Sarah Walmsley

2024

Primary cilia as a targetable node between biliary injury, senescence and regeneration in liver transplantation

Esser, H., Kilpatrick, A. M., Man, T. Y., Aird, R., Rodrigo-Torres, D., Buch, M. L., Boulter, L., Walmsley, S., Oniscu, G. C., Schneeberger, S., Ferreira-Gonzalez, S. & Forbes, S. J., Dec 2024, In: Journal of Hepatology. 81, 6, p. 1005-1022

Research output: Contribution to journal › Article › peer-review

Open Access

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How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia

Mirchandani, A. S., Sanchez Garcia, M. A. & Walmsley, S. R., 30 Sept 2024, In: Nature Reviews Immunology.

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Open Access

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Accelarated immune ageing is associated with COVID-19 disease severity

ISARIC4C Investigators, Adeloye, D., Baillie, J., Bularga, A., Daines, L., Lone, N., Mills, N., Newby, D., Pius, R., Shankar-Hari, M., Sheikh, A., Sudlow, C., Walmsley, S. & Zheng, B., 11 Jan 2024, In: Immunity and Ageing. 21, 1, 18 p., 6.

Research output: Contribution to journal › Article › peer-review

Open Access

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2023

Differential roles for the oxygen sensing enzymes PHD1 and PHD3 in the regulation of neutrophil metabolism and function

Watts, E., Willson, J. A., Arienti, S., Sadiku, P., Coelho, P., Sanchez Garcia, M. A., Zhang, A., Murphy, F., Dickinson, R., Mirchandani, A. S., Morrison, T., Lewis, A., Vermaelen, W., Ghesquiere, B., Carmeliet, P., Mazzone, M., Maxwell, P. H., Pugh, C. W., Dockrell, D. H. & Whyte, M. & 1 others, Walmsley, S. R., 11 Dec 2023, (E-pub ahead of print) In: Wellcome Open Research .

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Open Access

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Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study

The C-MORE/PHOSP-COVID Collaborative Group, Nov 2023, In: The Lancet Respiratory Medicine. 11, 11, p. 1003-1019 17 p.

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Open Access

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NRF2 activation reprogrammes defects in oxidative metabolism to restore macrophage function in COPD

Ryan, E., Sadiku, P., Coelho, P., Watts, E. R., Zhang, A., Howden, A. J. M., Sanchez Garcia, M. A., Bewley, M. A., Cole, J., McHugh, B., Vermaelen, W., Ghesquiere, B., Carmeliet, P., Rodriguez Blanco, G., von Kriegsheim, A., Sanchez, Y., Rumsey, W., Callahan, J. F., Cooper, G. & Parkinson, N. & 8 others, Baillie, J. K., Cantrell, D., McCafferty, J., Choudhury, G., Singh, D., Dockrell, D. H., Whyte, M. K. B. & Walmsley, S. R., 1 Feb 2023, (E-pub ahead of print) In: American Journal of Respiratory and Critical Care Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation

Mirchandani, A. S., Jenkins, S. J., Bain, C. C., Sanchez Garcia, M. A., Lawson, H., Coelho, P., Murphy, F., Griffith, D., Zhang, A., Morrison, T., Ly, T., Arienti, S., Sadiku, P., Watts, E. R., Dickinson, R., Reyes, L., Cooper, G., Clark, S., Lewis, D. & Kelly, V. & 22 others, Spanos, C., Musgrave, K. M., Delaney, L., Harper, I., Scott, J., Parkinson, N., Rostron, A. J., Baillie, J. K., Clohisey, S., Pridans, C., Campana, L., Starkey Lewis, P., Simpson, A. J., Dockrell, D. H., Schwarze, J., Hirani, N., Ratcliffe, P. J., Pugh, C. W., Kranc, K., Forbes, S. J., Whyte, M. K. B. & Walmsley, S. R., 27 May 2022, In: Nature Immunology.

Research output: Contribution to journal › Article › peer-review

Open Access

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2021

The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair

Mccowan, J., Fercoq, F., Kirkwood, P. M., T’jonck, W., Hegarty, L. M., Mawer, C. M., Cunningham, R., Mirchandani, A. S., Hoy, A., Humphries, D. C., Jones, G.-R., Hansen, C. G., Hirani, N., Jenkins, S. J., Henri, S., Malissen, B., Walmsley, S. R., Dockrell, D. H., Saunders, P. T. K. & Carlin, L. M. & 1 others, Bain, C. C., 19 Nov 2021, In: Science Immunology. 6, 65

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Neutrophil HIF-1α stabilisation is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle

Willson, J. A., Arienti, S., Sadiku, P., Reyes, L., Coelho, P., Morrison, T., Rinaldi, G., Dockrell, D. H., Whyte, M. K. B. & Walmsley, S. R., 19 Aug 2021, In: Blood.

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Open Access

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Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation

Virga, F., Cappellesso, F., Stijlemans, B., Henze, A.-T., Trotta, R., Van Audenaerde, J., Mirchandani, A. S., Sanchez Garcia, M. A., Vandewalle, J., Orso, F., Riera-Domingo, C., Griffa, A., Ivan, C., Smits, E., Laoui, D., Martelli, F., Langouche, L., Van den Berghe, G., Feron, O. & Ghesquiere, B. & 8 others, Prenen, H., Libert, C., Walmsley, S. R., Corbet, C., Van Ginderachter, J. A., Ivan, M., Taverna, D. & Mazzone, M., 7 May 2021, In: Science Advances.

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Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism

Watts, E. R., Howden, A. J. M., Morrison, T., Sadiku, P., Hukelmann, J. L., Von Kriegsheim, A., Ghesquière, B., Murphy, F., Mirchandani, A. S., Humphries, D. C., Grecian, R., Ryan, E. M., Coelho, P., Rodriguez-blanco, G., Plant, T. M., Dickinson, R. S., Finch, A. J., Vermaelen, W., Cantrell, D. A. & Whyte, M. K. B. & 1 others, Walmsley, S. R., 6 Apr 2021, (E-pub ahead of print) In: Journal of Clinical Investigation.

Research output: Contribution to journal › Article › peer-review

Open Access

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A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS

Reyes, L., Sanchez Garcia, M. A., Morrison, T., Howden, A. J. M., Watts, E. R., Arienti, S., Sadiku, P., Coelho, P., Mirchandani, A. S., Zhang, A., Hope, D., Clark , S. K., Singleton, J., Johnston, S., Grecian, R., Poon, A. S., McNamara, S., Harper, I., Fourman, M. H. & Brenes, A. J. & 14 others, Pathak, S., Lloyd, A., Rodriguez Blanco, G., von Kriegsheim, A., Ghesquiere, B., Vermaelen, W., Cologna, C. T., Dhaliwal, K., Hirani, N., Dockrell, D. H., Whyte, M. K. B., Griffith, D. M., Cantrell, D. & Walmsley, S. R., 22 Feb 2021, In: Wellcome Open Research .

Research output: Contribution to journal › Article › peer-review

Open Access

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Neutrophils Fuel Effective Immune Responses through Gluconeogenesis and Glycogenesis

Sadiku, P., Willson, J. A., Ryan, E. M., Sammut, D., Coelho, P., Watts, E. R., Grecian, R., Young, J. M., Bewley, M., Arienti, S., Mirchandani, A. S., Sanchez Garcia, M. A., Morrison, T., Zhang, A., Reyes, L., Griessler, T., Jheeta, P., Paterson, G. G., Graham, C. J. & Thompson, J. P. & 16 others, Baillie, K., Thompson, A. A. R., Morgan, J.-M., Acosta-Sanchez, A., Dardé, V. M., Duran, J., Guinovart, J. J., Rodriguez-Blanco, G., Von Kriegsheim, A., Meehan, R. R., Mazzone, M., Dockrell, D. H., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 2 Feb 2021, In: Cell Metabolism. 33, 2, p. 411-423.e4

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2020

Rate of replenishment and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages

Bain, C. C., Gibson, D. A., Steers, N. J., Boufea, K., Louwe, P. A., Doherty, C., González-huici, V., Gentek, R., Magalhaes-pinto, M., Shaw, T., Bajénoff, M., Bénézech, C., Walmsley, S. R., Dockrell, D. H., Saunders, P. T. K., Batada, N. N. & Jenkins, S. J., 26 Jun 2020, In: Science Immunology. 5, 48, eabc4466.

Research output: Contribution to journal › Article › peer-review

Open Access

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Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

Plant, T., Eamsamarng, S., Sanchez-Garcia, M. A., Reyes, L., Renshaw, S. A., Coelho, P., Mirchandani, A. S., Morgan, J.-M., Ellett, F. E., Morrison, T., Humphries, D., Watts, E. R., Murphy, F., Raffo-Iraolagoitia, X. L., Zhang, A., Cash, J. L., Loynes, C., Elks, P. M., Van Eeden, F. & Carlin, L. M. & 3 others, Furley, A. J. W., Whyte, M. K. B. & Walmsley, S. R., 1 Jun 2020, In: Journal of Clinical Investigation. 130, 6, p. 3221-3237

Research output: Contribution to journal › Article › peer-review

Open Access

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2019

Hypoxia modulates platelet purinergic signalling pathways

Paterson, G. G., Young, J. M., Willson, J. A., Graham, C. J., Dru, R. C., Lee, E. W., Torpey, G. S., Walmsley, S., Chan, M. V., Warner, T. D., Baillie, K. & Roger Thompson, A. A., 13 Dec 2019, (E-pub ahead of print) In: Thrombosis and Haemostasis.

Research output: Contribution to journal › Article › peer-review

Open Access

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IL4Rα signaling abrogates hypoxic neutrophil survival and limits acute lung injury responses in vivo

Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., Coelho, P., Watts, E. R., Sadiku, P., Griffith, D., Dickinson, R. S., Clark, E., Willson, J. A., Morrison, T., Mazzone, M., Carmeliet, P., Ghesquiere, B., O'Kane, C., McAuley, D. & Jenkins, S. J. & 2 others, Whyte, M. K. B. & Walmsley, S. R., 15 Jul 2019, In: American Journal of Respiratory and Critical Care Medicine. 200, 2, p. 235–246 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response

Sadiku, P. & Walmsley, S. R., 14 Mar 2019, (E-pub ahead of print) In: EMBO Reports. p. e47388

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

Hypoxia and reprogramming of host pathogen interactions

Ryan, E. M., Whyte, M. K. & Walmsley, S. R., 27 Nov 2018, (E-pub ahead of print) In: Current opinion in physiology. 7, p. 15-20

Research output: Contribution to journal › Article › peer-review

Open Access

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Inflammation and Hypoxia: HIF and PHD Isoform Selectivity

Watts, E. R. & Walmsley, S. R., 1 Nov 2018, In: Trends in Molecular Medicine.

Research output: Contribution to journal › Article › peer-review

Open Access

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Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease is Enhanced by Nrf2 Agonists

COPDMAP, Bewley, M. A., Budd, R. C., Ryan, E., Cole, J., Collini, P., Marshall, J., Kolsum, U., Beech, G., Emes, R. D., Tcherniaeva, I., Berbers, G. A. M., Walmsley, S. R., Donaldson, G., Wedzicha, J. A., Kilty, I., Rumsey, W., Sanchez, Y., Brightling, C. E. & Donnelly, L. E. & 4 others, Barnes, P. J., Singh, D., Whyte, M. K. B. & Dockrell, D. H., 15 Sept 2018, In: American Journal of Respiratory and Critical Care Medicine. 198, 6, p. 739-750 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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The role of neutrophils in cancer

Grecian, R., Whyte, M. & Walmsley, S., 22 Aug 2018, In: British Medical Bulletin.

Research output: Contribution to journal › Article › peer-review

Open Access

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Getting DAMP(s) Wets the Whistle for Neutrophil Recruitment

Watts, E. R. & Walmsley, S. R., 15 May 2018, (E-pub ahead of print) In: Immunity. 48, 5, p. 846-848 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo

Dickinson, R. S., Murphy, F., Doherty, C., Williams, S., Mirchandani, A., Willson, J. A., Scotti, J. S., Preston, G., Schofield, C. J., Whyte, M. K. B. & Walmsley, S. R., 26 Oct 2017, In: Wellcome Open Research . 2, p. 104

Research output: Contribution to journal › Article › peer-review

Open Access

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Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses

Sadiku, P., Willson, J. A., Dickinson, R., Murphy, F., Harris, A., Lewis, A., Sammut, D., Mirchandani, A. S., Ryan, E., Watts, E. R., Thompson, A. A. R., Marriott, H. M., Dockrell, D. H., Taylor, C. T., Schneider, M., Maxwell, P. H., Chilvers, E. R., Mazzone, M., Moral, V. & Pugh, C. W. & 6 others, Ratcliffe, P. J., Schofield, C. J., Ghesquiere, B., Carmeliet, P., Whyte, M. K. B. & Walmsley, S. R., 1 Sept 2017, In: Journal of Clinical Investigation. 127, 9, p. 3407-3420 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Hypoxia determines survival outcomes of bacterial infection through HIF-1α–dependent reprogramming of leukocyte metabolism

Thompson, A. A. R., Dickinson, R. S., Murphy, F., Thomson, J. P., Marriott, H. M., Tavares, A., Willson, J., Williams, L., Lewis, A., Mirchandani, A., Dos Santos Coelho, P., Doherty, C., Ryan, E., Watts, E., Morton, N. M., Forbes, S., Stimson, R. H., Hameed, A. G., Arnold, N. & Preston, J. A. & 15 others, Lawrie, A., Finisguerra, V., Mazzone, M., Sadiku, P., Goveia, J., Taverna, F., Carmeliet, P., Foster, S. J., Chilvers, E. R., Cowburn, A. S., Dockrell, D. H., Johnson, R. S., Meehan, R. R., Whyte, M. K. B. & Walmsley, S. R., 24 Feb 2017, In: Science Immunology. 2, 8, eaal2861.

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

Mutations in Succinate Dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1alpha expression

Jones, R., McDonald, K. E., Willson, J. A., Ghesquiere, B., Sammut, D., Daniel, E., Harris, A. J., Lewis, A., Thompson, A. A. R., Dickinson, R. S., Plant, T., Murphy, F., Sadiku, P., Keevil, B. G., Carmeliet, P., Whyte, M. K. B., Newell-Price, J. & Walmsley, S. R., 26 May 2016, In: Blood. 127, 21, p. 2641-2644 4 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

Exploring the HIFs, Buts and Maybes of Hypoxia Signalling in Disease: Lessons From Zebrafish Models

Elks, P. M., Renshaw, S. A., Meijer, A. H., Walmsley, S. & Van Eeden, F. J., 1 Nov 2015, In: Disease Models and Mechanisms. 8, 11, p. 1349-1360

Research output: Contribution to journal › Article › peer-review

Open Access

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MET is required for the recruitment of anti-tumoural neutrophils

Finisguerra, V., Di Conza, G., Di Matteo, M., Serneels, J., Costa, S., Thompson, A. A. R., Wauters, E., Walmsley, S., Prenen, H., Granot, Z., Casazza, A. & Mazzone, M., 18 Jun 2015, In: Nature. 522, 7556, p. 349-353 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism

Robertson, A. L., Holmes, G. R., Bojarczuk, A. N., Burgon, J., Loynes, C. A., Chimen, M., Sawtell, A. K., Hamza, B., Willson, J., Walmsley, S. R., Anderson, S. R., Coles, M. C., Farrow, S. N., Solari, R., Jones, S., Prince, L. R., Irimia, D., Rainger, G. E., Kadirkamanathan, V. & Whyte, M. K. B. & 1 others, Renshaw, S. A., 26 Feb 2014, In: Science Translational Medicine. 6, 225, 10 p., 225ra29.

Research output: Contribution to journal › Article › peer-review

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish

Thompson, A. A. R., Elks, P. M., Marriott, H. M., Eamsamarng, S., Higgins, K. R., Lewis, A., Williams, L., Parmar, S., Shaw, G., McGrath, E. E., Formenti, F., Van Eeden, F. J., Kinnula, V. L., Pugh, C. W., Sabroe, I., Dockrell, D. H., Chilvers, E. R., Robbins, P. A., Percy, M. J. & Simon, M. C. & 4 others, Johnson, R. S., Renshaw, S. A., Whyte, M. K. B. & Walmsley, S. R., 16 Jan 2014, In: Blood. 123, 3, p. 366-376 11 p.

Research output: Contribution to journal › Article › peer-review

2013

Hypoxia Inducible Factor Signaling Modulates Susceptibility to Mycobacterial Infection via a Nitric Oxide Dependent Mechanism

Elks, P. M., Brizee, S., van der Vaart, M., Walmsley, S. R., van Eeden, F. J., Renshaw, S. A. & Meijer, A. H., 19 Dec 2013, In: PLoS Pathogens. 9, 12, 16 p., 1003789.

Research output: Contribution to journal › Article › peer-review

Open Access

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Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination

Luong, L. A., Fragiadaki, M., Smith, J., Boyle, J., Lutz, J., Dean, J. L. E., Harten, S., Ashcroft, M., Walmsley, S. R., Haskard, D. O., Maxwell, P. H., Walczak, H., Pusey, C. & Evans, P. C., 7 Jun 2013, In: Circulation Research. 112, 12, p. 1583-1591 20 p.

Research output: Contribution to journal › Article › peer-review

Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., Zheng, L., Gardet, A., Tong, Z., Jany, S. S., Corr, S. C., Haneklaus, M., Caffrey, B. E., Pierce, K., Walmsley, S. & Beasley, F. C. & 12 others, Cummins, E., Nizet, V., Whyte, M., Taylor, C. T., Lin, H., Masters, S. L., Gottlieb, E., Kelly, V. P., Clish, C., Auron, P. E., Xavier, R. J. & O'Neill, L. A. J., 11 Apr 2013, In: Nature. 496, 7444, p. 238-242 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines

Basran, A., Jabeen, M., Bingle, L., Stokes, C. A., Dockrell, D., Whyte, M. K. B., Walmsley, S. R., Higgins, K. R., Vogel, S. N., Wilson, H. L., Prince, L. R., Prestwich, E. C., Sabroe, R. A., Parker, L. C. & Sabroe, I., Jan 2013, In: Journal of Leukocyte Biology. 93, 1, p. 7-19 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2012

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia

Marriott, H. M., Daigneault, M., Thompson, A. A. R., Walmsley, S. R., Gill, S. K., Witcher, D. R., Wroblewski, V. J., Hellewell, P. G., Whyte, M. K. B. & Dockrell, D., Nov 2012, In: Thorax. 67, 11, p. 985-992 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival

Juss, J. K., Hayhoe, R. P., Owen, C. E., Bruce, I., Walmsley, S. R., Cowburn, A. S., Kulkarni, S., Boyle, K. B., Stephens, L., Hawkins, P. T., Chilvers, E. R. & Condliffe, A. M., 24 Sept 2012, In: PLoS ONE. 7, 9, 15 p., e45933.

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Open Access

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Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis

McGrath, E. E., Lawrie, A., Marriott, H. M., Mercer, P., Cross, S. S., Arnold, N., Singleton, V., Thompson, A. A. R., Walmsley, S. R., Renshaw, S. A., Sabroe, I., Chambers, R. C., Dockrell, D. & Whyte, M. K. B., Sept 2012, In: Thorax. 67, 9, p. 796-803 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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A zebrafish model to study and therapeutically manipulate hypoxia signaling in tumorigenesis

Santhakumar, K., Judson, E. C., Elks, P. M., McKee, S., Elworthy, S., van Rooijen, E., Walmsley, S. S., Renshaw, S. A., Cross, S. S. & van Eeden, F. J. M., 15 Aug 2012, In: Cancer Research. 72, 16, p. 4017-27 11 p.

Research output: Contribution to journal › Article › peer-review

Loss of the Oxygen Sensor PHD3 Enhances the Innate Immune Response to Abdominal Sepsis

Kiss, J., Mollenhauer, M., Walmsley, S. R., Kirchberg, J., Radhakrishnan, P., Niemietz, T., Dudda, J., Steinert, G., Whyte, M. K. B., Carmeliet, P., Mazzone, M., Weitz, J. & Schneider, M., 15 Aug 2012, In: The Journal of Immunology. 189, 4, p. 1955-1965 11 p.

Research output: Contribution to journal › Article › peer-review

2011

Activation of hypoxia-inducible factor-1 alpha (Hif-1 alpha) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model

Elks, P. M., van Eeden, F. J., Dixon, G., Wang, X., Reyes-Aldasoro, C. C., Ingham, P. W., Whyte, M. K. B., Walmsley, S. R. & Renshaw, S. A., 21 Jul 2011, In: Blood. 118, 3, p. 712-722 11 p.

Research output: Contribution to journal › Article › peer-review

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

Walmsley, S. R., Chilvers, E. R., Thompson, A. A., Vaughan, K., Marriott, H. M., Parker, L. C., Shaw, G., Parmar, S., Schneider, M., Sabroe, I., Dockrell, D., Milo, M., Taylor, C. T., Johnson, R. S., Pugh, C. W., Ratcliffe, P. J., Maxwell, P. H., Carmeliet, P. & Whyte, M. K. B., Mar 2011, In: Journal of Clinical Investigation. 121, 3, p. 1053-1063 11 p.

Research output: Contribution to journal › Article › peer-review

Hypoxia Selectively Inhibits Respiratory Burst Activity and Killing of Staphylococcus aureus in Human Neutrophils

McGovern, N. N., Cowburn, A. S., Porter, L., Walmsley, S. R., Summers, C., Thompson, A. A. R., Anwar, S., Willcocks, L. C., Whyte, M. K. B., Condliffe, A. M. & Chilvers, E. R., Jan 2011, In: The Journal of Immunology. 186, 1, p. 453-463 11 p.

Research output: Contribution to journal › Article › peer-review

2010

Distinct Cell Death Programs in Monocytes Regulate Innate Responses Following Challenge with Common Causes of Invasive Bacterial Disease

Webster, S. J., Daigneault, M., Bewley, M. A., Preston, J. A., Marriott, H. M., Walmsley, S. R., Read, R. C., Whyte, M. K. B. & Dockrell, D., 1 Sept 2010, In: The Journal of Immunology. 185, 5, p. 2968-2979 12 p.

Research output: Contribution to journal › Article › peer-review

2008

Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin

Prince, L. R., Bianchi, S. M., Vaughan, K. M., Bewley, M. A., Marriott, H. M., Walmsley, S. R., Taylor, G. W., Buttle, D. J., Sabroe, I., Dockrell, D. & Whyte, M. K. B., 1 Mar 2008, In: The Journal of Immunology. 180, 5, p. 3502-3511 10 p.

Research output: Contribution to journal › Article › peer-review

2006

Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis

Walmsley, S. R., Cowburn, A. S., Clatworthy, M. R., Morrell, N. W., Roper, E. C., Singleton, V., Maxwell, P., Whyte, M. K. B. & Chilvers, E. R., 1 Nov 2006, In: Blood. 108, 9, p. 3176-3178 3 p.

Research output: Contribution to journal › Article › peer-review

2005

z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species

Cowburn, A., White, J., Deighton, J., Walmsley, S. & Chilvers, E., 1 Apr 2005, In: Blood. 105, 7, p. 2970-2972 3 p.

Research output: Contribution to journal › Article › peer-review

Hypoxia-induced neutrophil survival is mediated by HIF-1 alpha-dependent NF-kappa B activity

Walmsley, S., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R., Cramer, T., Sobolewski, A., Condliffe, A., Cowburn, A., Johnson, N. & Chilvers, E., 3 Jan 2005, In: Journal of Experimental Medicine. 201, 1, p. 105-115 11 p.

Research output: Contribution to journal › Article › peer-review

2004

Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils

Walmsley, S., Cowburn, A., Sobolewski, A., Murray, J., Farahi, N., Sabroe, I. & Chilvers, E., Jun 2004, In: Biochemical Society Transactions. 32, p. 456-460 5 p.

Research output: Contribution to journal › Article › peer-review

2002

Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis

Mecklenburgh, K., Walmsley, S., Cowburn, A., Wiesener, M., Reed, B., Upton, P., Deighton, J., Greening, A. & Chilvers, E., 15 Oct 2002, In: Blood. 100, 8, p. 3008-3016 9 p.

Research output: Contribution to journal › Article › peer-review

Sarah Walmsley

Research output

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