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Personal profile

Research Interests

My major research interest is in determining the genetic and epigenetic contribution to non-pathological age-related cognitive decline. I am interested in determining the type, number and specific genetic variants and proteins involved. I am also investigating genetic and epigenetic influences on the life-long trait of cognitive ability and personality traits and the influence of telomere length change, gene expression levels, protein levels and metabolites on cognitive and physical ageing. These studies are being performed using genomic, epigenomic, transcriptomic, proteomic, metabolomic, cognitive, physical and personality data from surviving members of the Scottish Mental Surveys of 1932 and 1947, on whom there are mental ability scores available at the age of 11 years, and extensive, cognitive, personality, physical, social and biochemical data available from later life. I am also involved with several national and international collaborations, giving me access to data from numerous other cohorts with similar data including CHARGE and UK Biobank. My main skills are in the identification of genes and biological pathways based on experimental biology and bioinformatics, genotyping methodologies, and omic-phenotype statistical modelling, using software such as R, SPSS, PLINK and Mach2qtl.

Teaching

MSc in Quantitative Genetics and Genome Analysis

 

Qualifications

1999 PhD (Expression and functional analysis of DMAHP/SIX5) University of Glasgow.

1994  BSc (Hons) Biological Sciences (Genetics) IIi, University of Leicester.

Administrative Roles

I am responsible for maintaining the genetic information in the Lothian Birth Cohort of 1921 and the Lothian Birth Cohort of 1936 databases. I coordinate genetic studies within the Lothian Birth Cohorts group. I am responsible for all biological samples relating to the Lothian Birth Cohorts of 1921 and 1936.

Education/Academic qualification

Doctor of Philosophy (PhD), University of Glasgow

Award Date: 1 Jan 1999

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Network

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  • Genome wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability

    Huguet, G., Schramm, C., Douard, E., Tamer, P., Main, A., Monin, P., England, J., Jizi, K., Renné, T., Poirier, M., Nowak, S., Martin, C-O., Younis, N., Knoth, I. S., Jean-louis, M., Saci, Z., Auger, M., Tihy, F., Mathonnet, G., Maftei, C. & 19 others, Léveillé, F., Porteous, D. J., Davies, G., Redmond, P., Harris, S., Hill, W. D., Lemyre, E., Schumann, G., Bourgeron, T., Pausova, Z., Paus, T., Karama, S., Lippe, S., Deary, I., Almasy, L., Labbe, A., Glahn, D. C., M.T Greenwood, C. & Jacquemont, S., 7 Jan 2021, In: Molecular Psychiatry. 14 p.

    Research output: Contribution to journalArticlepeer-review

  • Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life

    Cox, S., Harris, M., Ritchie, S. J., Buchanan, C., Valdes Hernandez, M., Corley, J., Taylor, A., Madole, J. W., Harris, S., Whalley, H., McIntosh, A. M., Russ, T. C., Bastin, M. E., Wardlaw, J., Deary, I. & Tucker-Drob, E. M., 4 Jan 2021, In: Molecular Psychiatry. 12 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • Attitudes to ageing, biomarkers of ageing and mortality: The Lothian Birth Cohort 1936

    McLachlan, K., Cole, J., Harris, S., Marioni, R., Deary, I. & Gale, C., 28 Jan 2020, In: Journal of Epidemiology & Community Health.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
  • Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

    Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A. T., Cartwright, J. H., Hellwege, J. N., Giri, A., Tragante, V., Thorleifsson, G., Liu, D. J., Prins, B. P., Stewart, I. D., Cabrera, C. P., Eales, J. & 260 others, Akbarov, A., Auer, P. L., Bielak, L. F., Bis, J. C., Braithwaite, V. S., Brody, J. A., Daw, E. W., Warren, H. R., Drenos, F., Nielsen, S. F., Faul, J. D., Fauman, E., Fava, C., Ferreira, T., Foley, C. N., Franceschini, N., Gao, H., Giannakopoulou, O., Giulianini, F., Gudbjartsson, D. F., Guo, X., Harris, S., Havulinna, A. S., Helgadottir, A., Huffman, J. E., Hwang, S-J., Kanoni, S., Kontto, J., Larson, M. G., Li-Gao, R., Lindström, J., Lotta, L. A., Lu, Y., Luan, J., Mahajan, A., Malerba, G., Masca, N. G. D., Mei, H., Menni, C., Mook-Kanamori, D. O., Mosen-Ansorena, D., Müller-Nurasyid, M., Paré, G., Paul, D. S., Perola, M., Poveda, A., Rauramaa, R., Richard, M., Richardson, T. G., Sepúlveda, N., Sim, X., Smith, A. V., Smith, J. A., Staley, J. R., Stančáková, A., Sulem, P., Thériault, S., Thorstensdottir, U., Trompet, S., Varga, T. V., Velez Edwards, D. R., Veronesi, G., Weiss, S., Willems, S. M., Yao, J., Young, R., Yu, B., Zhang, W., Hua Zhao, J., Zhao, W., Evangelou, E., Aeschbacher, S., Asllanaj, E., Blankenberg, S., Bonnycastle, L. L., Bork-Jensen, J., Brandslund, I., Braund, P. S., Burgess, S., Cho, K., Christensen, C., Connelly, J., de Mutsert, R., Dominiczak, A. F., Dörr, M., Eiriksdottir, G., Farmaki, A-E., Gaziano, J. M., Grarup, N., Grove-Gaona, M. L., Hallmans, G., Hansen, T., Have, C. T., Heiss, G., Jørgensen, M. E., Jousilahti, P., Kajantie, E., Kamat, M., Käräjämäki, A., Karpe, F., Koistinen, H. A., Kovesdy, C. P., Kuulasmaa, K., Laatikainen, T., Lannfelt, L., Lee, I., Lee, W., Linneberg, A., Martin, L. W., Moitry, M., Nadkarni, G. N., Neville, M. J., Palmer, C. N. A., Papanicolau, G. J., Pederson, O., Peters, J., Poulter, N., Rasheed, A., Rasmussen, K. L., William Rayner, N., Mägi, R., Renström, F., Rettig, R., Rossouw, J., Schreiner, P. J., Sever, P. J., Sigurdsson, E. L., Skaaby, T., Sun, Y. V., Sundstrom, J., Thorgeirsson, G., Esko, T., Trabetti, E., Tsao, P. S., Tuomi, T., Turner, S. T., Tzoulaki, I., Vaartjes, I., Vergnaud, A-C., Willer, C. J., Wilson, P. W. F., Witte, D. R., Yonova-Doing, E., Zhang, H., Naheed, A., Almgren, P., Amouyel, P., Asselbergs, F. W., Barnes, M. R., Blakemore, A. I. F., Boehnke, M., Bots, M. L., Bottinger, E. P., Buring, J. E., Chambers, J. C., Ida Chen, Y-D., Chowdry, R., Conen, D., Correa, A., Smith, G. D., De Boer, R. A., Deary, I., Dedoussis, G., Deloukas, P., Di Angelantonio, E., Elliot, P., Felix, S. B., Ferrières, J., Ford, I., Fornage, M., Franks, P. W., Franks, S., Frossard, P., Gambaro, G., Gaunt, T. R., Groop, L., Gudnason, V., Harris, T. B., Hayward, C., Hennig, B. J., Herzig, K-H., Ingelsson, E., Tuomilehto, J., Jarvelin, M-R., Wouter Jukema, J., Kardia, S. L. R., Kee, F., Kooner, J. S., Kooperberg, C., Lenore, L. J., Lind, L., Loos, R. J. F., al Shafi Majumder, A., Laakso, M., McCarthy, M. I., Melander, O., Mohlke, K. L., Murray, A. D., Nordestgaard, B. G., Orho-Melander, M., Packard, C. J., Padmanabhan, S., Palmas, W., Polasek, O., Porteous, D. J., Prentice, A. M., Province, M. A., Relton, C. L., Rice, K., Ridker, P. M., Rolandsson, O., Rosendaal, F. R., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sattar, N., H-H Sheu, W., Smith, B. H., Soranzo, N., Spector, T. D., Starr, J., Sebert, S., Taylor, K. D., Lakka, T. A., Timpson, N. J., Tobin, M. D., van der Harst, P., van der Meer, P., Ramachandran, V. S., Verweij, N., Virtamo, J., Völker, U., Weir, D. R., Zeggini, E., Charchar, F. J., Wareham, N. J., Langenberg, C., Tomaszewski, M., Butterworth, A. S., Caulfield, M., Danesh, J., Edwards, T. L., Holm, H., Hung, A. M., Lindgren, C. M., Liu, C., Manning, A. K., Morris, A. P., Morrison, A. C., O'Donnell, C. J., Psaty, B. M., Saleheen, D., Stefansson, K., Boerwinkle, E., Chasman, D. I., Levy, D., Newton-Cheh, C. H., Munroe, P. B. & Howson, J. M. M., 23 Nov 2020, In: Nature Genetics.

    Research output: Contribution to journalArticlepeer-review

  • Loss‐of‐function mutations in the ALPL gene presenting with adult onset osteoporosis and low serum concentrations of total alkaline phosphatase

    Alonso, N., Larraz‐Prieto, B., Berg, K., Lambert, Z., Redmond, P., Harris, S. E., Deary, I. J., Pugh, C., Prendergast, J. & Ralston, S. H., 8 Apr 2020, In: Journal of Bone and Mineral Research. 35, 4, p. 657-661 4 p.

    Research output: Contribution to journalArticlepeer-review

    Open Access
    File
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