Sarah Walmsley

Search results

• 2023

  NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

  Ryan, E., Sadiku, P., Coelho, P., Watts, E. R., Zhang, A., Howden, A. J. M., Sanchez Garcia, M. A., Bewley, M. A., Cole, J., McHugh, B., Vermaelen, W., Ghesquiere, B., Carmeliet, P., Rodriguez Blanco, G., von Kriegsheim, A., Sanchez, Y., Rumsey, W., Callahan, J. F., Cooper, G., Parkinson, N., & 8 othersBaillie, J. K., Cantrell, D., McCafferty, J., Choudhury, G., Singh, D., Dockrell, D. H., Whyte, M. K. B. & Walmsley, S. R., 1 Feb 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Chronic Obstructive Pulmonary Disease 100%
  • Macrophages 78%
  • Oxidation-Reduction 61%
  • malate dehydrogenase (decarboxylating) 30%
  • Antioxidants 23%
• 2022

  The emerging role for metabolism in fueling neutrophilic inflammation

  Morrison, T., Watts, E. R., Sadiku, P. & Walmsley, S. R., 3 Nov 2022, In: Immunological reviews.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  File

  • Neutrophils 100%
  • Inflammation 75%
  • Neutrophil Activation 40%
  • Glycolysis 33%
  • Carbon 31%

• Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

  Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Sanchez Garcia, M. A., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Morrison, T., Ly, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R., Reyes, L., Cooper, G., Clark, S., Lewis, D., Kelly, V., & 22 othersSpanos, C., Musgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N., Rostron, A. J., Baillie, J. K., Clohisey, S., Pridans, C., Campana, L., Starkey Lewis, P., Simpson, A. J., Dockrell, D. H., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. B. & Walmsley, S. R., 27 May 2022, In: Nature Immunology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Lung Injury 100%
  • Adult Respiratory Distress Syndrome 78%
  • Hypoxia 74%
  • Inflammation 55%
  • Pneumonia 38%

• Hypoxia shapes the immune landscape in lung injury promoting inflammation persistence

  Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Sanchez-Garcia, M. A., Reyes, L., Morrison, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R. S., Clark, S., Ly, T., Lewis, D., Kelly, V., Spanos, C., & 21 othersMusgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N. J., Rostron, A. J., Baillie, K. J., Clohisey, S., Pridans, C., Campana, L., Starkey-Lewis, P., Simpson, A. J., Dockrell, D., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. & Walmsley, S. R., 12 Mar 2022, bioRxiv, p. 1-53, 53 p.

  Research output: Working paper › Preprint

  • Lung Injury 100%
  • Acute Lung Injury 81%
  • Adult Respiratory Distress Syndrome 78%
  • Hypoxia 74%
  • Endotoxins 70%
• 2021

  The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

  Mccowan, J., Fercoq, F., Kirkwood, P. M., T’jonck, W., Hegarty, L. M., Mawer, C. M., Cunningham, R., Mirchandani, A. S., Hoy, A., Humphries, D. C., Jones, G., Hansen, C. G., Hirani, N., Jenkins, S. J., Henri, S., Malissen, B., Walmsley, S. R., Dockrell, D. H., Saunders, P. T. K., Carlin, L. M., & 1 othersBain, C. C., 19 Nov 2021, In: Science Immunology. 6, 65

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Early Growth Response Protein 2 100%
  • Alveolar Macrophages 57%
  • Granulocyte-Macrophage Colony-Stimulating Factor 27%
  • Health 25%
  • Transforming Growth Factor beta 11%

• Neutrophil HIF-1α stabilisation is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle

  Willson, J. A., Arienti, S., Sadiku, P., Reyes, L., Coelho, P., Morrison, T., Rinaldi, G., Dockrell, D. H., Whyte, M. K. B. & Walmsley, S. R., 19 Aug 2021, In: Blood.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • alpha-glycerophosphoric acid 100%
  • Reactive Oxygen Metabolite 64%
  • Glycerol 59%
  • Reactive Oxygen Species 55%
  • Neutrophils 54%

• A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS­­­

  Reyes, L., Sanchez Garcia, M. A., Morrison, T., Howden, A. J. M., Watts, E. R., Arienti, S., Sadiku, P., Coelho, P., Mirchandani, A. S., Zhang, A., Hope, D., Clark, S. K., Singleton, J., Johnston, S., Grecian, R., Poon, A. S., McNamara, S., Harper, I., Fourman, M. H., Brenes, A. J., & 14 othersPathak, S., Lloyd, A., Rodriguez Blanco, G., von Kriegsheim, A., Ghesquiere, B., Vermaelen, W., Cologna, C. T., Dhaliwal, K., Hirani, N., Dockrell, D. H., Whyte, M. K. B., Griffith, D. M., Cantrell, D. & Walmsley, S. R., 25 Jun 2021, (E-pub ahead of print) Wellcome Open Research, (wellcome Open Research).

  Research output: Working paper

  Open Access

  File

  • Coronavirus 100%
  • Adult Respiratory Distress Syndrome 87%
  • Neutrophils 62%
  • Severe Acute Respiratory Syndrome 15%
  • Neutrophil Activation 15%

• Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

  Virga, F., Cappellesso, F., Stijlemans, B., Henze, A-T., Trotta, R., Van Audenaerde, J., Mirchandani, A. S., Sanchez Garcia, M. A., Vandewalle, J., Orso, F., Riera-Domingo, C., Griffa, A., Ivan, C., Smits, E., Laoui, D., Martelli, F., Langouche, L., Van den Berghe, G., Feron, O., Ghesquiere, B., & 8 othersPrenen, H., Libert, C., Walmsley, S. R., Corbet, C., Van Ginderachter, J. A., Ivan, M., Taverna, D. & Mazzone, M., 7 May 2021, In: Science Advances.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Macrophages 100%
  • Inflammation 84%
  • Monocytes 71%
  • Sepsis 69%
  • human MIRN210 microRNA 55%

• Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism

  Watts, E. R., Howden, A. J. M., Morrison, T., Sadiku, P., Hukelmann, J. L., Von Kriegsheim, A., Ghesquière, B., Murphy, F., Mirchandani, A. S., Humphries, D. C., Grecian, R., Ryan, E. M., Coelho, P., Rodriguez-blanco, G., Plant, T. M., Dickinson, R. S., Finch, A. J., Vermaelen, W., Cantrell, D. A., Whyte, M. K. B., & 1 othersWalmsley, S. R., 6 Apr 2021, (E-pub ahead of print) In: Journal of Clinical Investigation.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Carbon 100%
  • Hypoxia 79%
  • Neutrophils 79%
  • Proteins 37%
  • Proteome 30%

• A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

  Reyes, L., Sanchez Garcia, M. A., Morrison, T., Howden, A. J. M., Watts, E. R., Arienti, S., Sadiku, P., Coelho, P., Mirchandani, A. S., Zhang, A., Hope, D., Clark, S. K., Singleton, J., Johnston, S., Grecian, R., Poon, A. S., McNamara, S., Harper, I., Fourman, M. H., Brenes, A. J., & 14 othersPathak, S., Lloyd, A., Rodriguez Blanco, G., von Kriegsheim, A., Ghesquiere, B., Vermaelen, W., Cologna, C. T., Dhaliwal, K., Hirani, N., Dockrell, D. H., Whyte, M. K. B., Griffith, D. M., Cantrell, D. & Walmsley, S. R., 22 Feb 2021, In: Wellcome Open Research .

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dexamethasone 100%
  • Coronavirus 98%
  • Adult Respiratory Distress Syndrome 86%
  • Antigen 65%
  • Neutrophils 61%

• S47 The NSCLC pleural metastatic environment influences the role neutrophils play in the immune checkpoint

  Grecian, R., Gwyer Findlay, E., Dhaliwal, K., Byron, A., Frame, M., Whyte, M. & Walmsley, S., 21 Feb 2021, p. A30.1-A30.

  Research output: Contribution to conference › Abstract

• Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

  Sadiku, P., Willson, J. A., Ryan, E. M., Sammut, D., Coelho, P., Watts, E. R., Grecian, R., Young, J. M., Bewley, M., Arienti, S., Mirchandani, A. S., Sanchez Garcia, M. A., Morrison, T., Zhang, A., Reyes, L., Griessler, T., Jheeta, P., Paterson, G. G., Graham, C. J., Thompson, J. P., & 16 othersBaillie, K., Thompson, A. A. R., Morgan, J-M., Acosta-Sanchez, A., Dardé, V. M., Duran, J., Guinovart, J. J., Rodriguez-Blanco, G., Von Kriegsheim, A., Meehan, R. R., Mazzone, M., Dockrell, D. H., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 2 Feb 2021, In: Cell Metabolism. 33, 2, p. 411-423.e4

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gluconeogenesis 100%
  • Neutrophils 64%
  • Glycogen 64%
  • Altitude Sickness 28%
  • Pyruvic Acid 22%
• 2020

  Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

  Bain, C. C., Gibson, D. A., Steers, N. J., Boufea, K., Louwe, P. A., Doherty, C., González-huici, V., Gentek, R., Magalhaes-pinto, M., Shaw, T., Bajénoff, M., Bénézech, C., Walmsley, S. R., Dockrell, D. H., Saunders, P. T. K., Batada, N. N. & Jenkins, S. J., 26 Jun 2020, In: Science Immunology. 5, 48, eabc4466.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Peritoneal Macrophages 100%
  • Phenotype 54%
  • Peritonitis 31%
  • Bone Marrow 22%
  • Sexual Maturation 20%

• Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

  Plant, T., Eamsamarng, S., Sanchez-Garcia, M. A., Reyes, L., Renshaw, S. A., Coelho, P., Mirchandani, A. S., Morgan, J-M., Ellett, F. E., Morrison, T., Humphries, D., Watts, E. R., Murphy, F., Raffo-Iraolagoitia, X. L., Zhang, A., Cash, J. L., Loynes, C., Elks, P. M., Van Eeden, F., Carlin, L. M., & 3 othersFurley, A. J. W., Whyte, M. K. B. & Walmsley, S. R., 1 Jun 2020, In: Journal of Clinical Investigation. 130, 6, p. 3221-3237

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Semaphorins 100%
  • Neutrophils 54%
  • Inflammation 41%
  • Neutrophil Infiltration 17%
  • Tail 14%

• The NSCLC pleural metastatic environment influences the role neutrophils play in the immune checkpoint

  Grecian, R., Findlay, E. G., Dhaliwal, K., Byron, A., Frame, M., Whyte, M. & Walmsley, S., 1 Jan 2020.

  Research output: Contribution to conference › Abstract
• 2019

  Hypoxia modulates platelet purinergic signalling pathways

  Paterson, G. G., Young, J. M., Willson, J. A., Graham, C. J., Dru, R. C., Lee, E. W., Torpey, G. S., Walmsley, S., Chan, M. V., Warner, T. D., Baillie, K. & Roger Thompson, A. A., 13 Dec 2019, (E-pub ahead of print) In: Thrombosis and Haemostasis.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Adenosine Diphosphate 100%
  • Hypoxia 79%
  • Blood Platelets 78%
  • vasodilator-stimulated phosphoprotein 66%
  • cangrelor 47%

• IL4Rα signaling abrogates hypoxic neutrophil survival and limits acute lung injury responses in vivo

  Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'Kane, C., McAuley, D., Jenkins, S. J., & 2 othersWhyte, M. K. B. & Walmsley, S. R., 15 Jul 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 2, p. 235–246 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Acute Lung Injury 100%
  • Neutrophils 68%
  • Interleukin-4 48%
  • Adult Respiratory Distress Syndrome 28%
  • Hypoxia 27%

• Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response

  Sadiku, P. & Walmsley, S. R., 14 Mar 2019, (E-pub ahead of print) In: EMBO Reports. p. e47388

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Myeloid Cells 100%
  • Metabolic 79%
  • Hypoxia 77%
  • Cellular Reprogramming 62%
  • Nutrient 52%
• 2018

  Hypoxia and reprogramming of host pathogen interactions

  Ryan, E. M., Whyte, M. K. & Walmsley, S. R., 27 Nov 2018, (E-pub ahead of print) In: Current opinion in physiology. 7, p. 15-20

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Host-Pathogen Interactions 100%
  • Pseudomonas 85%
  • Adaptive Immunity 78%
  • Innate Immunity 70%
  • Virulence 66%

• Inflammation and Hypoxia: HIF and PHD Isoform Selectivity

  Watts, E. R. & Walmsley, S. R., 1 Nov 2018, In: Trends in Molecular Medicine.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Protein Isoforms 100%
  • PHD Zinc Fingers 99%
  • Hypoxia 97%
  • Inflammation 72%
  • Mixed Function Oxygenases 69%

• Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists

  COPDMAP, Bewley, M. A., Budd, R. C., Ryan, E., Cole, J., Collini, P., Marshall, J., Kolsum, U., Beech, G., Emes, R. D., Tcherniaeva, I., Berbers, G. A. M., Walmsley, S. R., Donaldson, G., Wedzicha, J. A., Kilty, I., Rumsey, W., Sanchez, Y., Brightling, C. E., Donnelly, L. E., & 4 othersBarnes, P. J., Singh, D., Whyte, M. K. B. & Dockrell, D. H., 15 Sep 2018, In: American Journal of Respiratory and Critical Care Medicine. 198, 6, p. 739-750 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Alveolar Macrophages 100%
  • Phagocytosis 88%
  • Chronic Obstructive Pulmonary Disease 80%
  • Bacteria 27%
  • Macrophages 17%

• The role of neutrophils in cancer

  Grecian, R., Whyte, M. & Walmsley, S., 22 Aug 2018, In: British Medical Bulletin.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neutrophils 100%
  • Neoplasms 41%
  • Tumor Microenvironment 37%
  • Information Storage and Retrieval 16%
  • PubMed 14%

• Getting DAMP(s) Wets the Whistle for Neutrophil Recruitment

  Watts, E. R. & Walmsley, S. R., 15 May 2018, (E-pub ahead of print) In: Immunity. 48, 5, p. 846-848 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neutrophil Infiltration 100%
  • Pathogen-Associated Molecular Pattern Molecules 59%
  • Immunity 35%
• 2017

  Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo

  Dickinson, R. S., Murphy, F., Doherty, C., Williams, S., Mirchandani, A., Willson, J. A., Scotti, J. S., Preston, G., Schofield, C. J., Whyte, M. K. B. & Walmsley, S. R., 26 Oct 2017, In: Wellcome Open Research . 2, p. 104

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Prolyl Hydroxylases 100%
  • Pseudomonas 79%
  • Pyocyanin 60%
  • Intratracheal 58%
  • Exotoxin 56%

• Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

  Sadiku, P., Willson, J. A., Dickinson, R., Murphy, F., Harris, A., Lewis, A., Sammut, D., Mirchandani, A. S., Ryan, E., Watts, E. R., Thompson, A. A. R., Marriott, H. M., Dockrell, D. H., Taylor, C. T., Schneider, M., Maxwell, P. H., Chilvers, E. R., Mazzone, M., Moral, V., Pugh, C. W., & 6 othersRatcliffe, P. J., Schofield, C. J., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 1 Sep 2017, In: Journal of Clinical Investigation. 127, 9, p. 3407-3420 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Prolyl Hydroxylases 100%
  • Glycogen 74%
  • Neutrophils 55%
  • Mixed Function Oxygenases 32%
  • Glycolysis 14%

• Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

  Thompson, A. A. R., Dickinson, R. S., Murphy, F., Thomson, J. P., Marriott, H. M., Tavares, A., Willson, J., Williams, L., Lewis, A., Mirchandani, A., Dos Santos Coelho, P., Doherty, C., Ryan, E., Watts, E., Morton, N. M., Forbes, S., Stimson, R. H., Hameed, A. G., Arnold, N., Preston, J. A., & 15 othersLawrie, A., Finisguerra, V., Mazzone, M., Sadiku, P., Goveia, J., Taverna, F., Carmeliet, P., Foster, S. J., Chilvers, E. R., Cowburn, A. S., Dockrell, D. H., Johnson, R. S., Meehan, R. R., Whyte, M. K. B. & Walmsley, S. R., 24 Feb 2017, In: Science Immunology. 2, 8, eaal2861.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Bacterial Infections 100%
  • Leukocytes 84%
  • Hypoxia 84%
  • Morbidity 27%
  • Neutrophils 23%

• Hypoxia and host pathogen responses

  Walmsley, S. R. & Rupp, J., 20 Jan 2017, (E-pub ahead of print) In: Microbes and Infection. 19, 3, p. 143

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

  File
• 2016

  Mutations in Succinate Dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1alpha expression

  Jones, R., McDonald, K. E., Willson, J. A., Ghesquiere, B., Sammut, D., Daniel, E., Harris, A. J., Lewis, A., Thompson, A. A. R., Dickinson, R. S., Plant, T., Murphy, F., Sadiku, P., Keevil, B. G., Carmeliet, P., Whyte, M. K. B., Newell-Price, J. & Walmsley, S. R., 26 May 2016, In: Blood. 127, 21, p. 2641-2644 4 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
• 2015

  Exploring the HIFs, Buts and Maybes of Hypoxia Signalling in Disease: Lessons From Zebrafish Models

  Elks, P. M., Renshaw, S. A., Meijer, A. H., Walmsley, S. & Van Eeden, F. J., 1 Nov 2015, In: Disease Models and Mechanisms. 8, 11, p. 1349-1360

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Zebrafish 100%
  • Hypoxia 77%
  • Transcription Factors 18%
  • Oxygen 17%
  • Anniversaries and Special Events 15%

• MET is required for the recruitment of anti-tumoural neutrophils

  Finisguerra, V., Di Conza, G., Di Matteo, M., Serneels, J., Costa, S., Thompson, A. A. R., Wauters, E., Walmsley, S., Prenen, H., Granot, Z., Casazza, A. & Mazzone, M., 18 Jun 2015, In: Nature. 522, 7556, p. 349-353 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Neutrophils 100%
  • Hepatocyte Growth Factor 45%
  • Neoplasms 41%
  • Growth 19%
  • Neoplasm Metastasis 15%
• 2014

  A local circadian clock calls time on lung inflammation

  Thompson, A. A. R., Walmsley, S. R. & Whyte, M. K. B., Aug 2014, In: Nature Medicine. 20, 8, p. 809-811 3 p.

  Research output: Contribution to journal › Editorial

• Neutrophil energetics and oxygen sensing

  Walmsley, S. R. & Whyte, M. K. B., 1 May 2014, In: Blood. 123, 18, p. 2753-2754 4 p.

  Research output: Contribution to journal › Editorial

• HIF-mediated innate immune responses: cell signaling and therapeutic implications

  AJ, H., Thompson, A. A. R., Whyte, M. & Walmsley, S., May 2014, In: Hypoxic Signaling. 2, p. 47-58

  Research output: Contribution to journal › Literature review › peer-review

  Open Access

  File

  • Innate Immunity 100%
  • Hypoxia 85%
  • Signal Transduction 84%
  • Cell Hypoxia 45%
  • Angiogenesis Inducing Agents 20%

• A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism

  Robertson, A. L., Holmes, G. R., Bojarczuk, A. N., Burgon, J., Loynes, C. A., Chimen, M., Sawtell, A. K., Hamza, B., Willson, J., Walmsley, S. R., Anderson, S. R., Coles, M. C., Farrow, S. N., Solari, R., Jones, S., Prince, L. R., Irimia, D., Rainger, G. E., Kadirkamanathan, V., Whyte, M. K. B., & 1 othersRenshaw, S. A., 26 Feb 2014, In: Science Translational Medicine. 6, 225, 10 p., 225ra29.

  Research output: Contribution to journal › Article › peer-review

  • Zebrafish 100%
  • Neutrophils 77%
  • Anti-Inflammatory Agents 72%
  • Inflammation 57%
  • tanshinone 48%

• Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

  Thompson, A. A. R., Elks, P. M., Marriott, H. M., Eamsamarng, S., Higgins, K. R., Lewis, A., Williams, L., Parmar, S., Shaw, G., McGrath, E. E., Formenti, F., Van Eeden, F. J., Kinnula, V. L., Pugh, C. W., Sabroe, I., Dockrell, D. H., Chilvers, E. R., Robbins, P. A., Percy, M. J., Simon, M. C., & 4 othersJohnson, R. S., Renshaw, S. A., Whyte, M. K. B. & Walmsley, S. R., 16 Jan 2014, In: Blood. 123, 3, p. 366-376 11 p.

  Research output: Contribution to journal › Article › peer-review

  • endothelial PAS domain-containing protein 1 100%
  • Zebrafish 63%
  • Neutrophils 48%
  • Biological Role 38%
  • Hypoxia-Inducible Factor 1 29%
• 2013

  Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism

  Elks, P. M., Brizee, S., van der Vaart, M., Walmsley, S. R., van Eeden, F. J., Renshaw, S. A. & Meijer, A. H., 19 Dec 2013, In: PLoS Pathogens. 9, 12, 16 p., 1003789.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • mycobacterial diseases 100%
  • Mycobacterium marinum 66%
  • hypoxia 63%
  • tuberculosis 63%
  • nitric oxide 61%

• Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination

  Luong, L. A., Fragiadaki, M., Smith, J., Boyle, J., Lutz, J., Dean, J. L. E., Harten, S., Ashcroft, M., Walmsley, S. R., Haskard, D. O., Maxwell, P. H., Walczak, H., Pusey, C. & Evans, P. C., 7 Jun 2013, In: Circulation Research. 112, 12, p. 1583-1591 20 p.

  Research output: Contribution to journal › Article › peer-review

  • TNF Receptor-Associated Factor 6 100%
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins 80%
  • Hypoxia 54%
  • Endothelial Cells 50%
  • Ubiquitination 44%

• Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha

  Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., Zheng, L., Gardet, A., Tong, Z., Jany, S. S., Corr, S. C., Haneklaus, M., Caffrey, B. E., Pierce, K., Walmsley, S., Beasley, F. C., & 12 othersCummins, E., Nizet, V., Whyte, M., Taylor, C. T., Lin, H., Masters, S. L., Gottlieb, E., Kelly, V. P., Clish, C., Auron, P. E., Xavier, R. J. & O'Neill, L. A. J., 11 Apr 2013, In: Nature. 496, 7444, p. 238-242 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Succinic Acid 100%
  • Interleukin-1beta 78%
  • Lipopolysaccharides 71%
  • Deoxyglucose 31%
  • Macrophages 28%

• Hypoxia, the HIF pathway and neutrophilic inflammatory responses

  Thompson, A. A. R., Binham, J., Plant, T., Whyte, M. K. B. & Walmsley, S. R., Apr 2013, In: Biological Chemistry. 394, 4, p. 471-477 7 p.

  Research output: Contribution to journal › Literature review › peer-review

  • Hypoxia 100%
  • Transcription Factors 95%
  • Neutrophils 66%
  • Prolyl Hydroxylases 29%
  • Neutrophil Activation 26%

• Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines

  Basran, A., Jabeen, M., Bingle, L., Stokes, C. A., Dockrell, D., Whyte, M. K. B., Walmsley, S. R., Higgins, K. R., Vogel, S. N., Wilson, H. L., Prince, L. R., Prestwich, E. C., Sabroe, R. A., Parker, L. C. & Sabroe, I., Jan 2013, In: Journal of Leukocyte Biology. 93, 1, p. 7-19 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Interleukin-1 100%
  • Chemokines 94%
  • Neutrophils 78%
  • Inflammation 59%
  • Endotoxins 39%
• 2012

  A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia

  Marriott, H. M., Daigneault, M., Thompson, A. A. R., Walmsley, S. R., Gill, S. K., Witcher, D. R., Wroblewski, V. J., Hellewell, P. G., Whyte, M. K. B. & Dockrell, D., Nov 2012, In: Thorax. 67, 11, p. 985-992 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Pneumococcal Pneumonia 100%
  • Phagocytes 74%
  • Pneumonia 32%
  • Lung 27%
  • T-Lymphocytes 24%

• Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival

  Juss, J. K., Hayhoe, R. P., Owen, C. E., Bruce, I., Walmsley, S. R., Cowburn, A. S., Kulkarni, S., Boyle, K. B., Stephens, L., Hawkins, P. T., Chilvers, E. R. & Condliffe, A. M., 24 Sep 2012, In: PLoS ONE. 7, 9, 15 p., e45933.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Phosphatidylinositol 3-Kinase 100%
  • Intercellular Signaling Peptides and Proteins 80%
  • Protein Isoforms 79%
  • Neutrophils 77%
  • Granulocyte-Macrophage Colony-Stimulating Factor 28%

• Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

  McGrath, E. E., Lawrie, A., Marriott, H. M., Mercer, P., Cross, S. S., Arnold, N., Singleton, V., Thompson, A. A. R., Walmsley, S. R., Renshaw, S. A., Sabroe, I., Chambers, R. C., Dockrell, D. & Whyte, M. K. B., Sep 2012, In: Thorax. 67, 9, p. 796-803 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Idiopathic Pulmonary Fibrosis 100%
  • Lung Injury 87%
  • Fibrosis 61%
  • Tumor Necrosis Factor-alpha 59%
  • Ligands 58%

• A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis

  Santhakumar, K., Judson, E. C., Elks, P. M., McKee, S., Elworthy, S., van Rooijen, E., Walmsley, S. S., Renshaw, S. A., Cross, S. S. & van Eeden, F. J. M., 15 Aug 2012, In: Cancer Research. 72, 16, p. 4017-27 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Zebrafish 100%
  • Hypoxia 77%
  • Carcinogenesis 75%
  • 2-oxoglutarate 3-dioxygenase proline 59%
  • Transgenes 49%

• Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis

  Kiss, J., Mollenhauer, M., Walmsley, S. R., Kirchberg, J., Radhakrishnan, P., Niemietz, T., Dudda, J., Steinert, G., Whyte, M. K. B., Carmeliet, P., Mazzone, M., Weitz, J. & Schneider, M., 15 Aug 2012, In: The Journal of Immunology. 189, 4, p. 1955-1965 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Innate Immunity 100%
  • Sepsis 87%
  • Oxygen 77%
  • NF-kappa B 69%
  • Macrophages 45%
• 2011

  Activation of hypoxia-inducible factor-1 alpha (Hif-1 alpha) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

  Elks, P. M., van Eeden, F. J., Dixon, G., Wang, X., Reyes-Aldasoro, C. C., Ingham, P. W., Whyte, M. K. B., Walmsley, S. R. & Renshaw, S. A., 21 Jul 2011, In: Blood. 118, 3, p. 712-722 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Hypoxia-Inducible Factor 1 100%
  • Site-Directed Mutagenesis 82%
  • Zebrafish 80%
  • Neutrophils 62%
  • Apoptosis 48%

• Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

  Walmsley, S. R., Chilvers, E. R., Thompson, A. A., Vaughan, K., Marriott, H. M., Parker, L. C., Shaw, G., Parmar, S., Schneider, M., Sabroe, I., Dockrell, D., Milo, M., Taylor, C. T., Johnson, R. S., Pugh, C. W., Ratcliffe, P. J., Maxwell, P. H., Carmeliet, P. & Whyte, M. K. B., Mar 2011, In: Journal of Clinical Investigation. 121, 3, p. 1053-1063 11 p.

  Research output: Contribution to journal › Article › peer-review

  • 2-oxoglutarate 3-dioxygenase proline 100%
  • Neutrophils 43%
  • Inflammation 32%
  • Hypoxia 30%
  • Apoptosis 10%

• Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing of Staphylococcus aureus in Human Neutrophils

  McGovern, N. N., Cowburn, A. S., Porter, L., Walmsley, S. R., Summers, C., Thompson, A. A. R., Anwar, S., Willcocks, L. C., Whyte, M. K. B., Condliffe, A. M. & Chilvers, E. R., Jan 2011, In: The Journal of Immunology. 186, 1, p. 453-463 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Respiratory Burst 100%
  • Staphylococcus aureus 70%
  • Hypoxia 64%
  • Neutrophils 63%
  • NADPH Oxidases 23%
• 2010

  Distinct Cell Death Programs in Monocytes Regulate Innate Responses Following Challenge with Common Causes of Invasive Bacterial Disease

  Webster, S. J., Daigneault, M., Bewley, M. A., Preston, J. A., Marriott, H. M., Walmsley, S. R., Read, R. C., Whyte, M. K. B. & Dockrell, D., 1 Sep 2010, In: The Journal of Immunology. 185, 5, p. 2968-2979 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Monocytes 100%
  • Cell Death 91%
  • Caspase 1 49%
  • Apoptosis 49%
  • Klebsiella pneumoniae 42%
• 2009

  Hypoxia Hypoxia, hypoxia inducible factor and myeloid cell function

  Walmsley, S. R., Chilvers, E. R. & Whyte, M. K. B., 2009, In: Arthritis Research and Therapy. 11, 2, 7 p., 219.

  Research output: Contribution to journal › Literature review › peer-review

  • Myeloid Cells 100%
  • Hypoxia 77%
  • Critical Pathways 37%
  • Innate Immunity 30%
  • Neutrophils 25%