Sarah Harris

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Sarah Harris

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 https://orcid.org/0000-0002-4941-5106
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  • 2024

    DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain

    Gadd, D., Smith, H., Mullin, D., Chybowska, O., Hillary, R., Kimenai, D. M., Bernabeu, E., Cheng, Y., Fawns-Ritchie, C., Campbell, A., Page, D., Taylor, A., Corley, J., Valdés Hernández, M. C., Muñoz Maniega, S., Bastin, M. E., Wardlaw, J. M., Walker, R., Evans, K. L., McIntosh, A. M., & 8 othersHayward, C., Russ, T. C., Harris, S. E., Welsh, P., Sattar, N., Cox, S. R., McCartney, D. L. & Marioni, R. E., 10 Sept 2024, In: Nature. 16, 124.

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  • Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

    Chen, Z., Guo, X., Tao, R., Huyghe, J. R., Law, P. J., Fernandez-Rozadilla, C., Ping, J., Jia, G., Long, J., Li, C., Shen, Q., Xie, Y., Timofeeva, M. N., Thomas, M., Schmit, S. L., Díez-Obrero, V., Devall, M., Moratalla-Navarro, F., Fernandez-Tajes, J., Palles, C., & 185 othersSherwood, K., Briggs, S. E. W., Svinti, V., Donnelly, K., Farrington, S. M., Blackmur, J., Vaughan-Shaw, P. G., Shu, X-O., Lu, Y., Broderick, P., Studd, J., Harrison, T. A., Conti, D. V., Schumacher, F. R., Melas, M., Rennert, G., Obón-Santacana, M., Martín-Sánchez, V., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S-S., Shin, M-H., Shin, A., Ahn, Y-O., Kim, D-H., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y-T., Jia, W-H., Hopper, J. L., Jenkins, M. A., Win, A. K., Pai, R. K., Figueiredo, J. C., Haile, R. W., Gallinger, S., Woods, M. O., Newcomb, P. A., Duggan, D., Cheadle, J. P., Kaplan, R., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, J-P., Jousilahti, P., Knekt, P., Aaltonen, L. A., Rissanen, H., Pukkala, E., Eriksson, J. G., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-Sinisalo, L., Männistö, S., Albanes, D., Weinstein, S. J., Ruiz-Narvaez, E., Palmer, J. R., Buchanan, D. D., Platz, E. A., Visvanathan, K., Ulrich, C. M., Siegel, E., Brezina, S., Gsur, A., Campbell, P. T., Chang-Claude, J., Hoffmeister, M., Brenner, H., Slattery, M. L., Potter, J. D., Tsilidis, K. K., Schulze, M. B., Gunter, M. J., Murphy, N., Castells, A., Castellví-Bel, S., Moreira, L., Arndt, V., Shcherbina, A., Bishop, D. T., Giles, G. G., Southey, M. C., Idos, G. E., Mcdonnell, K. J., Abu-Ful, Z., Greenson, J. K., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y-R., Steinfelder, R., Keku, T. O., Van guelpen, B., Hudson, T. J., Hampel, H., Pearlman, R., Berndt, S. I., Hayes, R. B., Martinez, M. E., Thomas, S. S., Pharoah, P. D. P., Larsson, S. C., Yen, Y., Lenz, H-J., White, E., Li, L., Doheny, K. F., Pugh, E., Shelford, T., Chan, A. T., Cruz-Correa, M., Lindblom, A., Hunter, D. J., Joshi, A. D., Schafmayer, C., Scacheri, P. C., Kundaje, A., Schoen, R. E., Hampe, J., Stadler, Z. K., Vodicka, P., Vodickova, L., Vymetalkova, V., Edlund, C. K., Gauderman, W. J., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S. J., Van duijnhoven, F., Feskens, E. J. M., Sakoda, L. C., Gago-Dominguez, M., Wolk, A., Pardini, B., Fitzgerald, L. M., Lee, S. C., Ogino, S., Bien, S. A., Kooperberg, C., Li, C. I., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Yamaji, T., Sawada, N., Iwasaki, M., Le marchand, L., Wu, A. H., Qu, C., Mcneil, C. E., Coetzee, G., Hayward, C., Deary, I. J., Harris, S. E., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Lau, K. S., Zhao, H., Hsu, L., Cai, Q., Dunlop, M. G., Gruber, S. B., Houlston, R. S., Moreno, V., Casey, G., Peters, U., Tomlinson, I. & Zheng, W., 26 Apr 2024, In: Nature Communications. 15, 1, 3557.

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  • Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health

    Smith, H. M., Moodie, J. E., Monterrubio-Gómez, K., Gadd, D. A., Hillary, R. F., Chybowska, A. D., Mccartney, D. L., Campbell, A., Redmond, P., Page, D., Taylor, A., Corley, J., Harris, S. E., Valdés hernández, M., Muñoz maniega, S., Bastin, M. E., Wardlaw, J. M., Deary, I. J., Boardman, J. P., Mullin, D. S., & 3 othersRuss, T. C., Cox, S. R. & Marioni, R. E., 25 Mar 2024, In: Clinical Epigenetics. 16, 1

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  • General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning

    Moodie, J. E., Harris, S. E., Harris, M. A., Buchanan, C. R., Davies, G., Taylor, A., Redmond, P., Liewald, D. C. M., Valdés Hernández, M. D. C., Shenkin, S., Russ, T. C., Muñoz Maniega, S., Luciano, M., Corley, J., Stolicyn, A., Shen, X., Steele, D., Waiter, G., Sandu, A-L., Bastin, M. E., & 6 othersWardlaw, J. M., McIntosh, A., Whalley, H., Tucker-Drob, E. M., Deary, I. J. & Cox, S. R., Mar 2024, In: Human Brain Mapping. 45, 4, 21 p., e26641.

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  • Genome wide association study of Preserved Ratio Impaired Spirometry (PRISm)

    Higbee, D. H., Lirio, A., Hamilton, F., Granell, R., Wyss, A. B., London, S. J., Bartz, T. M., Gharib, S. A., Cho, M. H., Wan, E., Silverman, E., Crapo, J. D., Lominchar, J., Hansen, T., Grarup, N., Dantoft, T., Kårhus, L., Linneberg, A., O'Connor, G. T., Dupuis, J., & 25 othersXu, H., De Vries, M. M., Hu, X., Rich, S. S., Barr, R. G., Manichaikul, A., Wijnant, S. R. A., Brusselle, G. G., Lahouse, L., Li, X., Hernández Cordero, A. I., Obeidat, M., D Sin, D., Harris, S., Redmond, P., Taylor, A., Cox, S. R., Williams, A. T., Shrine, N., John, C., Guyatt, A. L., Hall, I. P., Davey Smith, G., Tobin, M. D. & Dodd, J. W., Jan 2024, In: European Respiratory Journal. 63, 12 p., 2300337 .

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  • Copy-number variants and polygenic risk for intelligence confer risk for autism spectrum disorder irrespective of their effects on cognitive ability

    Schmilovich, Z., Bourque, V. R., Douard, E., Huguet, G., Poulain, C., Ross, J. P., Alipour, P., Castonguay, C. É., Younis, N., Jean-Louis, M., Saci, Z., Pausova, Z., Paus, T., Schuman, G., Porteous, D., Davies, G., Redmond, P., Harris, S. E., Deary, I. J., Whalley, H., & 4 othersHayward, C., Dion, P. A., Jacquemont, S. & Rouleau, G. A., 2024, In: Frontiers in Psychiatry. 15, 1369767.

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  • Genetic control of DNA methylation is largely shared across European and East Asian populations

    Hatton, A., Cheng, F-F., Lin, T., Shen, R-J., Chen, J., Zheng, Z., Qu, J., Lyu, F., Harris, S. E., Cox, S. R., Jin, Z-B., Martin, N., Fan, D., Montgomery, G., Yang, J., Wray, N., Marioni, R. E., Visscher, P. & Mcrae, A., 2024, In: Nature Communications. 15, 1

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  • Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications

    Sterenborg, R. B. T. M., Steinbrenner, I., Li, Y., Bujnis, M. N., Naito, T., Marouli, E., Galesloot, T. E., Babajide, O., Andreasen, L., Astrup, A., Åsvold, B. O., Bandinelli, S., Beekman, M., Beilby, J. P., Bork-Jensen, J., Boutin, T., Brody, J. A., Brown, S. J., Brumpton, B., Campbell, P. J., & 123 othersCappola, A. R., Ceresini, G., Chaker, L., Chasman, D. I., Concas, M. P., Coutinho de Almeida, R., Cross, S. M., Cucca, F., Deary, I. J., Kjaergaard, A. D., Echouffo Tcheugui, J. B., Ellervik, C., Eriksson, J. G., Ferrucci, L., Freudenberg, J., Fuchsberger, C., Gieger, C., Giulianini, F., Gögele, M., Graham, S. E., Grarup, N., Gunjača, I., Hansen, T., Harding, B. N., Harris, S. E., Haunsø, S., Hayward, C., Hui, J., Ittermann, T., Jukema, J. W., Kajantie, E., Kanters, J. K., Kårhus, L. L., Kiemeney, L. A. L. M., Kloppenburg, M., Kühnel, B., Lahti, J., Langenberg, C., Lapauw, B., Leese, G., Li, S., Liewald, D. C. M., Linneberg, A., Lominchar, J. V. T., Luan, J., Martin, N. G., Matana, A., Meima, M. E., Meitinger, T., Meulenbelt, I., Mitchell, B. D., Møllehave, L. T., Mora, S., Naitza, S., Nauck, M., Netea-Maier, R. T., Noordam, R., Nursyifa, C., Okada, Y., Onano, S., Papadopoulou, A., Palmer, C. N. A., Pattaro, C., Pedersen, O., Peters, A., Pietzner, M., Polašek, O., Pramstaller, P. P., Psaty, B. M., Punda, A., Ray, D., Redmond, P., Richards, J. B., Ridker, P. M., Russ, T. C., Ryan, K. A., Olesen, M. S., Schultheiss, U. T., Selvin, E., Siddiqui, M. K., Sidore, C., Slagboom, P. E., Sørensen, T. I. A., Soto-Pedre, E., Spector, T. D., Spedicati, B., Srinivasan, S., Starr, J. M., Stott, D. J., Tanaka, T., Torlak, V., Trompet, S., Tuhkanen, J., Uitterlinden, A. G., van den Akker, E. B., van den Eynde, T., van der Klauw, M. M., van Heemst, D., Verroken, C., Visser, W. E., Vojinovic, D., Völzke, H., Waldenberger, M., Walsh, J. P., Wareham, N. J., Weiss, S., Willer, C. J., Wilson, S. G., Wolffenbuttel, B. H. R., Wouters, H. J. C. M., Wright, M. J., Yang, Q., Zemunik, T., Zhou, W., Zhu, G., Zöllner, S., Smit, J. W. A., Peeters, R. P., Köttgen, A., Teumer, A., Medici, M., DiscovEHR, GHS. & Center, R. G., 2024, In: Nature Communications. 15, 1, 18 p., 888.

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  • 2023

    Integration of datasets for individual prediction of DNA methylation-based biomarkers

    Merzbacher, C., Ryan, B., Goldsborough, T., Hillary, R. F., Campbell, A., Murphy, L., McIntosh, A. M., Liewald, D., Harris, S. E., Mcrae, A. F., Cox, S. R., Cannings, T. I., Vallejos, C. A., McCartney, D. L. & Marioni, R. E., 5 Dec 2023, In: Genome Biology. 24, 1, p. 278

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  • Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci

    de las Fuentes, L., Schwander, K. L., Brown, M. R., Bentley, A. R., Winkler, T. W., Sung, Y. J., Munroe, P. B., Miller, C. L., Aschard, H., Aslibekyan, S., Bartz, T. M., Bielak, L. F., Chai, J. F., Cheng, C-Y., Dorajoo, R., Feitosa, M. F., Guo, X., Hartwig, F. P., Horimoto, A., Kolčić, I., & 178 othersLim, E., Liu, Y., Manning, A. K., Marten, J., Musani, S. K., Noordam, R., Padmanabhan, S., Rankinen, T., Richard, M. A., Ridker, P. M., Smith, A. V., Vojinovic, D., Zonderman, A. B., Alver, M., Boissel, M., Christensen, K., Freedman, B. I., Gao, C., Giulianini, F., Harris, S. E., He, M., Hsu, F-C., Kühnel, B., Laguzzi, F., Li, X., Lyytikäinen, L-P., Nolte, I. M., Poveda, A., Rauramaa, R., Riaz, M., Robino, A., Sofer, T., Takeuchi, F., Tayo, B. O., van der Most, P. J., Verweij, N., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Zhan, Y., Amin, N., Arking, D. E., Ballantyne, C., Boerwinkle, E., Brody, J. A., Broeckel, U., Campbell, A., Canouil, M., Chai, X., Chen, Y-D. I., Chen, X., Chitrala, K. N., Concas, M. P., de Faire, U., de Mutsert, R., de Silva, H. J., de Vries, P. S., Do, A., Faul, J. D., Fisher, V., Floyd, J. S., Forrester, T., Friedlander, Y., Girotto, G., Gu, C. C., Hallmans, G., Heikkinen, S., Heng, C-K., Homuth, G., Hunt, S., Ikram, M. A., Jacobs Jr, D. R., Kavousi, M., Khor, C. C., Kilpeläinen, T. O., Koh, W-P., Komulainen, P., Langefeld, C. D., Liang, J., Liu, K., Liu, J., Lohman, K., Mägi, R., Manichaikul, A. W., McKenzie, C. A., Meitinger, T., Milaneschi, Y., Nauck, M., Nelson, C. P., O’Connell, J. R., Palmer, N. D., Pereira, A. C., Perls, T., Peters, A., Polašek, O., Raitakari, O. T., Rice, K., Rice, T. K., Rich, S. S., Sabanayagam, C., Schreiner, P. J., Shu, X-O., Sidney, S., Sims, M., Smith, J. A., Starr, J. M., Strauch, K., Tai, E. S., Taylor, K. D., Tsai, M. Y., Uitterlinden, A. G., van Heemst, D., Waldenberger, M., Wang, Y-X., Wei, W-B., Wilson, G., Xuan, D., Yao, J., Yu, C., Yuan, J-M., Zhao, W., Becker, D. M., Bonnefond, A., Bowden, D. W., Cooper, R. S., Deary, I. J., Divers, J., Esko, T., Franks, P. W., Froguel, P., Gieger, C., Jonas, J. B., Kato, N., Lakka, T. A., Leander, K., Lehtimäki, T., Magnusson, P. K. E., North, K. E., Ntalla, I., Penninx, B., Samani, N. J., Snieder, H., Spedicati, B., van der Harst, P., Völzke, H., Wagenknecht, L. E., Weir, D. R., Wojczynski, M. K., Wu, T., Zheng, W., Zhu, X., Bouchard, C., Chasman, D. I., Evans, M. K., Fox, E. R., Gudnason, V., Hayward, C., Horta, B. L., Kardia, S. L. R., Krieger, J. E., Mook-Kanamori, D. O., Peyser, P. A., Province, M. M., Psaty, B. M., Rudan, I., Sim, X., Smith, B. H., van Dam, R. M., van Duijn, C. M., Wong, T. Y., Arnett, D. K., Rao, D. C., Gauderman, J., Liu, C-T., Morrison, A. C., Rotter, J. I. & Fornage, M., Nov 2023, In: Frontiers in Genetics. 14, 16 p., 1235337.

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  • Identification of circulating proteins associated with general cognitive function among middle-aged and older adults final

    Tin, A., Fohner, A. E., Yang, Q., Brody, J. A., Davies, G., Yao, J., Liu, D., Caro, I., Lindbohm, J. V., Duggan, M. R., Meirelles, O., Harris, S. E., Gudmundsdottir, V., Taylor, A. M., Henry, A., Beiser, A. S., Shojaie, A., Coors, A., Fitzpatrick, A. L., Langenberg, C., & 37 othersSatizabal, C. L., Sitlani, C. M., Wheeler, E., Tucker-Drob, E. M., Bressler, J., Coresh, J., Bis, J. C., Candia, J., Jennings, L. L., Pietzner, M., Lathrop, M., Lopez, O. L., Redmond, P., Gerszten, R. E., Rich, S. S., Heckbert, S. R., Austin, T. R., Hughes, T. M., Tanaka, T., Emilsson, V., Vasan, R. S., Guo, X., Zhu, Y., Tzourio, C., Rotter, J. I., Walker, K. A., Ferrucci, L., Kivimäki, M., Breteler, M. M. B., Cox, S. R., Debette, S., Mosley, T. H., Gudnason, V. G., Launer, L. J., Psaty, B. M., Seshadri, S. & Fornage, M., Nov 2023, In: Communications Biology. 6, 14 p., 1117.

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  • Epigenome-wide association study reveals CpG sites associated with thyroid function and regulatory effects on KLF9

    Weihs, A., Chaker, L., Martin, T. C., Braun, K. V. E., Campbell, P. J., Cox, S. R., Fornage, M., Gieger, C., Grabe, H. J., Grallert, H., Harris, S., Kuhnel, B., Marioni, R. E., Martin, N., McCartney, D. L., Mcrae, A. F., Meisinger, C., van Meurs, J. B. J., Nano, J., Nauck, M., & 21 othersPeters, A., Prokisch, H., Roden, M., Selvin, E., Beekman, M., van Heemst, D., Slagboom, P. E., Swenson, B. R., Tin, A., Tsai, P-C., Uitterlinden, A. G., Visser, W. E., Völzke, H., Waldenberger, M., Walsh, J. P., Köttgen, A., Wilson, S. G., Peeters, R. P., Bell, J. T., Medici, M. & Teumer, A., 16 Mar 2023, In: Thyroid Journal Program. 33, 3, p. 301–311

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  • Refining epigenetic prediction of chronological and biological age

    Bernabeu, E., McCartney, D. L., Gadd, D., Hillary, R., Lu, A. T., Murphy, L., Wrobel, N., Campbell, A., Harris, S. E., Liewald, D. C., Hayward, C., Sudlow, C. L. M., Cox, S. R., Evans, K. L., Horvath, S., McIntosh, A. M., Robinson, M. R., Vallejos, C. A. & Marioni, R. E., 28 Feb 2023, In: Genome Medicine. 15, 1, 12.

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  • DNA methylation analysis is used to identify novel genetic loci associated with circulating fibrinogen levels in blood

    Hahn, J., Bressler, J., Domingo-Relloso, A., Chen, M., Mccartney, D. L., Teumer, A., Van dongen, J., Kleber, M. E., Aïssi, D., Swenson, B. R., Yao, J., Zhao, W., Huang, J., Xia, Y., Brown, M. R., Costeira, R., De geus, E. J. C., Delgado, G. E., Dobson, D. A., Elliott, P., & 38 othersGrabe, H. J., Guo, X., Harris, S. E., Huffman, J. E., Kardia, S. L. R., Liu, Y., Lorkowski, S., Marioni, R. E., Nauck, M., Ratliff, S. M., Sabater-Lleal, M., Spector, T. D., Suchon, P., Taylor, K. D., Thibord, F., Trégouët, D., Wiggins, K. L., Willemsen, G., Bell, J. T., Boomsma, D. I., Cole, S. A., Cox, S. R., Dehghan, A., Greinacher, A., Haack, K., März, W., Morange, P., Rotter, J. I., Sotoodehnia, N., Tellez-Plaza, M., Navas-Acien, A., Smith, J. A., Johnson, A. D., Fornage, M., Smith, N. L., Wolberg, A. S., Morrison, A. C. & De vries, P. S., 28 Jan 2023, (E-pub ahead of print) In: Journal of Thrombosis and Haemostasis.

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  • 2022

    Synaptic resilience is associated with maintained cognition during ageing

    King, D., Holt, K., Toombs, J., He, X., Dando, O., Okely, J., Rose, J., Gunn, C., Correia, A., Montero, C., Tulloch, J., Lamont, D., Taylor, A., Harris, S., Redmond, P., Cox, S. R., Henstridge, C., Deary, I. J., Smith, C. & Spires-Jones, T., 22 Dec 2022, (E-pub ahead of print) In: Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

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  • Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

    Fernandez-rozadilla, C., Timofeeva, M., Chen, Z., Law, P., Thomas, M., Schmit, S., Díez-obrero, V., Hsu, L., Fernandez-tajes, J., Palles, C., Sherwood, K., Briggs, S., Svinti, V., Donnelly, K., Farrington, S., Blackmur, J., Vaughan-shaw, P., Shu, X., Long, J., Cai, Q., & 190 othersGuo, X., Lu, Y., Broderick, P., Studd, J., Huyghe, J., Harrison, T., Conti, D., Dampier, C., Devall, M., Schumacher, F., Melas, M., Rennert, G., Obón-santacana, M., Martín-sánchez, V., Moratalla-navarro, F., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S., Shin, M., Shin, A., Ahn, Y., Kim, D., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y., Jia, W., Hopper, J., Jenkins, M., Win, A. K., Pai, R., Figueiredo, J., Haile, R., Gallinger, S., Woods, M., Newcomb, P., Duggan, D., Cheadle, J., Kaplan, R., Maughan, T., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, L., Jousilahti, P., Knekt, P., Aaltonen, L., Rissanen, H., Pukkala, E., Eriksson, J., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-sinisalo, L., Zanke, B., Männistö, S., Albanes, D., Weinstein, S., Ruiz-narvaez, E., Palmer, J., Buchanan, D., Platz, E., Visvanathan, K., Ulrich, C., Siegel, E., Brezina, S., Gsur, A., Campbell, P., Chang-claude, J., Hoffmeister, M., Brenner, H., Slattery, M., Potter, J., Tsilidis, K., Schulze, M., Gunter, M., Murphy, N., Castells, A., Castellví-bel, S., Moreira, L., Arndt, V., Shcherbina, A., Stern, M., Pardamean, B., Bishop, T., Giles, G., Southey, M., Idos, G., Mcdonnell, K., Abu-ful, Z., Greenson, J., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y., Steinfelder, R., Keku, T., Van Guelpen, B., Hudson, T., Hampel, H., Pearlman, R., Berndt, S., Hayes, R., Martinez, M. E., Thomas, S., Corley, D., Pharoah, P., Larsson, S., Yen, Y., Lenz, H., White, E., Li, L., Doheny, K., Pugh, E., Shelford, T., Chan, A., Cruz-correa, M., Lindblom, A., Hunter, D., Joshi, A., Schafmayer, C., Scacheri, P., Kundaje, A., Nickerson, D., Schoen, R., Hampe, J., Stadler, Z., Vodicka, P., Vodickova, L., Vymetalkova, V., Papadopoulos, N., Edlund, C., Gauderman, W., Thomas, D., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S., Van Duijnhoven, F., Feskens, E., Sakoda, L., Gago-dominguez, M., Wolk, A., Naccarati, A., Pardini, B., Fitzgerald, L., Lee, S. C., Ogino, S., Bien, S., Kooperberg, C., Li, C., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Tangen, C., Mardis, E., Yamaji, T., Sawada, N., Iwasaki, M., Haiman, C., Le Marchand, L., Wu, A., Qu, C., Mcneil, C., Coetzee, G., Hayward, C., Deary, I., Harris, S., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Moreno, V., Casey, G., Gruber, S., Tomlinson, I., Zheng, W., Dunlop, M., Houlston, R. & Peters, U., 20 Dec 2022, (E-pub ahead of print) In: Nature Genetics.

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  • Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors: The Lothian Birth Cohort 1936

    Corley, J., Conte, F., Harris, S. E., Taylor, A. M., Redmond, P., Russ, T. C., Deary, I. J. & Cox, S. R., 8 Dec 2022, (E-pub ahead of print) In: Molecular Psychiatry.

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  • Blood DNA methylation signatures of lifestyle exposures: Tobacco and alcohol consumption

    Chamberlain, J. D., Nusslé, S., Chapatte, L., Kinnaer, C., Petrovic, D., Pradervand, S., Bochud, M., Harris, S. E., Corley, J., Cox, S. R. & Gonseth Nusslé, S., 28 Nov 2022, In: Clinical Epigenetics. 14, 155.

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  • Life-course exposure to air pollution and biological ageing in the Lothian Birth Cohort 1936

    Baranyi, G., Deary, I. J., McCartney, D. L., Harris, S., Shortt, N., Reis, S., Russ, T., Ward Thompson, C., Vieno, M., Cox, S. R. & Pearce, J., 1 Nov 2022, In: Environment International. 169, 107501.

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  • Local CpG density affects the trajectory and variance of age-associated DNA methylation changes

    Higham, J., Kerr, L., Zhang, Q., Walker, R., Harris, S., Howard, D. M., Hawkins, E., Sandu, A., Douglas Steele, J., Waiter, G. D., Murray, A. D., Evans, K. L., McIntosh, A. M., Visscher, P. M., Deary, I. J., Cox, S. R. & Sproul, D., 17 Oct 2022, In: Genome Biology.

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  • Pulmonary function and blood DNA methylation: A multi-ancestry epigenome-wide association meta-analysis

    BIOS consortium, GoDMC, 1 Aug 2022, In: American Journal of Respiratory and Critical Care Medicine. 206, 3, p. 321-336

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  • Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate

    Mishra, A., Duplaà, C., Vojinovic, D., Suzuki, H., Sargurupremraj, M., Zilhão, N. R., Li, S., Bartz, T. M., Jian, X., Zhao, W., Hofer, E., Wittfeld, K., Harris, S. E., van der Auwera-Palitschka, S., Luciano, M., Bis, J. C., Adams, H. H. H., Satizabal, C. L., Gottesman, R. F., Gampawar, P. G., & 47 othersBülow, R., Weiss, S., Yu, M., Bastin, M. E., Lopez, O. L., Vernooij, M. W., Beiser, A. S., Völker, U., Kacprowski, T., Soumare, A., Smith, J. A., Knopman, D. S., Morris, Z., Zhu, Y., Rotter, J. I., Dufouil, C., Valdés Hernández, M., Muñoz Maniega, S., Lathrop, M., Boerwinkle, E., Schmidt, R., Ihara, M., Mazoyer, B., Yang, Q., Joutel, A., Tournier-Lasserve, E., Launer, L. J., Deary, I. J., Mosley, T. H., Amouyel, P., DeCarli, C. S., Psaty, B. M., Tzourio, C., Kardia, S. L. R., Grabe, H. J., Teumer, A., van Duijn, C. M., Schmidt, H., Wardlaw, J. M., Ikram, M. A., Fornage, M., Gudnason, V., Seshadri, S., Matthews, P. M., Longstreth, W. T., Couffinhal, T. & Debette, S., 2 May 2022, (E-pub ahead of print) In: Brain. awab432.

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  • A comparison of blood and brain-derived ageing and inflammation-related DNA methylation signatures and their association with microglial burdens

    Stevenson, A., McCartney, D., Gadd, D., Shireby, G., Hillary, R., King, D., Tzioras, M., Wrobel, N., Mccafferty, S., Murphy, L., McColl, B. W., Redmond, P., Taylor, A., Harris, S., Russ, T., McIntosh, A. M., Mill, J., Smith, C., Deary, I. J., Cox, S. R., & 2 othersMarioni, R. E. & Spires-Jones, T., 6 Apr 2022, (E-pub ahead of print) In: European Journal of Neuroscience.

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Circulating metabolome and white matter hyperintensities in women and men

    Sliz, E., Shin, J., Ahmad, S., Williams, D. M., Frenzel, S., Gauß, F., Harris, S. E., Henning, A., Valdes Hernandez, M. D. C., Hu, Y., Jiménez, B., Sargurupremraj, M., Sudre, C., Wang, R., Wittfeld, K., Yang, Q., Wardlaw, J. M., Völzke, H., Vernooij, M. W., Schott, J. M., & 19 othersRichards, M., Proitsi, P., Nauck, M., Lewis, M. R., Launer, L., Hosten, N., Grabe, H. J., Ghanbari, M., Deary, I. J., Cox, S. R., Chaturvedi, N., Barnes, J., Rotter, J. I., Debette, S., Ikram, M. A., Fornage, M., Paus, T., Seshadri, S. & Pausova, Z., 5 Apr 2022, In: Circulation. 145, 14, p. 1040-1052

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  • DNA methylome-wide association study of genetic risk for depression implicates antigen processing and immune responses

    Shen, X., Caramaschi, D., Adams, M. J., Walker, R. M., Min, J. L., Kwong, A., Hemani, G., Barbu, M. C., Whalley, H. C., Harris, S. E., Deary, I. J., Morris, S. W., Cox, S. R., Relton, C. L., Marioni, R. E., Evans, K. L. & Mcintosh, A. M., 31 Mar 2022, In: Genome Medicine. 14, 1

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  • Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin

    Joseph, C., Mariniello, M., Ayumi Yoshifuji, A., Schiano, G., Lake, J., Marten, J., Richmond, A., Huffman, J. E., Campbell, A., Harris, S., Troyanov, S., Cocca, M., Robino, A., Theriault, S., Eckardt, K-U., Wuttke, M., Cheng, Y., Corre, T., Kolcic, I., Black, C., & 23 othersBruat, V., Pina Concas, M., Sala, C., Aeschbacher, S., Schaefer, F., Bergmann, S., Campbell, H., Olden, M., Polasek, O., Porteous, D. J., Deary, I. J., Madore, F., Awadalla, P., Girotto, G., Ulivi, S., Conen, D., Wuehl, E., Olinger, E., Wilson, J. F., Bochud, M., Köttgen, A., Hayward, C. & Devuyst, O., 1 Mar 2022, In: Journal of the American Society of Nephrology. 33, 3, p. 511-529

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  • The genetic and epigenetic profile of serum S100β in the Lothian Birth Cohort 1936 and its relationship to Alzheimer’s disease

    A Gadd, D., I Mcgeachan, R., F Hillary, R., L Mccartney, D., E Harris, S., A Sherwood, R., Abbott, N. J., R Cox, S. & E Marioni, R., 27 Jan 2022, In: Wellcome Open Research. 6, p. 306

    Research output: Contribution to journal › Article › peer-review

    Open Access

  • Blood-based epigenome-wide analyses of cognitive abilities

    Mccartney, D. L., Hillary, R. F., Conole, E. L. S., Banos, D. T., Gadd, D. A., Walker, R. M., Nangle, C., Flaig, R., Campbell, A., Murray, A. D., Maniega, S. M., Valdés-hernández, M. D. C., Harris, M. A., Bastin, M. E., Wardlaw, J. M., Harris, S. E., Porteous, D. J., Tucker-Drob, E. M., Mcintosh, A. M., Evans, K. L., & 4 othersDeary, I. J., Cox, S. R., Robinson, M. R. & Marioni, R. E., 17 Jan 2022, In: Genome Biology. 23, 1, 26.

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  • Epigenetic scores for the circulating proteome as tools for disease prediction

    Gadd, D. A., Hillary, R. F., McCartney, D. L., Zaghlool, S. B., Stevenson, A. J., Cheng, Y., Fawns-Ritchie, C., Nangle, C., Campbell, A., Flaig, R., Harris, S. E., Walker, R. M., Shi, L., Tucker-Drob, E. M., Gieger, C., Peters, A., Waldenberger, M., Graumann, J., McRae, A. F., Deary, I. J., & 8 othersPorteous, D. J., Hayward, C., Visscher, P. M., Cox, S. R., Evans, K. L., McIntosh, A. M., Suhre, K. & Marioni, R. E., 13 Jan 2022, In: eLIFE. 11, 24 p., e71802.

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  • 2021

    Meta-analyses identify DNA methylation associated with kidney function and damage

    Schlosser, P., Tin, A., Matias-garcia, P. R., Thio, C. H. L., Joehanes, R., Liu, H., Weihs, A., Yu, Z., Hoppmann, A., Grundner-culemann, F., Min, J. L., Adeyemo, A. A., Agyemang, C., Ärnlöv, J., Aziz, N. A., Baccarelli, A., Bochud, M., Brenner, H., Breteler, M. M. B., Carmeli, C., & 94 othersChaker, L., Chambers, J. C., Cole, S. A., Coresh, J., Corre, T., Correa, A., Cox, S. R., De Klein, N., Delgado, G. E., Domingo-relloso, A., Eckardt, K., Ekici, A. B., Endlich, K., Evans, K. L., Floyd, J. S., Fornage, M., Franke, L., Fraszczyk, E., Gao, X., Gào, X., Ghanbari, M., Ghasemi, S., Gieger, C., Greenland, P., Grove, M. L., Harris, S. E., Hemani, G., Henneman, P., Herder, C., Horvath, S., Hou, L., Hurme, M. A., Hwang, S., Jarvelin, M., Kardia, S. L. R., Kasela, S., Kleber, M. E., Koenig, W., Kooner, J. S., Kramer, H., Kronenberg, F., Kühnel, B., Lehtimäki, T., Lind, L., Liu, D., Liu, Y., Lloyd-jones, D. M., Lohman, K., Lorkowski, S., Lu, A. T., Marioni, R. E., März, W., Mccartney, D. L., Meeks, K. A. C., Milani, L., Mishra, P. P., Nauck, M., Navas-acien, A., Nowak, C., Peters, A., Prokisch, H., Psaty, B. M., Raitakari, O. T., Ratliff, S. M., Reiner, A. P., Rosas, S. E., Schöttker, B., Schwartz, J., Sedaghat, S., Smith, J. A., Sotoodehnia, N., Stocker, H. R., Stringhini, S., Sundström, J., Swenson, B. R., Tellez-plaza, M., Van Meurs, J. B. J., Van Vliet-ostaptchouk, J. V., Venema, A., Verweij, N., Walker, R. M., Wielscher, M., Winkelmann, J., Wolffenbuttel, B. H. R., Zhao, W., Zheng, Y., Milani, L., Loh, M., Snieder, H., Levy, D., Waldenberger, M., Susztak, K., Köttgen, A. & Teumer, A., 9 Dec 2021, In: Nature Communications. 12, 1, 7174.

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  • DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging

    Conole, E. L. S., Stevenson, A. J., Maniega, S. M., Harris, S. E., Green, C., Valdés Hernández, M. D. C., Harris, M. A., Bastin, M. E., Wardlaw, Cbe, J. M., Deary, I. J., Miron, V. E., Whalley, H. C., Marioni, R. E. & Cox, S. R., 7 Dec 2021, In: Neurology. 97, 23, p. e2340-e2352 13 p.

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  • Creating and validating a DNA methylation-based proxy for interleukin-6

    Stevenson, A. J., Gadd, D. A., Hillary, R. F., Mccartney, D. L., Campbell, A., Walker, R. M., Evans, K. L., Harris, S. E., Spires-jones, T. L., Mcrae, A. F., Visscher, P. M., Mcintosh, A. M., Deary, I. J. & Marioni, R. E., 1 Dec 2021, In: The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. 76, 12, p. 2284-2292 9 p.

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  • Rare and low-frequency exonic variants and gene-by-smoking interactions in pulmonary function

    Yang, T., Jackson, V. E., Smith, A. V., Chen, H., Bartz, T. M., Sitlani, C. M., Psaty, B. M., Gharib, S. A., O’connor, G. T., Dupuis, J., Xu, J., Lohman, K., Liu, Y., Kritchevsky, S. B., Cassano, P. A., Flexeder, C., Gieger, C., Karrasch, S., Peters, A., Schulz, H., & 27 othersHarris, S. E., Starr, J. M., Deary, I. J., Manichaikul, A., Oelsner, E. C., Barr, R. G., Taylor, K. D., Rich, S. S., Bonten, T. N., Mook-kanamori, D. O., Noordam, R., Li-gao, R., Jarvelin, M-R., Wielscher, M., Terzikhan, N., Lahousse, L., Brusselle, G., Weiss, S., Ewert, R., Gläser, S., Homuth, G., Shrine, N., Hall, I. P., Tobin, M., London, S. J., Wei, P. & Morrison, A. C., 29 Sept 2021, In: Scientific Reports. 11, 1

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  • Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

    Mccartney, D. L., Min, J. L., Richmond, R. C., Lu, A. T., Sobczyk, M. K., Davies, G., Broer, L., Guo, X., Jeong, A., Jung, J., Kasela, S., Katrinli, S., Kuo, P., Matias-garcia, P. R., Mishra, P. P., Nygaard, M., Palviainen, T., Patki, A., Raffield, L. M., Ratliff, S. M., & 89 othersRichardson, T. G., Robinson, O., Soerensen, M., Sun, D., Tsai, P., Van Der Zee, M. D., Walker, R. M., Wang, X., Wang, Y., Xia, R., Xu, Z., Yao, J., Zhao, W., Correa, A., Boerwinkle, E., Dugué, P., Durda, P., Elliott, H. R., Gieger, C., De Geus, E. J. C., Harris, S. E., Hemani, G., Imboden, M., Kähönen, M., Kardia, S. L. R., Kresovich, J. K., Li, S., Lunetta, K. L., Mangino, M., Mason, D., Mcintosh, A. M., Mengel-from, J., Moore, A. Z., Murabito, J. M., Ollikainen, M., Pankow, J. S., Pedersen, N. L., Peters, A., Polidoro, S., Porteous, D. J., Raitakari, O., Rich, S. S., Sandler, D. P., Sillanpää, E., Smith, A. K., Southey, M. C., Strauch, K., Tiwari, H., Tanaka, T., Tillin, T., Uitterlinden, A. G., Van Den Berg, D. J., Van Dongen, J., Wilson, J. G., Wright, J., Yet, I., Arnett, D., Bandinelli, S., Bell, J. T., Binder, A. M., Boomsma, D. I., Chen, W., Christensen, K., Conneely, K. N., Elliott, P., Ferrucci, L., Fornage, M., Hägg, S., Hayward, C., Irvin, M., Kaprio, J., Lawlor, D. A., Lehtimäki, T., Lohoff, F. W., Milani, L., Milne, R. L., Probst-hensch, N., Reiner, A. P., Ritz, B., Rotter, J. I., Smith, J. A., Taylor, J. A., Van Meurs, J. B. J., Vineis, P., Waldenberger, M., Deary, I. J., Relton, C. L., Horvath, S. & Marioni, R. E., 29 Jun 2021, In: Genome Biology. 22, 1

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  • Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci

    De Las Fuentes, L., Sung, Y. J., Noordam, R., Winkler, T., Feitosa, M. F., Schwander, K., Bentley, A. R., Brown, M. R., Guo, X., Manning, A., Chasman, D. I., Aschard, H., Bartz, T. M., Bielak, L. F., Campbell, A., Cheng, C., Dorajoo, R., Hartwig, F. P., Horimoto, A. R. V. R., Li, C., & 202 othersLi-gao, R., Liu, Y., Marten, J., Musani, S. K., Ntalla, I., Rankinen, T., Richard, M., Sim, X., Smith, A. V., Tajuddin, S. M., Tayo, B. O., Vojinovic, D., Warren, H. R., Xuan, D., Alver, M., Boissel, M., Chai, J., Chen, X., Christensen, K., Divers, J., Evangelou, E., Gao, C., Girotto, G., Harris, S. E., He, M., Hsu, F., Kühnel, B., Laguzzi, F., Li, X., Lyytikäinen, L., Nolte, I. M., Poveda, A., Rauramaa, R., Riaz, M., Rueedi, R., Shu, X., Snieder, H., Sofer, T., Takeuchi, F., Verweij, N., Ware, E. B., Weiss, S., Yanek, L. R., Amin, N., Arking, D. E., Arnett, D. K., Bergmann, S., Boerwinkle, E., Brody, J. A., Broeckel, U., Brumat, M., Burke, G., Cabrera, C. P., Canouil, M., Chee, M. L., Chen, Y. I., Cocca, M., Connell, J., De Silva, H. J., De Vries, P. S., Eiriksdottir, G., Faul, J. D., Fisher, V., Forrester, T., Fox, E. F., Friedlander, Y., Gao, H., Gigante, B., Giulianini, F., Gu, C. C., Gu, D., Harris, T. B., He, J., Heikkinen, S., Heng, C., Hunt, S., Ikram, M. A., Irvin, M. R., Kähönen, M., Kavousi, M., Khor, C. C., Kilpeläinen, T. O., Koh, W., Komulainen, P., Kraja, A. T., Krieger, J. E., Langefeld, C. D., Li, Y., Liang, J., Liewald, D. C. M., Liu, C., Liu, J., Lohman, K. K., Mägi, R., Mckenzie, C. A., Meitinger, T., Metspalu, A., Milaneschi, Y., Milani, L., Mook-kanamori, D. O., Nalls, M. A., Nelson, C. P., Norris, J. M., O’connell, J., Ogunniyi, A., Padmanabhan, S., Palmer, N. D., Pedersen, N. L., Perls, T., Peters, A., Petersmann, A., Peyser, P. A., Polasek, O., Porteous, D. J., Raffel, L. J., Rice, T. K., Rotter, J. I., Rudan, I., Rueda-ochoa, O., Sabanayagam, C., Salako, B. L., Schreiner, P. J., Shikany, J. M., Sidney, S. S., Sims, M., Sitlani, C. M., Smith, J. A., Starr, J. M., Strauch, K., Swertz, M. A., Teumer, A., Tham, Y. C., Uitterlinden, A. G., Vaidya, D., Van Der Ende, M. Y., Waldenberger, M., Wang, L., Wang, Y., Wei, W., Weir, D. R., Wen, W., Yao, J., Yu, B., Yu, C., Yuan, J., Zhao, W., Zonderman, A. B., Becker, D. M., Bowden, D. W., Deary, I. J., Dörr, M., Esko, T., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Jonas, J. B., Kammerer, C. M., Kato, N., Lakka, T. A., Leander, K., Lehtimäki, T., Magnusson, P. K. E., Marques-vidal, P., Penninx, B. W. J. H., Samani, N. J., Van Der Harst, P., Wagenknecht, L. E., Wu, T., Zheng, W., Zhu, X., Bouchard, C., Cooper, R. S., Correa, A., Evans, M. K., Gudnason, V., Hayward, C., Horta, B. L., Kelly, T. N., Kritchevsky, S. B., Levy, D., Palmas, W. R., Pereira, A. C., Province, M. M., Psaty, B. M., Ridker, P. M., Rotimi, C. N., Tai, E. S., Van Dam, R. M., Van Duijn, C. M., Wong, T. Y., Rice, K., Gauderman, W. J., Morrison, A. C., North, K. E., Kardia, S. L. R., Caulfield, M. J., Elliott, P., Munroe, P. B., Franks, P. W., Rao, D. C. & Fornage, M., Jun 2021, In: Molecular Psychiatry. 26, p. 2111–2125

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  • Rare missense functional variants at COL4A1 and COL4A2 in sporadic intracerebral Hhmorrhage

    Chung, J., Hamilton, G., Kim, M., Marini, S., Montgomery, B. E., Henry, J. Q. A., Cho, A. E., Brown, D. L., Worrall, B. B., Meschia, J. F., Silliman, S. L., Selim, M., Tirschwell, D. L., Kidwell, C. S., Kissela, B. M., Greenberg, S. M., Viswanathan, A., Goldstein, J. N., Langefeld, C. D., Rannikmae, K., & 11 othersSudlow, C. L. M., Samarasekera, N., Rodrigues, M., Al-Shahi Salman, R., Prendergast, J., Harris, S., Deary, I. J., Woo, D., Rosand, J., Van Agtmael, T. & Anderson, C. D., 24 May 2021, In: Neurology.

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  • Variants associated with HHIP expression have sexdifferential effects on lung function

    Fawcett, K. A., Obeidat, M., Melbourne, C., Shrine, N., Guyatt, A. L., John, C., Luan, J., Richmond, A., Moksnes, M. R., Granell, R., Weiss, S., Imboden, M., May-Wilson, S., Hysi, P., Boutin, T. S., Portas, L., Flexeder, C., Harris, S. E., Wang, C. A., Lyytikäinen, L. P., & 55 othersPalviainen, T., Foong, R. E., Keidel, D., Minelli, C., Langenberg, C., Bossé, Y., Berge, M. V. D., Sin, D. D., Hao, K., Campbell, A., Porteous, D., Padmanabhan, S., Smith, B. H., Evans, D. M., Ring, S., Langhammer, A., Hveem, K., Willer, C., Ewert, R., Stubbe, B., Pirastu, N., Klaric, L., Joshi, P. K., Patasova, K., Massimo, M., Polasek, O., Starr, J. M., Karrasch, S., Strauch, K., Meitinger, T., Rudan, I., Rantanen, T., Pietiläinen, K., Kähönen, M., Raitakari, O. T., Hall, G. L., Sly, P. D., Pennell, C. E., Kaprio, J., Lehtimäki, T., Vitart, V., Deary, I. J., Jarvis, D., Wilson, J. F., Spector, T., Probst-Hensch, N., Wareham, N. J., Völzke, H., Henderson, J., Strachan, D. P., Brumpton, B. M., Hayward, C., Hall, I. P., Tobin, M. D. & Wain, L. V., 24 May 2021, In: Wellcome Open Research. 5, p. 1-20 20 p.

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  • Variants associated with HHIP expression have sex-differential effects on lung function

    Fawcett, K. A., Obeidat, M., Melbourne, C., Shrine, N., Guyatt, A. L., John, C., Luan, J., Richmond, A., Moksnes, M. R., Granell, R., Weiss, S., Imboden, M., May-wilson, S., Hysi, P., Boutin, T. S., Portas, L., Flexeder, C., Harris, S. E., Wang, C. A., Lyytikäinen, L., & 55 othersPalviainen, T., Foong, R. E., Keidel, D., Minelli, C., Langenberg, C., Bossé, Y., Van Den Berge, M., Sin, D. D., Hao, K., Campbell, A., Porteous, D., Padmanabhan, S., Smith, B. H., Evans, D. M., Ring, S., Langhammer, A., Hveem, K., Willer, C., Ewert, R., Stubbe, B., Pirastu, N., Klaric, L., Joshi, P. K., Patasova, K., Massimo, M., Polasek, O., Starr, J. M., Karrasch, S., Strauch, K., Meitinger, T., Rudan, I., Rantanen, T., Pietiläinen, K., Kähönen, M., Raitakari, O. T., Hall, G. L., Sly, P. D., Pennell, C. E., Kaprio, J., Lehtimäki, T., Vitart, V., Deary, I. J., Jarvis, D., Wilson, J. F., Spector, T., Probst-hensch, N., Wareham, N. J., Völzke, H., Henderson, J., Strachan, D. P., Brumpton, B. M., Hayward, C., Hall, I. P., Tobin, M. D. & Wain, L. V., 24 May 2021, In: Wellcome Open Research . 5, p. 111

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  • Epigenetic predictors of lifestyle traits applied to the blood and brain

    Gadd, D., Stevenson, A., Hillary, R., McCartney, D. L., Wrobel, N., Mccafferty, S., Murphy, L., Russ, T. C., Harris, S., Redmond, P., Taylor, A., Smith, C., Rose, J., Millar, T., Spires-Jones, T., Cox, S. R. & Marioni, R. E., 19 Apr 2021, In: Brain Communications.

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  • Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure

    Wang, H., Noordam, R., Cade, B. E., Schwander, K., Winkler, T. W., Lee, J., Sung, Y. J., Bentley, A. R., Manning, A. K., Aschard, H., Kilpeläinen, T. O., Ilkov, M., Brown, M. R., Horimoto, A. R., Richard, M., Bartz, T. M., Vojinovic, D., Lim, E., Nierenberg, J. L., Liu, Y., & 105 othersChitrala, K., Rankinen, T., Musani, S. K., Franceschini, N., Rauramaa, R., Alver, M., Zee, P. C., Harris, S. E., van der Most, P. J., Nolte, I. M., Munroe, P. B., Palmer, N. D., Kühnel, B., Weiss, S., Wen, W., Hall, K. A., Lyytikäinen, L-P., O'Connell, J., Eiriksdottir, G., Launer, L. J., de Vries, P. S., Arking, D. E., Chen, H., Boerwinkle, E., Krieger, J. E., Schreiner, P. J., Sidney, S., Shikany, J. M., Rice, K., Chen, Y-D. I., Gharib, S. A., Bis, J. C., Luik, A. I., Ikram, M. A., Uitterlinden, A. G., Amin, N., Xu, H., Levy, D., He, J., Lohman, K. K., Zonderman, A. B., Rice, T. K., Sims, M., Wilson, G., Sofer, T., Rich, S. S., Palmas, W., Yao, J., Guo, X., Rotter, J. I., Biermasz, N. R., Mook-Kanamori, D. O., Martin, L. W., Barac, A., Wallace, R. B., Gottlieb, D. J., Komulainen, P., Heikkinen, S., Mägi, R., Milani, L., Metspalu, A., Starr, J. M., Milaneschi, Y., Waken, R. J., Gao, C., Waldenberger, M., Peters, A., Strauch, K., Meitinger, T., Roenneberg, T., Völker, U., Dörr, M., Shu, X-O., Mukherjee, S., Hillman, D. R., Kähönen, M., Wagenknecht, L. E., Gieger, C., Grabe, H. J., Zheng, W., Palmer, L. J., Lehtimäki, T., Gudnason, V., Morrison, A. C., Pereira, A. C., Fornage, M., Psaty, B. M., van Duijn, C. M., Liu, C-T., Kelly, T. N., Evans, M. K., Bouchard, C., Fox, E. R., Kooperberg, C., Zhu, X., Lakka, T. A., Esko, T., North, K. E., Deary, I. J., Snieder, H., Penninx, B. W. J. H., Gauderman, W. J., Rao, D. C., Redline, S. & van Heemst, D., 15 Apr 2021, (E-pub ahead of print) In: Molecular Psychiatry.

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  • Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders

    Nabais, M. F., Laws, S. M., Lin, T., Vallerga, C. L., Armstrong, N. J., Blair, I. P., Kwok, J. B., Mather, K. A., Mellick, G. D., Sachdev, P. S., Wallace, L., Henders, A. K., Zwamborn, R. A. J., Hop, P. J., Lunnon, K., Pishva, E., Roubroeks, J. A. Y., Soininen, H., Tsolaki, M., Mecocci, P., & 50 othersLovestone, S., Kłoszewska, I., Vellas, B., Furlong, S., Garton, F. C., Henderson, R. D., Mathers, S., Mccombe, P. A., Needham, M., Ngo, S. T., Nicholson, G., Pamphlett, R., Rowe, D. B., Steyn, F. J., Williams, K. L., Anderson, T. J., Bentley, S. R., Dalrymple-alford, J., Fowder, J., Gratten, J., Halliday, G., Hickie, I. B., Kennedy, M., Lewis, S. J. G., Montgomery, G. W., Pearson, J., Pitcher, T. L., Silburn, P., Zhang, F., Visscher, P. M., Yang, J., Stevenson, A. J., Hillary, R. F., Marioni, R. E., Harris, S. E., Deary, I. J., Jones, A. R., Shatunov, A., Iacoangeli, A., Van Rheenen, W., Van Den Berg, L. H., Shaw, P. J., Shaw, C. E., Morrison, K. E., Al-chalabi, A., Veldink, J. H., Hannon, E., Mill, J., Wray, N. R. & Mcrae, A. F., 26 Mar 2021, In: Genome Biology. 22, 1

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  • Apolipoprotein E e4 allele status and later-life depression in the Lothian Birth Cohort 1936

    Iveson, M. H., Taylor, A., Harris, S. E., Deary, I. J. & Mcintosh, A. M., 2 Mar 2021, (E-pub ahead of print) In: Psychological Medicine. p. 1-9

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  • Genome-wide association study of circulating Interleukin 6 levels identifies novel loci

    Ahluwalia, T. S., Prins, B. P., Abdollahi, M., Armstrong, N. J., Aslibekyan, S., Bain, L., Jefferis, B., Baumert, J., Beekman, M., Ben-shlomo, Y., Bis, J. C., Mitchell, B. D., De Geus, E., Delgado, G. E., Marek, D., Eriksson, J., Kajantie, E., Kanoni, S., Kemp, J. P., Lu, C., & 106 othersMarioni, R. E., Mclachlan, S., Milaneschi, Y., Nolte, I. M., Petrelis, A. M., Porcu, E., Sabater-lleal, M., Naderi, E., Seppälä, I., Shah, T., Singhal, G., Standl, M., Teumer, A., Thalamuthu, A., Thiering, E., Trompet, S., Ballantyne, C. M., Benjamin, E. J., Casas, J. P., Toben, C., Dedoussis, G., Deelen, J., Durda, P., Engmann, J., Feitosa, M. F., Grallert, H., Hammarstedt, A., Harris, S. E., Homuth, G., Hottenga, J., Jalkanen, S., Jamshidi, Y., Jawahar, M. C., Jess, T., Kivimaki, M., Kleber, M. E., Lahti, J., Liu, Y., Marques-vidal, P., Mellström, D., Mooijaart, S. P., Müller-nurasyid, M., Penninx, B., Revez, J. A., Rossing, P., Räikkönen, K., Sattar, N., Scharnagl, H., Sennblad, B., Silveira, A., Pourcain, B. S., Timpson, N. J., Trollor, J., Van Dongen, J., Van Heemst, D., Visvikis-siest, S., Vollenweider, P., Völker, U., Waldenberger, M., Willemsen, G., Zabaneh, D., Morris, R. W., Arnett, D. K., Baune, B. T., Boomsma, D. I., Chang, Y. C., Deary, I. J., Deloukas, P., Eriksson, J. G., Evans, D. M., Ferreira, M. A., Gaunt, T., Gudnason, V., Hamsten, A., Heinrich, J., Hingorani, A., Humphries, S. E., Jukema, J. W., Koeing, W., Kumari, M., Kutalik, Z., Lawlor, D. A., Lehtimäki, T., März, W., Mather, K., Naitza, S., Nauck, M., Ohlsson, C., Price, J. F., Raitakari, O., Rice, K., Sachdev, P. S., Slagboom, E., Sørensen, T. I. A., Spector, T., Stacey, D., Stathopoulou, M. G., Tanaka, T., Wannamethee, S. G., Whincup, P., Rotter, J. I., Dehghan, A., Boerwinkle, E., Psaty, B. M., Snieder, H. & Alizadeh, B. Z., 30 Jan 2021, (E-pub ahead of print) In: Human Molecular Genetics. ddab023.

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  • Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits

    Sun, D., Richard, M. A., Musani, S. K., Sung, Y. J., Winkler, T. W., Schwander, K., Chai, J. F., Guo, X., Kilpeläinen, T. O., Vojinovic, D., Aschard, H., Bartz, T. M., Bielak, L. F., Brown, M. R., Chitrala, K., Hartwig, F. P., Horimoto, A. R. V. R., Liu, Y., Manning, A. K., Noordam, R., & 114 othersSmith, A. V., Harris, S. E., Kühnel, B., Lyytikäinen, L., Nolte, I. M., Rauramaa, R., Van Der Most, P. J., Wang, R., Ware, E. B., Weiss, S., Wen, W., Yanek, L. R., Arking, D. E., Arnett, D. K., Barac, A., Boerwinkle, E., Broeckel, U., Chakravarti, A., Chen, Y. I., Cupples, L. A., Davigulus, M. L., De Las Fuentes, L., De Mutsert, R., De Vries, P. S., Delaney, J. A. C., Diez Roux, A. V., Dörr, M., Faul, J. D., Fretts, A. M., Gallo, L. C., Grabe, H. J., Gu, C. C., Harris, T. B., Hartman, C. C. A., Heikkinen, S., Ikram, M. A., Isasi, C., Johnson, W. C., Jonas, J. B., Kaplan, R. C., Komulainen, P., Krieger, J. E., Levy, D., Liu, J., Lohman, K., Luik, A. I., Martin, L. W., Meitinger, T., Milaneschi, Y., O’connell, J. R., Palmas, W. R., Peters, A., Peyser, P. A., Pulkki-råback, L., Raffel, L. J., Reiner, A. P., Rice, K., Robinson, J. G., Rosendaal, F. R., Schmidt, C. O., Schreiner, P. J., Schwettmann, L., Shikany, J. M., Shu, X., Sidney, S., Sims, M., Smith, J. A., Sotoodehnia, N., Strauch, K., Tai, E. S., Taylor, K. D., Uitterlinden, A. G., Van Duijn, C. M., Waldenberger, M., Wee, H., Wei, W., Wilson, G., Xuan, D., Yao, J., Zeng, D., Zhao, W., Zhu, X., Zonderman, A. B., Becker, D. M., Deary, I. J., Gieger, C., Lakka, T. A., Lehtimäki, T., North, K. E., Oldehinkel, A. J., Penninx, B. W. J. H., Snieder, H., Wang, Y., Weir, D. R., Zheng, W., Evans, M. K., Gauderman, W. J., Gudnason, V., Horta, B. L., Liu, C., Mook-kanamori, D. O., Morrison, A. C., Pereira, A. C., Psaty, B. M., Amin, N., Fox, E. R., Kooperberg, C., Sim, X., Bierut, L., Rotter, J. I., Kardia, S. L. R., Franceschini, N., Rao, D. C. & Fornage, M., 14 Jan 2021, In: Human Genetics and Genomics Advances. 2, 1, p. 1-12 100013.

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  • Genome wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability

    Huguet, G., Schramm, C., Douard, E., Tamer, P., Main, A., Monin, P., England, J., Jizi, K., Renné, T., Poirier, M., Nowak, S., Martin, C-O., Younis, N., Knoth, I. S., Jean-louis, M., Saci, Z., Auger, M., Tihy, F., Mathonnet, G., Maftei, C., & 19 othersLéveillé, F., Porteous, D. J., Davies, G., Redmond, P., Harris, S., Hill, W. D., Lemyre, E., Schumann, G., Bourgeron, T., Pausova, Z., Paus, T., Karama, S., Lippe, S., Deary, I., Almasy, L., Labbe, A., Glahn, D. C., M.T Greenwood, C. & Jacquemont, S., 7 Jan 2021, (E-pub ahead of print) In: Molecular Psychiatry. 14 p.

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  • Three major dimensions of human brain cortical ageing in relation to cognitive decline across the eighth decade of life

    Cox, S., Harris, M., Ritchie, S. J., Buchanan, C., Valdes Hernandez, M., Corley, J., Taylor, A., Madole, J. W., Harris, S., Whalley, H., McIntosh, A. M., Russ, T. C., Bastin, M. E., Wardlaw, J., Deary, I. & Tucker-Drob, E. M., 4 Jan 2021, (E-pub ahead of print) In: Molecular Psychiatry. 12 p.

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  • Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus

    Tin, A., Schlosser, P., Matias-garcia, P. R., Thio, C. H. L., Joehanes, R., Liu, H., Yu, Z., Weihs, A., Hoppmann, A., Grundner-culemann, F., Min, J. L., Kuhns, V. L. H., Adeyemo, A. A., Agyemang, C., Ärnlöv, J., Aziz, N. A., Baccarelli, A., Bochud, M., Brenner, H., Bressler, J., & 83 othersBreteler, M. M. B., Carmeli, C., Chaker, L., Coresh, J., Corre, T., Correa, A., Cox, S. R., Delgado, G. E., Eckardt, K., Ekici, A. B., Endlich, K., Floyd, J. S., Fraszczyk, E., Gao, X., Gào, X., Gelber, A. C., Ghanbari, M., Ghasemi, S., Gieger, C., Greenland, P., Grove, M. L., Harris, S. E., Hemani, G., Henneman, P., Herder, C., Horvath, S., Hou, L., Hurme, M. A., Hwang, S., Kardia, S. L. R., Kasela, S., Kleber, M. E., Koenig, W., Kooner, J. S., Kronenberg, F., Kühnel, B., Ladd-acosta, C., Lehtimäki, T., Lind, L., Liu, D., Lloyd-jones, D. M., Lorkowski, S., Lu, A. T., Marioni, R. E., März, W., Mccartney, D. L., Meeks, K. A. C., Milani, L., Mishra, P. P., Nauck, M., Nowak, C., Peters, A., Prokisch, H., Psaty, B. M., Raitakari, O. T., Ratliff, S. M., Reiner, A. P., Schöttker, B., Schwartz, J., Sedaghat, S., Smith, J. A., Sotoodehnia, N., Stocker, H. R., Stringhini, S., Sundström, J., Swenson, B. R., Van Meurs, J. B. J., Van Vliet-ostaptchouk, J. V., Venema, A., Völker, U., Winkelmann, J., Wolffenbuttel, B. H. R., Zhao, W., Zheng, Y., Loh, M., Snieder, H., Waldenberger, M., Levy, D., Akilesh, S., Woodward, O. M., Susztak, K., Teumer, A. & Köttgen, A., 2021, In: Nature Communications. 12, 1, 7173 .

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  • 2020

    Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals

    Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A. T., Cartwright, J. H., Hellwege, J. N., Giri, A., Tragante, V., Thorleifsson, G., Liu, D. J., Prins, B. P., Stewart, I. D., Cabrera, C. P., Eales, J., & 260 othersAkbarov, A., Auer, P. L., Bielak, L. F., Bis, J. C., Braithwaite, V. S., Brody, J. A., Daw, E. W., Warren, H. R., Drenos, F., Nielsen, S. F., Faul, J. D., Fauman, E., Fava, C., Ferreira, T., Foley, C. N., Franceschini, N., Gao, H., Giannakopoulou, O., Giulianini, F., Gudbjartsson, D. F., Guo, X., Harris, S., Havulinna, A. S., Helgadottir, A., Huffman, J. E., Hwang, S-J., Kanoni, S., Kontto, J., Larson, M. G., Li-Gao, R., Lindström, J., Lotta, L. A., Lu, Y., Luan, J., Mahajan, A., Malerba, G., Masca, N. G. D., Mei, H., Menni, C., Mook-Kanamori, D. O., Mosen-Ansorena, D., Müller-Nurasyid, M., Paré, G., Paul, D. S., Perola, M., Poveda, A., Rauramaa, R., Richard, M., Richardson, T. G., Sepúlveda, N., Sim, X., Smith, A. V., Smith, J. A., Staley, J. R., Stančáková, A., Sulem, P., Thériault, S., Thorstensdottir, U., Trompet, S., Varga, T. V., Velez Edwards, D. R., Veronesi, G., Weiss, S., Willems, S. M., Yao, J., Young, R., Yu, B., Zhang, W., Hua Zhao, J., Zhao, W., Evangelou, E., Aeschbacher, S., Asllanaj, E., Blankenberg, S., Bonnycastle, L. L., Bork-Jensen, J., Brandslund, I., Braund, P. S., Burgess, S., Cho, K., Christensen, C., Connelly, J., de Mutsert, R., Dominiczak, A. F., Dörr, M., Eiriksdottir, G., Farmaki, A-E., Gaziano, J. M., Grarup, N., Grove-Gaona, M. L., Hallmans, G., Hansen, T., Have, C. T., Heiss, G., Jørgensen, M. E., Jousilahti, P., Kajantie, E., Kamat, M., Käräjämäki, A., Karpe, F., Koistinen, H. A., Kovesdy, C. P., Kuulasmaa, K., Laatikainen, T., Lannfelt, L., Lee, I., Lee, W., Linneberg, A., Martin, L. W., Moitry, M., Nadkarni, G. N., Neville, M. J., Palmer, C. N. A., Papanicolau, G. J., Pederson, O., Peters, J., Poulter, N., Rasheed, A., Rasmussen, K. L., William Rayner, N., Mägi, R., Renström, F., Rettig, R., Rossouw, J., Schreiner, P. J., Sever, P. J., Sigurdsson, E. L., Skaaby, T., Sun, Y. V., Sundstrom, J., Thorgeirsson, G., Esko, T., Trabetti, E., Tsao, P. S., Tuomi, T., Turner, S. T., Tzoulaki, I., Vaartjes, I., Vergnaud, A-C., Willer, C. J., Wilson, P. W. F., Witte, D. R., Yonova-Doing, E., Zhang, H., Naheed, A., Almgren, P., Amouyel, P., Asselbergs, F. W., Barnes, M. R., Blakemore, A. I. F., Boehnke, M., Bots, M. L., Bottinger, E. P., Buring, J. E., Chambers, J. C., Ida Chen, Y-D., Chowdry, R., Conen, D., Correa, A., Smith, G. D., De Boer, R. A., Deary, I., Dedoussis, G., Deloukas, P., Di Angelantonio, E., Elliot, P., Felix, S. B., Ferrières, J., Ford, I., Fornage, M., Franks, P. W., Franks, S., Frossard, P., Gambaro, G., Gaunt, T. R., Groop, L., Gudnason, V., Harris, T. B., Hayward, C., Hennig, B. J., Herzig, K-H., Ingelsson, E., Tuomilehto, J., Jarvelin, M-R., Wouter Jukema, J., Kardia, S. L. R., Kee, F., Kooner, J. S., Kooperberg, C., Lenore, L. J., Lind, L., Loos, R. J. F., al Shafi Majumder, A., Laakso, M., McCarthy, M. I., Melander, O., Mohlke, K. L., Murray, A. D., Nordestgaard, B. G., Orho-Melander, M., Packard, C. J., Padmanabhan, S., Palmas, W., Polasek, O., Porteous, D. J., Prentice, A. M., Province, M. A., Relton, C. L., Rice, K., Ridker, P. M., Rolandsson, O., Rosendaal, F. R., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sattar, N., H-H Sheu, W., Smith, B. H., Soranzo, N., Spector, T. D., Starr, J., Sebert, S., Taylor, K. D., Lakka, T. A., Timpson, N. J., Tobin, M. D., van der Harst, P., van der Meer, P., Ramachandran, V. S., Verweij, N., Virtamo, J., Völker, U., Weir, D. R., Zeggini, E., Charchar, F. J., Wareham, N. J., Langenberg, C., Tomaszewski, M., Butterworth, A. S., Caulfield, M., Danesh, J., Edwards, T. L., Holm, H., Hung, A. M., Lindgren, C. M., Liu, C., Manning, A. K., Morris, A. P., Morrison, A. C., O'Donnell, C. J., Psaty, B. M., Saleheen, D., Stefansson, K., Boerwinkle, E., Chasman, D. I., Levy, D., Newton-Cheh, C. H., Munroe, P. B. & Howson, J. M. M., 23 Nov 2020, (E-pub ahead of print) In: Nature Genetics.

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  • Multi-method genome- and epigenome-wide studies of inflammatory protein levels in healthy older adults

    Hillary, R., Trejo-Banos, D., Kousathanas, A., McCartney, D. L., Harris, S. E., Stevenson, A. J., Patxot, M., Ojavee, S. E., Zhang, Q., Liewald, D. C., Ritchie, C. W., Evans, K. L., Tucker-Drob, E. M., Wray, N. R., McRae, A. F., Visscher, P. M., Deary, I. J., Robinson, M. R. & Marioni, R. E., 8 Jul 2020, In: Genome Medicine. 12, 60.

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  • Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

    Moll, M., Sakornsakolpat, P., Shrine, N., Hobbs, B. D., DeMeo, D. L., John, C., Guyatt, A. L., McGeachie, M. J., Gharib, S. A., Obeidat, M., Lahousse, L., Wijnant, S. R. A., Brusselle, G., Meyers, D. A., Bleecker, E. R., Li, X., Tal-Singer, R., Manichaikul, A., Rich, S. S., Won, S., & 67 othersKim, W. J., Do, A. R., Washko, G. R., Barr, R. G., Psaty, B. M., Bartz, T. M., Hansel, N. N., Barnes, K., Hokanson, J. E., Crapo, J. D., Lynch, D., Bakke, P., Gulsvik, A., Hall, I. P., Wain, L., Soler Artigas, M., Jackson, V. E., Strachan, D. P., Hui, J., James, A. L., Kerr, S. M., Polasek, O., Vitart, V., Marten, J., Rudan, I., Kähönen, M., Surakka, I., Gieger, C., Karrasch, S., Rawal, R., Schulz, H., Deary, I. J., Harris, S. E., Enroth, S., Gyllensten, U., Imboden, M., Probst-Hensch, N. M., Lehtimäki, T., Raitakari, O. T., Langenberg, C., Luan, J., Wareham, N., Zhao, J. H., Hayward, C., Murray, A., Porteous, D. J., Smith, B. H., Jarvelin, M. R., Wielscher, M., Joshi, P. K., Kentistou, K. A., Timmers, P. RHJ., Wilson, J. F., Cook, J. P., Lind, L., Mahajan, A., Morris, A. P., Ewert, R., Homuth, G., Stubbe, B., Weiss, S., Zeggini, E., Weiss, S. T., Silverman, E. K., Dudbridge, F., Tobin, M. D. & Cho, M. H., 7 Jul 2020, (E-pub ahead of print) In: The Lancet Respiratory Medicine. 8, 7, p. 696-708 13 p.

    Research output: Contribution to journal › Article › peer-review

    Open Access
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