Tara Spires-Jones, FMedSci

Search results

• Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease - RNAseq data

  Spires-Jones, T. (Creator) & Dando, O. (Creator), EMBL's European Bioinformatics Institute, 2019

  https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-7856

  Dataset

• LTP data from MAPT-AD experiment and APP/PS1 experiment

  Oren, I. (Creator) & Spires-Jones, T. (Owner), Edinburgh DataVault, 2018

  DOI: 10.7488/bacc399c-0d03-41d6-92b9-a180d6dc7b84, https://datavault.ed.ac.uk/

  Dataset

• Spires-Jones archived raw lab data 2013-2018

  Spires-Jones, T. (Creator) & Spires-Jones, T. (Data Manager), Edinburgh DataVault, 1 Sept 2018

  https://datavault.ed.ac.uk/

  Dataset

• Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease - TEM data

  Spires-Jones, T. (Creator), Edinburgh DataShare, 17 Aug 2018

  DOI: 10.7488/ds/2417

  Dataset

• Image analysis macros for array tomography

  Spires-Jones, T. (Creator), Edinburgh DataShare, 24 Jul 2019

  DOI: 10.7488/ds/2592, https://doi.org/10.1101/393405

  Dataset

• Data from paper: Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer’s disease

  Spires-Jones, T. (Creator), Edinburgh DataShare, 23 Feb 2022

  DOI: 10.7488/ds/3412, https://doi.org/10.1101/2021.11.24.469829

  Dataset

• Data from paper: Predictive blood biomarkers and brain changes associated with age-related cognitive decline

  Spires-Jones, T. (Creator), Edinburgh DataShare, 22 Mar 2023

  DOI: 10.7488/ds/3826

  Dataset

• Array tomography image analysis macros 2024

  Spires-Jones, T. (Creator), Edinburgh DataShare, 13 Feb 2025

  DOI: 10.7488/ds/7875

  Dataset

• Data from paper: Evidence for trans-synaptic propagation of oligomeric tau in human Progressive Supranuclear Palsy

  Chang, Y. Y. (Creator), Spires-Jones, M. (Creator), Gilmore, M. (Creator), Holt, K. (Creator), Meftah, S. (Creator), Ravingerova, N. (Creator), Scutariu, C. (Creator), Taylor, L. (Creator), Hindley-Pollock, N. (Creator), Geary, B. (Creator), Spires-Jones, T. (Creator), Durrant, C. (Creator), Mcgeachan, R. (Creator), Keavey, L. (Creator) & Simzer, E. (Creator), Edinburgh DataShare, 7 Apr 2025

  DOI: 10.7488/ds/7908

  Dataset

• Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer’s disease - Kurucu et al

  Spires-Jones, T. (. (Creator), Edinburgh DataShare, 26 Jul 2021

  DOI: 10.7488/ds/3098, https://doi.org/10.1111/ene.15043

  Dataset

• Images from paper: Synaptic resilience is associated with maintained cognition during ageing

  King, D. (Creator) & Spires-Jones, T. (Owner), Edinburgh DataVault, 26 Oct 2022

  DOI: 10.7488/b9dcf607-1339-4127-a3c0-263ce9f3d164

  Dataset

• Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Array tomography data and Analysis macros

  Spires-Jones, T. (Creator) & Henstridge, C. (Creator), Edinburgh DataShare, 18 Dec 2017

  DOI: 10.7488/ds/2269, https://datashare.is.ed.ac.uk/handle/10283/2974 and one more link, https://datashare.is.ed.ac.uk/handle/10283/2975 (show fewer)

  Dataset

• 3D scanning electron microscope movie of human neocortex

  Moss, J. (Creator), Mcgeachan, R. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 17 Feb 2025

  DOI: 10.7488/ds/7877

  Dataset

• Non-fibrillar oligomeric amyloid-β within synapses: Data set from publication Pickett et al 2016 J Alz Dis

  Pickett, E. (Creator), Koffie, R. M. (Creator), Wegmann, S. (Creator), Henstridge, C. (Creator), Herrmann, A. (Creator), Colom-Cadena, M. (Creator), Lleo, A. (Creator), Kay, K. R. (Creator), Vaught, M. (Creator), Soberman, R. (Creator), Walsh, D. M. (Creator), Hyman, B. T. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 3 Jun 2016

  DOI: 10.7488/ds/1415

  Dataset

• Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer’s disease - Data from 2017 Publication

  Spires-Jones, T. (Creator) & Pickett, E. (Creator), Edinburgh DataShare, 6 Feb 2017

  DOI: 10.7488/ds/1706, http://onlinelibrary.wiley.com/doi/10.1002/syn.21965/full

  Dataset

• Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease

  Catalano, S. M. (Creator), Dando, O. (Creator), Hamby, M. E. (Creator), Izzo, N. J. (Creator), Smith, C. (Creator), Spires-Jones, T. (Creator), Colom Cadena, M. (Creator), Toombs, J. (Creator), Simzer, E. M. (Creator), Tulloch, J. (Creator), Jackson, R. (Creator), Catterson, J. (Creator), Rose, J. (Creator), Waybright, L. (Creator), Caggiano, A. O. (Creator), Davies, C. (Creator), Hooley, M. (Creator), Dunnett, S. (Creator), Tempelaar, R. (Creator) & Tzioras, M. (Creator), Edinburgh DataShare, 9 Jan 2024

  DOI: 10.7488/ds/7664, https://www.biorxiv.org/content/10.1101/2021.02.01.428238v2

  Dataset

• Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse: Data set from publication Henstridge et al 2015 Acta Neuropath Comms

  Henstridge, C. (Creator), Jackson, R. (Creator), Kim, J. (Creator), Herrmann, A. (Creator), Wright, A. K. (Creator), Harris, S. (Creator), Bastin, M. (Creator), Starr, J. (Creator), Wardlaw, J. (Creator), Gillingwater, T. (Creator), Smith, C. (Creator), McKenzie, C.-A. (Creator), Cox, S. (Creator), Deary, I. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 1 Jun 2016

  DOI: 10.7488/ds/1414

  Dataset

• Human tau increases amyloid beta plaque size but not amyloid beta-mediated synapse loss in a novel mouse model of Alzheimer’s disease: Data set from Jackson et al 2016 EJN

  Spires-Jones, T. (Creator) & Jackson, R. (Creator), Edinburgh DataShare, 28 Oct 2016

  DOI: 10.7488/ds/1507

  Dataset

• Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype - proteomics dataset

  Spires-Jones, T. (Creator) & Wishart, T. (Creator), PRIDE database hosted by European Bioinformatics Institute, EBI, May 2020

  https://www.ebi.ac.uk/pride/archive/projects/PXD013753

  Dataset

• Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

  Spires-Jones, T. (Creator), Edinburgh DataShare, 27 Jul 2023

  DOI: 10.7488/ds/7492, https://doi.org/10.1101/795930

  Dataset

• p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003

  Durrant, C. (Creator), Taylor, L. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 8 Feb 2024

  DOI: 10.7488/ds/7680, https://doi.org/10.1007/s00401-023-02667-w

  Dataset

• Carboxy Terminus Heat shock Protein 70 interacting Protein reduces tau-associated degenerative changes 

  Spires-Jones, T. (Creator), Edinburgh DataShare, 4 Sept 2015

  DOI: 10.7488/ds/296

  Dataset

• Data from paper: Synaptic resilience is associated with maintained cognition during ageing

  Toombs, J. (Creator), King, D. (Creator), Holt, K. (Creator), Dando, O. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 27 Oct 2022

  DOI: 10.7488/ds/3777, https://www.medrxiv.org/content/10.1101/2022.05.04.22274679v1

  Dataset

• Data from paper: Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10+16 mutation

  Spires-Jones, T. (Creator) & Dando, O. (Creator), Edinburgh DataShare, 13 Aug 2024

  DOI: 10.7488/ds/7790, https://doi.org/10.1111/nan.13006

  Dataset

• Research Plan - The effect of APOE genotype on microglial-mediated synapse loss in AD

  Spires-Jones, T. (Creator) & Tzioras, M. (Creator), Edinburgh DataShare, 5 Apr 2018

  DOI: 10.7488/ds/2335

  Dataset

• Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures

  Tulloch, J. (Creator), Rose, J. (Creator), Gobbo, F. (Creator), Chang, Y. Y. (Creator), McLay, L. (Creator), King, D. (Creator), Liaquat, I. (Creator), Spires-Jones, T. (Creator), Booker, S. (Creator), Brennan, P. (Creator), Durrant, C. (Creator), Elliott, J. (Creator), Mcgeachan, R. (Creator), Meftah, S. (Creator), Taylor, L. (Creator), Catterson, J. (Creator), Negro, D. (Creator), Bonthron, C. (Creator) & Holt, K. (Creator), Edinburgh DataShare, 7 Apr 2025

  DOI: 10.7488/ds/7890

  Dataset

• Data from Paper: Synaptic oligomeric tau in Alzheimer's disease - a potential culprit in the spread of tau pathology through the brain

  Spires-Jones, T. (Creator), Colom Cadena, M. (Creator) & Davies, C. (Creator), Edinburgh DataShare, 12 Apr 2023

  DOI: 10.7488/ds/3837

  Dataset

• Array Tomography Movie 

  Spires-Jones, T. (Creator), Edinburgh DataShare, 8 Sept 2015

  DOI: 10.7488/ds/297, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712649/

  Dataset