Susana Munoz Maniega

2015

Association of allostatic load with brain structure and cognitive ability in later life

Booth, T., Royle, N. A., Corley, J., Gow, A. J., Valdés Hernández, M. D. C., Munoz-Maniega, S., Ritchie, S. J., Bastin, M. E., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Mar 2015, In: Neurobiology of Aging. 36, 3, p. 1390-1399 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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White matter hyperintensities and normal-appearing white matter integrity in the aging brain

Muñoz Maniega, S., Valdés Hernández, M. C., Clayden, J. D., Royle, N. A., Murray, C., Morris, Z., Aribisala, B. S., Gow, A. J., Starr, J. M., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., 28 Feb 2015, In: Neurobiology of Aging. 36, 2, p. 909-918 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Compensation or inhibitory failure? Testing hypotheses of age-related right frontal lobe involvement in verbal memory ability using structural and diffusion MRI

Cox, S. R., Bastin, M. E., Ferguson, K. J., Allerhand, M., Royle, N. A., Munoz-Maniega, S., Starr, J. M., MacLullich, A. M. J., Wardlaw, J. M., Deary, I. J. & MacPherson, S. E., Feb 2015, In: Cortex. 63, p. 4-15 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Exploratory analysis of dietary intake and brain iron accumulation detected using magnetic resonance imaging in older individuals: the Lothian Birth Cohort 1936

Valdes Hernandez, M., Allan, J., Glatz, A., Kyle, J., Corley, J., Brett, C., Munoz-Maniega, S., Royle, N., Bastin, M., Starr, J., Deary, I. & Wardlaw, J., Jan 2015, In: The journal of nutrition, health & aging (JNHA). 19, 1, p. 64-69

Research output: Contribution to journal › Article › peer-review

Open Access

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A comparison of location of acute symptomatic versus 'silent' small vessel lesions

Valdes Hernandez, M., Maconick, L. C., Munoz-Maniega, S., Wang, X., Wiseman, S., Armitage, P., Doubal, F., Makin, S., Sudlow, C., Dennis, M., Deary, I., Bastin, M. & Wardlaw, J., 2015, In: International Journal of Stroke. 10, p. 1044–1050

Research output: Contribution to journal › Article › peer-review

Open Access

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Brain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936

Cox, S. R., Bastin, M. E., Ferguson, K. J., Munoz-Maniega, S., MacPherson, S. E., Deary, I. J., Wardlaw, J. M. & MacLullich, A. M. J., 2015, In: Neurobiology of Aging. 36, 1, p. 257-264 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Genes from a translational analysis support a multifactorial nature of white matter hyperintensities

Lopez, L., Hill, W. D., Harris, S. E., Valdes Hernandez, M., Munoz-Maniega, S., Bastin, M., Bailey, E. L., Smith, C., McBride, M. W., Mcclure, J. D., Graham, D., Dominiczak, A. F., Yang, Q., Fornage, M., Ikfram, MA., Debette, S., Launer, L., Bis, J. C., Schmidt, R., Seshadri, S., & 4 othersPorteous, D., Starr, J., Deary, I. & Wardlaw, J., 2015, In: Stroke. 46, 2, p. 341-347 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Structural brain MRI trait polygenic score prediction of cognitive abilities

Generation Scotland & SINAPSE Collaborative Grp, 2015, In: Twin Research and Human Genetics. 18, p. 738-745 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936

Booth, T., Mõttus, R., Corley, J., Gow, A. J., Henderson, R. D., Munoz-Maniega, S., Murray, C., Royle, N. A., Sprooten, E., Hernández, M. C. V., Bastin, M. E., Penke, L., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Dec 2014, In: Health Psychology. 33, 12, p. 1477-1486 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Lyall, D. M., Harris, S. E., Bastin, M. E., Munoz-Maniega, S., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Valdés Hernández, M., Royle, N. A., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., 23 Sept 2014, In: Translational Psychiatry. 4, 9, 7 p., e449.

Research output: Contribution to journal › Article › peer-review

Open Access

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Potential effect of skull thickening on the associations between cognition and brain atrophy in ageing

Aribisala, B. S., Royle, N. A., Valdés Hernández, M. C., Murray, C., Penke, L., Gow, A., Munoz-Maniega, S., Starr, J. M., Bastin, M., Deary, I. & Wardlaw, J., Sept 2014, In: Age and Ageing. 43, 5, p. 712-716 5 p.

Research output: Contribution to journal › Article › peer-review

Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936

Lyall, D. M., Harris, S. E., Bastin, M. E., Munoz-Maniega, S., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Hernandez, M. D. C. V., Royle, N. A., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., Jun 2014, In: Neurobiology of Aging. 35, 6, p. 1513.e25–1513.e33 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old age

Karama, S., Bastin, M. E., Murray, C., Royle, N. A., Penke, L., Munoz-Maniega, S., Gow, A. J., Corley, J., Valdés Hernández, M., Lewis, J. D., Rousseau, M-E., Lepage, C., Fonov, V., Collins, D. L., Booth, T., Rioux, P., Sherif, T., Adalat, R., Starr, J. M., Evans, A. C., & 2 othersWardlaw, J. M. & Deary, I. J., May 2014, In: Molecular Psychiatry. 19, 5, p. 555-559 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Quantitative multi-modal MRI of the hippocampus and cognitive ability in community-dwelling older subjects

Aribisala, B., Royle, N., Munoz-Maniega, S., Valdes Hernandez, M., Murray, C., Penke, L., Gow, A., Starr, J., Bastin, M., Deary, I. & Wardlaw, J., Apr 2014, In: Cortex. 53C, p. 34-44 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

Aribisala, B. S., Wiseman, S., Morris, Z., Valdes Hernandez, M., Royle, N. A., Munoz-Maniega, S., Gow, A. J., Corley, J., Bastin, M. E., Starr, J., Deary, I. J. & Wardlaw, J. M., 7 Jan 2014, In: Stroke. 45, 2, p. 605-607 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Morphologic, distributional, volumetric, and intensity characterization of periventricular hyperintensities

Hernández, M. C. V., Piper, R. J., Bastin, M. E., Royle, N. A., Munoz-Maniega, S., Aribisala, B. S., Murray, C., Deary, I. J. & Wardlaw, J. M., Jan 2014, In: American Journal of Neuroradiology. 35, 1, p. 55-62 8 p.

Research output: Contribution to journal › Article › peer-review

Differentiation of calcified regions and iron deposits in the ageing brain on conventional structural MR images: Calcium and Iron on Conventional MRI

Valdes Hernandez, M., Glatz, A., Kiker, A. J., Dickie, D., Aribisala, B. S., Royle, N. A., Munoz-Maniega, S., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., 2014, In: Journal of Magnetic Resonance Imaging. 40, p. 324-333

Research output: Contribution to journal › Article › peer-review

Open Access

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2013

Brain white matter damage in aging and cognitive ability in youth and older age

Valdés Hernández, M. D. C., Booth, T., Murray, C., Gow, A. J., Penke, L., Morris, Z., Munoz-Maniega, S., Royle, N. A., Aribisala, B. S., Bastin, M. E., Starr, J. M., Deary, I. J. & Wardlaw, J. M., Dec 2013, In: Neurobiology of Aging. 34, 12, p. 2740-2747 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Estimated maximal and current brain volume predict cognitive ability in old age

Royle, N. A., Booth, T., Valdés Hernández, M. C., Penke, L., Murray, C., Gow, A. J., Munoz-Maniega, S., Starr, J., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., Dec 2013, In: Neurobiology of Aging. 34, 12, p. 2726-2733 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Alzheimer's Disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936

Lyall, D. M., Royle, N. A., Harris, S. E., Bastin, M. E., Munoz-Maniega, S., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Valdes Hernandez, M., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., 15 Nov 2013, In: PLoS ONE. 8, 11, e80513.

Research output: Contribution to journal › Article › peer-review

Open Access

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Associations between level and change in physical function and brain volumes

Aribisala, B. S., Gow, A. J., Bastin, M. E., Valdes Hernandez, M., Murray, C., Royle, N. A., Munoz-Maniega, S., Starr, J. M., Deary, I. J. & Wardlaw, J. M., 12 Nov 2013, In: PLoS ONE. 8, 11, 9 p., 80386.

Research output: Contribution to journal › Article › peer-review

Open Access

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Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936

Booth, T., Bastin, M. E., Penke, L., Munoz-Maniega, S., Murray, C., Royle, N. A., Gow, A. J., Corley, J., Henderson, R. D., Hernández, M. D. C. V., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Sept 2013, In: Neuropsychology. 27, 5, p. 595-607 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936

McIntosh, A. M., Bastin, M. E., Luciano, M., Munoz-Maniega, S., Valdes Hernandez, M., Royle, N. A., Hall, J., Murray, C., Lawrie, S. M., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Jun 2013, In: Psychological Medicine. 43, 6, p. 1197-1206 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort 1936

Aribisala, B. S., Valdes Hernandez, M. C., Royle, N. A., Morris, Z., Munoz-Maniega, S., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., Apr 2013, In: European Radiology. 23, 4, p. 1084-1092 9 p.

Research output: Contribution to journal › Article › peer-review

Association Between Blood Pressure, Internal Carotid Artery Flow Parameters And Age-related White Matter Disease

Aribisala, B. S., Valdes Hernandez, M., Royle, N. A., Munoz-Maniega, S., Bastin, M., Deary, I. & Wardlaw, J. M., Feb 2013, In: Stroke. 44, 2, 1 p., AWP186.

Research output: Contribution to journal › Meeting abstract › peer-review

ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936

Lyall, D. M., Lopez, L. M., Bastin, M. E., Munoz-Maniega, S., Penke, L., Hernandez, M. D. C. V., Royle, N. A., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., Jan 2013, In: Behavior Genetics. 43, 1, p. 13-23 11 p.

Research output: Contribution to journal › Article › peer-review

Close Correlation between Quantitative and Qualitative Assessments of White Matter Lesions

Hernandez, M. D. C. V., Morris, Z., Dickie, D., Royle, N. A., Munoz-Maniega, S., Aribisala, B. S., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., 2013, In: Neuroepidemiology. 40, 1, p. 13-22 10 p.

Research output: Contribution to journal › Article › peer-review

Probabilistic Neighborhood Tractography in the Preterm Neonatal Brain at 3 T

Anblagan, D., Bastin, M., Kershaw, L., Munoz-Maniega, S., Clayden, J. D., Piyasena, C., Wilkinson, G., Roberts, N., Semple, S., Norman, J. & Boardman, J., 2013.

Research output: Contribution to conference › Abstract › peer-review

Open Access

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Probabilistic Neighbourhood Tractography in the Developing Brain

Anblagan, D., Bastin, M., Kershaw, L., Munoz-Maniega, S., Clayden, J. D., Piyasena, C., Wilkinson, G., Semple, S., Roberts, N., Norman, J. & Boardman, J., 2013.

Research output: Contribution to conference › Abstract › peer-review

Open Access

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Probabilistic Neighbourhood Tractography in the Preterm Neonatal Brain

Anblagan, D., Bastin, M., Kershaw, L., Munoz-Maniega, S., Clayden, J. D., Piyasena, C., Wilkinson, G., Roberts, N., Semple, S., Norman, J. & Boardman, J., 2013.

Research output: Contribution to conference › Abstract › peer-review

Open Access

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2012

ADRB2, white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936

Lyall, D., Lopez, L., Bastin, M., Munoz-Maniega, S., Penke, L., Hernandes, M. D. V., Royle, N., Starr, J., Porteous, D., Wardlaw, J. & Deary, I., Nov 2012, In: Behavior Genetics. 42, 6, p. 949-949 1 p.

Research output: Contribution to journal › Meeting abstract › peer-review

A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research

SINAPSE Collaborative Grp, Wardlaw, J. M., Brindle, W., Casado, A. M., Shuler, K., Henderson, M., Thomas, B., Macfarlane, J., Munoz-Maniega, S., Lymer, K., Morris, Z., Pernet, C., Nailon, W., Ahearn, T., Mumuni, A. N., Mugruza, C., McLean, J., Chakirova, G., Tao, Y., Simpson, J., & 9 othersStanfield, A. C., Johnston, H., Parikh, J., Royle, N. A., De Wilde, J., Bastin, M. E., Weir, N., Farrall, A. & Valdes Hernandez, M. C., Nov 2012, In: European Radiology. 22, 11, p. 2295-2303 9 p.

Research output: Contribution to journal › Article › peer-review

Brain white matter tract integrity as a neural foundation for general intelligence

Penke, L., Munoz-Maniega, S., Bastin, M., Valdes Hernandez, M., Murray, C., Royle, N., Starr, J., Wardlaw, J. & Deary, I., Oct 2012, In: Molecular Psychiatry. 17, 10, p. 1026-1030

Research output: Contribution to journal › Article › peer-review

Brain-wide white matter tract integrity is associated with information processing speed and general intelligence

Penke, L., Munoz-Maniega, S., Valdes Hernandez, M., Bastin, M. E., Murray, C., Royle, N. A., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Oct 2012, In: Molecular Psychiatry. 17, 10, p. 955-955 1 p.

Research output: Contribution to journal › Editorial › peer-review

Neuroprotective lifestyles and the aging brain Activity, atrophy, and white matter integrity

Gow, A. J., Bastin, M. E., Munoz-Maniega, S., Valdes Hernandez, M., Morris, Z., Murray, C., Royle, N. A., Starr, J. M., Deary, I. & Wardlaw, J. M., Oct 2012, In: Neurology. 79, 17, p. 1802-1808 7 p.

Research output: Contribution to journal › Article › peer-review

A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity

Lopez, L., Bastin, M. E., Munoz-Maniega, S., Penke, L., Davies, G., Christoforou, A., Valdes Hernandez, M., Royle, N. A., Tenesa, A., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., Aug 2012, In: Neurobiology of Aging. 33, 8, p. 1847.e1–1847.e14 14 p.

Research output: Contribution to journal › Article › peer-review

Brain structure and cognitive ageing: Imaging the Lothian Birth Cohort 1936

Bastin, M. E., Munoz-Maniega, S., Hernandez, D. C. V. M., Royle, N. A., Aribisala, B. S., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Aug 2012, In: Journal of Aging and Physical Activity. 20, p. S14-S15 2 p.

Research output: Contribution to journal › Meeting abstract

Brain iron deposits are associated with general cognitive ability and cognitive aging

Penke, L., Valdes Hernandez, M., Maniega, S. M., Gow, A. J., Murray, C., Starr, J., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., 1 Mar 2012, In: Neurobiology of Aging. 33, p. 510-517

Research output: Contribution to journal › Article › peer-review

Automatic segmentation of brain white matter and white matter lesions in normal aging: comparison of five multispectral techniques

Valdés Hernández, M. D. C., Gallacher, P. J., Bastin, M. E., Royle, N. A., Munoz-Maniega, S., Deary, I. J. & Wardlaw, J. M., Feb 2012, In: Magnetic Resonance Imaging. 30, 2, p. 222-9 8 p.

Research output: Contribution to journal › Article › peer-review

Color fusion of magnetic resonance images improves intracranial volume measurement in studies of aging

Valdes Hernandez, M., Royle, N., Jackson, M., Munoz-Maniega, S., Penke, L., Bastin, M., Deary, I. & Wardlaw, J., 2012, In: Open Journal of Radiology. 2, p. 1-9

Research output: Contribution to journal › Article › peer-review

Open Access

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2011

Brain Ageing, Cognition in Youth and Old Age, and Vascular Disease in the Lothian Birth Cohort 1936: Rationale, Design and Methodology of the Imaging Protocol

Wardlaw, J. M., Bastin, M. E., Valdes Hernandez, M., Muñoz Maniega, S., Royle, N. A., Morris, Z., Clayden, J. D., Sandeman, E. M., Eadie, E., Murray, C., Starr, J. M. & Deary, I. J., Dec 2011, In: International Journal of Stroke. 6, 6, p. 547-559 13 p.

Research output: Contribution to journal › Article › peer-review

TractoR: Magnetic Resonance Imaging and Tractography with R

Clayden, J. D., Maniega, S. M., Storkey, A. J., King, M. D., Bastin, M. E. & Clark, C. A., Oct 2011, In: Journal of Statistical Software. 44, 8, p. 1-18 18 p.

Research output: Contribution to journal › Article › peer-review

The volumetric measurement of brain imaging biomarkers for epidemiological studies can be misleading in the validation of image segmentation methods

Valdes Hernandez, M., Royle, N. A., Munoz-Maniega, S., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., Aug 2011, In: Journal of Epidemiology & Community Health. 65, p. A82-A83 2 p.

Research output: Contribution to journal › Meeting abstract

2010

A General Factor of Brain White Matter Integrity Predicts Information Processing Speed in Healthy Older People

Penke, L., Maniega, S. M., Murray, C., Gow, A. J., Valdes Hernandez, M., Clayden, J. D., Starr, J., Wardlaw, J. M., Bastin, M. E. & Deary, I. J., 2 Jun 2010, In: The Journal of Neuroscience. 30, 22, p. 7569-7574

Research output: Contribution to journal › Article › peer-review

Open Access

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White Matter Integrity in the Splenium of the Corpus Callosum is Related to Successful Cognitive Aging and Partly Mediates the Protective Effect of an Ancestral Polymorphism in ADRB2

Penke, L., Maniega, S. M., Houlihan, L. M., Murray, C., Gow, A. J., Clayden, J. D., Bastin, M. E., Wardlaw, J. M. & Deary, I. J., 1 Mar 2010, In: Behavior Genetics. 40, 2, p. 146-156

Research output: Contribution to journal › Article › peer-review

2009

The Relationship of Anterior Thalamic Radiation Integrity to Psychosis Risk Associated Neuregulin-1 Variants

Sprooten, E., Lymer, G. K., Maniega, S. M., McKirdy, J., Clayden, J. D., Bastin, M. E., Porteous, D., Johnstone, E. C., Lawrie, S. M., Hall, J. & McIntosh, A. M., 15 Apr 2009, In: Biological Psychiatry. 65, 8, p. 202S-203S 2 p.

Research output: Contribution to journal › Meeting abstract › peer-review

Reproducibility of tract segmentation between sessions using an unsupervised modelling-based approach

Clayden, J. D., Storkey, A. J., Maniega, S. M. & Bastin, M. E., Apr 2009, In: NeuroImage. 45, 2, p. 377-385 9 p.

Research output: Contribution to journal › Article › peer-review

The relationship of anterior thalamic radiation integrity to psychosis risk associated neuregulin-1 variants

Sprooten, E., Lymer, G. K., Maniega, S. M., McKirdy, J., Clayden, J. D., Bastin, M. E., Porteous, D., Johnstone, E. C., Lawrie, S. M., Hall, J. & McIntosh, A. M., Mar 2009, In: Molecular Psychiatry. 14, 3, p. 237-238 2 p.

Research output: Contribution to journal › Letter › peer-review

Lacunar stroke is associated with diffuse blood–brain barrier dysfunction

Wardlaw, J. M., Doubal, F., Armitage, P., Chappell, F., Carpenter, T., Munoz, S., Farrall, A., Sudlow, C., Dennis, M. & Dhillon, B., Feb 2009, In: Annals of Neurology. 65, 2, p. 194-202 9 p.

Research output: Contribution to journal › Article › peer-review

White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging

Sussmann, J. E., Lymer, G. K. S., McKirdy, J., Moorhead, T. W. J., Munoz-Maniega, S., Job, D., Hall, J., Bastin, M. E., Johnstone, E. C., Lawrie, S. M. & McIntosh, A. M., Feb 2009, In: Bipolar Disorders. 11, 1, p. 11-18 8 p.

Research output: Contribution to journal › Article › peer-review

Susana Munoz Maniega

Research output

Search results