Ted Hupp

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• Active

  Optimisation of synthetic antibody libraries

  Ball, K. & Hupp, T.

  Heriot-Watt University

  1/03/23 → 28/02/25

  Project: Research

• KATY: Knowledge At the Tip of Your fingers: Clinical Knowledge for Humanity

  Rajan, A. & Hupp, T.

  European Commission

  1/01/21 → 30/06/25

  Project: Research

  • Major Histocompatibility Complex 100%
  • Human Leukocyte Antigen 100%
  • Learning 100%
  • Building 100%
  • Prediction Rule 100%
• Finished

  Selection and characterisation of anti-peptide synthetic antibodies for comparison with conventional reagents

  Hupp, T. & Ball, K.

  UK-based charities

  5/01/22 → 4/04/22

  Project: Research

• Use of CRISPR-based genome-wide approach for identification of vulnerabilities in canine oral melanoma

  Parkinson, N., Parys, M., Argyle, D., Baillie, K., Hupp, T. & Schoenebeck, J.

  Non-EU-based charities

  1/03/21 → 28/02/23

  Project: Research

• Use of CRISPR-based genome-wide approach for identification of vulnerabilities in canine oral melanoma

  Parkinson, N., Parys, M., Argyle, D., Baillie, K., Hupp, T. & Schoenebeck, J.

  Non-EU-based charities

  1/03/21 → 28/02/23

  Project: Research

• KATY: Knowledge At the Tip of Your fingers: Clinical Knowledge for Humanity

  Hupp, T.

  EU government bodies

  1/01/21 → 31/12/24

  Project: Research

• Examination of drug leads for binding to a novel homotrimer cavity formed by the SARS-CoV-2 spike glycoprotein

  Carragher, N., Hupp, T. & Unciti-Broceta, A.

  UK-based charities

  1/08/20 → 30/04/21

  Project: Research

  • Spike 100%
  • Glycoprotein 20%
  • Virion 20%

• Developing antibody-bioconjugate platforms for use in metastatic cancers of unmet clinical need

  Hupp, T.

  UK industry, commerce and public corporations

  1/10/19 → 30/09/23

  Project: Research

• Developing antibody-bioconjugate platforms for use in metastatic cancers of unmet clinical need

  Hupp, T.

  Industrial Biotechnology Innovation Centre [DO NOT USE - USE funder SFC Scottish Funding Council]

  1/10/19 → 30/09/23

  Project: Research

• Neoantigen discovery pipeline- from basic science to better, personalized approach to canine cancer care

  Connelley, T., Hupp, T., Mellanby, R. & Parys, M.

  UK-based charities

  1/12/18 → 1/08/22

  Project: Research

• Optimizating The Expression Of A Recombinant Anti-CD20 IgG For The Treatment Of Canine Lymphoma

  Ball, K., Argyle, D., Hupp, T. & Parys, M.

  BBSRC

  1/08/18 → 31/07/19

  Project: Research

  • Monoclonal Antibodies 100%
  • Light Chain 100%
  • Hydrogen/Deuterium Exchange Mass Spectrometry 100%
  • Binding Antibody 100%
  • Paratope 100%

• Characterising the Cellular and Transcriptional Features of Lymphatic Metastasis in Oesophageal Adenocarcinoma

  Hupp, T. & Batada, N.

  UK-based charities

  1/01/18 → 31/12/18

  Project: Research

• Mechanistically informed Phenotypic Screening to Advance New Therapeutic Treatments for Oesophageal Cancer Patients

  Carragher, N., Hupp, T., O'Neill, R. & Unciti-Broceta, A.

  UK-based charities

  1/09/17 → 31/01/20

  Project: Research

  • Diseases 100%
  • Phenotype 80%
  • Ionophore 80%
  • Cells 80%
  • Esophageal Cancer 80%

• Identification of Novel Disease Markers to Improve CIN Detection in HPV Immunised Women

  Hupp, T.

  Other

  1/04/17 → 31/03/21

  Project: Research

• ICON6 Translational Work Plan

  Gourley, C. & Hupp, T.

  UK central government bodies/local authorities, health and hospital authorities, UK industry, commerce and public corporations

  1/01/16 → 28/02/18

  Project: Research

• DIAGNOSTIC PLATFORM DEVELOPMENT IN METASTATIC OESOPHAGEAL ADENOCARCINOMA

  Hupp, T.

  UK-based charities

  1/10/15 → 30/09/19

  Project: Research

• Diagnostic Platform Development in metastatic Oesophageal

  Hupp, T. & Arends, M.

  UK industry, commerce and public corporations

  1/10/15 → 30/09/19

  Project: Research

• Development and Characterization of p53 Mutant Isogenic Cell Lines

  Hupp, T.

  UK industry, commerce and public corporations

  1/03/14 → 31/08/16

  Project: Research

• The Development of SERS based protein-protein invteraction assays to evaluate bioactivity of Antibody-conjugates in cell signalling.

  Hupp, T.

  UK industry, commerce and public corporations

  1/10/13 → 30/09/17

  Project: Research

• The development of SERS-based protein-protein interaction assays to evaluate bioactivity of Antibody-conjugates in cell signalling

  Hupp, T.

  BBSRC

  1/09/13 → 31/08/17

  Project: Research

  • Nutlin 100%
  • Protein-Protein Interaction 52%
  • Protein Protein Interaction 52%
  • Pyruvate Dehydrogenase 50%
  • Dihydrolipoamide Dehydrogenase 50%

• Identification of novel monoclonal antibody-based therapeutic strategies for the improved diagnosis and treatment of soft tissue sarcoma

  Hupp, T.

  UK-based charities

  1/06/13 → 31/05/14

  Project: Research

• The Cloining, Optimization and Validation of Caninized-Phage Monoclonal Antibody Library for regulation of Cancer responses

  Hupp, T., Argyle, D. & Ball, K.

  BBSRC

  31/07/12 → 30/07/15

  Project: Research

  • Monoclonal Antibodies 100%
  • Light Chain 62%
  • CD20 62%
  • Development 56%
  • Hydrogen/Deuterium Exchange Mass Spectrometry 50%

• TOWARDS MONOCLONAL ANTIBODY THERAPY FOR CANCER: CONSTURCTION AND VALIDATION OF A CANINE PHAGE LIBRARY

  Hupp, T. & Argyle, D.

  UK-based charities

  1/01/12 → 30/06/13

  Project: Research

• EDINBURGH CLINICAL ACADEMIC TRIAL: TRAINING PROGRAMME

  Hupp, T.

  UK-based charities

  1/08/10 → 31/07/13

  Project: Research

  • Protein 100%
  • Binding Affinity 50%
  • Shotgun Proteomics 50%
  • Peptide 50%
  • Isomerase 50%

• PHD STUDENTSHIP: FUNCTION OF THE ANTERIOR GRADIENT PROTEIN FAMILY IN CARCINGOGENESIS

  Hupp, T.

  UK-based charities

  1/10/09 → 30/09/13

  Project: Research

  • Protein Protein Interaction 100%
  • P53 25%
  • Next Generation Sequencing 25%
  • Binding Affinity 25%
  • Paralogy 25%

• ubiquitin proteasome system

  Bradley, M., Hupp, T., Tyers, M. & Walkinshaw, M.

  UK industry, commerce and public corporations

  1/09/08 → 2/11/12

  Project: Research

• Evaluating the importance of Autophagy/Xenophagy in protecting the intestinal epithelium in Crohn's Disease

  Satsangi, J., Aldhous, M., Hupp, T., Nimmo, E. & Stevens, C.

  MRC

  1/09/08 → 31/01/12

  Project: Research

  • Protein 100%
  • Nested Gene 74%
  • Association 71%
  • Mutation 55%
  • Sequencing 54%

• Characterisation of primitive stem cell-like canince cancer cells : identification of therapeutic targets through genomics

  Argyle, D., Hupp, T. & Wallace, M.

  BBSRC

  17/03/08 → 16/03/11

  Project: Research

  • Cancer Stem Cell 100%
  • Stem Cell 87%
  • Cancer Cell 87%
  • Dog 70%
  • Osteosarcoma 61%

• Regulation of the Tumor Suppressor p53 in Response to DNA Damage

  Hupp, T.

  UK-based charities

  1/10/07 → 30/09/11

  Project: Research

  • Protein Protein Interaction 100%
  • P53 25%
  • Next Generation Sequencing 25%
  • Binding Affinity 25%
  • Paralogy 25%

• PROGRAMME GRANT

  Hupp, T.

  UK-based charities

  1/09/06 → 29/02/12

  Project: Research

  • P53 100%
  • Protein 89%
  • Conformation 85%
  • Alpha Oxidation 85%
  • Dimerization 85%

• Phd Studentship for Erin Worrall-Mechanism of MDM2-mediated ubiquitination of p53.

  Hupp, T.

  UK-based charities

  1/10/05 → 30/11/11

  Project: Research

• Studentship

  Hupp, T.

  UK-based charities

  1/10/05 → 30/09/08

  Project: Research

• RASOR-Radical Solutions for Researching the Proteome: Interdisciplinary Research Collaboration in proteomic technologies

  Langridge-Smith, P., Dryden, D., Hupp, T., Sadler, P. & Walton, A.

  BBSRC

  1/08/05 → 31/10/11

  Project: Research

  • Dielectrics 100%
  • Protein 78%
  • Acoustic Wave 75%
  • Droplet 56%
  • Low Voltage 47%

• The role of p300 substrate docking in site-specific acetylation of p53 (PhD Student ship)

  Hupp, T.

  UK-based charities

  1/10/04 → 30/09/07

  Project: Research

• RSE/Lloyds TSB Foundation for Scotland Personal Research Fellowship for Dr Ashley Craig: The role of Chk2 in mammalian ageing.

  Hupp, T. & Craig, A.

  UK-based charities

  1/10/04 → 30/09/07

  Project: Research

• SIGNAL TRANSDUCTION PATHWAYS

  Hupp, T.

  UK-based charities

  1/09/04 → 31/08/06

  Project: Research

• Function of novel anti-apoptosis stress protein expressed in Barretts oesophagus

  Hupp, T.

  UK-based charities

  2/08/04 → 31/05/08

  Project: Research

• Translational Research Programme

  Hupp, T.

  UK-based charities

  1/08/04 → 31/07/06

  Project: Research