Research output per year
Research output per year
- 22 results
Search results
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2025
Age-related impairment of intestinal inflammation resolution through an eicosanoid-immune-microbiota axis
Goepp, M., Milburn, J., Zhang, B., Dong, Y., Tyrrell, V., Zheng, X., Marshall, J., Bolsega, S., Basic, M., Glendinning, L., Ho, G.-T., Satsangi, J., Breyer, R. M., Narumiya, S., McSorley, H. J., Schwarze, J., Anderson, C., Dockrell, D. H., Rossi, A. G. & Bleich, A. & 6 others, , 14 May 2025, (E-pub ahead of print) In: Cell Host & Microbe. 33, 5, p. 671-687.e6Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2024
Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis.
Higgins, B., Simitsidellis, I., Zheng, X., Collins, F., Homer, N. Z. M., Denham, S. G., Simpson, J. P., Millar, M., Boswell, L., Lee, H. Y., Kim, Y. G., Park, K. H., Park, L. C., Sweeney, P. J., Feraille, G., Taddei, A., Chagras, D., Alvaraz, T., Webster, S. P. & Horne, A. & 2 others, , 2 Aug 2024, In: eLIFE.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2023
Kynurenine monooxygenase regulates inflammation during critical illness and recovery in experimental acute pancreatitis
Hayes, A. J., Zheng, X., O'Kelly, J., Neyton, L. P. A., Bochkina, N. A., Uings, I., Liddle, J., Baillie, J. K., Just, G., Binnie, M., Homer, N. Z. M., Murray, T. B. J., Baily, J., McGuire, K., Skouras, C., Garden, O. J., Webster, S. P., Iredale, J. P., Howie, S. E. M. & Mole, D. J., 29 Aug 2023, In: Cell Reports. 42, 8, p. 1-23 23 p., 112763.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2021
Prostaglandin E2 promotes intestinal inflammation via inhibiting microbiota-dependent regulatory T cells
Crittenden, S., Goepp, M., Pollock, J., Robb, C., Smyth, D. J., Zhou, Y., Andrews, R., Tyrrell, V., Gkikas, K., Adima, A., O'Connor, R. A., Davies, L., Li, X.-F., Yao, H. X., Ho, G.-T., Zheng, X., Mair, A., Vermeren, S., Qian, B.-Z. & Mole, D. J. & 12 others, , 12 Feb 2021, In: Science Advances.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2020
Study Protocol for RESORP – Resolution of Organ Injury in Acute Pancreatitis – an observational prospective cohort study
Sherif, A. E., McFadyen, R., Boyd, J., Ventre, C., Glenwright, M., Walker, K., Zheng, X., White, A., McFadyen, L., Connon, E., Damaskos, D., Steven, M., Wackett, A., Thomson, E., Cameron, D. C., Semple, S. I. K., Morris, D., Clark-Stewart, S., Graham, C. & Mole, D. J., 7 Dec 2020, In: BMJ Open.Research output: Contribution to journal › Article › peer-review
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Quantitative magnetic resonance imaging predicts individual future liver performance after liver resection for cancer
HepaT1ca Study Group, Mole, D. J., Fallowfield, J. A., Sherif, A. E., Kendall, T., Semple, S., Kelly, M., Ridgway, G., Connell, J. J., McGonigle, J., Banerjee, R., Brady, J. M., Zheng, X., Hughes, M., Neyton, L., McClintock, J., Tucker, G., Nailon, H., Patel, D. & Wackett, A. & 3 others, , 2 Dec 2020, In: PLoS ONE. 15, 12, e0238568.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Co-treatments to Boost IDO Activity and Inhibit Production of Downstream Catabolites Induce Durable Suppression of Experimental Autoimmune Encephalomyelitis
Lemos, H., Mohamed, E., Ou, R., McCardle, C., Zheng, X., McGuire, K., Homer, N. Z. M., Mole, D. J., Huang, L. & Mellor, A. L., 17 Jun 2020, In: Frontiers in Immunology. 11, p. 1256Research output: Contribution to journal › Article › peer-review
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Molecular patterns in acute pancreatitis reflect generalisable endotypes of the host response to systemic injury in humans
Neyton, L. P. A., Zheng, X., Skouras, C., Doeschl-Wilson, A., Gutmann, M., Uings, I. J., Rao, F. V., Nicolas, A., Marshall, C., Wilson, L.-M., Baillie, K. & Mole, D., 2 Jun 2020, (E-pub ahead of print) In: Annals of Surgery. n/a, n/a, n/a.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2019
Kynurenine 3-monooxygenase is a critical regulator of renal ischemia–reperfusion injury
Zheng, X., Zhang, A., Binnie, M., McGuire, K., Webster, S., Hughes, J., Howie, S. E. M. & Mole, D., 13 Feb 2019, (E-pub ahead of print) In: Experimental & Molecular Medicine (EMM). 51, 15.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2017
Detecting Drug-Target Binding in Cells using Fluorescence Activated Cell Sorting Coupled with Mass Spectrometry Analysis
Wilson, K., Webster, S. P., Iredale, J. P., Zheng, X., Homer, N. Z. M., Pham, N., Auer, M. & Mole, D. J., 18 Dec 2017, In: Methods and Applications in Fluorescence.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis
Walker, A. L., Ancellin, N., Beaufils, B., Bergeal, M., Binnie, M., Clapham, D., Haslam, C. P., Holmes, D. S., Hutchinson, J. P., Liddle, J., McBride, A., Mirguet, O., Mowat, C. G., Rowland, P., Tiberghien, N., Trottet, L., Uings, I., Webster, S. P., Zheng, X. & Mole, D. J., 27 Apr 2017, In: Journal of Medicinal Chemistry.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2016
Overexpression of human kynurenine-3-monooxygenase protects against 3-hydroxykynurenine-mediated apoptosis through bidirectional non-linear feedback
Wilson, K., Auer, M., Binnie, M., Zheng, X., Pham, N., Iredale, J. P., Webster, S. P. & Mole, D. J., 14 Apr 2016, (E-pub ahead of print) In: Cell Death and Disease. 7, p. e2197 e2197.Research output: Contribution to journal › Article › peer-review
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Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell–IL-22 axis
Duffin, R., O'Connor, R. A., Crittenden, S., Forster, T., Yu, C., Zheng, X., Smyth, D., Robb, C. T., Rossi, F., Skouras, C., Tang, S., Richards, J., Pellicoro, A., Weller, R. B., Breyer, R. M., Mole, D. J., Iredale, J. P., Anderton, S. M., Narumiya, S. & Maizels, R. M. & 4 others, , 18 Mar 2016, In: Science. 351, 6279, p. 1333-1338 6 p.Research output: Contribution to journal › Article › peer-review
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Kynurenine–3–monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis
Mole, D. J., Webster, S. P., Uings, I., Zheng, X., Binnie, M., Wilson, K., Hutchinson, J. P., Mirguet, O., Walker, A., Beaufils, B., Ancellin, N., Trottet, L., Bénéton, V., Mowat, C. G., Wilkinson, M., Rowland, P., Haslam, C., McBride, A., Homer, N. Z. M. & Baily, J. E. & 7 others, , Feb 2016, In: Nature Medicine. 22, 2, p. 202-209 8 p.Research output: Contribution to journal › Article › peer-review
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Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis
Skouras, C., Zheng, X., Binnie, M., Homer, N. Z. M., Murray, T. B. J., Robertson, D., Briody, L., Paterson, F., Spence, H., Derr, L., Hayes, A. J., Tsoumanis, A., Lyster, D., Parks, R. W., Garden, O. J., Iredale, J. P., Uings, I. J., Liddle, J., Wright, W. L. & Dukes, G. & 2 others, , 2016, In: Scientific Reports. 6, p. 33951Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2014
THE INTESTINAL MUCUS LAYER IS A CRITICAL COMPONENT OF THE GUT BARRIER THAT IS DAMAGED DURING ACUTE PANCREATITIS
Fishman, J. E., Levy, G., Alli, V., Zheng, X., Mole, D. J. & Deitch, E. A., Sept 2014, In: Shock: Injury, Inflammation and Sepsis. 42, 3, p. 264-270 7 p.Research output: Contribution to journal › Article › peer-review
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Bacterial expression of human kynurenine 3-monooxygenase: Solubility, activity, purification
Wilson, K., Mole, D. J., Binnie, M., Homer, N. Z. M., Zheng, X., Yard, B. A., Iredale, J. P., Auer, M. & Webster, S. P., Mar 2014, In: Protein Expression and Purification. 95, p. 96-103 8 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
2012
Adjuvanticity and toxicity of cobalt oxide nanoparticles as an alternative vaccine adjuvant
Cho, W.-S., Dart, K., Nowakowska, D. J., Zheng, X., Donaldson, K. & Howie, S. E., Oct 2012, In: Nanomedicine. 7, 10, p. 1495-1505 11 p.Research output: Contribution to journal › Article › peer-review
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2010
Vertebrate fatty acyl desaturase with Δ4 activity
Li, Y., Monroig, O., Zhang, L., Wang, S., Zheng, X., Dick, J. R., You, C. & Tocher, D. R., 28 Sept 2010, In: Proceedings of the National Academy of Sciences (PNAS). 107, 39, p. 16840-16845Research output: Contribution to journal › Article › peer-review
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2008
Characterizing barred galaxies in the Abell 901/902 supercluster from STAGES
Marinova, I., Jogee, S., Bacon, D., Balogh, M., Barden, M., Barazza, F. D., Bell, E. F., Boehm, A., Caldwell, J. A. R., Gray, M. E., Haeussler, B., Heymans, C., Jahnke, K., van Kampen, E., Koposov, S., Lane, K., McIntosh, D. H., Meisenheimer, K., Peng, C. Y. & Rix, H.-W. & 5 others, , 2008, NEW HORIZONS IN ASTRONOMY: FRANK N. BASH SYMPOSIUM 2007. Frebel, A., Maund, J., Shen, J. & Siegel, M. (eds.). SAN FRANCISCO: ASTRONOMICAL SOC PACIFIC, p. 231-234 4 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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Morphological transformations of galaxies in the A901/02 supercluster from STAGES
Heiderman, A., Jogee, S., Bacon, D., Balogh, M., Barden, M., Barazza, F. D., Bell, E. F., Boehm, A., Caldwell, J. A. R., Gray, M. E., Haeussler, B., Heymans, C., Jahnke, K., van Kampen, E., Koposov, S., Lane, K., Marinova, I., McIntosh, D., Meisenheimer, K. & Peng, C. Y. & 7 others, , 2008, NEW HORIZONS IN ASTRONOMY: FRANK N. BASH SYMPOSIUM 2007. Frebel, A., Maund, J., Shen, J. & Siegel, M. (eds.). SAN FRANCISCO: ASTRONOMICAL SOC PACIFIC, p. 211-214 4 p.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
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2004
Inadequacies in UK primary care allergy services: national survey of current provisions and perceptions of need
Levy, M. L., Price, D., Zheng, X., Simpson, C., Hannaford, P. & Sheikh, A., Apr 2004, In: Clinical & Experimental Allergy. 34, 4, p. 518-9 2 p.Research output: Contribution to journal › Article › peer-review