Age-related cognitive changes in healthy humans: influences from genetic variation in genes related to oxidative stress

Research output

Research output per year 2003 2005 2006 2007 2008 2015

• 22 Article
• 1 Editorial
• 1 Literature review

Research output per year

Research output per year

Search results

• 2015

  Genome-wide Studies of Verbal Declarative Memory in Nondemented Older People: The Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

  Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium, Debette, S., Ibrahim Verbaas, C. A., Bressler, J., Schuur, M., Smith, A., Bis, J. C., Davies, G., Wolf, C., Gudnason, V., Chibnik, L. B., Yang, Q., deStefano, A. L., de Quervain, D. J. F., Srikanth, V., Lahti, J., Grabe, H. J., Smith, J. A., Priebe, L., Yu, L., & 31 othersKarbalai, N., Hayward, C., Wilson, J. F., Campbell, H., Petrovic, K., Fornage, M., Chauhan, G., Yeo, R., Boxall, R., Becker, J., Stegle, O., Mather, K. A., Chouraki, V., Sun, Q., Rose, L. M., Resnick, S., Oldmeadow, C., Kirin, M., Wright, A. F., Jonsdottir, M. K., Vitart, V., Hastie, N. D., Zgaga, L., Rudan, I., Polasek, O., Liewald, D. C., Gow, A. J., Pattie, A., Starr, J. M., Porteous, D. & Deary, I. J., 15 Apr 2015, In: Biological Psychiatry. 77, 8, p. 749-763 15 p.

  Research output: Contribution to journal › Article › peer-review

  • Cohort Effect 100%
  • Aging 100%
  • Association 100%
  • Heart 100%
  • Older People 100%
• 2011

  MTHFR polymorphisms and cognitive ageing in the ninth decade: the Lothian Birth Cohort 1921

  Schiepers, O. J. G., Van Boxtel, M. P. J., Harris, S. E., Gow, A. J., Pattie, A., Brett, C. E., De Groot, R. H. M., Jolles, J., Starr, J. & Deary, I. J., Apr 2011, In: Genes, Brain and Behavior. 10, 3, p. 354-364 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Birth 100%
  • Cognitive Aging 100%
  • Polymorphism 100%
  • Age 66%
  • Life 33%
• 2010

  Variation in DISC1 is associated with anxiety, depression and emotional stability in elderly women

  Harris, S. E., Hennah, W., Thomson, P. A., Luciano, M., Starr, J., Porteous, D. J. & Deary, I. J., 1 Mar 2010, In: Molecular Psychiatry. 15, 3, p. 232-234 4 p.

  Research output: Contribution to journal › Article › peer-review
• 2009

  Association of KIBRA and memory

  Bates, T. C., Price, J., Harris, S., Marioni, R. E., Fowkes, F. G. R., Stewart, M., Murray, G. D., Whalley, L. J., Starr, J. & Deary, I. J., 2009, In: Neuroscience Letters. 458, 3, p. 140-143 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Memory 100%
  • Memory Test 33%
  • Substitution Reaction 33%
  • Intron 33%
  • Episodic Memory 33%
• 2008

  Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey

  Starr, J., Shiels, P. G., Harris, S. E., Pattie, A., Pearce, M. S., Relton, C. L. & Deary, I. J., 1 Dec 2008, In: Mechanisms of Ageing and Development. 129, 12, p. 745-751

  Research output: Contribution to journal › Article › peer-review

• Testing replication of a 5-SNP set for general cognitive ability in six population samples

  Luciano, M., Lind, P. A., Deary, I. J., Payton, A., Posthuma, D., Butcher, L. M., Bochdanovits, Z., Whalley, L. J., Visscher, P. M., Harris, S., Polderman, T. J. C., Davis, O. S. P., Wright, M. J., Starr, J., de Geus, E. J. C., Bates, T. C., Montgomery, G. W., Boomsma, D. I., Martin, N. G. & Plomin, R., 21 May 2008, In: European Journal of Human Genetics. 16, p. 1388-1395 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Cognitive Function 100%
  • Nucleotide 100%
  • Polymorphism 100%
  • Meta-Analysis 25%
  • Size 25%

• PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes

  Johnson, W., Harris, S. E., Starr, J., Whalley, L. J. & Deary, I. J., 21 Mar 2008, In: Neuroscience Letters. 434, 1, p. 50-55 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Diabetes 100%
  • Cognitive Decline 100%
  • Peroxisome Proliferator-Activated Receptor Gamma 100%
  • Genotype 100%
  • Cognitive Function 85%
• 2007

  A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition

  Harris, S. E., Fox, H., Wright, A. F., Hayward, C., Starr, J., Whalley, L. J. & Deary, I. J., 2 Jul 2007, In: BMC Genetics. 8, p. - 18 p., 43.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Oxidative Stress 100%
  • Cognition 100%
  • Cognitive Function 100%
  • Gene 100%
  • Cognitive Aging 100%

• COMT genotype and cognitive ability: A longitudinal aging study

  Starr, J., Fox, H., Harris, S. E., Deary, I. J. & Whalley, L. J., 21 Jun 2007, In: Neuroscience Letters. 421, 1, p. 57-61 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Valine 100%
  • Methyltransferase 100%
  • Aging 100%
  • Genotype 100%
  • Catechol Derivative 100%

• No association of CETP genotype with cognitive function or age-related cognitive change.

  Johnson, W., Harris, S. E., Collins, P., Starr, J., Whalley, L. J. & Deary, I. J., 13 Jun 2007, In: Neuroscience Letters. 420, 2, p. 189-192

  Research output: Contribution to journal › Article › peer-review

• Association between telomere length and heart disease in a narrow age cohort of older people

  Starr, J., McGurn, B., Harris, S. E., Whalley, L. J., Deary, I. J. & Shiels, P. G., Jun 2007, In: Experimental gerontology. 42, 6, p. 571-573 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Telomere Length 100%
  • Association 100%
  • Age 100%
  • Heart Disease 100%
  • Telomere Shortening 75%

• Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation

  Sisodiya, S. M., Thompson, P. J., Need, A., Harris, S. E., Weale, M. E., Wilkie, S. E., Michaelides, M., Free, S. L., Walley, N., Gumbs, C., Gerrelli, D., Ruddle, P., Whalley, L. J., Starr, J., Hunt, D. M., Goldstein, D. B., Deary, I. J. & Moore, A. T., Jun 2007, In: The American Journal of Medical Genetics - Part A (AJMG). 44, 6, p. 373-380 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Mutation 100%
  • Cognition 100%
  • Genetic Enhancement 100%
  • Rod-Cone Dystrophy 100%
  • Aptitude 60%

• The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence

  Mekel-Bobrov, N., Posthuma, D., Gilbert, S. L., Lind, P., Gosso, M. F., Luciano, M., Harris, S. E., Bates, T. C., Polderman, T. J. C., Whalley, L. J., Fox, H., Starr, J., Evans, P. D., Montgomery, G. W., Fernandes, C., Heutink, P., Martin, N. G., Boomsma, D. I., Deary, I. J., Wright, M. J., & 2 othersde Geus, E. J. C. & Lahn, B. T., 15 Mar 2007, In: Human Molecular Genetics. 16, 6, p. 600-608 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Evolutionary Adaptation 100%
  • Humans 100%
  • Gene 83%
  • Microcephaly 33%
  • Cognitive Function 33%
• 2006

  The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people

  Harris, S. E., Deary, I. J., Maclntyre, A., Lamb, K. J., Radhakrishnan, K., Starr, J., Whalley, L. J. & Shiels, P. G., 9 Oct 2006, In: Neuroscience Letters. 406, 3, p. 260-264 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Telomere Length 100%
  • Association 100%
  • Mortality 100%
  • Cognitive Aging 100%
  • Age 100%

• The brain-derived neurotrophic factor VaI66Met polymorphism is associated with age-related change in reasoning skills

  Harris, S. E., Fox, H., Wright, A. F., Hayward, C., Starr, J., Whalley, L. J. & Deary, I. J., May 2006, In: Molecular Psychiatry. 11, 5, p. 505-513 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Brain-Derived Neurotrophic Factor 100%
  • Polymorphism 100%
  • Reasoning 100%
  • Genotype 57%
  • Memory 42%

• Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD 11B1) and lifetime cognitive change

  Deary, I. J., Hayward, C., Permana, P. A., Nair, S., Whalley, L. J., Starr, J., Chapman, K. E., Walker, B. R. & Seckl, J. R., 23 Jan 2006, In: Neuroscience Letters. 393, 1, p. 74-77 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Cognitive Change 100%
  • Hydroxysteroid Dehydrogenase 100%
  • Gene 100%
  • Polymorphism 100%
  • Groups 60%
• 2005

  Association between genotype at an exonic SNP in DISC1 and normal cognitive aging

  Thomson, P. A., Harris, S. E., Starr, J., Whalley, L. J., Porteous, D. J. & Deary, I. J., 25 Nov 2005, In: Neuroscience Letters. 389, 1, p. 41-45 5 p.

  Research output: Contribution to journal › Article › peer-review

  • DISC1 100%
  • Single Nucleotide Polymorphism 100%
  • Association 100%
  • Genotyping 100%
  • Cognitive Aging 100%

• Genetic influences on oxidative stress and their association with normal cognitive ageing

  Kachiwala, S. J., Harris, S. E., Wright, A. F., Hayward, C., Starr, J., Whalley, L. J. & Deary, I. J., 30 Sept 2005, In: Neuroscience Letters. 386, 2, p. 116-120 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxidative Stress 100%
  • Gene 100%
  • Cognitive Aging 100%
  • Cognitive Function 100%
  • Genetic Influence 100%

• The functional COMT polymorphism, Val158Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds

  Harris, S. E., Wright, A. F., Hayward, C., Starr, J., Whalley, L. J. & Deary, I. J., 2 Sept 2005, In: Neuroscience Letters. 385, 1, p. 16 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Imagination 100%
  • Polymorphism 100%
  • Personality Trait 100%
  • Catechol-O-Methyltransferase 100%
  • Cognitive Function 50%

• KLOTHO genotype and cognitive ability in childhood and old age in the same individuals

  Deary, I. J., Harris, S. E., Fox, H. C., Hayward, C., Wright, A. F., Starr, J. & Whalley, L. J., 11 Apr 2005, In: Neuroscience Letters. 378, 1, p. 22-27 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Nonverbal Reasoning 100%
  • Cognitive Function 100%
  • Reasoning 50%
  • Abilities 25%
  • Cognition 25%

• Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing

  Deary, I. J., Hamilton, G., Hayward, C., Whalley, L. J., Powell, J., Starr, J. & Lovestone, S., 10 Jan 2005, In: Neuroscience Letters. 373, 2, p. 110-114 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Cognitive Aging 100%
  • Cognitive Function 100%
  • Polymorphism 100%
  • Reasoning 100%
  • DNA Polymorphism 100%
• 2003

  Lack of association between polymorphisms in angiotensin-converting-enzyme and methylenetetrahydrofolate reductase genes and normal cognitive ageing in humans

  Visscher, P. M., Tynan, M., Whiteman, M. C., Pattie, A., White, I., Hayward, C., Wright, A. F., Starr, J., Whalley, L. J. & Deary, I. J., 28 Aug 2003, In: Neuroscience Letters. 347, 3, p. 175-178 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Methylenetetrahydrofolate Reductase 100%
  • Human 100%
  • Association 100%
  • Angiotensin-Converting Enzyme 100%
  • Nested Gene 100%