Sarah Harris

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Sarah Harris

DR

 https://orcid.org/0000-0002-4941-5106

Personal profile

Research Interests

My major research interest is in determining the genetic and epigenetic contribution to non-pathological age-related cognitive decline. I am interested in determining the type, number and specific genetic variants and proteins involved. I am also investigating genetic and epigenetic influences on the life-long trait of cognitive ability and personality traits and the influence of telomere length change, gene expression levels, protein levels and metabolites on cognitive and physical ageing. These studies are being performed using genomic, epigenomic, transcriptomic, proteomic, metabolomic, cognitive, physical and personality data from surviving members of the Scottish Mental Surveys of 1932 and 1947, on whom there are mental ability scores available at the age of 11 years, and extensive, cognitive, personality, physical, social and biochemical data available from later life. I am also involved with several national and international collaborations, giving me access to data from numerous other cohorts with similar data including CHARGE and UK Biobank. My main skills are in the identification of genes and biological pathways based on experimental biology and bioinformatics, genotyping methodologies, and omic-phenotype statistical modelling, using software such as R, SPSS, PLINK and Mach2qtl.

Teaching

MSc in Quantitative Genetics and Genome Analysis

 

Qualifications

1999 PhD (Expression and functional analysis of DMAHP/SIX5) University of Glasgow.

1994  BSc (Hons) Biological Sciences (Genetics) IIi, University of Leicester.

Administrative Roles

I am responsible for maintaining the genetic information in the Lothian Birth Cohort of 1921 and the Lothian Birth Cohort of 1936 databases. I coordinate genetic studies within the Lothian Birth Cohorts group. I am responsible for all biological samples relating to the Lothian Birth Cohorts of 1921 and 1936.

Education/Academic qualification

Doctor of Philosophy (PhD), Expression and functional analysis of DMAHP/SIX5, University of Glasgow

Award Date: 1 Jan 1999

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Collaborations and top research areas from the last five years

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  • Effect sizes of APOE e4 on the same general cognitive ability test taken by the same people from age 11 to age 90: The Lothian Birth Cohorts 1921 and 1936

    Deary, I. J., Harris, S. E., Russ, T. C., Cox, S. R. & Corley, J., 6 Oct 2025, (E-pub ahead of print) In: Molecular Psychiatry. 12 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • A methylome-wide association study of major depression with out-of-sample case-control classification and trans-ancestry comparison

    Shen, X., Barbu, M., Caramaschi, D., Arathimos, R., Czamara, D., David, F. S., Dearman, A., Dilkes, E., Herrera-Rivero, M., Huider, F., Kuhn, L., Lu, K.-C., Palviainen, T., Schowe, A. M., Shireby, G., Weihs, A., Wong, C. C. Y., Davyson, E., Casey, H. & Adams, M. J. & 60 others, Allgaier, A.-K., Barber, M., Burrage, J., Caspi, A., Costeira, R., Dunn, E. C., Feldmann, L., Frank, J., Freisleder, F. J., Gadd, D. A., Greimel, E., Hannon, E., Harris, S. E., Homuth, G., Howard, D. M., Iurato, S., Korhonen, T., Lu, T.-P., Martin, N. G., Martins, J., McDermott, E., Meinert, S., Navarro, P., Ollikainen, M., Pehl, V., Piechaczek, C., Scherff, A. D., Stein, F., Streit, F., Teumer, A., Volzke, H., van Dongen, J., Walker, R. M., Yusupov, N., Arseneault, L., Bell, J. T., Berger, K., Binder, E., Boomsma, D. I., Cox, S. R., Dannlowski, U., Evans, K. L., Fisher, H. L., Forstner, A. J., Grabe, H. J., Kaprio, J., Kircher, T., Kopf-Beck, J., Kumari, M., Kuo, P.-H., Li, Q. S., Moffitt, T. E., Mulcahy, H., Murphy, T. M., Schulte-Korne, G., Mill, J., Lewis, C. M., van Dongen, J., Wray, N. R. & Mcintosh, A. M., Oct 2025, In: Nature Mental Health. 3, 10, p. 1152-1167 19 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • A large-scale genome-wide study of gene-sleep duration interactions for blood pressure in 811,405 individuals from diverse populations

    Nagarajan, P., Winkler, T. W., Bentley, A. R., Miller, C. L., Kraja, A. T., Schwander, K., Lee, S., Wang, W., Brown, M. R., Morrison, J. L., Giri, A., O'Connell, J. R., Bartz, T. M., de Las Fuentes, L., Gudmundsdottir, V., Guo, X., Harris, S. E., Huang, Z., Kals, M. & Kho, M. & 143 others, Lefevre, C., Luan, J., Lyytikäinen, L.-P., Mangino, M., Milaneschi, Y., Palmer, N. D., Rao, V., Rauramaa, R., Shen, B., Stadler, S., Sun, Q., Tang, J., Thériault, S., van der Graaf, A., van der Most, P. J., Wang, Y., Weiss, S., Westerman, K. E., Yang, Q., Yasuharu, T., Zhao, W., Zhu, W., Altschul, D., Ansari, M. A. Y., Anugu, P., Argoty-Pantoja, A. D., Arzt, M., Aschard, H., Attia, J. R., Bazzanno, L., Breyer, M. A., Brody, J. A., Cade, B. E., Chen, H.-H., Chen, Y.-D. I., Chen, Z., de Vries, P. S., Dimitrov, L. M., Do, A., Du, J., Dupont, C. T., Edwards, T. L., Evans, M. K., Faquih, T., Felix, S. B., Fisher-Hoch, S. P., Floyd, J. S., Graff, M., Gu, C., Gu, D., Hairston, K. G., Hanley, A. J., Heid, I. M., Heikkinen, S., Highland, H. M., Hood, M. M., Kähönen, M., Karvonen-Gutierrez, C. A., Kawaguchi, T., Kazuya, S., Kelly, T. N., Komulainen, P., Levy, D., Lin, H. J., Liu, P. Y., Marques-Vidal, P., McCormick, J. B., Mei, H., Meigs, J. B., Menni, C., Nam, K., Nolte, I. M., Pacheco, N. L., Petty, L. E., Polikowsky, H. G., Province, M. A., Psaty, B. M., Raffield, L. M., Raitakari, O. T., Rich, S. S., Riha, R. L., Risch, L., Risch, M., Ruiz-Narvaez, E. A., Scott, R. J., Sitlani, C. M., Smith, J. A., Sofer, T., Teder-Laving, M., Völker, U., Vollenweider, P., Wang, G., Willems van Dijk, K., Wilson, O. D., Xia, R., Yao, J., Young, K. L., Zhang, R., Zhu, X., Below, J. E., Böger, C. A., Conen, D., Cox, S. R., Dörr, M., Feitosa, M. F., Fox, E. R., Franceschini, N., Gharib, S. A., Gudnason, V., Harlow, S. D., He, J., Holliday, E. G., Kutalik, Z., Lakka, T. A., Lawlor, D. A., Lee, S., Lehtimäki, T., Li, C., Liu, C.-T., Mägi, R., Matsuda, F., Morrison, A. C., Penninx, B. W., Peyser, P. A., Rotter, J. I., Snieder, H., Spector, T. D., Wagenknecht, L. E., Wareham, N. J., Zonderman, A. B., North, K. E., Fornage, M., Million Veteran Program, Hung, A. M., Manning, A. K., Gauderman, J., Chen, H., Munroe, P. B., Rao, D. C., van Heemst, D., Redline, S., Noordam, R. & Wang, H., Aug 2025, In: Molecular Psychiatry. 30, 8, p. 3660-3672 13 p.

    Research output: Contribution to journal › Article › peer-review

  • A blood- and brain-based EWAS of smoking

    Chybowska, A. D., Bernabeu, E., Yousefi, P., Suderman, M., Hillary, R. F., Clark, R., MacGillivray, L., Murphy, L., Harris, S. E., Corley, J., Campbell, A., Spires-Jones, T. L., McCartney, D. L., Cox, S. R., Price, J. F., Evans, K. L. & Marioni, R. E., 4 Apr 2025, In: Nature Communications. 16, 1, 3210 .

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File

  • Development and validation of an epigenetic signature of allostatic load

    Chamberlain, J. D., Ackermann, D., Bochud, M., Booth, T., Chapatte, L., Corley, J., Cox, S. R., Harris, S. E., Kinnaer, C., Juster, R.-P., Locatelli, I., Nanchen, D., Ponte, B., Pruijm, M., Pradervand, S., Shiels, P. G., Stringhini, S., Nusslé, S. & Gonseth-Nusslé, S., Apr 2025, In: Bioscience reports. 45, 4, p. 247–262 16 p., BSR20241663.

    Research output: Contribution to journal › Article › peer-review

    Open Access
    File
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