William Cawthorn

2023

Turning the spotlight on Bone Marrow adipocytes: in haematological malignancy and non-malignant conditions

Austin, M. J., Kalampalika, F., Cawthorn, W. P. & Patel, B., 3 May 2023, In: British journal of haematology. 201, 4, p. 605-619

Research output: Contribution to journal › Article › peer-review

Open Access

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The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

Suchacki, K., Thomas, B. J., Matsumoto Ikushima, Y., Chen, K-C., Fyfe, C., Tavares, A. A. S., Sulston, R., Lovdel, A., Woodward, H. J., Han, X., Mattiucci, D., Brain, E. J., Alcaide-Corral, C. J., Kobayashi, H., Gray, G. A., Whitfield, P. D., Stimson, R. H., Morton, N. M., Johnstone, A. M. & Cawthorn, W. P., 25 Apr 2023, (E-pub ahead of print) In: eLIFE.

Research output: Contribution to journal › Article › peer-review

Open Access

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2022

A novel deep learning method for large-scale analysis of bone marrow adiposity using UK Biobank Dixon MRI data

Morris, D. M., Wang, C., Papanastasiou, G., Gray, C. D., Badr, S., Paccou, J., Semple, S. I. K., MacGillivray, T. & Cawthorn, W. P., 6 Dec 2022, medRxiv, (medRxiv).

Research output: Working paper › Preprint

The effects of caloric restriction on adipose tissue and metabolic health are sex- and age-dependent

Suchacki, K., Thomas, B. J., Fyfe, C., Tavares, A. A. S., Sulston, R., Lovdel, A., Woodward, H. J., Han, X., Mattiucci, D., Brain, E. J., Alcaide-Corral, C. J., Gray, G. A., Whitfield, P. D., Stimson, R. H., Morton, N. M., Johnstone, A. M. & Cawthorn, W. P., 22 Feb 2022, bioRxiv, (bioRxiv).

Research output: Working paper › Preprint

2021

Guidelines for biobanking of bone marrow adipose tissue and related cell types: Report of the Biobanking Working Group of the International Bone Marrow Adiposity Society

International Bone Marrow Adiposity Society (BMAS), 27 Sept 2021, In: Frontiers in Endocrinology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

Heydt, Q., Xintaropoulou, C., Clear, A., Austin, M., Pislariu, I., Miraki-Moud, F., Cutillas, P., Korfi, K., Calaminici, M., Cawthorn, W. P., Oldknow, K., Nagano, A., Gribben, J. G., Smith, M., Cavenagh, J. D., Oakervee, O., Castleton, A., Taussig, D., Peck, B., Wilczynska, A., & 4 othersMcNaughton, L., Bonnett, D., Mardakheh, F. & Patel, B., 17 Sept 2021, In: Nature Communications.

Research output: Contribution to journal › Article › peer-review

Open Access

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2020

Ablation of Enpp6 results in transient bone hypomineralization

Dillon, S., Oldknow, K., Hsu, S-N., Stephen, L., Wang, R., Cawthorn, W. P., Stewart, A. J., Nudelman, F., Morton, N. M. & Farquharson, C., 24 Nov 2020, (E-pub ahead of print) In: JBMR Plus.

Research output: Contribution to journal › Article › peer-review

Open Access

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PHOSPHO1 is a skeletal regulator of insulin resistance and obesity

Suchacki, K., Morton, N. M., Vary, C., Huesa, C., Yadav, M., Thomas, B., Turban, S., Bungar, L., Ball, D., Barrios-Llerena, M., Guntur, A., Khavandgar, Z., Cawthorn, W. P., Ferron, M., Karsenty, G., Murshed, M., Rosen, C. J., MacRae, V., Millan, J-L. & Farquharson, C., 22 Oct 2020, In: BMC Biology. 18, 149, 20 p., 149 (2020).

Research output: Contribution to journal › Article › peer-review

Open Access

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Bone marrow adipose tissue

Cawthorn, W. P., 26 Jun 2020, Encyclopedia of Bone Biology. Elsevier, p. 156-177 22 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis

Suchacki, K. J., Tavares, A. A. S., Mattiucci, D., Scheller, E. L., Papanastasiou, G., Gray, C., Sinton, M. C., Ramage, L. E., McDougald, W. A., Lovdel, A., Sulston, R. J., Thomas, B. J., Nicholson, B. M., Drake, A. J., Alcaide-Corral, C. J., Said, D., Poloni, A., Cinti, S., Macpherson, G. J., Dweck, M. R., & 8 othersAndrews, J. P. M., Williams, M. C., Wallace, R. J., van Beek, E. J. R., MacDougald, O. A., Morton, N. M., Stimson, R. H. & Cawthorn, W. P., 18 Jun 2020, In: Nature Communications. 11, 3097.

Research output: Contribution to journal › Article › peer-review

Open Access

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Standardised Nomenclature, Abbreviations, and Units for the study of Bone Marrow Adiposity: Report of the Nomenclature Working Group of the International Bone Marrow Adiposity Society

Bravenboer, N., Bredella, M. A., Chauveau, C., Corsi, A., Douni, E., Ferris, W. F., Riminucci, M., Robey, P. G., Rojas-Sutterlin, S., Rosen, C., Schulz, T. J. & Cawthorn, W., 24 Jan 2020, In: Frontiers in Endocrinology.

Research output: Contribution to journal › Article › peer-review

Open Access

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2019

Myeloma cells down‐regulate adiponectin in bone marrow adipocytes via TNF‐alpha

Morris, E. V., Suchacki, K. J., Hocking, J., Cartwright, R., Sowman, A., Gamez, B., Lea, R., Drake, M. T., Cawthorn, W. P. & Edwards, C. M., 30 Dec 2019, In: Journal of Bone and Mineral Research.

Research output: Contribution to journal › Article › peer-review

Open Access

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Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling

Craft, C. S., Robles, H., Lorenz, M. M., Hilker, E. D., Magee, K. L., Andersen, T. L., Cawthorn, W., MacDougald, O. A., Harris, C. A. & Scheller, E. L., 22 Nov 2019, In: Scientific Reports.

Research output: Contribution to journal › Article › peer-review

Open Access

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A comparison of the bone and growth phenotype of mdx, mdx:cmah-/- and mdx:utrn+/- murine models with the C57BL10 wildtype mouse

Wood, C. L., Suchaki, K. J., van 't Hof, R., Cawthorn, W. P., Dillon, S., Straub, V., Wong, S. C., Ahmed, S. F. & Farquharson, C., 21 Nov 2019, (E-pub ahead of print) In: Disease Models and Mechanisms.

Research output: Contribution to journal › Article › peer-review

Open Access

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Fat cell progenitors get singled out

Chau, Y. & Cawthorn, W. P., 26 Apr 2019, In: Science. 364, 6438, p. 328-329

Research output: Contribution to journal › Article › peer-review

Open Access

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2018

New Insights Into the Long Non-coding RNA SRA: Physiological Functions and Mechanisms of Action

Sheng, L., Ye, L., Zhang, D., Cawthorn, W. & Xu, B., 6 Sept 2018, In: Frontiers in Medicine. 5, p. 244

Research output: Contribution to journal › Article › peer-review

Open Access

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Molecular Interaction of Bone Marrow Adipose Tissue with Energy Metabolism

Suchacki, K. J. & Cawthorn, W. P., 1 Jun 2018, In: Current Molecular Biology Reports. 4, 2, p. 41-49 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

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Adipose specific disruption of seipin causes early-onset generalised lipodystrophy and altered fuel utilisation without severe metabolic disease

Mcilroy, G. D., Suchacki, K., Roelofs, A. J., Yang, W., Fu, Y., Bai, B., Wallace, R. J., De Bari, C., Cawthorn, W. P., Han, W., Delibegovic, M. & Rochford, J. J., 31 Jan 2018, (E-pub ahead of print) In: Molecular Metabolism.

Research output: Contribution to journal › Article › peer-review

Open Access

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Bone marrow adipocytes resist lipolysis and remodeling in response to β-adrenergic stimulation

Scheller, E. L., Khandaker, S., Learman, B. S., Cawthorn, W. P., Anderson, L. M., Pham, H. A., Robles, H., Wang, Z., Li, Z., Parlee, S. D., Simon, B. R., Mori, H., Bree, A. J., Craft, C. S. & MacDougald, O. A., 31 Jan 2018, In: Bone.

Research output: Contribution to journal › Article › peer-review

Open Access

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2017

Skeletal energy homeostasis: a paradigm of endocrine discovery

Oldknow, K., Roberts, F., Lovdel, A., Farquharson, C., Morton, N., MacRae, V. & Cawthorn, W., Jul 2017, In: Journal of Endocrinology. 234, 1

Research output: Contribution to journal › Article › peer-review

Open Access

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2016

Increased Circulating Adiponectin in Response to Thiazolidinediones: Investigating the Role of Bone Marrow Adipose Tissue

Sulston, R. J., Learman, B. S., Zhang, B., Scheller, E. L., Parlee, S. D., Simon, B. R., Mori, H., Bree, A. J., Wallace, R. J., Krishnan, V., Macdougald, O. A. & Cawthorn, W. P., 21 Sept 2016, In: Frontiers in Endocrinology. 7

Research output: Contribution to journal › Article › peer-review

Open Access

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Inside out: Bone marrow adipose tissue as a source of circulating adiponectin

Cawthorn, W., Scheller, E., Burr, A. & MacDougald, O. A., 1 Jul 2016, In: Adipocyte. 5, 3, p. 251-269 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

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Bone marrow adipose tissue: formation, function and regulation

Oldknow, K., Cawthorn, W. & Rosen, C. J., 1 Jun 2016, In: Current Opinion in Pharmacology.

Research output: Contribution to journal › Article › peer-review

Open Access

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Marrow adipose tissue: trimming the fat

Scheller, E., Cawthorn, W., Burr, A., Horowitz, M. C. & MacDougald, O. A., Jun 2016, In: Trends in Endocrinology & Metabolism. 27, 6, p. 392-403 12 p.

Research output: Contribution to journal › Literature review › peer-review

Open Access

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Bone marrow adipose tissue as an endocrine organ: close to the bone?

Sulston, R. & Cawthorn, W., 5 May 2016, (E-pub ahead of print) In: Hormone Molecular Biology and Clinical Investigation. p. 1868-1883

Research output: Contribution to journal › Article › peer-review

Open Access

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Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion

Mori, H., Yao, Y., Learman, B. S., Kurozumi, K., Ishida, J., Ramakrishnan, S. K., Overmyer, K. A., Xue, X., Cawthorn, W. P., Reid, M. A., Taylor, M., Ning, X., Shah, Y. M. & Macdougald, O. A., 10 Feb 2016, In: Scientific Reports. 6, p. 21520

Research output: Contribution to journal › Article › peer-review

Open Access

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Expansion of bone marrow adipose tissue during caloric restriction is associated with increased circulating glucocorticoids and not with hypoleptinemia.

Cawthorn, W. P., Scheller, E. L., Parlee, S. D., Pham, H. A., Learman, B. S., Redshaw, C., Sulston, R., Burr, A., Das, A., Simon, B. R., Mori, H., Bree, A. J., Schell, B., Krishnan, V. & MacDougald, O. A., 1 Feb 2016, In: Endocrinology. 157, 2, p. 508-521 26696121.

Research output: Contribution to journal › Article › peer-review

Open Access

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2015

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

Scheller, E. L., Doucette, C. R., Learman, B. S., Cawthorn, W. P., Khandaker, S., Schell, B., Wu, B., Ding, S-Y., Bredella, M. A., Fazeli, P. K., Khoury, B., Jepsen, K. J., Pilch, P. F., Klibanski, A., Rosen, C. J. & MacDougald, O. A., 6 Aug 2015, In: Nature Communications. 6, 15 p., 7808.

Research output: Contribution to journal › Article › peer-review

Open Access

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Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation

Patel, M. N., Bernard, W. G., Milev, N. B., Cawthorn, W. P., Figg, N., Hart, D., Prieur, X., Virtue, S., Hegyi, K., Bonnafous, S., Bailly-Maitre, B., Chu, Y., Griffin, J. L., Mallat, Z., Considine, R. V., Tran, A., Gual, P., Takeuchi, O., Akira, S., Vidal-Puig, A., & 2 othersBennett, M. R. & Sethi, J. K., 13 Jan 2015, In: Proceedings of the National Academy of Sciences (PNAS). 112, 2, p. 506-511 6 p.

Research output: Contribution to journal › Article › peer-review

Reciprocal Control of Osteogenic and Adipogenic Differentiation by ERK/MAP Kinase Phosphorylation of Runx2 and PPAR! Transcription Factors

Ge, C., Cawthorn, W., Li, Y., Zhao, G., MacDougald, O. A. & Franceschi, R., 2015, In: Journal of Cellular Physiology.

Research output: Contribution to journal › Article › peer-review

Open Access

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2014

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

Cawthorn, W. P., Scheller, E. L., Learman, B. S., Parlee, S. D., Simon, B. R., Mori, H., Ning, X., Bree, A. J., Schell, B., Broome, D. T., Soliman, S. S., DelProposto, J. L., Lumeng, C. N., Mitra, A., Pandit, S. V., Gallagher, K. A., Miller, J. D., Krishnan, V., Hui, S. K., Bredella, M. A., & 5 othersFazeli, P. K., Klibanski, A., Horowitz, M. C., Rosen, C. J. & MacDougald, O. A., 5 Aug 2014, In: Cell Metabolism. 20, 2, p. 368-375 8 p.

Research output: Contribution to journal › Article › peer-review

Multiplexed microfluidic enzyme assays for simultaneous detection of lipolysis products from adipocytes

Dugan, C. E., Cawthorn, W. P., MacDougald, O. A. & Kennedy, R. T., Aug 2014, In: Analytical and bioanalytical chemistry. 406, 20, p. 4851-4859 9 p.

Research output: Contribution to journal › Article › peer-review

SRA Regulates Adipogenesis by Modulating p38/JNK Phosphorylation and Stimulating Insulin Receptor Gene Expression and Downstream Signaling

Liu, S., Xu, R., Gerin, I., Cawthorn, W. P., MacDougald, O. A., Chen, X-W., Saltiel, A. R., Koenig, R. J. & Xu, B., 17 Apr 2014, In: PLoS ONE. 9, 4, 10 p., 95416.

Research output: Contribution to journal › Article › peer-review

Open Access

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Sweet Taste Receptor Deficient Mice Have Decreased Adiposity and Increased Bone Mass

Simon, B. R., Learman, B. S., Parlee, S. D., Scheller, E. L., Mori, H., Cawthorn, W. P., Ning, X., Krishnan, V., Ma, Y. L., Tyrberg, B. & MacDougald, O. A., 22 Jan 2014, In: PLoS ONE. 9, 1, 11 p., 86454.

Research output: Contribution to journal › Article › peer-review

Open Access

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2013

Artificial Sweeteners Stimulate Adipogenesis and Suppress Lipolysis Independently of Sweet Taste Receptors

Simon, B. R., Parlee, S. D., Learman, B. S., Mori, H., Scheller, E. L., Cawthorn, W. P., Ning, X., Gallagher, K., Tyrberg, B., Assadi-Porter, F. M., Evans, C. R. & MacDougald, O. A., 8 Nov 2013, In: Journal of Biological Chemistry. 288, 45, p. 32475-32489 15 p.

Research output: Contribution to journal › Article › peer-review

The Transcription Factor Paired-Related Homeobox 1 (Prrx1) Inhibits Adipogenesis by Activating Transforming Growth Factor-beta (TGF beta) Signaling

Du, B., Cawthorn, W. P., Su, A., Doucette, C. R., Yao, Y., Hemati, N., Kampert, S., McCoin, C., Broome, D. T., Rosen, C. J., Yang, G. & MacDougald, O. A., 1 Feb 2013, In: Journal of Biological Chemistry. 288, 5, p. 3036-3047 12 p.

Research output: Contribution to journal › Article › peer-review

2012

An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes

Gburcik, V., Cawthorn, W. P., Nedergaard, J., Timmons, J. A. & Cannon, B., Oct 2012, In: American Journal of Physiology-Endocrinology and Metabolism . 303, 8, p. E1053-E1060 8 p.

Research output: Contribution to journal › Article › peer-review

Secreted frizzled-related protein 5 suppresses adipocyte mitochondrial metabolism through WNT inhibition

Mori, H., Prestwich, T. C., Reid, M. A., Longo, K. A., Gerin, I., Cawthorn, W. P., Susulic, V. S., Krishnan, V., Greenfield, A. & MacDougald, O. A., Jul 2012, In: Journal of Clinical Investigation. 122, 7, p. 2405-2416 12 p.

Research output: Contribution to journal › Article › peer-review

Adipose tissue stem cells: the great WAT hope

Cawthorn, W. P., Scheller, E. L. & MacDougald, O. A., Jun 2012, In: Trends in Endocrinology & Metabolism. 23, 6, p. 270-277 8 p.

Research output: Contribution to journal › Literature review › peer-review

Adipose tissue stem cells meet preadipocyte commitment: going back to the future

Cawthorn, W. P., Scheller, E. L. & MacDougald, O. A., Feb 2012, In: Journal of lipid research. 53, 2, p. 227-246 20 p.

Research output: Contribution to journal › Literature review › peer-review

Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a beta-catenin-dependent mechanism

Cawthorn, W. P., Bree, A. J., Yao, Y., Du, B., Hemati, N., Martinez-Santibanez, G. & MacDougald, O. A., Feb 2012, In: Bone. 50, 2, p. 477-489 13 p.

Research output: Contribution to journal › Article › peer-review

2011

The influence of Leucine-rich amelogenin peptide on MSC fate by inducing Wnt10b expression

Wen, X., Cawthorn, W. P., MacDougald, O. A., Stupp, S. I., Snead, M. L. & Zhou, Y., Sept 2011, In: Biomaterials. 32, 27, p. 6478-6486 9 p.

Research output: Contribution to journal › Article › peer-review

2010

Multiple Roles for the Non-Coding RNA SRA in Regulation of Adipogenesis and Insulin Sensitivity

Xu, B., Gerin, I., Miao, H., Dang Vu-Phan, N. V., Johnson, C. N., Xu, R., Chen, X-W., Cawthorn, W. P., MacDougald, O. A. & Koenig, R. J., 2 Dec 2010, In: PLoS ONE. 5, 12, 21 p., 14199.

Research output: Contribution to journal › Article › peer-review

2009

The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation

Boyle, K. B., Hadaschik, D., Virtue, S., Cawthorn, W. P., Ridley, S. H., O'Rahilly, S. & Siddle, K., May 2009, In: Cell Death & Differentiation (CDD). 16, 5, p. 782-789 8 p.

Research output: Contribution to journal › Article › peer-review

Dact1, a Nutritionally Regulated Preadipocyte Gene, Controls Adipogenesis by Coordinating the Wnt/beta-Catenin Signaling Network

Lagathu, C., Christodoulides, C., Virtue, S., Cawthorn, W. P., Franzin, C., Kimber, W. A., Nora, E. D., Campbell, M., Medina-Gomez, G., Cheyette, B. N. R., Vidal-Puig, A. J. & Sethi, J. K., Mar 2009, In: Diabetes . 58, 3, p. 609-619 11 p.

Research output: Contribution to journal › Article › peer-review

2008

TNF-alpha and adipocyte biology

Cawthorn, W. P. & Sethi, J. K., 9 Jan 2008, In: FEBS Letters. 582, 1, p. 117-131 15 p.

Research output: Contribution to journal › Literature review › peer-review

2007

Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway

Cawthorn, W. P., Heyd, F., Hegyi, K. & Sethi, J. K., Jul 2007, In: Cell Death & Differentiation (CDD). 14, 7, p. 1361-1373 13 p.

Research output: Contribution to journal › Article › peer-review

IGF-binding protein-2 protects against the development of obesity and insulin resistance

Wheatcroft, S. B., Kearney, M. T., Shah, A. M., Ezzat, V. A., Miell, J. R., Modo, M., Williams, S. C. R., Cawthorn, W. P., Medina-Gomez, G., Vidal-Puig, A., Sethi, J. K. & Crossey, P. A., Feb 2007, In: Diabetes . 56, 2, p. 285-294 10 p.

Research output: Contribution to journal › Article › peer-review

2006

The Wnt antagonist Dickkopf-1 and its receptors are coordinately regulated during early human adipogenesis

Christodoulides, C., Laudes, M., Cawthorn, WP., Schinner, S., Soos, M., O'Rahilly, S., Sethi, JK. & Vidal-Puig, A., 15 Jun 2006, In: Journal of Cell Science. 119, 12, p. 2613-2620 8 p.

Research output: Contribution to journal › Article › peer-review

William Cawthorn

Research output

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