Synthetic biology tools applied to the production of anticancer drug taxol in S. Cerevisiae and its optimization through biosensors

Prize: Fellowships awarded competitively

Description

This proposal aims to design and build the complete taxol biosynthetic pathway in S. cerevisiae (19 steps) and optimize it through the use of biosensors, minimizing the time and costs associated to optimize such complex routes. Achieving the synthesis of such an important compound in a heterologous host, while reaching pharmaceutically relevant concentrations would have a profound environmental, industrial and social impact, crystallizing the promises of synthetic biology, and allowing greater access to the population of the benefits of taxol and its derivatives.
Degree of recognitionInternational
Granting OrganisationsUC Berkeley

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