Sandrine Prost graduated from the University Pierre and Marie Curie, (Paris VI, France) with a PhD in molecular pharmacology studying mechanisms of resistance to antitumor agents that target topoisomerases. She then joined the University of Edinburgh as a European Commission Marie Curie Research Fellow to work on the role of P53 in apoptosis and DNA repair.

Her interests developed from carcinogenesis and the role of tumour suppressor genes in cell responses to injury, in particular the effects of DNA damage & the cell cycle responses to a wider theme of cell injury. She became senior lecturer in 2001 in the Liver Injury & Repair Group of the university department of Pathology.

Her research took her to embrace image analysis of clinical biopsies and she developped multiplex immunostaining which is currentlly central to her research interest of identifying potential markers to help prognosis and management of a variety of diseases.

Sandrine Prost is interested in the cellular reactions to injury and their role in determining pathogenesis and disease outcome. Her current translational research aims to identify within clinical biopsy tissues tissue new biomarker combinations to improve the recognition and management a variety of disease. For example she used RNAscope (ACDbio) to sensitively detect low level hepatitis viral RNA in situ within tissue samples and multispectral imaging (Nuance Perkin Elmer, Polaris Akoya) in the per-cell evaluation of multiple (5+) markers on clinical biopsy samples to provide a detailed comparative in situ phenotyping study of macrophages in clinical inflammatory and allo-immune conditions affecting the liver and kidney as well as phenotyping the immune environment in COVID lungs. She is also interested in the immuno-environment in cancer.

Division of Pathology