Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

2023

Sleep quality, perivascular spaces and brain health markers in ageing: A longitudinal study in the Lothian Birth Cohort 1936

Aribisala, B. S., Valdés Hernández, M. D. C., Okely, J. A., Cox, S. R., Ballerini, L., Dickie, D. A., Wiseman, S. J., Riha, R. L., Muñoz Maniega, S., Radakovic, R., Taylor, A., Pattie, A., Corley, J., Redmond, P., Bastin, M. E., Deary, I. & Wardlaw, J. M., Jun 2023, In: Sleep medicine. 106, p. 123-131

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White matter, cognition and psychotic-like experiences in UK Biobank

Bosma, M. J., Cox, S. R., Ziermans, T., Buchanan, C. R., Shen, X., Tucker-Drob, E. M., Adams, M. J., Whalley, H. C. & Lawrie, S. M., Apr 2023, In: Psychological Medicine. 53, 6, p. 2370-2379 10 p.

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Rare genetic variants underlie outlying levels of DNA methylation and gene-expression

Chundru, V. K., Marioni, R. E., Prendergast, J., Lin, T., Beveridge, A. J., Martin, N. G., Montgomery, G. W., Hume, D. A., Deary, I. J., Visscher, P. M., Wray, N. R. & McRae, A. F., 15 Feb 2023, (E-pub ahead of print) In: Human Molecular Genetics. 32, 11, p. 1912-1921 10 p.

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Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936

Clancy, U., Radakovic, R., Doubal, F., Hernández, M. D. C. V., Maniega, S. M., Taylor, A. M., Corley, J., Chappell, F. M., Russ, T. C., Cox, S. R., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., Jan 2023, In: International Journal of Geriatric Psychiatry. 38, 1, e5855.

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DNAmFitAge: Biological age indicator incorporating physical fitness

Mcgreevy, K. M., Radak, Z., Torma, F., Jokai, M., Lu, A. T., Belsky, D. W., Binder, A., Marioni, R. E., Ferrucci, L., Pośpiech, E., Branicki, W., Ossowski, A., Sitek, A., Spólnicka, M., Raffield, L. M., Reiner, A. P., Cox, S., Kobor, M., Corcoran, D. L. & Horvath, S., 2023, In: Aging. 15

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2022

DNA methylation GrimAge version 2

Lu, A. T., Binder, A. M., Zhang, J., Yan, Q., Reiner, A. P., Cox, S. R., Corley, J., Harris, S., Kuo, P-L., Moore, A. Z., Bandinelli, S., Stewart, J., Wang, C., Hamlat, E. J., Epel, E. S., Schwartz, J., Whitsel, E. A., Correa, A., Ferrucci, L., Marioni, R. E., & 1 othersHorvath, S., 14 Dec 2022, (E-pub ahead of print) In: Aging. 14, 23, p. 9484—9549

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Predictors of longitudinal cognitive ageing from age 70 to 82 including APOE e4 status, early-life and lifestyle factors: The Lothian Birth Cohort 1936

Corley, J., Conte, F., Harris, S. E., Taylor, A. M., Redmond, P., Russ, T. C., Deary, I. J. & Cox, S. R., 8 Dec 2022, (E-pub ahead of print) In: Molecular Psychiatry.

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Blood DNA methylation signatures of lifestyle exposures: Tobacco and alcohol consumption

Chamberlain, J. D., Nusslé, S., Chapatte, L., Kinnaer, C., Petrovic, D., Pradervand, S., Bochud, M., Harris, S. E., Corley, J., Cox, S. R. & Gonseth Nusslé, S., 28 Nov 2022, In: Clinical Epigenetics. 14, 155.

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Assessment of perivascular space filtering methods using a three-dimensional computational model

Bernal, J., Valdés-hernández, M. D. C., Escudero, J., Duarte, R., Ballerini, L., Bastin, M. E., Deary, I. J., Thrippleton, M. J., Touyz, R. M. & Wardlaw, J. M., 1 Nov 2022, In: Magnetic Resonance Imaging. 93, p. 33-51

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Cognitive change before old age (11 to 70) predicts cognitive change during old age (70 to 82)

Conte, F., Okely, J. A., Hamilton, O., Corley, J., Page, D., Redmond, P., Taylor, A. M., Russ, T. C., Deary, I. J. & Cox, S. R., 15 Sept 2022, (E-pub ahead of print) In: Psychological Science. p. 1-15

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Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects

Robertson, N. A., Latorre Crespo, E., Terradas Terradas, M., Lemos Portela, J., Purcell, A. C., Livesey, B., Hillary, R., Murphy, L., Fawkes, A., MacGillivray, L., Copland, M., Marioni, R. E., Marsh, J. A., Harris, S. A., Cox, S. R., Deary, I. J., Schumacher, L. J., Kirschner, K. & Chandra, T., 4 Jul 2022, In: Nature Medicine.

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Mediterranean-type diet and brain structural change from 73 to 79 years in the Lothian Birth Cohort 1936

Luciano, M., Corley, J., Valdés Hernández, M. C., Craig, L. C. A., Mcneill, G., Bastin, M. E., Deary, I. J., Cox, S. R. & Wardlaw, J. M., Apr 2022, In: The journal of nutrition, health & aging (JNHA). 26, 4, p. 368-372

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2020

Inflammation as a risk factor for the development of frailty in the Lothian Birth Cohort 1936

Welstead, M., Muniz-Terrera, G., Russ, T. C., Corley, J., Taylor, A. M., Gale, C. R. & Luciano, M., 1 Oct 2020, In: Experimental gerontology. 139, 111055.

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Adherence to the MIND diet is associated with 12-year all-cause mortality in older adults

Corley, J., 3 Sept 2020, (E-pub ahead of print) In: Public Health Nutrition.

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Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive Declines

Madole, J. W., Ritchie, S. J., Cox, S. R., Buchanan, C. R., Valdés Hernández, M., Muñoz Maniega, S., Wardlaw, J. M., Harris, M. A. H., Bastin, M. E., Deary, I. J. & Tucker-Drob, E. M., 15 Jun 2020, (E-pub ahead of print) In: Biological Psychiatry. N/A, p. 1-12

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Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

Armstrong, N. J., Mather, K. A., Sargurupremraj, M., Knol, M. J., Malik, R., Satizabal, C. L., Yanek, L. R., Wen, W., Gudnason, V. G., Dueker, N. D., Elliott, L. T., Hofer, E., Bis, J., Jahanshad, N., Li, S., Logue, M. A., Luciano, M., Scholz, M., Smith, A. V., Trompet, S., & 66 othersVojinovic, D., Xia, R., Alfaro-almagro, F., Ames, D., Amin, N., Amouyel, P., Beiser, A. S., Brodaty, H., Deary, I. J., Fennema-notestine, C., Gampawar, P. G., Gottesman, R., Griffanti, L., Jack, C. R., Jenkinson, M., Jiang, J., Kral, B. G., Kwok, J. B., Lampe, L., C.m. Liewald, D., Maillard, P., Marchini, J., Bastin, M. E., Mazoyer, B., Pirpamer, L., Rafael Romero, J., Roshchupkin, G. V., Schofield, P. R., Schroeter, M. L., Stott, D. J., Thalamuthu, A., Trollor, J., Tzourio, C., Van Der Grond, J., Vernooij, M. W., Witte, V. A., Wright, M. J., Yang, Q., Morris, Z., Siggurdsson, S., Psaty, B., Villringer, A., Schmidt, H., Haberg, A. K., Van Duijn, C. M., Jukema, J. W., Dichgans, M., Sacco, R. L., Wright, C. B., Kremen, W. S., Becker, L. C., Thompson, P. M., Mosley, T. H., Wardlaw, J. M., Ikram, M. A., Adams, H. H. H., Seshadri, S., Sachdev, P. S., Smith, S. M., Launer, L., Longstreth, W., Decarli, C., Schmidt, R., Fornage, M., Debette, S. & Nyquist, P. A., 10 Jun 2020, In: Stroke.

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Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study

Beaudet, G., Tsuchida, A., Petit, L., Tzourio, C., Caspers, S., Schreiber, J., Pausova, Z., Patel, Y., Paus, T., Schmidt, R., Pirpamer, L., Sachdev, P. S., Brodaty, H., Kochan, N. A., Trollor, J. N., Wen, W., Armstrong, N. J., Deary, I., Bastin, M., Wardlaw, J., & 6 othersMuñoz Maniega, S., Witte, A. V., Villringer, A., Duering, M., Debette, S. & Mazoyer, B., 4 May 2020, In: Frontiers in psychiatry. 11, 342.

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The effect of network thresholding and weighting on structural brain networks in the UK Biobank

Buchanan, C. R., Bastin, M. E., Ritchie, S. J., Liewald, D. C., Madole, J. W., Tucker-drob, E. M., Deary, I. J. & Cox, S. R., May 2020, In: NeuroImage. 211, 116443.

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Corticosteroids and regional variations in thickness of the human cerebral cortex across the lifespan

Parker, N., French, L., Vidal-Pineiro, D., Shin, J., Adams, H. H. H., Brodaty, H., Cox, S., Deary, I., Fjell, A. M., Frenzel, S., Grabe, H. J., Hosten, N., Arfan Ikram, M., Jian, J., Knol, M., Mazoyer, B., Mishra, A., Sachdev, P. S., Salum, G., Satizabal, C. L., & 12 othersSchmidt, H., Schmidt, R., Seshadri, S., Schumann, G., Völzke, H., Walhovd, K., Wen, W., Wittfield, K., Yang, Q., Debette, S., Pausova, Z. & Paus, T., 21 Mar 2020, In: Cerebral Cortex. bhz108.

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Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

neuroCHARGE Cognitive Working group & ENIGMA Consortium, 20 Mar 2020, (E-pub ahead of print) In: Cerebral Cortex. bhaa035.

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The genetic architecture of the human cerebral cortex

Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group, Grasby, K. L., Jahanshad, N., Painter, J. N., Colodro-conde, L., Bralten, J., Hibar, D. P., Lind, P. A., Pizzagalli, F., Ching, C. R. K., Mcmahon, M. A. B., Shatokhina, N., Zsembik, L. C. P., Thomopoulos, S. I., Zhu, A. H., Strike, L. T., Agartz, I., Alhusaini, S., Almeida, M. A. A., Alnæs, D., & 31 othersAmlien, I. K., Andersson, M., Ard, T., Armstrong, N. J., Ashley-koch, A., Atkins, J. R., Bernard, M., Brouwer, R. M., Buimer, E. E. L., Bülow, R., Bürger, C., Cannon, D. M., Chakravarty, M., Chen, Q., Cheung, J. W., Couvy-duchesne, B., Dale, A. M., Dalvie, S., De Araujo, T. K., De Zubicaray, G. I., De Zwarte, S. M. C., Den Braber, A., Doan, N. T., Dohm, K., Ehrlich, S., Harris, M. A., Luciano, M., Wardlaw, J. M., Doherty, C. P., Bastin, M. E. & Deary, I. J., 20 Mar 2020, In: Science. 367, 6484, 14 p., eaay6690.

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Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

Harris, S., Cox, S., Bell, S., Marioni, R., Prins, B. P., Pattie, A., Corley, J., Muñoz Maniega, S., Valdes Hernandez, M., Morrison, Z., John, S. L., Bronson, P. G., Tucker-Drob, E. M., Starr, J., Bastin, M., Wardlaw, J., Butterworth, A. S. & Deary, I., 10 Feb 2020, In: Nature Communications. 11, 800.

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Fluctuating asymmetry in brain structure and general intelligence in 73-Year-olds

Moodie, J. E., Ritchie, S., Cox, S., Harris, M., Muñoz Maniega, S., Valdes Hernandez, M., Pattie, A., Corley, J., Bastin, M., Starr, J., Wardlaw, J. & Deary, I., 31 Jan 2020, In: Intelligence. 78, 101407.

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Physical frailty and decline in general and specific cognitive abilities: The Lothian Birth Cohort 1936

Gale, C., Ritchie, S. J., Starr, J. & Deary, I., 9 Jan 2020, In: Journal of Epidemiology & Community Health. 74, p. 108-113

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Sleep and brain morphological changes in the eighth decade of life

Aribisala, B. S., Riha, R. L., Valdes Hernandez, M., Maniega, S. M., Cox, S., Radakovic, R., Taylor, A., Pattie, A., Corley, J., Redmond, P., Bastin, M. E., Starr, J., Deary, I. & Wardlaw, J. M., Jan 2020, In: Sleep medicine. 65

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Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936

Ballerini, L., Booth, T., Hernández, M. D. C. V., Wiseman, S., Lovreglio, R., Maniega, S. M., Morris, Z., Pattie, A., Corley, J., Gow, A., Bastin, M. E., Deary, I. J. & Wardlaw, J., 2020, In: NeuroImage: Clinical. 25, 102120.

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2019

Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

Jia, T., Chu, C., Liu, Y., van Dongen, J., Papastergios, E., Armstrong, N. J., Bastin, M. E., Carrillo-roa, T., den Braber, A., Harris, M., Jansen, R., Liu, J., Luciano, M., Ori, A. P. S., Roiz-Santianez, R., Ruggeri, B., Sarkisyan, D., Shin, J., Sungeun, K., Tordesillas-Gutierrez, D., & 62 othersVan't Ent, D., Ames, D., Artiges, E., Bakalkin, G., Banaschewski, T., Bokde, A. L. W., Brodaty, H., Bromberg, U., Brouwer, R. M., Büchel, C., Quinlan, E. B., Cahn, W., de Zubicaray, G. I., Ehrlich, S., Ekström, T. J., Flor, H., Fröhner, J. H., Frouin, V., Garavan, H., Gowland, P. A., Heinz, A., Hoare, J., Ittermann, B., Jahanshad, N., Jiang, J., Kwok, J. B. J., Martin, N. G., Martinot, J-L., Mather, K. A., McMahon, K. L., Mcrae, A. F., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Sämann, P. G., Schofield, P. R., Smolka, M. N., Stein, D. J., Strike, L. T., Teeuw, J., Thalamuthu, A., Trollor, J. N., Walter, H., Wardlaw, J. M., Wen, W., Whelan, R., Apostolova, L. G., Binder, E. B., Boomsma, D., Calhoun, V. D., Crespo-Facorro, B., Deary, I. J., Hulshoff Pol, H. E., Ophoff, R. A., Pausova, Z., Sachdev, P. S., Saykin, A. J., Wright, M. J., Thompson, P. M., Schumann, G. & Desrivières, S., 6 Dec 2019, (E-pub ahead of print) In: Molecular Psychiatry. N/A, p. 1-12

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An epigenetic predictor of death captures multi-modal measures of brain health

Hillary, R., Stevenson, A. J., Cox, S. R., McCartney, D. L., Harris, S. E., Seeboth, A., Higham, J., Sproul, D., Taylor, A., Redmond, P., Corley, J., Pattie, A., del C. Valdés Hernández, M., Muñoz-Maniega, S., Bastin, M. E., Wardlaw, J. M., Horvath, S., Ritchie, C. W., Spires-Jones, T. L., McIntosh, A. M., & 3 othersEvans, K. L., Deary, I. J. & Marioni, R. E., 3 Dec 2019, In: Molecular Psychiatry. N/A, p. 1-11 11 p.

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Genetic architecture of subcortical brain structures in 38,851 individuals

Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., Van Der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V., & 269 othersLi, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., Den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C-Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., De Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., Van Eijk, K. R., Cavalleri, G. L., Van Der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., Van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B-C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J-J., Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., Van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., Van Tol, M-J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., Van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J-L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., Van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van ‘t Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., Van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., Destefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., Van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., Decarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., 30 Nov 2019, In: Nature Genetics. 51, 11, p. 1624–1636 13 p.

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Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936

Corley, J., Cox, S., Harris, S., Valdes Hernandez, M., Munoz-Maniega, S., Bastin, M., Wardlaw, J., Starr, J., Marioni, R. & Deary, I., 7 Oct 2019, In: Translational Psychiatry. 9, 248.

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Structural brain imaging correlates of general intelligence in UK Biobank

Cox, S. R., Ritchie, S. J., Fawns-Ritchie, C., Tucker-Drob, E. M. & Deary, I. J., 30 Sept 2019, In: Intelligence. 76, 13 p., 101376.

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What do older people do when sitting and why? Implications for decreasing sedentary behavior

USP Team, Aug 2019, In: Gerontologist. 59, 4, p. 686-697 12 p.

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Brain peak width of skeletonised mean diffusivity (PSMD) and cognitive function in later life

Deary, I., Ritchie, S. J., Muñoz Maniega, S., Cox, S., Valdes Hernandez, M., Luciano, M., Starr, J., Wardlaw, J. & Bastin, M., 26 Jul 2019, (E-pub ahead of print) In: Frontiers in psychiatry. 10, 524.

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Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

Muñoz Maniega, S., Meijboom, R., Chappell, F. M., del C. Valdés Hernández, M., Starr, J. M., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., 25 Jul 2019, In: Frontiers in Neurology. 10, 784.

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Associations between vascular risk factors and brain MRI indices in UK Biobank

Cox, S. R., Lyall, D. M., Ritchie, S. J., Bastin, M. E., Harris, M. A., Buchanan, C. R., Fawns-Ritchie, C., Barbu, M., de Nooij, L., Reus, L. M., Alloza, C., Shen, X., Neilson, E., Alderson, H. L., Hunter, S., Liewald, D. C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Pell, J. P., & 4 othersTucker-Drob, E. M., Wardlaw, J. M., Gale, C. R. & Deary, I. J., 21 Jul 2019, In: European Heart Journal. 40, 28, p. 2290–2300 11 p.

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Individual differences in cognitive processes underlying Trail Making Test-B performance in old age: The Lothian Birth Cohort 1936

MacPherson, S. E., Allerhand, M., Cox, S. R. & Deary, I. J., Jul 2019, In: Intelligence. 75, p. 23-32

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Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: Effect on cognition and associations with mineral deposition

Valdes Hernandez, M., Ballerini, L., Glatz, A., Munoz-Maniega, S., Gow, A., Bastin, M., Starr, J., Deary, I. & Wardlaw, J., 27 Jun 2019, (E-pub ahead of print) In: Brain imaging and behavior.

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Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

McGrory, S., Ballerini, L., Doubal, F. N., Staals, J., Allerhand, M., Valdes Hernandez, M. D. C., Wang, X., MacGillivray, T., Doney, A. S. F., Dhillon, B., Starr, J. M., Bastin, M. E., Trucco, E., Deary, I. J. & Wardlaw, J. M., 19 Apr 2019, In: Scientific Reports. 9, 11 p., 6320.

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Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: A meta-analysis

Marini, S., Crawford, K., Morotti, A., Lee, M. J., Pezzini, A., Moomaw, C. J., Flaherty, M. L., Montaner, J., Roquer, J., Jimenez-conde, J., Giralt-steinhauer, E., Elosua, R., Cuadrado-godia, E., Soriano-tarraga, C., Slowik, A., Jagiella, J. M., Pera, J., Urbanik, A., Pichler, A., Hansen, B. M., & 32 othersMccauley, J. L., Tirschwell, D. L., Selim, M., Brown, D. L., Silliman, S. L., Worrall, B. B., Meschia, J. F., Kidwell, C. S., Testai, F. D., Kittner, S. J., Schmidt, H., Enzinger, C., Deary, I. J., Rannikmae, K., Samarasekera, N., Salman, R. A., Sudlow, C. L., Klijn, C. J. M., Van Nieuwenhuizen, K. M., Fernandez-cadenas, I., Delgado, P., Norrving, B., Lindgren, A., Goldstein, J. N., Viswanathan, A., Greenberg, S. M., Falcone, G. J., Biffi, A., Langefeld, C. D., Woo, D., Rosand, J. & Anderson, C. D., 1 Apr 2019, In: JAMA Neurology. p. 480-491

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Sleep and cognitive aging in the eighth decade of life

Cox, S. R., Ritchie, S. J., Allerhand, M., Hagenaars, S. P., Radakovic, R., Breen, D. P., Davies, G., Riha, R. L., Harris, S., Starr, J. M. & Deary, I. J., Apr 2019, In: Sleep. 42, 4, 12 p., zsz019.

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Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity

Lyall, D. M., Cox, S., Lyall, L. M., Celis-morales, C. A., Cullen, B., Mackay, D. F., Ward, J., Strawbridge, R. J., McIntosh, A., Sattar, N. A., Smith, D. J., Cavanagh, J., Deary, I. & Pell, J. P., 22 Mar 2019, (E-pub ahead of print) In: Brain imaging and behavior.

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Open Access

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Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images

Ortiz-ramón, R., Valdés Hernández, M. D. C., González-castro, V., Makin, S., Armitage, P. A., Aribisala, B. S., Bastin, M. E., Deary, I. J., Wardlaw, J. M. & Moratal, D., 16 Mar 2019, (E-pub ahead of print) In: Computerized Medical Imaging and Graphics. 74, p. 12-24

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Open Access

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An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort

Hamilton, O., Zhang, Q., Mcrae, A. F., Walker, R., Morris, S., Redmond, P., Campbell, A., Murray, A., Porteous, D., Evans, K., McIntosh, A., Deary, I. & Marioni, R., 6 Mar 2019, In: International Journal of Obesity.

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Open Access

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Longitudinal multi-centre brain imaging studies: guidelines and practical tips for accurate and reproducible imaging endpoints and data sharing

Wiseman, S. J., Meijboom, R., Valdés Hernández, M. D. C., Pernet, C., Sakka, E., Job, D., Waldman, A. D. & Wardlaw, J. M., 7 Jan 2019, (E-pub ahead of print) In: Trials. 20, 1

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Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci

Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R. D., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S., Boehnke, M., & 156 othersBots, M. L., Brazel, D. M., Chambers, J. C., Chang-claude, J., Chen, C., Corley, J., Chou, Y., David, S. P., De Boer, R. A., De Leeuw, C. A., Dennis, J. G., Dominiczak, A. F., Dunning, A. M., Easton, D. F., Eaton, C., Elliott, P., Evangelou, E., Faul, J. D., Foroud, T., Goate, A., Gong, J., Grabe, H. J., Haessler, J., Haiman, C., Hallmans, G., Hammerschlag, A. R., Harris, S. E., Hattersley, A., Heath, A., Hsu, C., Iacono, W. G., Kanoni, S., Kapoor, M., Kaprio, J., Kardia, S. L., Karpe, F., Kontto, J., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Laakso, M., Lai, D., Langenberg, C., Le, N., Lettre, G., Loukola, A., Luan, J., Madden, P. A. F., Mangino, M., Marioni, R. E., Marouli, E., Marten, J., Martin, N. G., Mcgue, M., Michailidou, K., Mihailov, E., Moayyeri, A., Moitry, M., Müller-nurasyid, M., Naheed, A., Nauck, M., Neville, M. J., Nielsen, S. F., North, K., Perola, M., Pharoah, P. D. P., Pistis, G., Polderman, T. J., Posthuma, D., Poulter, N., Qaiser, B., Rasheed, A., Reiner, A., Renström, F., Rice, J., Rohde, R., Rolandsson, O., Samani, N. J., Samuel, M., Schlessinger, D., Scholte, S. H., Scott, R. A., Sever, P., Shao, Y., Shrine, N., Smith, J. A., Starr, J. M., Stirrups, K., Stram, D., Stringham, H. M., Tachmazidou, I., Tardif, J., Thompson, D. J., Tindle, H. A., Tragante, V., Trompet, S., Turcot, V., Tyrrell, J., Vaartjes, I., Van Der Leij, A. R., Van Der Meer, P., Varga, T. V., Verweij, N., Völzke, H., Wareham, N. J., Warren, H. R., Weir, D. R., Weiss, S., Wetherill, L., Yaghootkar, H., Yavas, E., Jiang, Y., Chen, F., Zhan, X., Zhang, W., Zhao, W., Zhao, W., Zhou, K., Amouyel, P., Blankenberg, S., Caulfield, M. J., Chowdhury, R., Cucca, F., Deary, I. J., Deloukas, P., Di Angelantonio, E., Ferrario, M., Ferrières, J., Franks, P. W., Frayling, T. M., Frossard, P., Hall, I. P., Hayward, C., Jansson, J., Jukema, J. W., Kee, F., Männistö, S., Metspalu, A., Munroe, P. B., Nordestgaard, B. G., Palmer, C. N. A., Salomaa, V., Sattar, N., Spector, T., Strachan, D. P., Van Der Harst, P., Zeggini, E., Saleheen, D., Butterworth, A. S., Wain, L. V., Abecasis, G. R., Danesh, J., Tobin, M. D., Vrieze, S., Liu, D. J. & Howson, J. M. M., 7 Jan 2019, (E-pub ahead of print) In: Molecular Psychiatry.

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Association of whole-genome and NETRIN1 signaling pathway-derived polygenic risk scores for Major Depressive Disorder and white matter microstructure in UK Biobank

Barbu, M. C., Zeng, Y., Shen, X., Cox, S. R., Clarke, T., Gibson, J., Adams, M. J., Johnstone, M., Haley, C. S., Lawrie, S. M., Deary, I. J., Mcintosh, A. M. & Whalley, H. C., 1 Jan 2019, In: Biological psychiatry. Cognitive neuroscience and neuroimaging. 4, 1, p. 91-100 10 p.

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Tracking the epigenetic clock across the human life course: A meta-analysis of longitudinal cohort data

Marioni, R., Suderman, M. J., Chen, B. H., Horvath, S., Bandinelli, S., Morris, T. J., Becker, S., Ferrucci, L., Pedersen, N. L., Relton, C. L., Deary, I. & Hägg, S., Jan 2019, In: The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences. 74, 1, p. 1-5 gly060.

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Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Chauhan, G., Adams, H. H. H., Satizabal, C. L., Bis, J. C., Teumer, A., Sargurupremraj, M., Hofer, E., Trompet, S., Hilal, S., Smith, A. V., Jian, X., Malik, R., Traylor, M., Pulit, S. L., Amouyel, P., Mazoyer, B., Zhu, Y., Kaffashian, S., Schilling, S., Beecham, G. W., & 130 othersMontine, T. J., Schellenberg, G. D., Kjartansson, O., Guðnason, V., Knopman, D. S., Griswold, M. E., Windham, B. G., Gottesman, R. F., Mosley, T. H., Schmidt, R., Saba, Y., Schmidt, H., Takeuchi, F., Yamaguchi, S., Nabika, T., Kato, N., Rajan, K. B., Aggarwal, N. T., De Jager, P. L., Evans, D. A., Psaty, B. M., Rotter, J. I., Rice, K., Lopez, O. L., Liao, J., Chen, C., Cheng, C., Wong, T. Y., Ikram, M. K., Van Der Lee, S. J., Amin, N., Chouraki, V., Destefano, A. L., Aparicio, H. J., Romero, J. R., Maillard, P., Decarli, C., Wardlaw, J. M., Hernández, M. D. C. V., Luciano, M., Liewald, D., Deary, I. J., Starr, J. M., Bastin, M. E., Muñoz Maniega, S., Slagboom, P. E., Beekman, M., Deelen, J., Uh, H., Lemmens, R., Brodaty, H., Wright, M. J., Ames, D., Boncoraglio, G. B., Hopewell, J. C., Beecham, A. H., Blanton, S. H., Wright, C. B., Sacco, R. L., Wen, W., Thalamuthu, A., Armstrong, N. J., Chong, E., Schofield, P. R., Kwok, J. B., Van Der Grond, J., Stott, D. J., Ford, I., Jukema, J. W., Vernooij, M. W., Hofman, A., Uitterlinden, A. G., Van Der Lugt, A., Wittfeld, K., Grabe, H. J., Hosten, N., Von Sarnowski, B., Völker, U., Levi, C., Jimenez-conde, J., Sharma, P., Sudlow, C. L. M., Rosand, J., Woo, D., Cole, J. W., Meschia, J. F., Slowik, A., Thijs, V., Lindgren, A., Melander, O., Grewal, R. P., Rundek, T., Rexrode, K., Rothwell, P. M., Arnett, D. K., Jern, C., Johnson, J. A., Benavente, O. R., Wasssertheil-smoller, S., Lee, J., Wong, Q., Mitchell, B. D., Rich, S. S., Mcardle, P. F., Geerlings, M. I., Van Der Graaf, Y., De Bakker, P. I. W., Asselbergs, F. W., Srikanth, V., Thomson, R., Mcwhirter, R., Moran, C., Callisaya, M., Phan, T., Rutten-jacobs, L. C. A., Bevan, S., Tzourio, C., Mather, K. A., Sachdev, P. S., Van Duijn, C. M., Worrall, B. B., Dichgans, M., Kittner, S. J., Markus, H. S., Ikram, M. A., Fornage, M., Launer, L. J., Seshadri, S., Longstreth, W. T. & Debette, S., 2019, In: Neurology.

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2018

Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study

Alloza, C., Cox, S. R., Blesa Cábez, M., Redmond, P., Whalley, H. C., Ritchie, S. J., Muñoz Maniega, S., del C Valdés Hernández, M., Tucker-Drob, E. M., Lawrie, S. M., Wardlaw, J. M., Deary, I. J. & Bastin, M. E., 31 Dec 2018, In: NeuroImage. 183, p. 884-896 13 p.

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Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing

Stevenson, A., McCartney, D. L., Harris, S., Taylor, A., Redmond, P., Starr, J., Zhang, Q., McRae, A. F., Wray, N. R., Spires-Jones, T., McColl, B., McIntosh, A., Deary, I. & Marioni, R., 20 Dec 2018, In: Clinical Epigenetics.

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Brain imaging and cognitive ageing in the Lothian Birth Cohort 1936: III

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Search results