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2015
Post-mortem brain analyses of the Lothian Birth Cohort 1936: Extending lifetime cognitive and brain phenotyping to the level of the synapse
Henstridge, C., JAckson, R., Kim, J., Herrmann, A., Wright, A. K., Harris, S., Bastin, M., Starr, J., Wardlaw, J., Gillingwater, T., Smith, C., McKenzie, C.-A., Cox, S., Deary, I. & Spires-Jones, T., 4 Sept 2015, In: Acta Neuropathologica Communications. 3, 53Research output: Contribution to journal › Article › peer-review
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Beyond a bigger brain: Multivariable structural brain imaging and intelligence
Ritchie, S., Booth, T., Valdes Hernandez, M., Corley, J., Munoz-Maniega, S., Gow, A., Royle, N., Pattie, A., Karama, S., Starr, J., Bastin, M., Wardlaw, J. & Deary, I., Jul 2015, In: Intelligence. 51, p. 47–56 10 p.Research output: Contribution to journal › Article › peer-review
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Coupled changes in brain white matter microstructure and fluid intelligence in later life
Ritchie, S. J., Bastin, M. E., Tucker-Drob, E. M., Munoz-Maniega, S., Engelhardt, L. E., Cox, S. R., Royle, N. A., Gow, A. J., Corley, J., Pattie, A., Taylor, A. M., Valdes Hernandez, M. D. C., Starr, J. M., Wardlaw, J. M. & Deary, I., 3 Jun 2015, In: The Journal of Neuroscience. 35, 22, p. 8672-8682 11 p.Research output: Contribution to journal › Article › peer-review
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Proton spectroscopic imaging of brain metabolites in basal ganglia of healthy older adults
Parikh, J., Thrippleton, M., Murray, C., Armitage, P., Harris, B., Andrews, P., Wardlaw, J., Starr, J., Deary, I. & Marshall, I., Jun 2015, In: Magnetic Resonance Materials in Physics, Biology and Medicine. 28, 3, p. 251-257Research output: Contribution to journal › Article › peer-review
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Is education associated with improvements in general cognitive ability, or in specific skills?
Ritchie, S. J., Bates, T. C. & Deary, I. J., May 2015, In: Developmental Psychology. 51, 5, p. 573-582 10 p.Research output: Contribution to journal › Article › peer-review
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Intelligence in childhood and atherosclerosis of the carotid and peripheral arteries in later life: The Lothian Birth Cohort 1936
Gale, C., Eadie, E., Thomas, A., Bastin, M., Starr, J., Wardlaw, J. & Deary, I., 27 Apr 2015, In: PLoS ONE. 10, 4, 7 p., e0125280.Research output: Contribution to journal › Article › peer-review
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Common genetic variants influence human subcortical brain structures
Hibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., Andersson, M., Aribisala, B. S., Armstrong, N. J., Bernard, M., Bohlken, M. M., Boks, M. P., Bralten, J., Brown, A. A., Mallar Chakravarty, M., Chen, Q. & Ching, C. R. K. & 272 others, , 9 Apr 2015, In: Nature. 520, 7546, p. 224-229 6 p.Research output: Contribution to journal › Article › peer-review
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Multi-Ethnic Genome-Wide Association Study of Cerebral White Matter Hyperintensities on MRI
Verhaaren, B. F. J., Debette, S., Bis, J. C., Smith, J. A., Ikram, M. K., Adams, H. H., Beecham, A. H., Rajan, K. B., Lopez, L. M., Barral, S., van Buchem, M. A., van der Grond, J., Smith, A. V., Hegenscheid, K., Aggarwal, N. T., de Andrade, M., Atkinson, E. J., Beekman, M., Beiser, A. S. & Blanton, S. H. & 82 others, , Apr 2015, In: Circulation: Cardiovascular Genetics. 8, 2, p. 398-+ 54 p.Research output: Contribution to journal › Article › peer-review
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Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data
Kochunov, P., Jahanshad, N., Marcus, D., Winkler, A., Sprooten, E., Nichols, T. E., Wright, S. N., Hong, L. E., Patel, B., Behrens, T., Jbabdi, S., Andersson, J., Lenglet, C., Yacoub, E., Moeller, S., Auerbach, E., Ugurbil, K., Sotiropoulos, S. N., Brouwer, R. M. & Landman, B. & 33 others, , 4 Mar 2015, In: NeuroImage. 111, p. 300-311 12 p.Research output: Contribution to journal › Article › peer-review
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Association of allostatic load with brain structure and cognitive ability in later life
Booth, T., Royle, N. A., Corley, J., Gow, A. J., Valdés Hernández, M. D. C., Munoz-Maniega, S., Ritchie, S. J., Bastin, M. E., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Mar 2015, In: Neurobiology of Aging. 36, 3, p. 1390-1399 10 p.Research output: Contribution to journal › Article › peer-review
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White matter hyperintensities and normal-appearing white matter integrity in the aging brain
Muñoz Maniega, S., Valdés Hernández, M. C., Clayden, J. D., Royle, N. A., Murray, C., Morris, Z., Aribisala, B. S., Gow, A. J., Starr, J. M., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., 28 Feb 2015, In: Neurobiology of Aging. 36, 2, p. 909-918 9 p.Research output: Contribution to journal › Article › peer-review
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Cigarette smoking and thinning of the brain's cortex
Karama, S., Ducharme, S., Corley, J., Chouinard-Decorte, F., Starr, J., Wardlaw, J., Bastin, M. & Deary, I., 10 Feb 2015, In: Molecular Psychiatry. 20, p. 778–785Research output: Contribution to journal › Article › peer-review
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Compensation or inhibitory failure? Testing hypotheses of age-related right frontal lobe involvement in verbal memory ability using structural and diffusion MRI
Cox, S. R., Bastin, M. E., Ferguson, K. J., Allerhand, M., Royle, N. A., Munoz-Maniega, S., Starr, J. M., MacLullich, A. M. J., Wardlaw, J. M., Deary, I. J. & MacPherson, S. E., Feb 2015, In: Cortex. 63, p. 4-15 12 p.Research output: Contribution to journal › Article › peer-review
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Automated segmentation of multifocal basal ganglia T2*-weighted MRI hypointensities
Glatz, A., Bastin, M., Kiker, A., Deary, I., Wardlaw, J. & Hernandez, M. D. C. V., 15 Jan 2015, In: NeuroImage. 105, p. 332-346 15 p.Research output: Contribution to journal › Article › peer-review
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Exploratory analysis of dietary intake and brain iron accumulation detected using magnetic resonance imaging in older individuals: the Lothian Birth Cohort 1936
Valdes Hernandez, M., Allan, J., Glatz, A., Kyle, J., Corley, J., Brett, C., Munoz-Maniega, S., Royle, N., Bastin, M., Starr, J., Deary, I. & Wardlaw, J., Jan 2015, In: The journal of nutrition, health & aging (JNHA). 19, 1, p. 64-69Research output: Contribution to journal › Article › peer-review
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A comparison of location of acute symptomatic versus 'silent' small vessel lesions
Valdes Hernandez, M., Maconick, L. C., Munoz-Maniega, S., Wang, X., Wiseman, S., Armitage, P., Doubal, F., Makin, S., Sudlow, C., Dennis, M., Deary, I., Bastin, M. & Wardlaw, J., 2015, In: International Journal of Stroke. 10, p. 1044–1050Research output: Contribution to journal › Article › peer-review
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Brain white matter integrity and cortisol in older men: the Lothian Birth Cohort 1936
Cox, S. R., Bastin, M. E., Ferguson, K. J., Munoz-Maniega, S., MacPherson, S. E., Deary, I. J., Wardlaw, J. M. & MacLullich, A. M. J., 2015, In: Neurobiology of Aging. 36, 1, p. 257-264 8 p.Research output: Contribution to journal › Article › peer-review
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Genes from a translational analysis support a multifactorial nature of white matter hyperintensities
Lopez, L., Hill, W. D., Harris, S. E., Valdes Hernandez, M., Munoz-Maniega, S., Bastin, M., Bailey, E. L., Smith, C., McBride, M. W., Mcclure, J. D., Graham, D., Dominiczak, A. F., Yang, Q., Fornage, M., Ikfram, M., Debette, S., Launer, L., Bis, J. C., Schmidt, R. & Seshadri, S. & 4 others, , 2015, In: Stroke. 46, 2, p. 341-347 7 p.Research output: Contribution to journal › Article › peer-review
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Structural brain MRI trait polygenic score prediction of cognitive abilities
Generation Scotland & SINAPSE Collaborative Grp, 2015, In: Twin Research and Human Genetics. 18, p. 738-745 8 p.Research output: Contribution to journal › Article › peer-review
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2014
Personality, Health, and Brain Integrity: The Lothian Birth Cohort Study 1936
Booth, T., Mõttus, R., Corley, J., Gow, A. J., Henderson, R. D., Munoz-Maniega, S., Murray, C., Royle, N. A., Sprooten, E., Hernández, M. C. V., Bastin, M. E., Penke, L., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Dec 2014, In: Health Psychology. 33, 12, p. 1477-1486 10 p.Research output: Contribution to journal › Article › peer-review
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Correlational structure of ‘frontal’ tests and intelligence tests indicates two components with asymmetrical neurostructural correlates in old age
Cox, S. R., MacPherson, S. E., Ferguson, K. J., Nissan, J., Royle, N. A., Maclullich, A. M. J., Wardlaw, J. M. & Deary, I. J., 1 Sept 2014, In: Intelligence. 46, p. 94-106Research output: Contribution to journal › Article › peer-review
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Potential effect of skull thickening on the associations between cognition and brain atrophy in ageing
Aribisala, B. S., Royle, N. A., Valdés Hernández, M. C., Murray, C., Penke, L., Gow, A., Munoz-Maniega, S., Starr, J. M., Bastin, M., Deary, I. & Wardlaw, J., Sept 2014, In: Age and Ageing. 43, 5, p. 712-716 5 p.Research output: Contribution to journal › Article › peer-review
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Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling
Kochunov, P., Jahanshad, N., Sprooten, E., Nichols, T. E., Mandl, R. C., Almasy, L., Booth, T., Brouwer, R. M., Curran, J. E., de Zubicaray, G. I., Dimitrova, R., Duggirala, R., Fox, P. T., Elliot Hong, L., Landman, B. A., Lemaitre, H., Lopez, L., Martin, N. G., McMahon, K. L. & Mitchell, B. D. & 21 others, , 15 Jul 2014, In: NeuroImage. 95, p. 136-150 15 p.Research output: Contribution to journal › Article › peer-review
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Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function
Tang, W., Kowgier, M., Loth, D. W., Soler Artigas, M., Joubert, B. R., Hodge, E., Gharib, S. A., Smith, A. V., Ruczinski, I., Gudnason, V., Mathias, R. A., Harris, T. B., Hansel, N. N., Launer, L. J., Barnes, K. C., Hansen, J. G., Albrecht, E., Aldrich, M. C., Allerhand, M. & Barr, R. G. & 59 others, , 1 Jul 2014, In: PLoS ONE. 9, 7, p. e100776Research output: Contribution to journal › Article › peer-review
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The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data
Alzheimer's Dis Neuroimaging, EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study SYS Grp, Thompson, P. M., Stein, J. L., Medland, S. E., Hibar, D. P., Vasquez, A. A., Renteria, M. E., Toro, R., Jahanshad, N., Schumann, G., Franke, B., Wright, M. J., Martin, N. G., Agartz, I., Alda, M., Alhusaini, S. & Almasy, L. & 34 others, , Jun 2014, In: Brain imaging and behavior. 8, 2, p. 153-182 30 p.Research output: Contribution to journal › Article › peer-review
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Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old age
Karama, S., Bastin, M. E., Murray, C., Royle, N. A., Penke, L., Munoz-Maniega, S., Gow, A. J., Corley, J., Valdés Hernández, M., Lewis, J. D., Rousseau, M.-E., Lepage, C., Fonov, V., Collins, D. L., Booth, T., Rioux, P., Sherif, T., Adalat, R., Starr, J. M. & Evans, A. C. & 2 others, , May 2014, In: Molecular Psychiatry. 19, 5, p. 555-559 5 p.Research output: Contribution to journal › Article › peer-review
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Quantitative multi-modal MRI of the hippocampus and cognitive ability in community-dwelling older subjects
Aribisala, B., Royle, N., Munoz-Maniega, S., Valdes Hernandez, M., Murray, C., Penke, L., Gow, A., Starr, J., Bastin, M., Deary, I. & Wardlaw, J., Apr 2014, In: Cortex. 53C, p. 34-44 11 p.Research output: Contribution to journal › Article › peer-review
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Blood Pressure, Internal Carotid Artery Flow Parameters, and Age-Related White Matter Hyperintensities
Aribisala, B., Morris, Z., Eadie, E., Thomas, A., Gow, A., Valdes Hernandez, M., Royle, N., Bastin, M., Starr, J., Deary, I. & Wardlaw, J., 8 Feb 2014, In: Hypertension. 63, 5, p. 1011-1018 8 p.Research output: Contribution to journal › Article › peer-review
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Circulating Inflammatory Markers Are Associated With Magnetic Resonance Imaging-Visible Perivascular Spaces But Not Directly With White Matter Hyperintensities
Aribisala, B. S., Wiseman, S., Morris, Z., Valdes Hernandez, M., Royle, N. A., Munoz-Maniega, S., Gow, A. J., Corley, J., Bastin, M. E., Starr, J., Deary, I. J. & Wardlaw, J. M., 7 Jan 2014, In: Stroke. 45, 2, p. 605-607 3 p.Research output: Contribution to journal › Article › peer-review
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A systematic review of brain frontal lobe parcellation techniques in magnetic resonance imaging
Cox, S. R., Ferguson, K. J., Royle, N. A., Shenkin, S. D., MacPherson, S. E., Maclullich, A. M. J., Deary, I. J. & Wardlaw, J. M., Jan 2014, In: Brain Structure and Function. 219, 1, p. 1-22 22 p.Research output: Contribution to journal › Article › peer-review
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Morphologic, distributional, volumetric, and intensity characterization of periventricular hyperintensities
Hernández, M. C. V., Piper, R. J., Bastin, M. E., Royle, N. A., Munoz-Maniega, S., Aribisala, B. S., Murray, C., Deary, I. J. & Wardlaw, J. M., Jan 2014, In: American Journal of Neuroradiology. 35, 1, p. 55-62 8 p.Research output: Contribution to journal › Article › peer-review
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Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities
Wardlaw, J. M., Allerhand, M., Doubal, F. N., Valdes Hernandez, M., Morris, Z., Gow, A. J., Bastin, M., Starr, J. M., Dennis, M. S. & Deary, I. J., 2014, In: Neurology. 82, p. 1331-1338Research output: Contribution to journal › Article › peer-review
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2013
Brain white matter damage in aging and cognitive ability in youth and older age
Valdés Hernández, M. D. C., Booth, T., Murray, C., Gow, A. J., Penke, L., Morris, Z., Munoz-Maniega, S., Royle, N. A., Aribisala, B. S., Bastin, M. E., Starr, J. M., Deary, I. J. & Wardlaw, J. M., Dec 2013, In: Neurobiology of Aging. 34, 12, p. 2740-2747 8 p.Research output: Contribution to journal › Article › peer-review
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Estimated maximal and current brain volume predict cognitive ability in old age
Royle, N. A., Booth, T., Valdés Hernández, M. C., Penke, L., Murray, C., Gow, A. J., Munoz-Maniega, S., Starr, J., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., Dec 2013, In: Neurobiology of Aging. 34, 12, p. 2726-2733 8 p.Research output: Contribution to journal › Article › peer-review
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Alzheimer's Disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936
Lyall, D. M., Royle, N. A., Harris, S. E., Bastin, M. E., Munoz-Maniega, S., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Valdes Hernandez, M., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., 15 Nov 2013, In: PLoS ONE. 8, 11, e80513.Research output: Contribution to journal › Article › peer-review
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Associations between level and change in physical function and brain volumes
Aribisala, B. S., Gow, A. J., Bastin, M. E., Valdes Hernandez, M., Murray, C., Royle, N. A., Munoz-Maniega, S., Starr, J. M., Deary, I. J. & Wardlaw, J. M., 12 Nov 2013, In: PLoS ONE. 8, 11, 9 p., 80386.Research output: Contribution to journal › Article › peer-review
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Brain White Matter Tract Integrity and Cognitive Abilities in Community-Dwelling Older People: The Lothian Birth Cohort, 1936
Booth, T., Bastin, M. E., Penke, L., Munoz-Maniega, S., Murray, C., Royle, N. A., Gow, A. J., Corley, J., Henderson, R. D., Hernández, M. D. C. V., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Sept 2013, In: Neuropsychology. 27, 5, p. 595-607 13 p.Research output: Contribution to journal › Article › peer-review
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Incidental Findings on Brain MR Imaging in Older Community-Dwelling Subjects Are Common but Serious Medical Consequences Are Rare: A Cohort Study
Sandeman, E. M., Valdes Hernandez, M. D. C., Morris, Z., Bastin, M. E., Murray, C., Gow, A. J., Corley, J., Henderson, R., Deary, I., Starr, J. M. & Wardlaw, J. M., 15 Aug 2013, In: PLoS ONE. 8, 8, 8 p., e71467.Research output: Contribution to journal › Article › peer-review
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Seropositivity for CMV and IL-6 levels are associated with grip strength and muscle size in the elderly
Kilgour, A. H. M., Firth, C., Harrison, R., Moss, P., Bastin, M. E., Wardlaw, J. M., Deary, I. J. & Starr, J. M., 13 Aug 2013, In: Immunity and Ageing. 10, 1, 8 p., 33.Research output: Contribution to journal › Article › peer-review
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Modeling multisystem biological risk in later life: Allostatic load in the lothian birth cohort study 1936: Modeling of Allostatic Load
Booth, T., Starr, J. M. & Deary, I., 1 Jul 2013, In: American Journal of Human Biology. 25, 4, p. 538-543 6 p.Research output: Contribution to journal › Article › peer-review
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Influence of thickening of the inner skull table on intracranial volume measurement in older people
Royle, N. A., Hernández, M. C. V., Maniega, S. M., Arabisala, B. S., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., Jul 2013, In: Magnetic Resonance Imaging. 31, 6, p. 918-922 5 p.Research output: Contribution to journal › Article › peer-review
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Neuroticism, depressive symptoms and white-matter integrity in the Lothian Birth Cohort 1936
McIntosh, A. M., Bastin, M. E., Luciano, M., Munoz-Maniega, S., Valdes Hernandez, M., Royle, N. A., Hall, J., Murray, C., Lawrie, S. M., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Jun 2013, In: Psychological Medicine. 43, 6, p. 1197-1206 10 p.Research output: Contribution to journal › Article › peer-review
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Brain atrophy associations with white matter lesions in the ageing brain: the Lothian Birth Cohort 1936
Aribisala, B. S., Valdes Hernandez, M. C., Royle, N. A., Morris, Z., Munoz-Maniega, S., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., Apr 2013, In: European Radiology. 23, 4, p. 1084-1092 9 p.Research output: Contribution to journal › Article › peer-review
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Assessing the performance of atlas-based prefrontal brain parcellation in an aging cohort
Aribisala, B. S., Cox, S. R., Ferguson, K. J., MacPherson, S. E., Maclullich, A. M. J., Royle, N. A., Valdés Hernández, M. C., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., Mar 2013, In: Journal of computer assisted tomography. 37, 2, p. 257-264 8 p.Research output: Contribution to journal › Article › peer-review
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ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936
Lyall, D. M., Lopez, L. M., Bastin, M. E., Munoz-Maniega, S., Penke, L., Hernandez, M. D. C. V., Royle, N. A., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., Jan 2013, In: Behavior Genetics. 43, 1, p. 13-23 11 p.Research output: Contribution to journal › Article › peer-review
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Characterization of multifocal T2*-weighted MRI hypointensities in the basal ganglia of elderly, community-dwelling subjects
Glatz, A., Valdés Hernández, M. C., Kiker, A. J., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., 2013, In: NeuroImage. 82, p. 470-480 11 p.Research output: Contribution to journal › Article › peer-review
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Close Correlation between Quantitative and Qualitative Assessments of White Matter Lesions
Hernandez, M. D. C. V., Morris, Z., Dickie, D., Royle, N. A., Munoz-Maniega, S., Aribisala, B. S., Bastin, M. E., Deary, I. J. & Wardlaw, J. M., 2013, In: Neuroepidemiology. 40, 1, p. 13-22 10 p.Research output: Contribution to journal › Article › peer-review
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2012
Brain white matter tract integrity as a neural foundation for general intelligence
Penke, L., Munoz-Maniega, S., Bastin, M., Valdes Hernandez, M., Murray, C., Royle, N., Starr, J., Wardlaw, J. & Deary, I., Oct 2012, In: Molecular Psychiatry. 17, 10, p. 1026-1030Research output: Contribution to journal › Article › peer-review
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Neuroprotective lifestyles and the aging brain Activity, atrophy, and white matter integrity
Gow, A. J., Bastin, M. E., Munoz-Maniega, S., Valdes Hernandez, M., Morris, Z., Murray, C., Royle, N. A., Starr, J. M., Deary, I. & Wardlaw, J. M., Oct 2012, In: Neurology. 79, 17, p. 1802-1808 7 p.Research output: Contribution to journal › Article › peer-review
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A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity
Lopez, L., Bastin, M. E., Munoz-Maniega, S., Penke, L., Davies, G., Christoforou, A., Valdes Hernandez, M., Royle, N. A., Tenesa, A., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., Aug 2012, In: Neurobiology of Aging. 33, 8, p. 1847.e1–1847.e14 14 p.Research output: Contribution to journal › Article › peer-review