Research output per year
Research output per year
Personal profile
My research in a nutshell
My research focuses on the role of oxygen sensing and hypoxia signalling pathway in adipocytes in models of obesity. Hypoxia and the HIF system are implicated in the metabolic dysfunction of obesity. I have shown that adipocyte HIF regulates 2 key adipose functions (1) fat cell lipid storage/release (Michailidou et al, 2015 Diabetes) and (2) blood vessel growth in fat tissue (Michailidou et al, 2012 JBC, 2015 Diabetes). My ongoing research seeks to identify how hypoxia-induced metabolic reprogramming of adipocytes can be targeted in obesity and obesity related pathologies.
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Collaborations and top research areas from the last five years
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Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality
Wang, R., Gomez Salazar, M., Pruñonosa Cervera, I., Coutts, A., French, K., Pinto, M. M., Gohlke, S., García-Martín, R., Blüher, M., Schofield, C. J., Kourtzelis, I., Stimson, R. H., Bénézech, C., Christian, M., Schulz, T. J., Gudmundsson, E. F., Jennings, L. L., Gudnason, V. G., Chavakis, T., Morton, N. M., & 2 others, 29 Aug 2024, In: Nature Communications. 15, 1, 7483.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Hypoxia-driven metabolic reprogramming of adipocytes fuels cancer cell proliferation
Aird, R., Wills, J., Roby, K. F., Benezech, C., Stimson, R. H., Wabitsch, M., Pollard, J. W., Finch, A. & Michailidou, Z., 18 Oct 2022, In: Frontiers in Endocrinology. 13, 12 p., 989523.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels
Magalhaes, M. S., Smith, P., Portman, J., Jackson-Jones, L. H., Bain, C. C., Ramachandran, P., Michailidou, Z., Stimson, R. H., Dweck, M. R., Denby, L., Henderson, N. C., Jenkins, S. J. & Benezech, C., 21 Jul 2021, (E-pub ahead of print) In: Nature Communications.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Fate of Adipose Progenitor Cells in Obesity-Related Chronic Inflammation
Pyrina, I., Chung, KJ., Michailidou, Z., Koutsilieris, M., Chavakis, T. & Chatzigeorgiou, A., 14 Jul 2020, In: Frontiers in Cell and Developmental Biology.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Fundamental roles for hypoxia signalling in adipose tissue metabolism and inflammation in obesity
Michailidou, Z., 21 Sept 2019, (E-pub ahead of print) In: Current opinion in physiology.Research output: Contribution to journal › Article › peer-review
Open AccessFile
Press/Media
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Dr Zoi Michailidou leads research into treatments for fat-related diseases
7/11/14
1 item of Media coverage
Press/Media: Research