Datasets
- 28 results
Search results
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Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer's Disease - RNAseq data
Spires-Jones, T. (Creator) & Dando, O. (Creator), EMBL's European Bioinformatics Institute, 2019
https://www.ebi.ac.uk/biostudies/arrayexpress/studies/E-MTAB-7856
Dataset
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LTP data from MAPT-AD experiment and APP/PS1 experiment
Oren, I. (Creator) & Spires-Jones, T. (Owner), Edinburgh DataVault, 2018
DOI: 10.7488/bacc399c-0d03-41d6-92b9-a180d6dc7b84, https://datavault.ed.ac.uk/
Dataset
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Spires-Jones archived raw lab data 2013-2018
Spires-Jones, T. (Creator) & Spires-Jones, T. (Data Manager), Edinburgh DataVault, 1 Sept 2018
Dataset
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Region-specific depletion of synaptic mitochondria in the brains of patients with Alzheimer's disease - TEM data
Spires-Jones, T. (Creator), Edinburgh DataShare, 17 Aug 2018
DOI: 10.7488/ds/2417
Dataset
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Image analysis macros for array tomography
Spires-Jones, T. (Creator), Edinburgh DataShare, 24 Jul 2019
DOI: 10.7488/ds/2592, https://doi.org/10.1101/393405
Dataset
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Data from paper: Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer’s disease
Spires-Jones, T. (Creator), Edinburgh DataShare, 23 Feb 2022
DOI: 10.7488/ds/3412, https://doi.org/10.1101/2021.11.24.469829
Dataset
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Data from paper: Predictive blood biomarkers and brain changes associated with age-related cognitive decline
Spires-Jones, T. (Creator), Edinburgh DataShare, 22 Mar 2023
DOI: 10.7488/ds/3826
Dataset
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Array tomography image analysis macros 2024
Spires-Jones, T. (Creator), Edinburgh DataShare, 13 Feb 2025
DOI: 10.7488/ds/7875
Dataset
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Data from paper: Evidence for trans-synaptic propagation of oligomeric tau in human Progressive Supranuclear Palsy
Chang, Y. Y. (Creator), Spires-Jones, M. (Creator), Gilmore, M. (Creator), Holt, K. (Creator), Meftah, S. (Creator), Ravingerova, N. (Creator), Scutariu, C. (Creator), Taylor, L. (Creator), Hindley-Pollock, N. (Creator), Geary, B. (Creator), Spires-Jones, T. (Creator), Durrant, C. (Creator), Mcgeachan, R. (Creator), Keavey, L. (Creator) & Simzer, E. (Creator), Edinburgh DataShare, 7 Apr 2025
DOI: 10.7488/ds/7908
Dataset
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Inhibitory synapse loss and accumulation of amyloid beta in inhibitory presynaptic terminals in Alzheimer’s disease - Kurucu et al
Spires-Jones, T. (. (Creator), Edinburgh DataShare, 26 Jul 2021
DOI: 10.7488/ds/3098, https://doi.org/10.1111/ene.15043
Dataset
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Images from paper: Synaptic resilience is associated with maintained cognition during ageing
King, D. (Creator) & Spires-Jones, T. (Owner), Edinburgh DataVault, 26 Oct 2022
DOI: 10.7488/b9dcf607-1339-4127-a3c0-263ce9f3d164
Dataset
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Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis - Array tomography data and Analysis macros
Spires-Jones, T. (Creator) & Henstridge, C. (Creator), Edinburgh DataShare, 18 Dec 2017
DOI: 10.7488/ds/2269, https://datashare.is.ed.ac.uk/handle/10283/2974 and one more link, https://datashare.is.ed.ac.uk/handle/10283/2975 (show fewer)
Dataset
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3D scanning electron microscope movie of human neocortex
Moss, J. (Creator), Mcgeachan, R. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 17 Feb 2025
DOI: 10.7488/ds/7877
Dataset
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Non-fibrillar oligomeric amyloid-β within synapses: Data set from publication Pickett et al 2016 J Alz Dis
Pickett, E. (Creator), Koffie, R. M. (Creator), Wegmann, S. (Creator), Henstridge, C. (Creator), Herrmann, A. (Creator), Colom-Cadena, M. (Creator), Lleo, A. (Creator), Kay, K. R. (Creator), Vaught, M. (Creator), Soberman, R. (Creator), Walsh, D. M. (Creator), Hyman, B. T. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 3 Jun 2016
DOI: 10.7488/ds/1415
Dataset
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Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer’s disease - Data from 2017 Publication
Spires-Jones, T. (Creator) & Pickett, E. (Creator), Edinburgh DataShare, 6 Feb 2017
DOI: 10.7488/ds/1706, http://onlinelibrary.wiley.com/doi/10.1002/syn.21965/full
Dataset
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Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Catalano, S. M. (Creator), Dando, O. (Creator), Hamby, M. E. (Creator), Izzo, N. J. (Creator), Smith, C. (Creator), Spires-Jones, T. (Creator), Colom Cadena, M. (Creator), Toombs, J. (Creator), Simzer, E. M. (Creator), Tulloch, J. (Creator), Jackson, R. (Creator), Catterson, J. (Creator), Rose, J. (Creator), Waybright, L. (Creator), Caggiano, A. O. (Creator), Davies, C. (Creator), Hooley, M. (Creator), Dunnett, S. (Creator), Tempelaar, R. (Creator) & Tzioras, M. (Creator), Edinburgh DataShare, 9 Jan 2024
DOI: 10.7488/ds/7664, https://www.biorxiv.org/content/10.1101/2021.02.01.428238v2
Dataset
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Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse: Data set from publication Henstridge et al 2015 Acta Neuropath Comms
Henstridge, C. (Creator), Jackson, R. (Creator), Kim, J. (Creator), Herrmann, A. (Creator), Wright, A. K. (Creator), Harris, S. (Creator), Bastin, M. (Creator), Starr, J. (Creator), Wardlaw, J. (Creator), Gillingwater, T. (Creator), Smith, C. (Creator), McKenzie, C.-A. (Creator), Cox, S. (Creator), Deary, I. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 1 Jun 2016
DOI: 10.7488/ds/1414
Dataset
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Human tau increases amyloid beta plaque size but not amyloid beta-mediated synapse loss in a novel mouse model of Alzheimer’s disease: Data set from Jackson et al 2016 EJN
Spires-Jones, T. (Creator) & Jackson, R. (Creator), Edinburgh DataShare, 28 Oct 2016
DOI: 10.7488/ds/1507
Dataset
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Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype - proteomics dataset
Spires-Jones, T. (Creator) & Wishart, T. (Creator), PRIDE database hosted by European Bioinformatics Institute, EBI, May 2020
https://www.ebi.ac.uk/pride/archive/projects/PXD013753
Dataset
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Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8
Spires-Jones, T. (Creator), Edinburgh DataShare, 27 Jul 2023
DOI: 10.7488/ds/7492, https://doi.org/10.1101/795930
Dataset
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p-tau Ser356 is associated with Alzheimer’s disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003
Durrant, C. (Creator), Taylor, L. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 8 Feb 2024
DOI: 10.7488/ds/7680, https://doi.org/10.1007/s00401-023-02667-w
Dataset
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Carboxy Terminus Heat shock Protein 70 interacting Protein reduces tau-associated degenerative changes
Spires-Jones, T. (Creator), Edinburgh DataShare, 4 Sept 2015
DOI: 10.7488/ds/296
Dataset
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Data from paper: Synaptic resilience is associated with maintained cognition during ageing
Toombs, J. (Creator), King, D. (Creator), Holt, K. (Creator), Dando, O. (Creator) & Spires-Jones, T. (Creator), Edinburgh DataShare, 27 Oct 2022
DOI: 10.7488/ds/3777, https://www.medrxiv.org/content/10.1101/2022.05.04.22274679v1
Dataset
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Data from paper: Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10+16 mutation
Spires-Jones, T. (Creator) & Dando, O. (Creator), Edinburgh DataShare, 13 Aug 2024
DOI: 10.7488/ds/7790, https://doi.org/10.1111/nan.13006
Dataset
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Research Plan - The effect of APOE genotype on microglial-mediated synapse loss in AD
Spires-Jones, T. (Creator) & Tzioras, M. (Creator), Edinburgh DataShare, 5 Apr 2018
DOI: 10.7488/ds/2335
Dataset
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Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures
Tulloch, J. (Creator), Rose, J. (Creator), Gobbo, F. (Creator), Chang, Y. Y. (Creator), McLay, L. (Creator), King, D. (Creator), Liaquat, I. (Creator), Spires-Jones, T. (Creator), Booker, S. (Creator), Brennan, P. (Creator), Durrant, C. (Creator), Elliott, J. (Creator), Mcgeachan, R. (Creator), Meftah, S. (Creator), Taylor, L. (Creator), Catterson, J. (Creator), Negro, D. (Creator), Bonthron, C. (Creator) & Holt, K. (Creator), Edinburgh DataShare, 7 Apr 2025
DOI: 10.7488/ds/7890
Dataset
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Data from Paper: Synaptic oligomeric tau in Alzheimer's disease - a potential culprit in the spread of tau pathology through the brain
Spires-Jones, T. (Creator), Colom Cadena, M. (Creator) & Davies, C. (Creator), Edinburgh DataShare, 12 Apr 2023
DOI: 10.7488/ds/3837
Dataset
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Array Tomography Movie
Spires-Jones, T. (Creator), Edinburgh DataShare, 8 Sept 2015
DOI: 10.7488/ds/297, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3712649/
Dataset