A Hundred at Ninety: the common cause Hypothesis of Ageing tested in four waves of the Lothian Birth Cohort 1921

Research output

Research output per year 2009 2011 2012 2014 2015 2020

• 114 Article
• 1 Chapter (peer-reviewed)
• 1 Poster
• 1 Meeting abstract

Research output per year

Research output per year

Search results

• 2020

  DNA methylation-based measures of accelerated biological ageing and the risk of dementia in the oldest-old: a study of the Lothian Birth Cohort 1921

  Sibbett, R. A., Altschul, D. M., Marioni, R. E., Deary, I. J., Starr, J. M. & Russ, T. C., 28 Feb 2020, In: BMC Psychiatry. 20, 1, 91.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dementia 100%
  • DNA 100%
  • Biological Product 100%
  • DNA Methylation 100%
  • Epigenetics 45%
• 2019

  Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

  Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R. D., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S., Boehnke, M., & 156 othersBots, M. L., Brazel, D. M., Chambers, J. C., Chang-claude, J., Chen, C., Corley, J., Chou, Y., David, S. P., De Boer, R. A., De Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A., Hsu, C., Iacono, W. G., Kanoni, S., Kapoor, M., Kaprio, J., Kardia, S. L., Karpe, F., Kontto, J., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Laakso, M., Lai, D., Langenberg, C., Le, N., Lettre, G., Loukola, A., Luan, J., Madden, P. A. F., Mangino, M., Marioni, R. E., Marouli, E., Marten, J., Martin, N. G., Mcgue, M., Michailidou, K., Mihailov, E., Moayyeri, A., Moitry, M., Müller-nurasyid, M., Naheed, A., Nauck, M., Neville, M. J., Nielsen, S. F., North, K., Perola, M., Pharoah, P. D. P., Pistis, G., Polderman, T. J., Posthuma, D., Poulter, N., Qaiser, B., Rasheed, A., Reiner, A., Renström, F., Rice, J., Rohde, R., Rolandsson, O., Samani, N. J., Samuel, M., Schlessinger, D., Scholte, S. H., Scott, R. A., Sever, P., Shao, Y., Shrine, N., Smith, J. A., Starr, J. M., Stirrups, K., Stram, D., Stringham, H. M., Tachmazidou, I., Tardif, J., Thompson, D. J., Tindle, H. A., Tragante, V., Trompet, S., Turcot, V., Tyrrell, J., Vaartjes, I., Van Der Leij, A. R., Van Der Meer, P., Varga, T. V., Verweij, N., Völzke, H., Wareham, N. J., Warren, H. R., Weir, D. R., Weiss, S., Wetherill, L., Yaghootkar, H., Yavas, E., Jiang, Y., Chen, F., Zhan, X., Zhang, W., Zhao, W., Zhao, W., Zhou, K., Amouyel, P., Blankenberg, S., Caulfield, M. J., Chowdhury, R., Cucca, F., Deary, I. J., Deloukas, P., Di Angelantonio, E., Ferrario, M., Ferrières, J., Franks, P. W., Frayling, T. M., Frossard, P., Hall, I. P., Hayward, C., Jansson, J., Jukema, J. W., Kee, F., Männistö, S., Metspalu, A., Munroe, P. B., Nordestgaard, B. G., Palmer, C. N. A., Salomaa, V., Sattar, N., Spector, T., Strachan, D. P., Van Der Harst, P., Zeggini, E., Saleheen, D., Butterworth, A. S., Wain, L. V., Abecasis, G. R., Danesh, J., Tobin, M. D., Vrieze, S., Liu, D. J. & Howson, J. M. M., 7 Jan 2019, (E-pub ahead of print) In: Molecular Psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Gene Locus 100%
  • Smoking 100%
  • Single-Nucleotide Polymorphism 80%
  • Association 30%
  • Sample 10%

• Tracking the epigenetic clock across the human life course: A meta-analysis of longitudinal cohort data

  Marioni, R., Suderman, M. J., Chen, B. H., Horvath, S., Bandinelli, S., Morris, T. J., Becker, S., Ferrucci, L., Pedersen, N. L., Relton, C. L., Deary, I. & Hägg, S., Jan 2019, In: The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. 74, 1, p. 1-5 gly060.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Clock 100%
  • Meta-Analysis 100%
  • Datum 100%
  • Epigenetics 100%
  • Life 100%
• 2018

  Predicting change in quality of life from age 79 to 90 in the Lothian Birth Cohort 1921

  Brett, C. E., Dykiert, D., Starr, J. M. & Deary, I. J., 23 Nov 2018, (E-pub ahead of print) In: Quality of Life Research. 28, 3, p. 737–749

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Quality of Life 100%
  • Health 100%
  • Loneliness 75%
  • Abilities 50%
  • Mood 50%

• Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

  Feitosa, M. F., Kraja, A. T., Chasman, D. I., Sung, Y. J., Winkler, T. W., Ntalla, I., Guo, X., Franceschini, N., Cheng, C., Sim, X., Vojinovic, D., Marten, J., Musani, S. K., Li, C., Bentley, A. R., Brown, M. R., Schwander, K., Richard, M. A., Noordam, R., Aschard, H., & 254 othersBartz, T. M., Bielak, L. F., Dorajoo, R., Fisher, V., Hartwig, F. P., Horimoto, A. R. V. R., Lohman, K. K., Manning, A. K., Rankinen, T., Smith, A. V., Tajuddin, S. M., Wojczynski, M. K., Alver, M., Boissel, M., Cai, Q., Campbell, A., Chai, J. F., Chen, X., Divers, J., Gao, C., Goel, A., Hagemeijer, Y., Harris, S. E., He, M., Hsu, F., Jackson, A. U., Kähönen, M., Kasturiratne, A., Komulainen, P., Kühnel, B., Laguzzi, F., Luan, J., Matoba, N., Nolte, I. M., Padmanabhan, S., Riaz, M., Rueedi, R., Robino, A., Said, M. A., Scott, R. A., Sofer, T., Stančáková, A., Takeuchi, F., Tayo, B. O., Van Der Most, P. J., Varga, T. V., Vitart, V., Wang, Y., Ware, E. B., Warren, H. R., Weiss, S., Wen, W., Yanek, L. R., Zhang, W., Zhao, J. H., Afaq, S., Amin, N., Amini, M., Arking, D. E., Aung, T., Boerwinkle, E., Borecki, I., Broeckel, U., Brown, M., Brumat, M., Burke, G. L., Canouil, M., Chakravarti, A., Charumathi, S., Ida Chen, Y., Connell, J. M., Correa, A., De Las Fuentes, L., De Mutsert, R., De Silva, H. J., Deng, X., Ding, J., Duan, Q., Eaton, C. B., Ehret, G., Eppinga, R. N., Evangelou, E., Faul, J. D., Felix, S. B., Forouhi, N. G., Forrester, T., Franco, O. H., Friedlander, Y., Gandin, I., Gao, H., Ghanbari, M., Gigante, B., Gu, C. C., Gu, D., Hagenaars, S. P., Hallmans, G., Harris, T. B., He, J., Heikkinen, S., Heng, C., Hirata, M., Howard, B. V., Ikram, M. A., John, U., Katsuya, T., Khor, C. C., Kilpeläinen, T. O., Koh, W., Krieger, J. E., Kritchevsky, S. B., Kubo, M., Kuusisto, J., Lakka, T. A., Langefeld, C. D., Langenberg, C., Launer, L. J., Lehne, B., Lewis, C. E., Li, Y., Lin, S., Liu, J., Liu, J., Loh, M., Louie, T., Mägi, R., Mckenzie, C. A., Meitinger, T., Metspalu, A., Milaneschi, Y., Milani, L., Mohlke, K. L., Momozawa, Y., Nalls, M. A., Nelson, C. P., Sotoodehnia, N., Norris, J. M., O'connell, J. R., Palmer, N. D., Perls, T., Pedersen, N. L., Peters, A., Peyser, P. A., Poulter, N., Raffel, L. J., Raitakari, O. T., Roll, K., Rose, L. M., Rosendaal, F. R., Rotter, J. I., Schmidt, C. O., Schreiner, P. J., Schupf, N., Scott, W. R., Sever, P. S., Shi, Y., Sidney, S., Sims, M., Sitlani, C. M., Smith, J. A., Snieder, H., Starr, J. M., Strauch, K., Stringham, H. M., Tan, N. Y. Q., Tang, H., Taylor, K. D., Teo, Y. Y., Tham, Y. C., Turner, S. T., Uitterlinden, A. G., Vollenweider, P., Waldenberger, M., Wang, L., Wang, Y. X., Wei, W. B., Williams, C., Yao, J., Yu, C., Yuan, J., Zhao, W., Zonderman, A. B., Becker, D. M., Boehnke, M., Bowden, D. W., Chambers, J. C., Deary, I. J., Esko, T., Farrall, M., Franks, P. W., Freedman, B. I., Froguel, P., Gasparini, P., Gieger, C., Jonas, J. B., Kamatani, Y., Kato, N., Kooner, J. S., Kutalik, Z., Laakso, M., Laurie, C. C., Leander, K., Lehtimäki, T., Study, L. C., Magnusson, P. K. E., Oldehinkel, A. J., Penninx, B. W. J. H., Polasek, O., Porteous, D. J., Rauramaa, R., Samani, N. J., Scott, J., Shu, X., Van Der Harst, P., Wagenknecht, L. E., Wareham, N. J., Watkins, H., Weir, D. R., Wickremasinghe, A. R., Wu, T., Zheng, W., Bouchard, C., Christensen, K., Evans, M. K., Gudnason, V., Horta, B. L., Kardia, S. L. R., Liu, Y., Pereira, A. C., Psaty, B. M., Ridker, P. M., Van Dam, R. M., Gauderman, W. J., Zhu, X., Mook-kanamori, D. O., Fornage, M., Rotimi, C. N., Cupples, L. A., Kelly, T. N., Fox, E. R., Hayward, C., Van Duijn, C. M., Tai, E. S., Wong, T. Y., Kooperberg, C., Palmas, W., Rice, K., Morrison, A. C., Elliott, P., Caulfield, M. J., Munroe, P. B., Rao, D. C., Province, M. A., Levy, D. & Kuivaniemi, H., 18 Jun 2018, In: PLoS ONE. 13, 6, p. e0198166 36 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetic Association 100%
  • Nested Gene 100%
  • Blood Pressure 100%
  • Blood Pressure Regulation 28%
  • Sample 14%

• Identifying gene targets for brain-related traits using transcriptomic and methylomic data from blood

  Qi, T., Wu, Y., Zeng, J., Zhang, F., Xue, A., Jiang, L., Zhu, Z., Kemper, K., Yengo, L., Zheng, Z., Marioni, R. E., Montgomery, G. W., Deary, I. J., Wray, N. R., Visscher, P. M., Mcrae, A. F. & Yang, J., 11 Jun 2018, In: Nature Communications. 9, 1, p. 1-12 2282.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Transcriptomics 100%
  • Nested Gene 100%
  • Expression Quantitative Trait Loci 75%
  • DNA Methylation 75%
  • Sample Size 50%

• Effects of between-person differences and within-person changes in symptoms of anxiety and depression on older-age cognitive performance

  Laukka, E. J., Dykiert, D., Allerhand, M., Starr, J. & Deary, I., Jun 2018, In: Psychological Medicine. 48, 8, p. 1350-1358 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Performance 100%
  • Depression 100%
  • Anxiety 100%
  • Depression Scale 27%
  • Cognitive Function 18%

• Transitions across cognitive states and death among older adults in relation to education: A multistate survival model using data from six longitudinal studies

  Robitaille, A., Van Den Hout, A., Machado, R. J. M., Bennett, D. A., Čukić, I., Deary, I. J., Hofer, S. M., Hoogendijk, E. O., Huisman, M., Johansson, B., Koval, A. V., van der Noordt, M., Piccinin, A. M., Rijnhart, J. J. M., Singh-Manoux, A., Skoog, J., Skoog, I., Starr, J., Vermunt, L., Clouston, S., & 1 othersMuniz Terrera, G., 1 Feb 2018, (E-pub ahead of print) In: Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 14, 4, p. 462-472 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Longitudinal Analysis 100%
  • Transition 100%
  • Survival 100%
  • Death 100%
  • Education 100%

• Meta-analysis of epigenome-wide association studies of cognitive abilities

  Marioni, R., Mcrae, A. F., Bressler, J., Colicino, E., Hannon, E., Li, S., prada, D., Smith, J. A., Trevisi, L., Tsai, P-C., Vojinovic, D., Simino, J., Levy, D., Liu, C., Mendelson, M. M., Satizabal, C. L., Yang, Q., Jhun, M. A., Kardia, S. L. R., Zhao, W., & 27 othersBandinelli, S., Ferrucci, L., Hernandez, D., Singleton, A. B., Harris, S., Starr, J., Kiel, D. P., McLean, R. R., Just, A. C., Schwartz, J., Spiro, A., Vokonas, P., Amin, N., Ikram, M. A., Uitterlinden, A. G., van Meurs, J. B. J., Spector, T. D., Steves, C., Baccarelli, A. A., Bell, J. T., van Duijn, C. M., Fornage, M., Hsu, Y-H., Mill, J., Mosley, T. H., Seshadri, S. & Deary, I., 8 Jan 2018, In: Nature.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Epigenome 100%
  • Meta-Analysis 100%
  • Aptitude 100%
  • Association 100%
• 2017

  Identification, replication and characterization of epigenetic remodelling in the aging genome: A cross population analysis

  Li, S., Christiansen, L., Christensen, K., Kruse, T. A., Redmond, P., Marioni, R., Deary, I. & Tan, Q., 15 Aug 2017, (E-pub ahead of print) In: Scientific Reports. 7, p. 1-8 8183.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Aging 100%
  • Age 100%
  • Epigenetics 100%
  • Gene 30%
  • Nested Gene 30%

• Risk factors for dementia in the ninth decade of life and beyond: A study of the Lothian Birth Cohort 1921

  Sibbett, R., Russ, T. C., Deary, I. & Starr, J., 2 Jun 2017, In: BMC Psychiatry. 17, p. 1-10 10 p., 205.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Dementia 100%
  • Hypertension 18%
  • Logistic Regression Analysis 12%
  • Diabetes Mellitus 6%
  • Statin (Protein) 6%

• Lifecourse Activity Participation From Early, Mid, and Later Adulthood as Determinants of Cognitive Aging: The Lothian Birth Cohort 1921

  Gow, A. J., Pattie, A. & Deary, I. J., Jan 2017, In: The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences. 72, 1, p. 25-37

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Aging 100%
  • Cognitive Function 100%
  • Cognitive Decline 40%
  • Leisure Activity 40%
  • Physical Activity 40%
• 2016

  The epigenetic clock and telomere length are independently associated with chronological age and mortality

  Marioni, R., Harris, S., Deary, I., Visscher, P. M., Wray, N. R., Mcrae, A. F., Von Zglinicki, T., Shah, S. & Martin-ruiz, C., 13 Apr 2016, (E-pub ahead of print) In: International Journal of Epidemiology.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Telomere Length 100%
  • Mortality 100%
  • Age 100%
  • Birth 33%

• Life review in advanced age: qualitative research on the 'start in life' of 90-year-olds in the Lothian Birth Cohort 1921

  Lapsley, H., Pattie, A., Starr, J. M. & Deary, I. J., 1 Apr 2016, In: BMC Geriatrics. 16, 1, p. 74

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Age 100%
  • Childbirth 100%
  • Qualitative Research 100%
  • Questionnaires 41%
  • Family 33%

• A study of common Mendelian disease carriers across ageing British cohorts: Meta-analyses reveal heterozygosity for alpha 1-antitrypsin deficiency increases respiratory capacity and height

  North, T-L., Ben-Shlomo, Y., Cooper, C., Deary, I. J., Gallacher, J., Kivimaki, M., Kumari, M., Martin, R. M., Pattie, A., Sayer, A. A., Starr, J. M., Wong, A., Kuh, D., Rodriguez, S. & Day, I. N. M., 1 Feb 2016, (E-pub ahead of print) In: Journal of Medical Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Height 100%
  • Aging 100%
  • Heterozygosity 100%
  • Alpha 1-Antitrypsin 100%
  • Protease Inhibitor 87%

• GWAS for executive function and processing speed suggests involvement of the CADM2 gene

  Generation Scotland, Ibrahim-Verbaas, C. A., Bressler, J., Debette, S., Schuur, M., Smith, A. V., Bis, J. C., Davies, G., Trompet, S., Smith, J. A., Wolf, C., Chibnik, L. B., Liu, Y., Vitart, V., Kirin, M., Petrovic, K., Polasek, O., Zgaga, L., Fawns-Ritchie, C., Hoffmann, P., & 31 othersKarjalainen, J., Lahti, J., Llewellyn, D. J., Schmidt, C. O., Mather, K. A., Chouraki, V., Sun, Q., Resnick, S. M., Rose, L. M., Oldmeadow, C., Stewart, M., Smith, B. H., Gudnason, V., Yang, Q., Mirza, S. S., Jukema, J. W., deJager, P. L., Harris, T. B., Liewald, D., Amin, N., Gow, A. J., Pattie, A., Starr, J. M., McLachlan, S., Porteous, D. J., Price, J. F., Rudan, I., Hayward, C., Wright, A. F., Wilson, J. F. & Deary, I., Feb 2016, In: Molecular Psychiatry. 21, p. 189-197

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Executive Function 100%
  • Processing Speed 100%
  • Cell Adhesion Molecule 100%
  • Nested Gene 100%

• Polygenic risk for coronary artery disease is associated with cognitive ability in older adults

  Generation Scotland, Hagenaars, S. P., Harris, S. E., Clarke, T-K., Hall, L., Luciano, M., Fernandez-Pujals, A. M., Davies, G., Hayward, C., Starr, J. M., Porteous, D. J., McIntosh, A. M. & Deary, I. J., 28 Jan 2016, In: International Journal of Epidemiology. 45, 2, p. 433-440

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Coronary Artery Disease 100%
  • Cognitive Function 100%
  • Older Adult 100%
  • Association 50%
  • Meta-Analysis 12%

• Genome-wide autozygosity is associated with lower general cognitive ability

  Howrigan, D. P., Simonson, M. A., Davies, G., Harris, S. E., Tenesa, A., Starr, J. M., Liewald, D. C., Deary, I. J., McRae, A., Wright, M. J., Montgomery, G. W., Hansell, N., Martin, N. G., Payton, A., Horan, M., Ollier, W. E., Abdellaoui, A., Boomsma, D. I., DeRosse, P., Knowles, E. E. M., & 27 othersGlahn, D. C., Djurovic, S., Melle, I., Andreassen, O. A., Christoforou, A., Steen, V. M., Hellard, S. L., Sundet, K., Reinvang, I., Espeseth, T., Lundervold, A. J., Giegling, I., Konte, B., Hartmann, A. M., Rujescu, D., Roussos, P., Giakoumaki, S., Burdick, K. E., Bitsios, P., Donohoe, G., Corley, R. P., Visscher, P. M., Pendleton, N., Malhotra, A. K., Neale, B. M., Lencz, T. & Keller, M. C., 2016, In: Molecular Psychiatry. 21, 6, p. 837-843

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Aptitude 100%
  • Progeny 60%
  • Fitness 40%
  • Allele 40%
  • Mutation 20%
• 2015

  Integrative pathway genomics of lung function and airflow obstruction

  CHARGE Consortium; SpiroMeta Consortium, Gharib, S. A., Loth, D. W., Soler Artigas, M., Birkland, T. P., Wilk, J. B., Wain, L. V., Brody, J. A., Obeidat, M., Hancock, D. B., Tang, W., Rawal, R., Boezen, H. M., Imboden, M., Huffman, J. E., Lahousse, L., Alves, A. C., Manichaikul, A., Hui, J., Morrison, A. C., & 30 othersRamasamy, A., Smith, A. V., Gudnason, V., Surakka, I., Vitart, V., Evans, D. M., Strachan, D. P., Deary, I. J., Hofman, A., Gläser, S., Wilson, J. F., North, K. E., Zhao, J. H., Heckbert, S. R., Jarvis, D. L., Probst-Hensch, N., Schulz, H., Barr, R. G., Jarvelin, M-R., O'Connor, G. T., Kähönen, M., Cassano, P. A., Hysi, P. G., Dupuis, J., Hayward, C., Psaty, B. M., Hall, I. P., Parks, W. C., Tobin, M. D. & London, S. J., 22 Dec 2015, In: Human Molecular Genetics. 24, 23, p. 6836-48 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Lung 100%
  • Airway Obstruction 100%
  • Genome Wide Association Study 100%
  • Analysis 66%
  • Biological Product 50%

• Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

  BIOS-consortium, Kato, N., Loh, M., Takeuchi, F., Verweij, N., Wang, X., Zhang, W., Kelly, T. N., Saleheen, D., Lehne, B., Mateo Leach, I., Drong, A. W., Abbott, J., Wahl, S., Tan, S-T., Scott, W. R., Campanella, G., Chadeau-Hyam, M., Afzal, U., Ahluwalia, T. S., & 31 othersBonder, M. J., Chen, P., Dehghan, A., Edwards, T. L., Esko, T., Go, M. J., Harris, S. E., Hartiala, J., Kasela, S., Kasturiratne, A., Khor, C-C., Kleber, M. E., Li, H., Mok, Z. Y., Nakatochi, M., Sapari, N. S., Saxena, R., Stewart, A. F. R., Stolk, L., Tabara, Y., Teh, A. L., Wu, Y., Wu, J-Y., Zhang, Y., Aits, I., Da Silva Couto Alves, A., Das, S., Davies, G., Liewald, D. C. M., Starr, J. M. & Deary, I. J., 21 Sept 2015, In: Nature Genetics. 47, 11, p. 1282-93 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Locus 100%
  • Genome-Wide Association Study 100%
  • DNA Methylation 100%
  • Blood Pressure 100%
  • Single Nucleotide Polymorphism 40%

• Meta-analysis of genome-wide association studies for extraversion: Findings from the Genetics of Personality Consortium

  Generation Scotland, van den Berg, S. M., de Moor, M. H. M., Verweij, K. J. H., Krueger, R. F., Luciano, M., Arias Vasquez, A., Matteson, L. K., Derringer, J., Esko, T., Amin, N., Gordon, S. D., Hansell, N. K., Hart, A. B., Seppälä, I., Huffman, J. E., Konte, B., Lahti, J., Lee, M., Miller, M., & 31 othersNutile, T., Tanaka, T., Teumer, A., Viktorin, A., Wedenoja, J., Abdellaoui, A., Abecasis, G. R., Adkins, D. E., Agrawal, A., Allik, J., Appel, K., Bigdeli, T. B., Busonero, F., Campbell, H., Costa, P. T., Smith, G. D., Davies, G., de Wit, H., Ding, J., Engelhardt, B. E., Eriksson, J. G., Fedko, I. O., Liewald, D. C., Polasek, O., Starr, J. M., Zgaga, L., Porteous, D., Hayward, C., Rudan, I., Deary, I. J. & Wilson, J. F., 11 Sept 2015, (E-pub ahead of print) In: Behavior Genetics. 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Personality 100%
  • Meta-Analysis 100%
  • Extraversion 100%
  • Genome-Wide Association Study 100%
  • Personality Trait 42%

• Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

  Genetics of Personality Consortium, 31 Jul 2015, In: JAMA Psychiatry. 72, 7, p. 642-650 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Meta-Analysis 100%
  • Association 100%
  • Neurosis 100%
  • Major Depressive Episode 100%
  • Genome Wide Association Study 100%

• Directional dominance on stature and cognition in diverse human populations

  Joshi, P. K., Esko, T., Mattsson, H., Eklund, N., Gandin, I., Nutile, T., Jackson, A. U., Schurmann, C., Smith, A. V., Zhang, W., Okada, Y., Stančáková, A., Faul, J. D., Zhao, W., Bartz, T. M., Concas, M. P., Franceschini, N., Enroth, S., Vitart, V., Trompet, S., & 30 othersGuo, X., Chasman, D. I., O'Connel, J. R., Corre, T., Nongmaithem, S. S., Chen, Y., Mangino, M., Ruggiero, D., Campbell, A., Davies, G., Haley, C., Harris, S. E., Hastie, N. D., Kerr, S. M., Liewald, D. C. M., Navarro, P., Redmond, P., Wild, S., BioBank Japan Project, Morris, A. D., Starr, J. M., Deary, I. J., Pirastu, N., Wilson, J. G., Rudan, I., Porteous, D. J., Hayward, C., Wright, A. F., Campbell, H. & Wilson, J. F., 23 Jul 2015, In: Nature. 523, 7561, p. 459-462 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Cognition 100%
  • Homozygosity 100%
  • Body Height 100%
  • Health 20%
  • Fitness 10%

• Improving Phenotypic Prediction by Combining Genetic and Epigenetic Associations

  BIOS Consortium, Shah, S., Bonder, M. J., Marioni, R. E., Zhu, Z., McRae, A. F., Zhernakova, A., Harris, S. E., Liewald, D., Henders, A. K., Mendelson, M. M., Liu, C., Joehanes, R., Liang, L., Levy, D., Martin, N. G., Starr, J. M., Wijmenga, C., Wray, N. R., Yang, J., & 4 othersMontgomery, G. W., Franke, L., Deary, I. J. & Visscher, P. M., 2 Jul 2015, In: American Journal of Human Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Body Mass 100%
  • Association 100%
  • Genetics 100%
  • Methylation 80%

• Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index

  Clarke, T-K., Hall, L. S., Fernandez-Pujals, A. M., MacIntyre, D. J., Thomson, P., Hayward, C., Smith, B. H., Padmanabhan, S., Hocking, L. J., Deary, I. J., Porteous, D. J. & McIntosh, A. M., 30 Jun 2015, In: Translational Psychiatry. 5, e592.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Body Mass Index 100%
  • Depression 100%
  • Obesity 100%
  • Psychological Distress 100%
  • Major Depressive Disorder 100%

• Rare and low-frequency variants and their association with plasma levels of fibrinogen, FVII, FVIII, and vWF

  Huffman, J. E., de Vries, P., Morrison, A. C., Sabater-Lleal, M., Kacprowski, T., Auer, P. L., Brody, J. A., Chasman, D. I., Chen, M-H., Guo, X., Lin, L-A., Marioni, R., muller-nurasyid, M., Yanek, L. R., Pankratz, N., Grove, M. L., de Maat, M. P. M., Cushman, M., Wiggins, K. L., Qi, L., & 47 othersSennblad, B., Harris, S., Polašek, O., Riess, H., Rivadeneira, F., Rose, L. M., Goel, A., Taylor, K. D., Teumer, A., Uitterlinden, A. G., Vaidya, D., Yao, J., Tang, W., Levy, D., Waldenberger, M., Becker, D. M., Folsom, A. R., Giulianini, F., Greinacher, A., Hofman, A., Huang, C-C., Kooperberg, C., Silveira, A., Starr, J. M., Strauch, K., Strawbridge, R. J., Wright, A. F., McKnight, B., Franco, O. H., Zakai, N., Mathias, R. A., Psaty, B. M., Ridker, P. M., Tofler, G. H., Voelker, U., Watkins, H., Fornage, M., Hamsten, A., Deary, I., Boerwinkle, E., Koenig, W., Rotter, J. I., Hayward, C., Dehghan, A., Reiner, A. P., O'Donnell, C. J. & Smith, N. L., 23 Jun 2015, In: Blood.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Factor VII 100%
  • Fibrinogen 100%
  • Association 100%
  • Blood Level 100%
  • Von Willebrand Factor 100%

• Independent evidence for an association between general cognitive ability and a genetic locus for educational attainment

  Trampush, J. W., Lencz, T., Knowles, E., Davies, G., Guha, S., Pe'er, I., Liewald, D. C., Starr, J. M., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., Mukherjee, S., DeRosse, P., Lundervold, A., Steen, V. M., John, M., Espeseth, T., Raikkonen, K., & 33 othersWiden, E., Palotie, A., Eriksson, J. G., Giegling, I., Konte, B., Ikeda, M., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Horan, M., Scult, M., Dickinson, D., Straub, R. E., Donohoe, G., Morris, D., Corvin, A., Gill, M., Hariri, A., Weinberger, D. R., Pendleton, N., Iwata, N., Darvasi, A., Bitsios, P., Rujescu, D., Lahti, J., Le Hellard, S., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C. & Malhotra, A. K., 10 Jun 2015, In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 168, 5, p. 363-373 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Gene Locus 100%
  • Association 100%
  • Cognitive Function 100%
  • Mental Capacity 100%
  • Genome Wide Association Study 36%

• Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

  Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Debette, S., Ibrahim Verbaas, C. A., Bressler, J., Schuur, M., Smith, A., Bis, J. C., Davies, G., Wolf, C., Gudnason, V., Chibnik, L. B., Yang, Q., deStefano, A. L., de Quervain, D. J. F., Srikanth, V., Lahti, J., Grabe, H. J., Smith, J. A., Priebe, L., Yu, L., & 31 othersKarbalai, N., Hayward, C., Wilson, J. F., Campbell, H., Petrovic, K., Fornage, M., Chauhan, G., Yeo, R., Boxall, R., Becker, J., Stegle, O., Mather, K. A., Chouraki, V., Sun, Q., Rose, L. M., Resnick, S., Oldmeadow, C., Kirin, M., Wright, A. F., Jonsdottir, M. K., Vitart, V., Hastie, N. D., Zgaga, L., Rudan, I., Polasek, O., Liewald, D. C., Gow, A. J., Pattie, A., Starr, J. M., Porteous, D. & Deary, I. J., 15 Apr 2015, In: Biological Psychiatry. 77, 8, p. 749-763 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cohort Effect 100%
  • Aging 100%
  • Association 100%
  • Heart 100%
  • Older People 100%

• Genetic basis of a cognitive complexity metric

  Hansell, N. K., Halford, G. S., Andrews, G., Shum, D. H. K., Harris, S. E., Davies, G., Franic, S., Christoforou, A., Zietsch, B., Painter, J., Medland, S. E., Ehli, E. A., Davies, G. E., Steen, V. M., Lundervold, A. J., Reinvang, I., Montgomery, G. W., Espeseth, T., Hulshoff Pol, H. E., Starr, J. M., & 5 othersMartin, N. G., Le Hellard, S., Boomsma, D. I., Deary, I. J. & Wright, M. J., 10 Apr 2015, In: PLoS ONE. 10, 4, p. e0123886

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genetics 100%
  • Processing 57%
  • Nested Gene 57%
  • Sample 42%
  • Working Memory 42%

• Disentangling wording and substantive factors in the spiritual well-being scale

  Murray, A. L., Johnson, W., Gow, A. J. & Deary, I. J., Apr 2015, In: Psychology of Religion and Spirituality. 7, 2, p. 120-129 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • substantive 100%
  • Spiritual well-being 100%
  • Wellbeing 100%
  • Validity 66%
  • Shapes 33%

• Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population

  Clarke, T-K., Lupton, M. K., Fernandez-Pujals, A. M., Starr, J., Davies, G., Cox, S., Pattie, A., Liewald, D. C., Hall, L. S., MacIntyre, D. J., Smith, B. H., Hocking, L. J., Padmanabhan, S., Thomson, P. A., Hayward, C., Hansell, N. K., Montgomery, G. W., Medland, S. E., Martin, N. G., Wright, M. J., & 3 othersPorteous, D. J., Deary, I. J. & McIntosh, A. M., 10 Mar 2015, In: Molecular Psychiatry.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Autism Spectrum Disorder 100%
  • Cognitive Function 100%
  • Attention Deficit 50%
  • Attention Deficit Hyperactivity Disorder 50%
  • Adolescents 16%

• Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)

  Davies, G., Armstrong, N., Bis, J. C., Bressler, J., Chouraki, V., Giddaluru, S., Hofer, E., Ibrahim-Verbaas, C. A., Kirin, M., Lahti, J., van der Lee, S. J., Le Hellard, S., Liu, T., Marioni, R. E., Oldmeadow, C., Postmus, I., Smith, A. V., Smith, J. A., Thalamuthu, A., Thomson, R., & 109 othersVitart, V., Wang, J., Yu, L., Zgaga, L., Zhao, W., Boxall, R., Harris, S. E., Hill, W. D., Liewald, D. C., Luciano, M., Adams, H., Ames, D., Amin, N., Amouyel, P., Assareh, A. A., Au, R., Becker, J. T., Beiser, A., Berr, C., Bertram, L., Boerwinkle, E., Buckley, B. M., Campbell, H., Corley, J., De Jager, P. L., Dufouil, C., Eriksson, J. G., Espeseth, T., Faul, J. D., Ford, I., Generation Scotland, Gottesman, R. F., Griswold, M. E., Gudnason, V., Harris, T. B., Heiss, G., Hofman, A., Holliday, E. G., Huffman, J., Kardia, S. L. R., Kochan, N., Knopman, D. S., Kwok, J. B., Lambert, J-C., Lee, T., Li, G., Li, S-C., Loitfelder, M., Lopez, O. L., Lundervold, A. J., Lundqvist, A., Mather, K. A., Mirza, S. S., Nyberg, L., Oostra, B. A., Palotie, A., Papenberg, G., Pattie, A., Petrovic, K., Polasek, O., Psaty, B. M., Redmond, P., Reppermund, S., Rotter, J. I., Schmidt, H., Schuur, M., Schofield, P. W., Scott, R. J., Steen, V. M., Stott, D. J., van Swieten, J. C., Taylor, K. D., Trollor, J., Trompet, S., Uitterlinden, A. G., Weinstein, G., Widen, E., Windham, B. G., Jukema, J. W., Wright, A. F., Wright, M. J., Yang, Q., Amieva, H., Attia, J. R., Bennett, D. A., Brodaty, H., de Craen, A. J. M., Hayward, C., Ikram, M. A., Lindenberger, U., Nilsson, L-S., Porteous, D. J., Räikkönen, K., Reinvang, I., Rudan, I., Sachdev, P. S., Schmidt, R., Schofield, P. R., Srikanth, V., Starr, J. M., Turner, S. T., Weir, D. R., Wilson, J. F., Duijn, C. V., Launer, L., Fitzpatrick, A. L., Seshadri, S., Mosley Jr, T. H. & Deary, I. J., 28 Feb 2015, In: Molecular Psychiatry. 20, 2, p. 183-192 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Cognition 100%
  • Genetics 100%
  • Nested Gene 100%
  • Single-Nucleotide Polymorphism 60%

• DNA methylation age of blood predicts all-cause mortality in later life

  Marioni, R. E., Shah, S., McRae, A. F., Chen, B. H., Colicino, E., Harris, S. E., Gibson, J., Henders, A. K., Redmond, P., Cox, S. R., Pattie, A., Corley, J., Murphy, L., Martin, N. G., Montgomery, G. W., Feinberg, A. P., Fallin, M. D., Multhaup, M. L., Jaffe, A. E., Joehanes, R., & 11 othersSchwartz, J., Just, A. C., Lunetta, K. L., Murabito, J. M., Starr, J. M., Horvath, S., Baccarelli, A. A., Levy, D., Visscher, P. M., Wray, N. R. & Deary, I. J., 30 Jan 2015, In: Genome Biology. 16, 12 p., 25.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • All Cause Mortality 100%
  • Life 100%
  • DNA Methylation 100%
  • Age 100%
  • Mortality 23%

• Cognitive consequences of overweight and obesity in the ninth decade of life?

  Dahl Aslan, A. K., Starr, J. M., Pattie, A. & Deary, I., 2015, In: Age and Ageing. 44, 1, p. 59-65

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Body Mass Index 100%
  • Obesity 100%
  • Latent Growth Model 25%
  • Cognition 25%
• 2014

  Religiosity is negatively associated with later-life intelligence, but not with age-related cognitive decline

  Ritchie, S. J., Gow, A. J. & Deary, I. J., 1 Sept 2014, In: Intelligence. 46, p. 9-17

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Decline 100%
  • Religiosity 100%
  • Life 100%
  • Cognitive 100%
  • Cognitive Decline 100%

• Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function

  Tang, W., Kowgier, M., Loth, D. W., Soler Artigas, M., Joubert, B. R., Hodge, E., Gharib, S. A., Smith, A. V., Ruczinski, I., Gudnason, V., Mathias, R. A., Harris, T. B., Hansel, N. N., Launer, L. J., Barnes, K. C., Hansen, J. G., Albrecht, E., Aldrich, M. C., Allerhand, M., Barr, R. G., & 59 othersBrusselle, G. G., Couper, D. J., Curjuric, I., Davies, G., Deary, I. J., Dupuis, J., Fall, T., Foy, M., Franceschini, N., Gao, W., Gläser, S., Gu, X., Hancock, D. B., Heinrich, J., Hofman, A., Imboden, M., Ingelsson, E., James, A., Karrasch, S., Koch, B., Kritchevsky, S. B., Kumar, A., Lahousse, L., Li, G., Lind, L., Lindgren, C., Liu, Y., Lohman, K., Lumley, T., McArdle, W. L., Meibohm, B., Morris, A. P., Morrison, A. C., Musk, B., North, K. E., Palmer, L. J., Probst-Hensch, N. M., Psaty, B. M., Rivadeneira, F., Rotter, J. I., Schulz, H., Smith, L. J., Sood, A., Starr, J. M., Strachan, D. P., Teumer, A., Uitterlinden, A. G., Völzke, H., Voorman, A., Wain, L. V., Wells, M. T., Wilk, J. B., Williams, O. D., Heckbert, S. R., Stricker, B. H., London, S. J., Fornage, M., Hall, I. P. & Cassano, P. A., 1 Jul 2014, In: PLoS ONE. 9, 7, p. e100776

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Gene Locus 75%
  • Gene Expression 50%
  • Cohort Study 50%
  • Association 50%

• Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory

  van den Berg, S. M., de Moor, M. H. M., McGue, M., Pettersson, E., Terracciano, A., Verweij, K. J. H., Amin, N., Derringer, J., Esko, T., van Grootheest, G., Hansell, N. K., Huffman, J., Konte, B., Lahti, J., Luciano, M., Matteson, L. K., Viktorin, A., Wouda, J., Agrawal, A., Allik, J., & 68 othersBierut, L., Broms, U., Campbell, H., Smith, G. D., Eriksson, J. G., Ferrucci, L., Franke, B., Fox, J-P., de Geus, E. J. C., Giegling, I., Gow, A. J., Grucza, R., Hartmann, A. M., Heath, A. C., Heikkilä, K., Iacono, W. G., Janzing, J., Jokela, M., Kiemeney, L., Lehtimäki, T., Madden, P. A. F., Magnusson, P. K. E., Northstone, K., Nutile, T., Ouwens, K. G., Palotie, A., Pattie, A., Pesonen, A-K., Polasek, O., Pulkkinen, L., Pulkki-Råback, L., Raitakari, O. T., Realo, A., Rose, R. J., Ruggiero, D., Seppälä, I., Slutske, W. S., Smyth, D. C., Sorice, R., Starr, J. M., Sutin, A. R., Tanaka, T., Verhagen, J., Vermeulen, S., Vuoksimaa, E., Widen, E., Willemsen, G., Wright, M. J., Zgaga, L., Rujescu, D., Metspalu, A., Wilson, J. F., Ciullo, M., Hayward, C., Rudan, I., Deary, I. J., Räikkönen, K., Arias Vasquez, A., Costa, P. T., Keltikangas-Järvinen, L., van Duijn, C. M., Penninx, B. W. J. H., Krueger, R. F., Evans, D. M., Kaprio, J., Pedersen, N. L., Martin, N. G. & Boomsma, D. I., Jul 2014, In: Behavior Genetics. 44, 4, p. 295-313 19 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Personality 100%
  • Application 100%
  • Item Response Theory 100%
  • Inventories 100%
  • Harmonization 100%

• GWAS-based pathway analysis differentiates between fluid and crystallized intelligence

  Christoforou, A., Espeseth, T., Davies, G., Fernandes, C. P. D., Giddaluru, S., Mattheisen, M., Tenesa, A., Harris, S. E., Liewald, D. C., Payton, A., Ollier, W., Horan, M., Pendleton, N., Haggarty, P., Djurovic, S., Herms, S., Hoffman, P., Cichon, S., Starr, J. M., Lundervold, A., & 4 othersReinvang, I., Steen, V. M., Deary, I. J. & Le Hellard, S., 28 Jun 2014, In: Genes, Brain and Behavior. 13, 7, p. 663-674

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Genome-Wide Association Study 100%
  • Intelligence 100%
  • Liquid 100%
  • Analysis 100%
  • Genome Wide Association Study 100%

• Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936

  Lyall, D. M., Harris, S. E., Bastin, M. E., Munoz-Maniega, S., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Hernandez, M. D. C. V., Royle, N. A., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., Jun 2014, In: Neurobiology of Aging. 35, 6, p. 1513.e25–1513.e33 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Alzheimer's Disease 100%
  • Brain 100%
  • White Matter 100%
  • Apolipoprotein E 100%
  • Gene 100%

• Predicting cognitive ability in ageing cohorts using Type 2 diabetes genetic risk

  Luciano, M., Mõttus, R., Harris, S. E., Davies, G., Payton, A., Ollier, W. E. R., Horan, M. A., Starr, J. M., Porteous, D. J., Pendleton, N. & Deary, I. J., Jun 2014, In: Diabetic Medicine. 31, 6, p. 714-720 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Maturity Onset Diabetes of the Young 100%
  • Genetic Risk 100%
  • Aging 100%
  • Non Insulin Dependent Diabetes Mellitus 100%
  • Diabetes 100%

• Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old age

  Karama, S., Bastin, M. E., Murray, C., Royle, N. A., Penke, L., Munoz-Maniega, S., Gow, A. J., Corley, J., Valdés Hernández, M., Lewis, J. D., Rousseau, M-E., Lepage, C., Fonov, V., Collins, D. L., Booth, T., Rioux, P., Sherif, T., Adalat, R., Starr, J. M., Evans, A. C., & 2 othersWardlaw, J. M. & Deary, I. J., May 2014, In: Molecular Psychiatry. 19, 5, p. 555-559 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Brain 100%
  • Cognitive Aging 14%
  • Cognitive Tests 7%
  • Magnetic Resonance Imaging 7%

• The total burden of rare, non-synonymous exome genetic variants is not associated with childhood or late-life cognitive ability

  Marioni, R. E., Penke, L., Davies, G., Huffman, J. E., Hayward, C. & Deary, I. J., 22 Apr 2014, In: Proceedings of the Royal Society B-Biological Sciences. 281, 1781, 7 p., 20140117.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Aptitude 100%
  • Childhood 100%
  • Life 100%
  • Exome 100%
  • Genetic Divergence 100%

• Lower Ankle-Brachial Index Is Related to Worse Cognitive Performance in Old Age

  Laukka, E. J., Starr, J. M. & Deary, I. J., Mar 2014, In: Neuropsychology. 28, 2, p. 281-289 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Performance 100%
  • Processing Speed 66%
  • Nonverbal Reasoning 33%
  • Working Memory 33%
  • Cognition 33%

• Association of Low-Frequency and Rare Coding-Sequence Variants with Blood Lipids and Coronary Heart Disease in 56,000 Whites and Blacks

  NHLBI GO Exome Sequencing Project, Peloso, G. M., Auer, P. L., Bis, J. C., Voorman, A., Morrison, A. C., Stitziel, N. O., Brody, J. A., Khetarpal, S. A., Crosby, J. R., Fomage, M., Isaacs, A., Jakobsdottir, J., Feitosa, M. F., Davies, G., Huffman, J. E., Manichaikul, A., Davis, B., Lohman, K., Joon, A. Y., & 31 othersSmith, A. V., Grove, M. L., Zanoni, P., Redon, V., Demissie, S., Lawson, K., Peters, U., Carlson, C., Jackson, R. D., Ryckman, K. K., Mackey, R. H., Robinson, J. G., Siscovick, D. S., Schreiner, P. J., Mychaleckyj, J. C., Pankow, J. S., Holman, A., Uitterlinden, A. G., Harris, T. B., Taylor, K. D., Stafford, J. M., Reynolds, L. M., Marioni, R. E., Dehghan, A., Franco, O. H., Patele, A. P., Starr, J. M., Rudan, I., Hayward, C., Polasek, O. & Deary, I. J., 6 Feb 2014, In: American Journal of Human Genetics. 94, 2, p. 223-232 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Blood Lipids 100%
  • Cholesterol 100%
  • Association 100%
  • Low-Density Lipoprotein 60%
  • Nested Gene 60%

• Childhood intelligence is heritable, highly polygenic and associated with FNBP1L

  Wellcome Trust Case Control Consortium 2 (WTCCC2), Benyamin, B., Pourcain, B., Davis, O. S., Davies, G., Hansell, N. K., Brion, M-J., Kirkpatrick, R. M., Cents, R. A. M., Franić, S., Miller, M. B., Haworth, C. M. A., Meaburn, E., Price, T. S., Evans, D. M., Timpson, N., Kemp, J., Ring, S., McArdle, W., Medland, S. E., & 24 othersYang, J., Harris, S. E., Liewald, D. C., Scheet, P., Xiao, X., Hudziak, J. J., de Geus, E. J. C., Jaddoe, V. W. V., Starr, J. M., Verhulst, F. C., Pennell, C., Tiemeier, H., Iacono, W. G., Palmer, L. J., Montgomery, G. W., Martin, N. G., Boomsma, D. I., Posthuma, D., McGue, M., Wright, M. J., Davey Smith, G., Deary, I. J., Plomin, R. & Visscher, P. M., Feb 2014, In: Molecular Psychiatry. 19, 2, p. 253-8 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Childhood 100%
  • Intelligence 100%
  • Predictor 54%
  • Sample Size 18%
  • Single-Nucleotide Polymorphism 18%

• Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)

  Lencz, T., Knowles, E., Davies, G., Guha, S., Liewald, D. C., Starr, J. M., Djurovic, S., Melle, I., Sundet, K., Christoforou, A., Reinvang, I., Mukherjee, S., Derosse, P., Lundervold, A., Steen, V. M., John, M., Espeseth, T., Räikkönen, K., Widen, E., Palotie, A., & 26 othersEriksson, J. G., Giegling, I., Konte, B., Ikeda, M., Roussos, P., Giakoumaki, S., Burdick, K. E., Payton, A., Ollier, W., Horan, M., Donohoe, G., Morris, D., Corvin, A., Gill, M., Pendleton, N., Iwata, N., Darvasi, A., Bitsios, P., Rujescu, D., Lahti, J., Hellard, S. L., Keller, M. C., Andreassen, O. A., Deary, I. J., Glahn, D. C. & Malhotra, A. K., Feb 2014, In: Molecular Psychiatry. 19, 2, p. 168-174 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Dementia Praecox 100%
  • Cognitive Function 100%
  • Genomics 100%
  • Schizophrenia 100%
  • Genome-Wide Association Study 16%

• Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities

  Aribisala, B. S., Wiseman, S., Morris, Z., Valdes Hernandez, M., Royle, N. A., Munoz-Maniega, S., Gow, A. J., Corley, J., Bastin, M. E., Starr, J., Deary, I. J. & Wardlaw, J. M., 7 Jan 2014, In: Stroke. 45, 2, p. 605-607 3 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • White Matter 100%
  • Magnetic Resonance Imaging 100%
  • Inflammation 66%
  • Birth 33%
  • Association 33%

• Human cognitive ability is influenced by genetic variation in components of postsynaptic signalling complexes assembled by NMDA receptors and MAGUK proteins

  Hill, W. D., Davies, G., Van De Lagemaat, L. N., Christoforou, A., Marioni, R. E., Fernandes, C. P. D., Liewald, D. C., Croning, M. D. R., Payton, A., Craig, L. C. A., Whalley, L. J., Horan, M., Ollier, W., Hansell, N. K., Wright, M. J., Martin, N. G., Montgomery, G. W., Steen, V. M., Le Hellard, S., Espeseth, T., & 7 othersLundervold, A. J., Reinvang, I., Starr, J. M., Pendleton, N., Grant, S. G. N., Bates, T. C. & Deary, I. J., 7 Jan 2014, In: Translational Psychiatry. 4, 1, 8 p., 341.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mutation 100%
  • NMDA Receptor 100%
  • Aptitude 100%
  • Membrane-Associated Guanylate Kinase 100%
  • Protein Kinase 100%

• A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing

  Davies, G., Harris, S., Reynolds, C. A., Payton, A., Knight, H. M., Liewald, D. C., Lopez, L. M., Luciano, M., Gow, A. J., Henderson, R., Murray, C., Pattie, A., Fox, H. C., Redmond, P., Lutz, M. W., Chiba-Falek, O., Linnertz, C., Saith, S., Haggarty, P., McNeill, G., & 15 othersKe, X., Ollier, W., Horan, M., Roses, A. D., Ponting, C. P., Porteous, D. J., Tenesa, A., Corley, J., Pickles, A., Starr, J. M., Whalley, L. J., Pedersen, N. L., Pendleton, N., Visscher, P. M. & Deary, I. J., Jan 2014, In: Molecular Psychiatry. 19, 1, p. 76-87 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Genome-Wide Association Study 100%
  • Apolipoprotein E 100%
  • Cognitive Aging 100%
  • Translocase 55%
  • Outer Mitochondrial Membrane 55%

• Polygenic Risk for Alzheimer's Disease is not Associated with Cognitive Ability or Cognitive Aging in Non-Demented Older People

  Harris, S. E., Davies, G., Luciano, M., Payton, A., Fox, H. C., Haggarty, P., Ollier, W., Horan, M., Porteous, D. J., Starr, J. M., Whalley, L. J., Pendleton, N. & Deary, I. J., 2014, In: Journal of Alzheimer's Disease. 39, 3, p. 565-574 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Alzheimer's Disease 100%
  • Cognitive Aging 100%
  • Cognitive Function 100%
  • Cognitive Change 57%
  • Cognitive Decline 14%