of Immunology. 183, 11, p. 7388-7397 10 p.Research output: Contribution to journal › Article › peer-review
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LAT Polices T Cell Activation
Brownlie, R. & Zamoyska, R., 21 Aug 2009, In: Immunity. 31, 2, p. 174-176 3 p.Research output: Contribution to journal › Editorial › peer-review
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T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance
Salmond, R. J., Filby, A., Qureshi, I., Caserta, S. & Zamoyska, R., Mar 2009, In: Immunological reviews. 228, p. 9-22 14 p.Research output: Contribution to journal › Literature review › peer-review
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An Essential Role for the Stalk Region of CD8 beta in the Coreceptor Function of CD8
Rettig, L., McNeill, L., Sarner, N., Guillaume, P., Luescher, I., Tolaini, M., Kioussis, D. & Zamoyska, R., 1 Jan 2009, In: The Journal of Immunology. 182, 1, p. 121-129 9 p.Research output: Contribution to journal › Article › peer-review
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2008
Long-lasting persistence of central and effector memory CD4 T cells is influenced by the strength of signal through the TCR
Caserta, S., Mondino, A. & Zamoyska, R., Dec 2008, In: Immunology . 125, p. 77-78 2 p.Research output: Contribution to journal › Meeting abstract › peer-review
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T cell receptor signalling to ribosomal protein S6
Salmond, R. J. & Zamoyska, R., Dec 2008, In: Immunology . 125, p. 46-46 1 p.Research output: Contribution to journal › Meeting abstract › peer-review
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Itch(-/-)alpha beta and gamma delta T cells independently contribute to autoimmunity in Itchy mice
Parravicini, V., Field, A-C., Tomlinson, P. D., Basson, M. A. & Zamoyska, R., 15 Apr 2008, In: Blood. 111, 8, p. 4273-4282 10 p.Research output: Contribution to journal › Article › peer-review