Research output per year
Research output per year
Personal profile
My research in a nutshell
Our research is focused on nuclear chromatin control of gene expression in mammalian and vertebrate embryos, stem cells, reprogrammed cells and yeast-based models. We investigate the dynamics of epigenetic DNA methylation and histone modifications essential for early development, differentiation and cell fate reprogramming. These marks create an epigenetic ‘landscape’ that supports cell type specific gene regulatory networks but can also provide an epigenetic readout of exposures, ageing and other conditions. We study these epigenetic mechanisms in tissue specification, including cardiovascular development, the developmental origins of disease and regeneration. Our research interests centre on chromatin-mediated gene repression mechanisms and chromatin remodelling in gene activation. We have discovered that heterochromatin matures late in development but is induced early in mouse embryonic stem cells; and that epigenetic marks can rapidly adapt to cell culture.
Teaching
MScR in Biomedical Sciences (Life Sciences) - Course Module Organiser
Keywords
- Q Science (General)
- Epigenetics
- Chromatin
- Development
- Cardiovascular
- Stem Cells
- Cell Reprogramming
- Histone Modification
- DNA Methylation
Fingerprint
Dive into the research topics where Sari Pennings is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
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Rett syndrome: Interferon-γ to the rescue?
Meehan, R. R. & Pennings, S., 4 Nov 2024, (E-pub ahead of print) In: EMBO Molecular Medicine.Research output: Contribution to journal › Comment/debate › peer-review
Open AccessFile -
Activation of transcription factor circuity in 2i-induced ground state pluripotency is independent of repressive global epigenetic landscapes
Shukla, R., Mjoseng, H. K., Thomson, J., Kling, S., Sproul, D., Dunican, D., Ramsahoye, B., Wongtawan, T., Treindl, F., Templin, M. F., Adams, I., Pennings, S. & Meehan, R., 20 Aug 2020, In: Nucleic Acids Research.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency
McLaughlin, K., Flyamer, I. M., Thomson, J. P., Mjoseng, H. K., Shukla, R., Williamson, I., Grimes, G. R., Illingworth, R. S., Adams, I. R., Pennings, S., Meehan, R. R. & Bickmore, W. A., 12 Nov 2019, In: Cell Reports. 29, 7, p. 1974-1985.e6 18 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Dynamics and Mechanisms of DNA Methylation Reprogramming
Pennings, S., Revuelta, A., Mclaughlin, K. A., Abd Hadi, N. A., Petchreing, P., Ottaviano, R. & Meehan, R. R., 31 May 2019, Epigenetics and Regeneration. Elsevier, p. 19-45Research output: Chapter in Book/Report/Conference proceeding › Chapter
Open AccessFile -
The Stem Cell Niche: Interactions between Stem Cells and Their Environment
Pennings, S., Liu, K. J. & Qian, H., 14 Oct 2018, (E-pub ahead of print) In: Stem Cells International.Research output: Contribution to journal › Editorial › peer-review
Open AccessFile
Activities
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Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network
Vernimmen, D. (Organiser), Pennings, S. (Organiser), AlBawardi, W. (Speaker), Doyle, L. (Speaker) & Alhussini, A. (Speaker)
19 Mar 2025Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network
Vernimmen, D. (Organiser), Pennings, S. (Organiser), Malysz, K. (Speaker), Watson, J. (Speaker) & Friman, E. (Speaker)
13 Nov 2024Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network
Vernimmen, D. (Organiser) & Pennings, S. (Organiser)
5 Jun 2024Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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Edinburgh Chromatin, Epigenetics and Transcriptional Regulation Network
Vernimmen, D. (Organiser), Pennings, S. (Organiser), Benabdallah, N. (Speaker), Kumar, Y. (Speaker), Witteveldt, J. (Speaker) & Bresson, S. (Speaker)
6 Mar 2024Activity: Participating in or organising an event types › Participation in workshop, seminar, course
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BBSRC (External organisation)
Pennings, S. (Member)
1 Feb 2024 → 31 Mar 2024Activity: Membership types › Membership of peer review panel or committee
Prizes
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Senior Fellowship of the Higher Education Academy (SFHEA)
Pennings, S. (Recipient), 25 Aug 2021
Prize: Fellowships awarded competitively
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Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology
Meehan, R. (Principal Investigator), Meehan, R. (Principal Investigator) & Pennings, S. (Co-investigator)
Natural Environment Research Council
1/08/21 → 31/07/25
Project: Research
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Hazard Identification Platform to Assess the Health Impacts from Indoor and Outdoor Air Pollutant Exposures, through Mechanistic Toxicology
Pennings, S. (Principal Investigator) & Meehan, R. (Co-investigator)
1/08/21 → 31/07/25
Project: Research
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Epigenetics in Embryo Development and Embryonic Stem Cells - KAU SACB PhD Scholarship
Pennings, S. (Principal Investigator)
1/12/18 → …
Project: Other (Non-Funded/Miscellaneous)
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Molecular embryology approaches to investigate epigenetic roles in early development - Thai Government Scholarship
Pennings, S. (Principal Investigator)
15/09/15 → …
Project: Other (Non-Funded/Miscellaneous)
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DNA methylation dynamics and epigenetic diversity in development and cell reprogramming - Malaysian Government PhD Scholarship
Pennings, S. (Principal Investigator)
1/10/13 → …
Project: Other (Non-Funded/Miscellaneous)