Brain white matter imaging and cognitive ageing in the Lothian Birth Cohort of 1936

Research output

Research output per year 2009 2012 2013 2015 2020

• 113 Article
• 5 Meeting abstract
• 3 Poster
• 2 Literature review
• 1 More
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2020

  Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive Declines

  Madole, J. W., Ritchie, S. J., Cox, S. R., Buchanan, C. R., Valdés Hernández, M., Muñoz Maniega, S., Wardlaw, J. M., Harris, M. A. H., Bastin, M. E., Deary, I. J. & Tucker-Drob, E. M., 15 Jun 2020, (E-pub ahead of print) In: Biological Psychiatry. N/A, p. 1-12

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Cognitive Disorders 20%
  • Magnetic Resonance Imaging of Brain 20%
  • Alzheimer's Disease 20%
  • Gray Matter Volume 20%

• Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

  Armstrong, N. J., Mather, K. A., Sargurupremraj, M., Knol, M. J., Malik, R., Satizabal, C. L., Yanek, L. R., Wen, W., Gudnason, V. G., Dueker, N. D., Elliott, L. T., Hofer, E., Bis, J., Jahanshad, N., Li, S., Logue, M. A., Luciano, M., Scholz, M., Smith, A. V., Trompet, S., & 66 othersVojinovic, D., Xia, R., Alfaro-almagro, F., Ames, D., Amin, N., Amouyel, P., Beiser, A. S., Brodaty, H., Deary, I. J., Fennema-notestine, C., Gampawar, P. G., Gottesman, R., Griffanti, L., Jack, C. R., Jenkinson, M., Jiang, J., Kral, B. G., Kwok, J. B., Lampe, L., C.m. Liewald, D., Maillard, P., Marchini, J., Bastin, M. E., Mazoyer, B., Pirpamer, L., Rafael Romero, J., Roshchupkin, G. V., Schofield, P. R., Schroeter, M. L., Stott, D. J., Thalamuthu, A., Trollor, J., Tzourio, C., Van Der Grond, J., Vernooij, M. W., Witte, V. A., Wright, M. J., Yang, Q., Morris, Z., Siggurdsson, S., Psaty, B., Villringer, A., Schmidt, H., Haberg, A. K., Van Duijn, C. M., Jukema, J. W., Dichgans, M., Sacco, R. L., Wright, C. B., Kremen, W. S., Becker, L. C., Thompson, P. M., Mosley, T. H., Wardlaw, J. M., Ikram, M. A., Adams, H. H. H., Seshadri, S., Sachdev, P. S., Smith, S. M., Launer, L., Longstreth, W., Decarli, C., Schmidt, R., Fornage, M., Debette, S. & Nyquist, P. A., 10 Jun 2020, In: Stroke.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Genetic Divergence 100%
  • Genome Wide Association Study 100%
  • Genetic Variation 100%
  • Genetics 66%
  • Genetic Correlation 66%

• Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study

  Beaudet, G., Tsuchida, A., Petit, L., Tzourio, C., Caspers, S., Schreiber, J., Pausova, Z., Patel, Y., Paus, T., Schmidt, R., Pirpamer, L., Sachdev, P. S., Brodaty, H., Kochan, N. A., Trollor, J. N., Wen, W., Armstrong, N. J., Deary, I., Bastin, M., Wardlaw, J., & 6 othersMuñoz Maniega, S., Witte, A. V., Villringer, A., Duering, M., Debette, S. & Mazoyer, B., 4 May 2020, In: Frontiers in psychiatry. 11, 342.

  Research output: Contribution to journal › Article › peer-review

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  • Diffusion Tensor Imaging 100%
  • Fractional Anisotropy 62%
  • Diffusion MRI 25%

• Corticosteroids and regional variations in thickness of the human cerebral cortex across the lifespan

  Parker, N., French, L., Vidal-Pineiro, D., Shin, J., Adams, H. H. H., Brodaty, H., Cox, S., Deary, I., Fjell, A. M., Frenzel, S., Grabe, H. J., Hosten, N., Arfan Ikram, M., Jian, J., Knol, M., Mazoyer, B., Mishra, A., Sachdev, P. S., Salum, G., Satizabal, C. L., & 12 othersSchmidt, H., Schmidt, R., Seshadri, S., Schumann, G., Völzke, H., Walhovd, K., Wen, W., Wittfield, K., Yang, Q., Debette, S., Pausova, Z. & Paus, T., 21 Mar 2020, In: Cerebral Cortex. bhz108.

  Research output: Contribution to journal › Article › peer-review

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  • Cerebral Cortex 100%
  • Nervous System Cell 33%
  • Pyramidal Cell 33%
  • Mineralocorticoid Receptor 33%
  • Gene Expression 33%

• Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

  neuroCHARGE Cognitive Working group & ENIGMA Consortium, 20 Mar 2020, (E-pub ahead of print) In: Cerebral Cortex. bhaa035.

  Research output: Contribution to journal › Article › peer-review

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  • Cerebral Cortex 100%
  • Behavior (Neuroscience) 50%
  • Cognitive Function 50%
  • Visual Cortex 50%
  • Genome-Wide Association Study 50%

• The genetic architecture of the human cerebral cortex

  Enhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group, Grasby, K. L., Jahanshad, N., Painter, J. N., Colodro-conde, L., Bralten, J., Hibar, D. P., Lind, P. A., Pizzagalli, F., Ching, C. R. K., Mcmahon, M. A. B., Shatokhina, N., Zsembik, L. C. P., Thomopoulos, S. I., Zhu, A. H., Strike, L. T., Agartz, I., Alhusaini, S., Almeida, M. A. A., Alnæs, D., & 31 othersAmlien, I. K., Andersson, M., Ard, T., Armstrong, N. J., Ashley-koch, A., Atkins, J. R., Bernard, M., Brouwer, R. M., Buimer, E. E. L., Bülow, R., Bürger, C., Cannon, D. M., Chakravarty, M., Chen, Q., Cheung, J. W., Couvy-duchesne, B., Dale, A. M., Dalvie, S., De Araujo, T. K., De Zubicaray, G. I., De Zwarte, S. M. C., Den Braber, A., Doan, N. T., Dohm, K., Ehrlich, S., Harris, M. A., Luciano, M., Wardlaw, J. M., Doherty, C. P., Bastin, M. E. & Deary, I. J., 20 Mar 2020, In: Science. 367, 6484, 14 p., eaay6690.

  Research output: Contribution to journal › Article › peer-review

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  • Cerebral Cortex 100%
  • Genetic Architecture 100%
  • Surface Area 100%
  • Parkinson's Disease 50%
  • Cognitive Function 50%

• Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

  Harris, S., Cox, S., Bell, S., Marioni, R., Prins, B. P., Pattie, A., Corley, J., Muñoz Maniega, S., Valdes Hernandez, M., Morrison, Z., John, S. L., Bronson, P. G., Tucker-Drob, E. M., Starr, J., Bastin, M., Wardlaw, J., Butterworth, A. S. & Deary, I., 10 Feb 2020, In: Nature Communications. 11, 800.

  Research output: Contribution to journal › Article › peer-review

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  • Cognitive Function 100%
  • Blood Plasma 33%
  • Magnetic Resonance Imaging 16%
  • Proteomics 16%

• Fluctuating asymmetry in brain structure and general intelligence in 73-Year-olds

  Moodie, J. E., Ritchie, S., Cox, S., Harris, M., Muñoz Maniega, S., Valdes Hernandez, M., Pattie, A., Corley, J., Bastin, M., Starr, J., Wardlaw, J. & Deary, I., 31 Jan 2020, In: Intelligence. 78, 101407.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Brain Asymmetry 100%
  • Isoniazid 100%
  • Cognitive Functioning 100%
  • Factor Analysis 50%
  • Cognitive Tests 25%

• Sleep and brain morphological changes in the eighth decade of life

  Aribisala, B. S., Riha, R. L., Valdes Hernandez, M., Maniega, S. M., Cox, S., Radakovic, R., Taylor, A., Pattie, A., Corley, J., Redmond, P., Bastin, M. E., Starr, J., Deary, I. & Wardlaw, J. M., Jan 2020, In: Sleep medicine. 65

  Research output: Contribution to journal › Article › peer-review

  Open Access

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• Computational quantification of brain perivascular space morphologies: Associations with vascular risk factors and white matter hyperintensities. A study in the Lothian Birth Cohort 1936

  Ballerini, L., Booth, T., Hernández, M. D. C. V., Wiseman, S., Lovreglio, R., Maniega, S. M., Morris, Z., Pattie, A., Corley, J., Gow, A., Bastin, M. E., Deary, I. J. & Wardlaw, J., 2020, In: NeuroImage: Clinical. 25, 102120.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Hypertension 100%
  • Cerebrovascular Accident 100%
  • Magnetic Resonance Imaging 100%
  • Magnetic Resonance Imaging of Brain 66%
  • Hypercholesterolemia 50%
• 2019

  Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

  Jia, T., Chu, C., Liu, Y., van Dongen, J., Papastergios, E., Armstrong, N. J., Bastin, M. E., Carrillo-roa, T., den Braber, A., Harris, M., Jansen, R., Liu, J., Luciano, M., Ori, A. P. S., Roiz-Santianez, R., Ruggeri, B., Sarkisyan, D., Shin, J., Sungeun, K., Tordesillas-Gutierrez, D., & 62 othersVan't Ent, D., Ames, D., Artiges, E., Bakalkin, G., Banaschewski, T., Bokde, A. L. W., Brodaty, H., Bromberg, U., Brouwer, R. M., Büchel, C., Quinlan, E. B., Cahn, W., de Zubicaray, G. I., Ehrlich, S., Ekström, T. J., Flor, H., Fröhner, J. H., Frouin, V., Garavan, H., Gowland, P. A., Heinz, A., Hoare, J., Ittermann, B., Jahanshad, N., Jiang, J., Kwok, J. B. J., Martin, N. G., Martinot, J-L., Mather, K. A., McMahon, K. L., Mcrae, A. F., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Sämann, P. G., Schofield, P. R., Smolka, M. N., Stein, D. J., Strike, L. T., Teeuw, J., Thalamuthu, A., Trollor, J. N., Walter, H., Wardlaw, J. M., Wen, W., Whelan, R., Apostolova, L. G., Binder, E. B., Boomsma, D., Calhoun, V. D., Crespo-Facorro, B., Deary, I. J., Hulshoff Pol, H. E., Ophoff, R. A., Pausova, Z., Sachdev, P. S., Saykin, A. J., Wright, M. J., Thompson, P. M., Schumann, G. & Desrivières, S., 6 Dec 2019, (E-pub ahead of print) In: Molecular Psychiatry. N/A, p. 1-12

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • DNA Methylation 100%
  • Epigenetics 100%
  • Epigenome 100%
  • Meta-Analysis 100%
  • Epigenomics 100%

• An epigenetic predictor of death captures multi-modal measures of brain health

  Hillary, R., Stevenson, A. J., Cox, S. R., McCartney, D. L., Harris, S. E., Seeboth, A., Higham, J., Sproul, D., Taylor, A., Redmond, P., Corley, J., Pattie, A., del C. Valdés Hernández, M., Muñoz-Maniega, S., Bastin, M. E., Wardlaw, J. M., Horvath, S., Ritchie, C. W., Spires-Jones, T. L., McIntosh, A. M., & 3 othersEvans, K. L., Deary, I. J. & Marioni, R. E., 3 Dec 2019, In: Molecular Psychiatry. N/A, p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • DNA Methylation 100%
  • Cognitive Decline 50%
  • Hazard Ratio 25%
  • Neuroimaging 25%

• Genetic architecture of subcortical brain structures in 38,851 individuals

  Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., Van Der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V., & 269 othersLi, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-Vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., Den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-Santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-Partida, G., Amin, N., Hilal, S., Nho, K., Mirza-Schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-Gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C-Y., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., De Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., de Geus, E. J. C., Tsolaki, M., Erk, S., Van Eijk, K. R., Cavalleri, G. L., Van Der Wee, N. J. A., McIntosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., Van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B-C., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., van der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J-J., Simmons, A., Meyer-Lindenberg, A., Cahn, W., Whelan, C. D., Van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-Facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., Van Tol, M-J., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., Van Rooij, D., Djurovic, S., Deary, I. J., McMahon, K. L., Müller-Myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J-L., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., Van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., van ‘t Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., Van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-Seiferth, N., Hartman, C. A., Destefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., Van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., Decarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., 30 Nov 2019, In: Nature Genetics. 51, 11, p. 1624–1636 13 p.

  Research output: Contribution to journal › Article › peer-review

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  • Brain Development 100%
  • Nervous System Disorder 100%
  • Brainstem 100%
  • Thalamus 100%
  • Globus pallidus 100%

• Epigenetic signatures of smoking associate with cognitive function, brain structure, and mental and physical health outcomes in the Lothian Birth Cohort 1936

  Corley, J., Cox, S., Harris, S., Valdes Hernandez, M., Munoz-Maniega, S., Bastin, M., Wardlaw, J., Starr, J., Marioni, R. & Deary, I., 7 Oct 2019, In: Translational Psychiatry. 9, 248.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Epigenetics 100%
  • Mental Health 100%
  • DNA Methylation 100%
  • Cognitive Function 100%
  • Magnetic Resonance Imaging 33%

• Structural brain imaging correlates of general intelligence in UK Biobank

  Cox, S. R., Ritchie, S. J., Fawns-Ritchie, C., Tucker-Drob, E. M. & Deary, I. J., 30 Sept 2019, In: Intelligence. 76, 13 p., 101376.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Tests 100%
  • Brain Imaging 100%
  • Magnetic Resonance Imaging 66%
  • Gray Matter 33%
  • Occipital Lobe 33%

• Brain peak width of skeletonised mean diffusivity (PSMD) and cognitive function in later life

  Deary, I., Ritchie, S. J., Muñoz Maniega, S., Cox, S., Valdes Hernandez, M., Luciano, M., Starr, J., Wardlaw, J. & Bastin, M., 26 Jul 2019, (E-pub ahead of print) In: Frontiers in psychiatry. 10, 524.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Cognitive Function 100%
  • Gray Matter 50%
  • Magnetic Resonance Imaging of Brain 50%

• Spatial Gradient of Microstructural Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities in Older Age

  Muñoz Maniega, S., Meijboom, R., Chappell, F. M., del C. Valdés Hernández, M., Starr, J. M., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., 25 Jul 2019, In: Frontiers in Neurology. 10, 784.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Fractional Anisotropy 100%
  • White Matter 100%
  • Magnetic Resonance Imaging 100%
  • Longitudinal Study 50%
  • Cognitive Disorders 20%

• Perivascular spaces in the centrum semiovale at the beginning of the 8th decade of life: Effect on cognition and associations with mineral deposition

  Valdes Hernandez, M., Ballerini, L., Glatz, A., Munoz-Maniega, S., Gow, A., Bastin, M., Starr, J., Deary, I. & Wardlaw, J., 27 Jun 2019, (E-pub ahead of print) In: Brain imaging and behavior.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Perivascular Space 100%
  • Iron 100%
  • Cognitive Function 100%
  • Microvessel 66%
  • Magnetic Resonance Imaging 50%

• Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study

  McGrory, S., Ballerini, L., Doubal, F. N., Staals, J., Allerhand, M., Valdes Hernandez, M. D. C., Wang, X., MacGillivray, T., Doney, A. S. F., Dhillon, B., Starr, J. M., Bastin, M. E., Trucco, E., Deary, I. J. & Wardlaw, J. M., 19 Apr 2019, In: Scientific Reports. 9, 11 p., 6320.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Cerebrovascular Disease 100%
  • Cerebrovascular Accident 100%
  • Microvessel 100%
  • Magnetic Resonance Imaging 33%
  • White Matter Disease 33%

• Association of apolipoprotein E with intracerebral hemorrhage risk by race/ethnicity: A meta-analysis

  Marini, S., Crawford, K., Morotti, A., Lee, M. J., Pezzini, A., Moomaw, C. J., Flaherty, M. L., Montaner, J., Roquer, J., Jimenez-conde, J., Giralt-steinhauer, E., Elosua, R., Cuadrado-godia, E., Soriano-tarraga, C., Slowik, A., Jagiella, J. M., Pera, J., Urbanik, A., Pichler, A., Hansen, B. M., & 32 othersMccauley, J. L., Tirschwell, D. L., Selim, M., Brown, D. L., Silliman, S. L., Worrall, B. B., Meschia, J. F., Kidwell, C. S., Testai, F. D., Kittner, S. J., Schmidt, H., Enzinger, C., Deary, I. J., Rannikmae, K., Samarasekera, N., Salman, R. A., Sudlow, C. L., Klijn, C. J. M., Van Nieuwenhuizen, K. M., Fernandez-cadenas, I., Delgado, P., Norrving, B., Lindgren, A., Goldstein, J. N., Viswanathan, A., Greenberg, S. M., Falcone, G. J., Biffi, A., Langefeld, C. D., Woo, D., Rosand, J. & Anderson, C. D., 1 Apr 2019, In: JAMA Neurology. p. 480-491

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Cerebral Hemorrhage 100%
  • Meta-Analysis 100%
  • Apolipoprotein E 100%
  • High-Risk Population 100%
  • Structured Interview 100%

• Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity

  Lyall, D. M., Cox, S., Lyall, L. M., Celis-morales, C. A., Cullen, B., Mackay, D. F., Ward, J., Strawbridge, R. J., McIntosh, A., Sattar, N. A., Smith, D. J., Cavanagh, J., Deary, I. & Pell, J. P., 22 Mar 2019, (E-pub ahead of print) In: Brain imaging and behavior.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Apolipoprotein E4 100%
  • Magnetic Resonance Imaging 25%
  • Cognitive Function 25%
  • Gray Matter 25%
  • Brain Imaging 25%

• Identification of the presence of ischaemic stroke lesions by means of texture analysis on brain magnetic resonance images

  Ortiz-ramón, R., Valdés Hernández, M. D. C., González-castro, V., Makin, S., Armitage, P. A., Aribisala, B. S., Bastin, M. E., Deary, I. J., Wardlaw, J. M. & Moratal, D., 16 Mar 2019, (E-pub ahead of print) In: Computerized Medical Imaging and Graphics. 74, p. 12-24

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Feature Selection 100%
  • Texture Analysis 100%
  • Feature Extraction 100%
  • Deep Learning Method 100%
  • classification result 100%
• 2018

  Polygenic risk score for schizophrenia and structural brain connectivity in older age: A longitudinal connectome and tractography study

  Alloza, C., Cox, S. R., Blesa Cábez, M., Redmond, P., Whalley, H. C., Ritchie, S. J., Muñoz Maniega, S., del C Valdés Hernández, M., Tucker-Drob, E. M., Lawrie, S. M., Wardlaw, J. M., Deary, I. J. & Bastin, M. E., 31 Dec 2018, In: NeuroImage. 183, p. 884-896 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

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  • Tractography 100%
  • Fractional Anisotropy 100%
  • Cingulum 50%
  • Cognitive Function 50%
  • Diffusion MRI 50%

• GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes

  Franceschini, N., Giambartolomei, C., De Vries, P. S., Finan, C., Bis, J. C., Huntley, R. P., Lovering, R. C., Tajuddin, S. M., Winkler, T. W., Graff, M., Kavousi, M., Dale, C., Smith, A. V., Hofer, E., Van Leeuwen, E. M., Nolte, I. M., Lu, L., Scholz, M., Sargurupremraj, M., Pitkänen, N., & 137 othersFranzén, O., Joshi, P. K., Noordam, R., Marioni, R. E., Hwang, S., Musani, S. K., Schminke, U., Palmas, W., Isaacs, A., Correa, A., Zonderman, A. B., Hofman, A., Teumer, A., Cox, A. J., Uitterlinden, A. G., Wong, A., Smit, A. J., Newman, A. B., Britton, A., Ruusalepp, A., Sennblad, B., Hedblad, B., Pasaniuc, B., Penninx, B. W., Langefeld, C. D., Wassel, C. L., Tzourio, C., Fava, C., Baldassarre, D., O’leary, D. H., Teupser, D., Kuh, D., Tremoli, E., Mannarino, E., Grossi, E., Boerwinkle, E., Schadt, E. E., Ingelsson, E., Veglia, F., Rivadeneira, F., Beutner, F., Chauhan, G., Heiss, G., Snieder, H., Campbell, H., Völzke, H., Markus, H. S., Deary, I. J., Jukema, J. W., De Graaf, J., Price, J., Pott, J., Hopewell, J. C., Liang, J., Thiery, J., Engmann, J., Gertow, K., Rice, K., Taylor, K. D., Dhana, K., Kiemeney, L. A. L. M., Lind, L., Raffield, L. M., Launer, L. J., Holdt, L. M., Dörr, M., Dichgans, M., Traylor, M., Sitzer, M., Kumari, M., Kivimaki, M., Nalls, M. A., Melander, O., Raitakari, O., Franco, O. H., Rueda-ochoa, O. L., Roussos, P., Whincup, P. H., Amouyel, P., Giral, P., Anugu, P., Wong, Q., Malik, R., Rauramaa, R., Burkhardt, R., Hardy, R., Schmidt, R., De Mutsert, R., Morris, R. W., Strawbridge, R. J., Wannamethee, S. G., Hägg, S., Shah, S., Mclachlan, S., Trompet, S., Seshadri, S., Kurl, S., Heckbert, S. R., Ring, S., Harris, T. B., Lehtimäki, T., Galesloot, T. E., Shah, T., De Faire, U., Plagnol, V., Rosamond, W. D., Post, W., Zhu, X., Zhang, X., Guo, X., Saba, Y., Dehghan, A., Seldenrijk, A., Morrison, A. C., Hamsten, A., Psaty, B. M., Van Duijn, C. M., Lawlor, D. A., Mook-kanamori, D. O., Bowden, D. W., Schmidt, H., Wilson, J. G., Rotter, J. I., Wardlaw, J. M., Deanfield, J., Halcox, J., Lyytikäinen, L., Loeffler, M., Evans, M. K., Debette, S., Humphries, S. E., Völker, U., Gudnason, V., Hingorani, A. D., Björkegren, J. L. M., Casas, J. P. & O’donnell, C. J., 3 Dec 2018, In: Nature Communications. 9, 1, 5141.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Intima-Media Thickness 100%
  • Genome Wide Association Study 100%
  • Cardiovascular System 100%
  • Genome-Wide Association Study 100%
  • Carotid Artery 83%

• The association between carotid atheroma and cerebral cortex structure at age 73

  Alhusaini, S., Karama, S., Nguyen, T-V., Thiel, A., Bernhardt, B., Cox, S., Corley, J., Taylor, A., Evans, A. C., Starr, J., Bastin, M., Wardlaw, J., Deary, I. & Ducharme, S., Oct 2018, In: Annals of Neurology. 84, 4, p. 576-587

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Carotid Artery Stenosis 100%
  • Cerebral Cortex 100%
  • Stenosis 100%
  • Carotid Atherosclerosis 22%
  • Intima-Media Thickness 11%

• Brain age predicts mortality

  Cole, J. H., Ritchie, S. J., Bastin, M. E., Valdés Hernández, M. C., Muñoz Maniega, S., Royle, N., Corley, J., Pattie, A., Harris, S. E., Zhang, Q., Wray, N. R., Redmond, P., Marioni, R. E., Starr, J. M., Cox, S. R., Wardlaw, J. M., Sharp, D. J. & Deary, I. J., 31 May 2018, In: Molecular Psychiatry. 23, p. 1385-1392 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Biological Marker 100%
  • Cognitive Disorders 100%
  • DNA Methylation 100%
  • Gray Matter 100%
  • Epigenetics 100%

• Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits

  Wu, Y., Zeng, J., Zhang, F., Zhu, Z., Qi, T., Zheng, Z., Luke R, L-J., Marioni, R., Martin, N. G., Montgomery, G. W., Deary, I. J., Visscher, P., Mcrae, A. F. & Yang, J., 2 Mar 2018, (E-pub ahead of print) In: Nature Communications. 9, p. 1-14 14 p., 918.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • DNA Methylation 100%
  • Tamsulosin 100%
  • Regulatory Element 40%
  • Genome Wide Association Study 40%
  • Genetic Divergence 20%

• Cognitive abilities, brain white matter hyperintensity volume and structural network connectivity in older age

  Wiseman, S. J., Booth, T., Ritchie, S. J., Cox, S. R., Muñoz Maniega, S., Valdes Hernandez, M. D. C., Dickie, D. A., Royle, N. A., Starr, J. M., Deary, I. J., Wardlaw, J. M. & Bastin, M. E., 28 Feb 2018, In: Human Brain Mapping. 39, 2, p. 622-632 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Processing Speed 100%
  • Information Processing 100%
  • Magnetic Resonance Imaging 20%
  • Healthy Aging 20%

• Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume

  Ritchie, S. J., Dickie, D. A., Cox, S., Valdes Hernandez, M., Sibbett, R., Pattie, A., Anblagan, D., Redmond, P., Royle, N., Corley, J., Muñoz Maniega, S., Taylor, A., Karama, S., Booth, T., Gow, A., Starr, J., Bastin, M., Wardlaw, J. & Deary, I., Feb 2018, In: Neurobiology of Aging. 62, p. 146-158

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Gray Matter 50%

• Brain cortical characteristics of lifetime cognitive ageing

  Cox, S. R., Bastin, M. E., Ritchie, S. J., Dickie, D. A., Liewald, D. C., Muñoz Maniega, S., Redmond, P., Royle, N. A., Pattie, A., Valdes Hernandez, M., Corley, J., Aribisala, B. S., McIntosh, A. M., Wardlaw, J. M. & Deary, I. J., 31 Jan 2018, In: Brain Structure and Function. 223, 1, p. 509–518 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Brain 100%

• Coupled changes in hippocampal structure and cognitive ability in later life

  Anblagan, D., Valdes Hernandez, M., Ritchie, S. J., Aribisala, B., Royle, N., Hamilton, I., Cox, S., Gow, A., Pattie, A., Corley, J., Starr, J., Muñoz Maniega, S., Bastin, M., Deary, I. & Wardlaw, J., 4 Jan 2018, (E-pub ahead of print) In: Brain and Behavior.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Fractional Anisotropy 57%
  • Relaxation Time 50%
  • Hippocampus 28%
  • Verbal Memory 28%
• 2017

  Dietary iodine exposure and brain structures and cognition in older people. Exploratory analysis in the Lothian Birth Cohort 1936

  Valdes Hernandez, M., Kyle, J., Allan, J., Allerhand, M., Clark, H., Muñoz Maniega, S., Royle, N., Gow, A., Pattie, A., Corley, J., Bastin, M., Starr, J., Wardlaw, J., Deary, I. & Combet, E., Nov 2017, In: The journal of nutrition, health & aging (JNHA). 21, 9, p. 971-979

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Iodine Deficiency 100%
  • Dairy Consumption 100%
  • Fish Consumption 100%
  • Public Health 50%

• Risk and protective factors for structural brain ageing in the eighth decade of life

  Ritchie, S. J., Tucker-Drob, E. M., Cox, S., Dickie, D. A., Valdes Hernandez, M., Corley, J., Royle, N., Redmond, P., Muñoz Maniega, S., Pattie, A., Aribisala, B., Taylor, A., Clarke, T-K., Gow, A., Starr, J., Bastin, M., Wardlaw, J. & Deary, I., Nov 2017, In: Brain Structure and Function. 222, 8, p. 1-14 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Magnetic Resonance Imaging 100%
  • Gray Matter 50%
  • Fractional Anisotropy 50%

• Brain grey and white matter predictors of verbal ability traits in older age: The Lothian Birth Cohort 1936

  Hoffman, P., Cox, S. R., Dykiert, D., Muñoz Maniega, S., Valdes Hernandez, M. C., Bastin, M. E., Wardlaw, J. M. & Deary, I. J., 1 Aug 2017, In: NeuroImage. 156, p. 394-402 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Magnetic Resonance Imaging 100%
  • Verbal Knowledge 100%
  • Gray Matter 100%
  • Fractional Anisotropy 75%
  • Cognitive Function 50%

• Interaction of APOE e4 and poor glycemic control predicts white matter hyperintensity growth from 73-76

  Cox, S., Ritchie, S. J., Dickie, D. A., Pattie, A., Royle, N., Corley, J., Aribisala, B., Harris, S., Valdes Hernandez, M., Gow, A., Muñoz Maniega, S., Starr, J., Bastin, M., Wardlaw, J. & Deary, I., Jun 2017, In: Neurobiology of Aging. 54, p. 54-58

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Hypertension 100%
  • Magnetic Resonance Imaging 100%
  • Magnetic Resonance Imaging of Brain 100%
  • Body Mass Index 100%
  • Hemoglobin A1c 100%
• 2016

  Do Cognitive and Physical Functions Age in Concert from Age 70 to 76? Evidence from the Lothian Birth Cohort 1936

  Ritchie, S. J., Tucker-Drob, E. M., Starr, J. M. & Deary, I. J., 5 Dec 2016, (E-pub ahead of print) In: The Spanish Journal of Psychology. 19, p. E90

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Growth Curve 50%

• Associations between education and brain structure at age 73 years, adjusted for age 11 IQ

  Cox, S., Dickie, D. A., Ritchie, S. J., Karama, S., Pattie, A., Royle, N., Corley, J., Aribisala, B., Valdes Hernandez, M. C., Muñoz Maniega, S., Starr, J., Bastin, M., Evans, A. C., Wardlaw, J. & Deary, I., Oct 2016, In: Neurology. 87, 17, p. 1820-1826 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fractional Anisotropy 100%
  • Sensory Cortex 50%
  • Frontal Lobe 50%
  • Magnetic Resonance Imaging of Brain 50%
  • Parietal Cortex 50%

• Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936

  Field, T. S., Doubal, F., Johnson, W., Backhouse, E., McHutchison, C., Cox, S., Corley, J., Pattie, A., Gow, A., Shenkin, S., Cvoro, V., Morris, Z., Staals, J., Bastin, M., Deary, I. & Wardlaw, J., 19 Sept 2016, In: Aging. 8, 9, p. 2039-2061

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Logistic Regression 100%
  • Multiple Testing 100%
  • Magnetic Resonance Imaging 100%
  • Cerebrovascular Disease 100%
  • Psychometric Testing 66%

• Getting Spearman off the skyhook: One more in a century (since Thomson, 1916) of attempts to vanquish g

  Deary, I., Cox, S. & Ritchie, S. J., 2 Aug 2016, (E-pub ahead of print) In: Psychological Inquiry. 27, 3, p. 192-199

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Process 100%
  • Latent Trait 100%

• Brain white matter structure and information processing speed in healthy older age

  Kuznetsova, K., Muñoz Maniega, S., Ritchie, S. J., Cox, S. R., Storkey, A. J., Starr, J. M., Wardlaw, J. M., Deary, I. J. & Bastin, M. E., 31 Jul 2016, In: Brain Structure and Function. 221, 6, p. 3223-3235

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Processing Speed 100%
  • Information Processing 100%
  • Cognitive Function 66%
  • Fractional Anisotropy 50%
  • Cognitive Decline 16%

• Trait Conscientiousness and the Personality Meta-Trait Stability are Associated with Regional White Matter Microstructure

  Lewis, G. J., Cox, S., Booth, T., Muñoz Maniega, S., Royle, N., Valdes Hernandez, M., Wardlaw, J., Bastin, M. & Deary, I., 24 Mar 2016, (E-pub ahead of print) In: Social Cognitive and Affective Neuroscience.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Fractional Anisotropy 100%
  • Conscientiousness Trait 100%
  • Uncinate Fasciculus 60%
  • Personality Traits 40%
  • Magnetic Resonance Imaging 20%

• Development and initial evaluation of a semi-automatic approach to assess perivascular spaces on conventional magnetic resonance images

  Wang, X., Valdes Hernandez, M., Doubal, F., Chappell, F., Piper, R. J., Deary, I. & Wardlaw, J., 15 Jan 2016, In: Journal of Neuroscience Methods. 257, p. 34-44

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Rating Scale 100%
  • White Matter 100%
  • Perivascular Space 100%
  • Magnetic Resonance Imaging 100%
  • Linear Regression 50%

• Volumetric and correlational implications of brain parcellation method selection: a 3-way comparison in the frontal lobes.

  Cox, S., McKenzie, T., Aribisala, B., Royle, N., MacPherson, S. E., Maclullich, A., Bastin, M., Wardlaw, J., Deary, I. & Ferguson, K., 2016, In: Journal of computer assisted tomography. 40, p. 53-60

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Frontal Lobe 100%
  • Stereology 66%
  • Magnetic Resonance Imaging 33%
  • Individual Differences 33%
  • Cognitive Function 33%
• 2015

  Intelligence and socioeconomic position in childhood in relation to frailty and cumulative allostatic load in later life: The Lothian Birth Cohort 1936

  Gale, C., Booth, T., Starr, J. & Deary, I., 23 Dec 2015, In: Journal of Epidemiology & Community Health. p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Mental Capacity 100%
  • Frailty 100%
  • Triglyceride 50%
  • HDL-Cholesterol 50%
  • Blood Pressure 50%

• ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

  ENIGMA Consortium, Thompson, P. M., Andreassen, O. A., Arias-Vasquez, A., Bearden, C. E., Boedhoe, P. S., Brouwer, R. M., Buckner, R. L., Buitelaar, J. K., Bulayeva, K. B., Cannon, D. M., Cohen, R. A., Conrod, P. J., Dale, A. M., Deary, I. J., Dennis, E. L., de Reus, M. A., Desrivieres, S., Dima, D., Donohoe, G., & 31 othersFisher, S. E., Fouche, J-P., Francks, C., Frangou, S., Franke, B., Ganjgahi, H., Garavan, H., Glahn, D. C., Grabe, H. J., Guadalupe, T., Gutman, B. A., Hashimoto, R., Hibar, D. P., Holland, D., Hoogman, M., Pol, H. E. H., Hosten, N., Jahanshad, N., Kelly, S., Kochunov, P., Kremen, W. S., Lee, P. H., Mackey, S., Martin, N. G., Mazoyer, B., McDonald, C., Medland, S. E., Morey, R. A., Nichols, T. E., Paus, T. & Wardlaw, J. M., 4 Dec 2015, (E-pub ahead of print) In: NeuroImage.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Schizophrenia 100%
  • Normal Development 100%
  • Neuroimaging Study 100%
  • Genetic Influence 100%
  • Major Depression 100%

• APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds

  Lyall, D. M., Munoz-Maniega, S., Harris, S., Bastin, M., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Valdes Hernandez, M., Royle, N., Starr, J., Porteous, D., Deary, I. & Wardlaw, J., Dec 2015, In: International Journal of Stroke. 10, 8, p. 1297-1300

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Alzheimer's Disease 100%
  • Gene Locus 100%
  • Cerebrovascular Disease 66%
  • Cerebral Hemorrhage 66%
  • Disease Predisposition 66%

• Brain volumetric changes and cognitive ageing during the eighth decade of life

  Ritchie, S. J., Dickie, D., Cox, S., Valdes Hernandez, M., Corley, J., Royle, N., Pattie, A., Aribisala, B., Redmond, P., Munoz-Maniega, S., Taylor, A., Sibbett, R., Gow, A., Starr, J., Bastin, M., Wardlaw, J. & Deary, I., Dec 2015, In: Human Brain Mapping. 36, p. 4910–4925

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Function 100%
  • Cognitive Aging 100%
  • Cognitive Decline 50%
  • Processing Speed 50%
  • Fluid Intelligence 50%

• Does white matter structure or hippocampal volume mediate associations between cortisol and cognitive ageing?

  Cox, S., MacPherson, S. E., Ferguson, K., Royle, N., Munoz-Maniega, S., Valdes Hernandez, M., Bastin, M., Maclullich, A., Wardlaw, J. & Deary, I., Dec 2015, In: Psychoneuroendocrinology. 62, p. 129–137

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Cognitive Aging 100%
  • Cortisol 100%
  • Magnetic Resonance Imaging 60%
  • Cognitive Function 40%
  • Salivary Cortisol 40%

• Total MRI load of cerebral small vessel disease and cognitive ability in older people

  Staals, J., Booth, T., Morris, Z., Bastin, M. E., Gow, A. J., Corley, J., Redmond, P., Starr, J., Deary, I. J. & Wardlaw, J. M., 31 Oct 2015, In: Neurobiology of Aging. 36, 10, p. 2806-2811

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File

  • Small Vessel Disease 100%
  • Cerebrovascular Disease 100%
  • Magnetic Resonance Imaging 100%
  • Cognitive Function 100%
  • Cognitive Disorders 14%

• Genome-wide association studies identify genetic loci for low von Willebrand factor levels

  van Loon, J., Dehghan, A., Weihong, T., Trompet, S., McArdle, W. L., Asselbergs, F. F. W., Chen, M-H., Lopez, L. M., Huffman, J. E., Leebeek, F. W. G., Basu, S., Stott, D. J., Rumley, A., Gansevoort, R. T., Davies, G., Wilson, J. J. F., Witteman, J. C. M., Cao, X., de Craen, A. J. M., Bakker, S. J. L., & 13 othersPsaty, B. M., Starr, J. M., Hofman, A., Wouter Jukema, J., Deary, I. J., Hayward, C., van der Harst, P., Lowe, G. D. O., Folsom, A. R., Strachan, D. P., Smith, N., de Maat, M. P. M. & O'Donnell, C., 21 Oct 2015, (E-pub ahead of print) In: European Journal of Human Genetics. 24, 7, p. 1035-1040

  Research output: Contribution to journal › Article › peer-review

  • Von Willebrand Disease 100%
  • Blood Group O 100%