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Collaborations and top research areas from the last five years
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Self-regulating gene therapy ameliorates phenotypes and overcomes gene dosage sensitivity in a mouse model of Rett syndrome
Ross, P. D., Gadalla, K. K. E., Thomson, S. R., Selfridge, J., Bahey, N. G., Benito, J., Burstein, S. R., McMinn, R., Bolon, B., Hector, R. D. & Cobb, S. R., 2 Apr 2025, In: Science Translational Medicine. 17, 792, p. eadq3614Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Rett syndrome
Gold, W. A., Percy, A. K., Neul, J. L., Cobb, S. R., Pozzo-Miller, L., Issar, J. K., Ben-Zeev, B., Vignoli, A. & Kaufmann, W. E., 7 Nov 2024, In: Nature Reviews Disease Primers. 10, 84.Research output: Contribution to journal › Review article › peer-review
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Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons
Bracha, S., Johnson, H. J., Pranckevicius, N. A., Catto, F., Economides, A. E., Litvinov, S., Hassi, K., Rigoli, M. T., Cheroni, C., Bonfanti, M., Valenti, A., Stucchi, S., Attreya, S., Ross, P. D., Walsh, D., Malachi, N., Livne, H., Eshel, R., Krupalnik, V. & Levin, D. & 8 others, , Aug 2024, In: Nature Microbiology. 9, 8, p. 2051-2072 22 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Novel MECP2 gene therapy is effective in a multicenter study using two mouse models of Rett syndrome and is safe in non-human primates
Powers, S., Likhite, S., Gadalla, K. K., Miranda, C. J., Huffenberger, A. J., Dennys, C., Foust, K. D., Morales, P., Pierson, C. R., Rinaldi, F., Perry, S., Bolon, B., Wein, N., Cobb, S., Kaspar, B. K. & Meyer, K. C., 6 Sept 2023, In: Molecular Therapy. 31, 9, p. 2767-2782 16 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Convergent cerebrospinal fluid proteomes and metabolic ontologies in humans and animal models of Rett syndrome
Zlatic, S. A., Duong, D., Gadalla, K. K. E., Murage, B., Ping, L., Shah, R., Fink, J. J., Khwaja, O., Swanson, L. C., Sahin, M., Rayaprolu, S., Kumar, P., Rangaraju, S., Bird, A., Tarquinio, D., Carpenter, R., Cobb, S. & Faundez, V., 16 Sept 2022, In: iScience. 25, 9, 28 p., 104966.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Developing Efficient Trans-splicing Therapies In Neurodevelopmental Disorders 2024
Cobb, S. (Principal Investigator)
1/01/24 → 31/12/26
Project: Research
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Developing a gene therapy for the treatment of Creatine Transporter Deficiency Syndrome
Cobb, S. (Principal Investigator)
1/03/23 → 28/02/25
Project: Research
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Assessing the therapeutic potential of an AAV-based gene therapy in SYNGAP1 haploinsufficiency
Cobb, S. (Principal Investigator) & Kind, P. (Co-investigator)
1/09/22 → 31/08/24
Project: Research
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Imaging macroscopic cortical dynamics to understand sensorimotor dysfunction and recovery in a mouse model of Rett Syndrome
Cobb, S. (Principal Investigator) & Duguid, I. (Co-investigator)
1/02/22 → 31/01/25
Project: Research
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Imaging macroscopic cortical dynamics to understand sensorimotor dysfunction and recovery in a mouse model of Rett Syndrome
Duguid, I. (Principal Investigator) & Cobb, S. (Co-investigator)
1/02/22 → 31/01/26
Project: Research
Press/Media
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Scottish Neuroscience Initiative Takes Basic Science From Lab to Clinic
Kind, P., Bird, A., Cobb, S. & Rochefort, N.
1/01/24
1 item of Media coverage
Press/Media: Research