Research output per year
Research output per year
Project Details
Key findings
SynthSys research directly funded by this award published 110 primary papers and 13 reviews, generating many new theoretical tools and experimental methods, as well as revealing for the first time how yeast transcription pauses at a splicing checkpoint, how mouse macrophage cells downregulate cholesterol synthesis as an antiviral defense, and that eukaryotic cells have a paradigm-shifting, non-transcriptional 24-hour clock.
SynthSys created durable research platforms for biochemistry and quantitative proteomics (the Kinetic Parameter Facility, KPF), for informatics (SBSI and online repositories BioDare and PlaSMo), and for interdisciplinary research management.
SynthSys created a new, sustainable Centre for interdisciplinary biology, attracting £22.4M further external funding and new academic staff, and thus doubling the number of Systems Biology research groups at the University of Edinburgh.
SynthSys created durable research platforms for biochemistry and quantitative proteomics (the Kinetic Parameter Facility, KPF), for informatics (SBSI and online repositories BioDare and PlaSMo), and for interdisciplinary research management.
SynthSys created a new, sustainable Centre for interdisciplinary biology, attracting £22.4M further external funding and new academic staff, and thus doubling the number of Systems Biology research groups at the University of Edinburgh.
| Acronym | SynthSys; formerly CSBE |
|---|---|
| Status | Finished |
| Effective start/end date | 8/01/07 → 31/12/12 |
| Links | http://www.synthsys.ed.ac.uk |
Funding
- BBSRC: £11,114,199.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
Research output
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The circadian clock gene circuit controls protein and phosphoprotein rhythms in Arabidopsis thaliana
Krahmer, J., Hindle, M., Perby, L. K., Mogensen, H. K., Nielsen, T. H., Halliday, K. J., VanOoijen, G., LeBihan, T. & Millar, A. J., 1 Jan 2022, In: Molecular & Cellular Proteomics (MCP). 21, 1, 20 p., 100172.Research output: Contribution to journal › Article › peer-review
Open AccessFile -
Period estimation and rhythm detection in timeseries data using BioDare2, the free, online, community resource
Zieliński, T., Hay, J. & Millar, A. J., 22 Oct 2021, (E-pub ahead of print) Plant Circadian Networks: Methods and Protocols. Springer, Vol. 2398. p. 15-32 18 p. (Methods in molecular biology (Clifton, N.J.)).Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review
Open AccessFile -
Circadian protein regulation in the green lineage II. The clock gene circuit controls a phospho-dawn in Arabidopsis thaliana
Krahmer, J., Hindle, M., Perby, L. K., Nielsen, T. H., Van Ooijen, G., Halliday, K. J., Bihan, T. L. & Millar, A. J., 8 Sept 2019, bioRxiv, at Cold Spring Harbor Laboratory.Research output: Working paper
Open Access
Datasets
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Temporal analysis of RNA turnover in Interferon Gamma treated bone marrow-derived macrophages
Robertson, K. (Creator) & Ghazal, P. (Creator), National Center for Biotechnology Information (Gene Expression Omnibus), 7 Mar 2016
DOI: 10.7488/210e1946-2590-49ec-8a1d-a31667d1b3bb, https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE63290 and one more link, http://10.1371/journal.pbio.1002364 (show fewer)
Dataset
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Spatiotemporal clock patterns in the leaf blade
Millar, A. (Creator), Wenden, B. (Creator) & Hodge, S. (Creator), Edinburgh DataShare, 4 May 2021
DOI: 10.7488/ds/3030, https://www.pnas.org/content/early/2012/04/09/1118814109
Dataset
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Data, Code and Models for Flis et al. RS Open Biology 2015
Millar, A. (Creator), Zielinski, T. (Data Manager), Flis, A. (Creator), Mengin, V. (Creator), Stitt, M. (Creator), Fernández, A. P. (Creator), McWatters, H. G. (Creator) & Halliday, K. (Creator), The Royal Society, 2015
https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820611467827 and 30 more links, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820610743262, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820611319996, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820611188065, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820611587928, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820606741450, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12820610913763, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13228354371807, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12962296599986, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=12962294335805, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=2841, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=2842, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=2843 , https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13228298288040, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13227619871305, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13228357183121, http://sourceforge.net/projects/biodare/, http://www.biodare.ed.ac.uk, http://sourceforge.net/projects/sbsi/, http://www.sbsi.ed.ac.uk, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_71&version=1, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_71&version=2, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1041&version=1, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1042&version=1, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1043&version=1, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1044&version=1, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13227622661196, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=13228357183121, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=3488, https://www.biodare.ed.ac.uk/robust/ShowExperiment.action?experimentId=3492, http://www.plasmo.ed.ac.uk/plasmo/models/model.shtml?accession=PLM_1045&version=1 (show fewer)
Dataset
Activities
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Invited talk: Using linked models to understand how clock gene sequences build whole-organism traits
Andrew Millar (Invited speaker)
Jul 2022Activity: Academic talk or presentation types › Invited talk
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Hutton seminar: "Watching plant clock genes run the organism, to understand growth and selection in crops"
Andrew Millar (Invited speaker)
6 Jun 2018Activity: Academic talk or presentation types › Invited talk
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External examiner for Ph.D.: Understanding the Complex Dynamics of the Molecular Circadian Clock and Designing a Metric of Clock Disruption in Cancer
Andrew Millar (Examiner)
18 May 2018Activity: Examination types › External Examiner or Assessor