Research output per year
Research output per year
PROF
Accepting PhD Students
Neurodegenerative diseases affect cells in the nervous system called neurons. Twenty million people worldwide are diagnosed with a neurodegenerative disease each year, and at present they are all progressive and incurable.
The Chandran group links clinical activity with laboratory research into two such conditions: multiple sclerosis and motor neurone disease. Measuring disease course and treatment outcomes through disease bio-registers builds an increasingly accurate clinical picture.
In parallel, studies in the lab —including using human stem cells—focus on understanding what is going wrong in the neurons and supporting cells called glia. Bringing these two strands together, the group aims to develop novel regenerative therapies and bring them to early-phase clinical trials.
Can the damaged brain repair itself? Prof Chandran's talk at TED Global (Feb 2014)
Professor Siddharthan Chandran works in the emerging discipline of Regenerative Neurology. His research combines laboratory activity that includes human stem cells with specialist clinics (multiple sclerosis [MS] and motor neurone disease [MND]) to both study disease as well as undertake early-phase clinical trials.
The ultimate aim is to develop novel regenerative therapies for neurodegenerative disease.
Based at the Anne Rowling Regenerative Neurology Clinic, clinical research is founded on specialist clinics and linked disease registries to develop a clinical experimental infrastructure for longitudinal studies. Current collaborative clinical projects include:
Research in the lab is focused on the glial-neuronal interaction in health and disease. Current approaches include:
At the University of Edinburgh, Professor Chandran is:
Doctor in Philosophy, University of Cambridge
Award Date: 1 Jan 2000
Bachelor of Medicine, University of Southampton
Award Date: 1 Jan 1990
Bachelor of Science, University of Southampton
Award Date: 1 Jan 1989
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Meijboom, R. (Presenter), Valdes Hernandez, M. (Contributor), Wiseman, S. (Contributor), York, B. (Contributor), Colville, S. (Contributor), Chandran, S. (Contributor), Connick, P. (Contributor) & Waldman, A. (Contributor)
Activity: Participating in or organising an event types › Participation in conference
Chandran, S. (Member)
Activity: Consultancy types › Contribution to the work of national or international committees and working groups
Chandran, S. (Member)
Activity: Membership types › Membership of external research organisation
Chandran, S. (Member)
Activity: Membership types › Membership of peer review panel or committee
Chandran, S. (Member)
Activity: Membership types › Membership of peer review panel or committee
Chandran, S. (Recipient), 2017
Prize: Election to learned society
Thangaraj Selvaraj, B. (Principal Investigator), Carragher, N. (Co-investigator), Chandran, S. (Co-investigator), Graham, R. (Co-investigator), Hardingham, G. (Co-investigator), Newton, J. (Co-investigator) & Pal, S. (Co-investigator)
Motor Neurone Disease Association
1/10/24 → 31/03/26
Project: Research
Tam, J. (Principal Investigator), Chandran, S. (Co-investigator) & Pal, S. (Co-investigator)
1/10/24 → 30/09/27
Project: Research
Kline, R. (Principal Investigator), Chandran, S. (Co-investigator), Chandran, S. (Co-investigator), Gillingwater, T. (Co-investigator), Gillingwater, T. (Co-investigator), Thangaraj Selvaraj, B. (Co-investigator), Thangaraj Selvaraj, B. (Co-investigator) & Wishart, T. (Co-investigator)
1/06/24 → 31/05/27
Project: Research
Pal, S. (Principal Investigator), Chandran, S. (Co-investigator) & Newton, J. (Co-investigator)
1/11/23 → 31/10/28
Project: Research
Pal, S. (Principal Investigator) & Chandran, S. (Co-investigator)
1/08/23 → 31/12/26
Project: Research
Longden, J. (Creator), Chandran, S. (Owner) & Story, D. (Data Manager), Edinburgh DataVault, Sept 2029
Dataset
Longden, J. (Creator), Chandran, S. (Owner) & Story, D. (Data Manager), Edinburgh DataVault, Jun 2029
Dataset
Longden, J. (Creator), Chandran, S. (Owner) & Story, D. (Data Manager), Edinburgh DataVault, Mar 2029
Dataset
Longden, J. (Creator), Chandran, S. (Owner) & Story, D. (Data Manager), Edinburgh DataVault, Feb 2029
Dataset
Longden, J. (Creator), Chandran, S. (Owner) & Story, D. (Data Manager), Edinburgh DataVault, Jan 2029
Dataset
2/12/17
1 Media contribution
Press/Media: Research
26/09/17
1 item of Media coverage
Press/Media: Expert Comment
31/12/16 → 1/01/17
8 items of Media coverage
Press/Media: Research
Ffrench-Constant, C. & Chandran, S.
10/01/10
144 items of Media coverage
Press/Media: Research
Chandran, S. & Ffrench-Constant, C.
2/10/13
1 item of Media coverage
Press/Media: Research