Research output per year
Research output per year
Personal profile
My research in a nutshell
Me and my team are investigating the mechanisms of inhibitory neurotransmission that contribute to neuronal circuit function in diseases of the nervous system, notably: neurodevelopmental disorders, epilepsy, and neurodegeneration. To achieve this, we are combining electrophysiological recordings from acute and cultured tissue from rodents and human brains, combined with anatomical and biochemical analyses.
Current Research Interests
My research research interests revolve around the function and plasticity of metabotropic inhibitory neurotransmitter receptors regulating the function of neurons. In particular, we are focusing on how plasticity of metabotropic receptors contributes to long-term functional properties of neuronal circuits.
Education/Academic qualification
Doctor of Philosophy (PhD), Inhibiting Inhibition: Interactions among interneurons of the hippocampus, University of Glasgow
Award Date: 1 Jan 2011
Bachelor of Science, University of Edinburgh
Award Date: 1 Jan 2008
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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GABAergic neurons exhibit subtype-specific changes in the developing somatosensory cortex of a rat model of Fragile X Syndrome
Sumera, A., Crichton, A., Kind, P. C., Sibley, C. R. & Booker, S. A., 26 May 2026, In: Frontiers in Neuroscience. 20, 1819200.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
GABAB Receptor signaling in CA1 Pyramidal Cells is not Regulated by Aging in the APP/PS1 Mouse Model of Amyloid Pathology
Meftah, S., Wilson, M. A., Elliott, J., McLay, L., Dobrovolskis, V., Rosencrans, S., Taylor, L. W., Mugnaini, C., Mostallino, R., Durrant, C. S. & Booker, S. A., 6 Feb 2026, In: eNeuro. 13, 2Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Elevated somatostatin interneuron long-term potentiation minimally regulates temporoammonic plasticity in a mouse model of Fragile X Syndrome
Wilson, M., Sumera, A., Berk, E. & Booker, S. A., 15 Jan 2026, In: Frontiers in pharmacology.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
McGeachan, R. I., Meftah, S., Taylor, L. W., Catterson, J. H., Negro, D., Bonthron, C., Holt, K., Tulloch, J., Rose, J. L., Gobbo, F., Chang, Y. Y., Elliott, J., McLay, L., King, D., Liaquat, I., Spires-Jones, T. L., Booker, S. A., Brennan, P. M. & Durrant, C. S., Dec 2025, In: Nature Communications. 16, 1, p. 1-22 22 p., 3753.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
GABAB receptors negatively modulate excitatory plasticity at the mossy fiber synapses onto parvalbumin-expressing Basket and Axo-axonic cells in the Dentate Gyrus
Loureiro, R., Booker, S. A., Kulik, A. & Vida, I., 18 Nov 2025, In: Frontiers in synaptic neuroscience. 17, 1656759.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Edinburgh Human Brain Cluster: Enhancing Investigation of Live Human Brain Slice Models with Deep Patient Phenotyping
Brennan, P. (Principal Investigator), Baillie, K. (Co-investigator), Booker, S. (Co-investigator), Durrant, C. (Co-investigator), Smith, C. (Co-investigator) & Spires-Jones, T. (Co-investigator)
14/11/25 → 13/11/29
Project: Research
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A Spinning Disk Super-resolution Microscope For High Throughput Organ Mapping And Ultra-fast Live Cell Imaging Of Signalling Networks
Porter, I. (Principal Investigator), Garcia Burgos, A. (Co-investigator), Wheeler, A. (Co-investigator), Muir, C. (Co-investigator), Surmeli, G. (Co-investigator), Davies, J. (Co-investigator), Zoupi, L. (Co-investigator), Evans, M. (Co-investigator), Choudhury, M. (Co-investigator), Rochefort, N. (Co-investigator), Booker, S. (Co-investigator), Ribeiro dos Louros, S. (Co-investigator) & Theil, T. (Co-investigator)
1/08/25 → 31/07/26
Project: Research
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A spinning disk super-resolution microscope for high throughput organ mapping and ultra-fast live cell imaging of signalling networks
Porter, I. (Principal Investigator), Booker, S. (Co-investigator), Choudhury, M. (Co-investigator), Davies, J. (Co-investigator), Evans, M. (Co-investigator), Garcia Burgos, A. (Co-investigator), Muir, C. (Co-investigator), Ribeiro dos Louros, S. (Co-investigator), Rochefort, N. (Co-investigator), Surmeli, G. (Co-investigator), Theil, T. (Co-investigator), Wheeler, A. (Co-investigator) & Zoupi, L. (Co-investigator)
Biotechnology and Biological Sciences Research Council
1/08/25 → 31/07/26
Project: Research
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Targeting early-life intervention for treatment of neurodevelopmental disorders
Booker, S. (Principal Investigator)
1/05/24 → 30/04/27
Project: Research
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GABAergic synaptic mechanisms contributing to cortical dysfunction in Alzheimers Disease
Booker, S. (Principal Investigator)
2/10/23 → 1/10/27
Project: Research
Datasets
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Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Tulloch, J. (Creator), Rose, J. (Creator), Gobbo, F. (Creator), Chang, Y. Y. (Creator), McLay, L. (Creator), King, D. (Creator), Liaquat, I. (Creator), Spires-Jones, T. (Creator), Booker, S. (Creator), Brennan, P. (Creator), Durrant, C. (Creator), Elliott, J. (Creator), Mcgeachan, R. (Creator), Meftah, S. (Creator), Taylor, L. (Creator), Catterson, J. (Creator), Negro, D. (Creator), Bonthron, C. (Creator) & Holt, K. (Creator), Edinburgh DataShare, 7 Apr 2025
DOI: 10.7488/ds/7890
Dataset
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Data from: Presynaptic GABAB receptors functionally uncouple somatostatin interneurons from the active hippocampal network
Booker, S. A. (Creator), Harada, H. (Creator), Elguate, C. (Creator), Bank, J. (Creator), Marlene, B. (Creator), Kulik, A. (Creator) & Vida, I. (Creator), Dryad, 19 Feb 2020
DOI: 10.5061/dryad.gt160v2, https://datadryad.org/dataset/doi:10.5061/dryad.gt160v2 and one more link, https://zenodo.org/records/4937186 (show fewer)
Dataset