Research output per year
Research output per year
Personal profile
Current Research Interests
Investigating new mechanisms of bone formation and vascular calcification.
Research Interests
Our group undertakes research in bone formation and vascular calcification. We examine the mechanisms of differentiation and calcification in growth plate chondrocytes, osteoblasts, vascular smooth muscle cells and valvular interstitial cells. Our research employs transgenic models and clinical samples and utilises use a range of molecular, histological and imaging techniques. The elucidation of new mechanisms of bone formation and vascular calcification may identify new potential therapeutic targets in human and animal disease.
Positions available
PhD studentship opportunities
Projects are available for individuals with self arranged funding, who are able to meet University tuition fees and living expenses through dedicated fellowships and/or private means. Please contact Dr Vicky MacRae ([email protected]) for details.
Administrative Roles
The Roslin Institute Seminar Committee
The Roslin Institute Animal Welfare and Ethics Committee
The Bone Research Society Committee
Teaching
Cell motility lecture and tutorials in The Animal Body (I) (1st year BVMS)
Supervision of postgraduate, honours and summer student research projects.
Education/Academic qualification
Doctor of Philosophy (PhD), Growth associated and stress-induced myopathies in the domestic chicken (Gallus domesticus), University of Edinburgh, College of Medicine
Jan 2001 → Dec 2003
Biological Sciences (Zoology Honours) , Bachelor of Science, University of Edinburgh
Oct 1997 → Jun 2000
External positions
Postdoctoral research scientist 'Mechanisms of initiation of bone mineralisation', Roslin Institute
Jan 2007 → Dec 2008
Postdoctoral research scientist 'The role of SOCS2 in bone growth', Roslin Institute
Nov 2006 → Jan 2007
Research fellow, 'The role of cytokines in the growth retardation associated with paediatric chronic inflammatory disorders', Royal Hospital for Sick Children
May 2004 → Oct 2006
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A protective role for FGF-23 in local defence against disrupted arterial wall integrity?
Zhu, D., Mackenzie, N. C. W., Millan, J. L., Farquharson, C. & Macrae, V. E., Jun 2013, In: Molecular and Cellular Endocrinology. 372, 1-2, p. 1-11Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Pharmacological Inhibition of PHOSPHO1 Suppresses Vascular Smooth Muscle Cell Calcification
Kiffer-Moreira, T., Yadav, M. C., Zhu, D., Narisawa, S., Sheen, C., Stec, B., Cosford, N. D., Dahl, R., Farquharson, C., Hoylaerts, M. F., MacRae, V. E. & Millan, J. L., Jan 2013, In: Journal of Bone and Mineral Research. 28, 1, p. 81-91 11 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Altered Bone Development and an Increase in FGF-23 Expression in Enpp1-/- Mice
Mackenzie, N. C. W., Zhu, D., Milne, E. M., van 't Hof, R., Martin, A., Quarles, D. L., Millán, J. L., Farquharson, C. & Macrae, V. E., Feb 2012, In: PLoS ONE. 7, 2, e32177.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick
MacRae, V., Davey, M., McTeir, L., Narisawa, S., Yadav, M. C., Millan, J. L. & Farquharson, C., 2010, In: Bone. 46, 4, p. 1146-55 10 p.Research output: Contribution to journal › Article › peer-review
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The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells
Zhu, D., Mackenzie, N. C. W., Millan, J. L., Farquharson, C. & MacRae, V. E., 2011, In: PLoS ONE. 6, 5, 10 p., e19595.Research output: Contribution to journal › Article › peer-review
Open AccessFile
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Using AI to assess senescence and mitochondrial morphology in calcifying VSMCs
14/02/24 → 13/08/25
Project: Research
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ISP 2023/28 Consumables - Functional Genetics
Burdon, T., Davey, M., Farquharson, C., Headon, D., Lawrence, A., MacRae, V. & Meddle, S.
1/04/23 → 31/03/28
Project: Research
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Roslin Foundation - PP2023 - Mike McGrew
McGrew, M., Davey, M. & MacRae, V.
1/08/23 → 31/03/24
Project: Research
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FTMA 3: Developing a collaboration with the Marine Environmental Research Laboratory (MERL), Machrihanish, Scotland.
21/02/22 → 31/03/22
Project: Research
Datasets
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SkyScan bone micro CT data from Carmen Huesa and Neil Mackenzie
MacRae, V. (Creator) & Farquharson, C. (Data Collector), Edinburgh DataVault, 2016
DOI: 10.7488/51775df3-022a-4e88-884c-ca2cd7f68abd
Dataset
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A novel fluorescein-bisphosphonate based diagnostic tool for the detection of hydroxyapatite in both cell and tissue models
Hulme, A. (Creator), Cui lin, L. (Creator), Sim, A. (Creator), Rashdan, N. (Creator), Moss, A. J. (Creator), Nudelman, F. (Creator), Dweck, M. (Creator) & MacRae, V. (Creator), Edinburgh DataShare, 9 Nov 2018
DOI: 10.7488/ds/2467
Dataset
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Gene expression in the cardiovascular system of the domestic sheep (Ovis aries)
Hume, D. (Creator), Corcoran, B. (Creator), MacRae, V. (Creator), Summers, K. (Creator), Hooker, S. (Creator), Tsang, G. (Creator), Clark, E. (Creator) & Markby, G. A. (Creator), Edinburgh DataShare, 27 Apr 2020
DOI: 10.7488/ds/2808, https://datashare.is.ed.ac.uk/handle/10283/2786
Dataset
Press/Media
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Dr Vicky MacRae links testosterone to heart attacks
21/04/16
10 items of Media coverage
Press/Media: Research
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Testosterone linked to heart attacks in men, research by Dr Vicky McRae suggests
22/04/16
1 item of Media coverage
Press/Media: Research